Cytokine Production and Human Cytomegalovirus Load in Allogeneic Hematopoietic Stem Cell Transplantation Outcome

TA Silva**, JF Correia-Silva, RG Resende, MHNG Abreu, AL Teixeira, H Bittencourt, RS Gomez

Objective: To investigate the impact of cytokine levels (IL-1β, IL-6, IL-10, IFN-γ and TNF-α) and Human cytomegalovirus (HCMV) load in the saliva and blood on the survival of  llogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients.

Study Design: Samples were obtained from 63 patients 7 days before and 21 days after allo-HSCT. Cytokine levels were assessed by ELISA, and HCMV load was determined by real- me PCR.

Results: The increase of IL-6 in the saliva and the reduction of IFN-γ in the blood before allo-HSCT were associated with increased risk of death. Moreover, the increase of IL-6 in the blood and of HCMV in the saliva after allo-HSCT were also associated with increased risk of death.

Conclusions: Cytokine levels and HCMV load were associated with the increased risk of death. The findings suggest a potential function of these biomarkers in the determination of allo-HSCT survival.

Keywords: Allogeneic HSCT; Cytokines; HCMV; Surviva

Published on: Jun 17, 2016 Pages: 3-10

Full Text PDF Full Text HTML DOI: 10.17352/2455-8591.000008
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