Kanagaraja Karunakaran Parathan*
Department of Internal Medicine, Clinical Hematology Division, Bone Marrow Transplant, PGIMER, India
Received: 20 June, 2016; Accepted: 05 October, 2016; Published: 06 October, 2016
Dr, Kanagaraja Karunakaran Parathan, Clinical Hematology Division, Department of Internal Medicine, Bone Marrow Transplant, PGIMER, India, E-mail:
Parathan KK (2016) A Synchronous Presentation of AITL with Adenocarcinoma of Lung. Int J Immunother Cancer Res 2(1): 011-013. 10.17352/2455-8591.000009
© 2016 Parathan KK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
AITL; Adenocarcinoma; Lung nodule; Synchronous malignancy
Angioimmunoblastic T-cell lymphoma (AITL) is a frequent subtype of peripheral T – cell lymphoma (PTCL) characterized by generalized lymphadenopathy, hepatosplenomegaly, and frequent B - symptoms. Extranodal manifestations are quite common in this subtype of Non Hodgkins Lymphoma which is characterized by frequent skin involvement. However, the extranodal disease should be evaluated thoroughly and a tissue diagnosis must be obtained to confirm lymphomatous involvement when the presentation is not classical. Here we report a case of AITL who presented with lung mass suspected to be due to lymphomatous involvement, but turned out to be a synchronous presentation of an adenocarcinoma of the lung. The possible relation between the two conditions is also elucidated.
Angioimmunoblastic T-cell lymphoma usually presents in Stage III or IV disease and pulmonary involvement is seen in up to 10% of these cases . However all pulmonary masses in these patients are not due to lymphoma. Any atypical lung mass, even in a proven case of disseminated lymphoma, should be subjected to pathologic evaluation for exact characterization of its nature.
A 62-year-old man presented with progressive dyspnea and fever for two months. The physical examination revealed generalized lymphadenopathy with ascites, bilateral pleural effusion and pedal edema. He also had bilateral wheezes and hepatosplenomegaly. Hemogram revealed microcytic hypochromic anemia. (Hb = 8.8g/dl, MCV = 74.3fL & PCV = 30 %), platelet count of 108*109/L and WBC count of 11.3*109/L with eosinophilia (Neutrophils 74%, Lymphocytes 10%, Monocytes 6%, Eosinophils 10%). Renal and liver function tests were normal. Chest X-ray revealed an opacity in the right upper lobe (Figure 1A).
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