Open Access Research Article Article ID: IJVSR-5-133

    Does Dexmedetomidine Protect the Visceral Organs against the Asphxia

    Ayse Mizrak*

    Background: This study was conducted to determine whether dexmedetomidine exhibits a protective effect against sudden and short term hypoxia on brain, heart, lung, liver, and kidney in rat model which sudden hyperglycemia and hypertension developed.

    Methods: In this randomised and double blind study, the experiment was performed on 30 male Wistar Albino rats 250-300 g weight. The rats were randomly assigned into 2 groups which are control group (C, n = 15), and dexmedetomidine group (D, n = 15). All rats were made hyperglycemic by a single injection of streptozotocin (STZ) (50 mg/kg) then, adrenalin (0.03 mg/kg) was injected intraperitonealy to make sudden hypertension. Dexmedetomidine (10 µg/kg/min, total dose 2.5-3.3 µg) was infused intraperitonealy in group D, and saline to group C. They were sacrified until observing siyanosis on the feet and stopping the body movement. 

    Results: The incidence of liver’s congession (p=0.01) and the incidence of schistocytes (p=0.4) in group C were significantly higher than in group D. The grade of congession in group C was significantly higher than in group D (p=0.004). In group C, the mean arterial blood pressure (MAP) (p= 0.0001), heart rate (HR) (p= 0.004), and the blood glucose (p= 0.0001) values after-experiments period were significantly higher than the values before-experiments period. 

    Conclusions: Dexmedetomidine 10 µg/kg/min could protect the liver against the congession and lung against the severe congession but could not protect the brain, heart and kidney in hyperglycemic and hypertensive rat model.


    Published on: Jan 6, 2019 Pages: 1-6

    Full Text PDF Full Text HTML DOI: 10.17352/ijvsr.000033
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