Acute Effect of Aliskiren on Smoking-Induced Endothelial Dysfunction in Smoker

Haruhito Adam Uchida*, Hatsuzo Uchida and Jun Wada

Background: We aimed to examine the acute effect of aliskiren on smoking-induced endothelial dysfunction in smoker.

Methods: Nineteen male smokers were enrolled. After all participants smoked a cigarette, their endothelial function was assessed with brachial artery flow mediated dilation (FMD). An hour after the administration of aliskiren, they smoked again, their FMD was assessed again. A month later, all measurements were performed again without the administration of aliskiren as a control. Blood pressure, plasma renin activity, and serum interleukin-6 concentration were also examined at the same time of FMD measurement.

Results: A cigarette smoking led to an acute endothelial dysfunction (6.5 ± 1.7% to 3.4 ± 1.0 %, P = 0.02). Aliskiren administration significantly suppressed blood pressure and plasma renin activity, furthermore, improved FMD (6.7 ± 0.5% to 8.1 ± 0.8 %, P = 0.03). Aliskiren significantly reduced serum interleukin-6 concentration, but not in control.

Conclusion: Aliskiren has a beneficial effect on smoking-induced acute endothelial dysfunction.

Keywords: Endothelial function; Smoking; Aliskiren; Interleukin-6

Published on: Oct 27, 2014 Pages: 38-41

Full Text PDF Full Text HTML DOI: 10.17352/2455-2976.000010