Alexander KC Leung1*, Amy AM Leung2 and Benjamin Barankin3
1Clinical Professor of Pediatrics, The University of Calgary, The Alberta Children's Hospital, Calgary, Alberta, Canada
2Medical Student, Faculty of Medicine and Dentistry, University of Alberta Edmonton, Alberta, Canada
3Dermatologist & Medical Director, Toronto Dermatology Centre, Toronto, Ontario, Canada
Received: 30 July, 2015; Accepted: 08 September, 2015; Published: 10 September, 2015
Dr Alexander KC Leung, Clinical Professor of Pediatrics, The University of Calgary, Pediatric Consultant, The Alberta Children's Hospital, #200, 233-16th Avenue NW, Calgary, Alberta, Canada, T2M 0H5, Tel: (403) 230 3300; Fax: (403) 230-3322; E-mail:
Leung AKC, Leung AAM, Barankin B (2015) Schamberg Disease in a 54-Year-Old Chinese Woman. Int J Dermatol Clin Res 1(2): 018-019. DOI: 10.17352/2455-8605.000008
© 2015 Leung AKC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Schamberg purpura; Progressive pigmentary purpura; Chinese
Schamberg disease, also known as Schamberg purpura or progressive pigmentary purpura, is characterized by orange-brown or reddish-brown macules/patches with overlaying purpuric spots simulating “cayenne pepper”. We report a 54-year-old Chinese woman with Schamberg disease presenting with purpuric macules and patches of varying sizes on the ankles, legs, and knees. The lesions were nonblanchable and nonpalpable and asymptomatic. Close inspection of the lesions revealed pinpoint petechiae resembling grains of cayenne pepper superimposed on the reddish-brown macules/patches. To our knowledge, Schamberg disease has not been reported in the scientific literature in Chinese patients.
Schamberg disease, also known as Schamberg purpura or progressive pigmentary purpura, is characterized by orange-brown or reddish-brown macules/patches with overlaying purpuric spots simulating “cayenne pepper” [1,2]. The condition was first described in 1901 by Jay Frank Schamberg who reported a 15-year-old boy with a 5-year history of “diffuse, reddish-brown, non-elevated, irregular oval patches with borders consisting of pin-head size, reddish-brown, scarcely elevated puncta or cayenne-pepper spots” . The condition now bears his name. To our knowledge, Schamberg disease has not been reported in Chinese patients. The purpose of this communication is to alert the medical profession to the existence of this condition in Chinese patients so that the diagnosis would not be overlooked.
A 54-year-old Chinese woman presented with a 2-month history of an asymptomatic, erythematous eruption on her legs. The lesions began on her ankles and spread proximally to the legs and knees. The patient noted steady accumulation of new lesions and their coalescence into wider areas of discoloration. There was no history of recent fever, upper respiratory tract infection, and trauma or drug intake. The patient was diagnosed with an adenocarcinoma in the ascending colon 3 years ago and had a right hemicolectomy performed. The post-operative course was uneventful. She had no known allergies. Family history was negative of similar skin findings or any bleeding disorder.
Physical examination revealed purpuric macules and patches of varying sizes on the ankles, legs, and knees (Figure 1). The lesions were nonblanchable and nonpalpable. Close inspection of the lesions revealed pinpoint petechiae resembling grains of cayenne pepper superimposed on the reddish-brown macules/patches. The rest of the physical examination was unremarkable.
- Can B, Turkoglu Z, Kavala M, Zindanci I, Kural E (2011) Successful treatment of generalized childhood Schamberg's disease with narrowband ultraviolet B therapy. Photodermatol Photoimmunol Photomed 27: 216-218.
- Torrelo A, Requena C, Mediero IG, Zambrano A (2003) Schamberg disease in children: a review of 13 cases. J Am Acad Dermatol 48: 31-33.
- Schamberg JF (1901) A peculiar progressive pigmentary disease of the skin. Br J Dermatol 13: 1-5.
- Basak PY, Ergin S (2001) Should pentoxifylline be regarded as an effective treatment for Schamberg's disease? J Am Acad Dermatol 44: 548-549.
- Park JH, Kang HY (2013) Generalized Schamberg disease in a child. Ann Dermatol 28: 524-525.
- Bauman ML, Steiner I (1980) Schamberg's disease: a review of the literature and case report. J Am Podiatry Assoc 70: 508-511.
- Kanwar AJ, Thami GP (1999) Familial Schamberg's disease. Dermatology 198: 175-176.
- Nagata K, Danno K, Tanaka S (1999) Unilateral Schamberg disease in a 14-year-old Japanese boy. J Dermatol 26: 348-351.