Mediastinal Tuberculosis Lymphadenitis during Anti-TNF Therapy - Case Report

Bruno Cesar da Silva, Fabio Carneiro Vosqui Nascimento, Sonyara Rauedys Oliveira Lisboa, Eduardo Antonio Gonçalves Ramos, Valdiana Cristina Surlo, Tatiana Senna Galvão Nonato Alves and Genoile Oliveira Santana

Tuberculosis is described during the use of monoclonal antibodies against tumour necrosis factor (TNF) for Crohn’s disease treatment. We report a case of a 44 year old man that developed fever, night sweats and weight loss during immunosuppressive and anti-TNF therapy for Crohn’s disease. After extensive investigation we performed mediastinoscopy with biopsy of the paratracheal lymph node. A istopathological study revealed caseous necrosis. The patient improved after therapy against tuberculosis. During anti-TNF therapy, the diagnosis of tuberculosis may be mainly difficult when an atypical location is present. Clinical skills are important mainly in countries where tuberculosis is endemic.

Keywords: Inflammatory bowel disease; Anti-TNF;Tuberculosis

Published on: Oct 14, 2015 Pages: 38-40

Full Text PDF Full Text HTML DOI: 10.17352/2455-2283.000008
Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos CrossMark