Open Access Research Article Article ID: JHCSR-1-106

    Development of Mucoadhesive Gel Microbicide to Target Mucosal HIV Reservoirs

    Ranjita Shegokar and Kamalinder K Singh*

    The wide use of microbicide is mainly depends on its effectiveness, less frequent application,

    ready availability and most importantly cost. The aim of this work was to develop affordable microbicide

    mucoadhesive gel formulation of synthetic anti HIV drug, stavudine and to characterise it in terms

    of its physical properties, mucoadhesiveness and spreadability. The purpose of the present study

    was also to compare different dissolution media used for in vitro release of vaginal dosage form. The

    gels were tested for antimicrobial, spermicidal and anti-HIV activity. Gels prepared using Carbopols

    and Polycarbophil were transparent and homogenous and had excellent mucoadhesion index - and

    showed fast drug release profile. Gels showed very good antimicrobial action against pathological



    Published on: Dec 18, 2014 Pages: 27-33

    Full Text PDF Full Text HTML DOI: 10.17352/2455-3786.000006
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