Abstract

    Open Access Research Article Article ID: JHCSR-5-127

    Predictors of mortality among adult patients enrolled on Antiretroviral Therapy in Hiwotfana specialized University Hospital, Eastern Ethiopia: Retrospective Cohort study

    Endalkachew Mekonnen Eticha, Ashenafi Beru Gemeda

    Objective: Mortality of Human Immunodeficiency Virus (HIV)- infected patients have been reduced substantially since the introduction of Antiretroviral Therapy (ART). However, many studies have shown high mortality. But the factors associated with this high mortality are poorly characterized. So this retrospective cohort study aims to determine mortality and identify predictors of it among patients on ART at Hiwotfana specialized university Hospital (HFSUH).

    Result: A total of 61 (11.9%) deaths were observed giving an overall mortality rate of 2.8 per 100 person years. Advanced WHO stages (hazard ratio (HR) =3.44, 95% CI: 1.73 - 6.85), baseline CD4 count less than 200cells/mm3 (HR=3.18, 955 CI: 1.671- 6.06), regimen changed (HR=23.62, 95% CI: 9.95 - 56.05), and being anemic (HR=3.23, 95% CI: 1.71 - 6.11) were the independent predictors of mortality. Patients who started AZT based initial regimen had a lower risk of mortality (HR=0.29, 95% CI=0.13 - 0.64) when compared with the D4T based regimen.

    Keywords:

    Published on: Nov 10, 2018 Pages: 7-11

    Full Text PDF Full Text HTML DOI: 10.17352/2455-3786.000027
    Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos CrossMark

    Global Views

    Case Reports

    Peertechz Tweets

    Pinterest on JHCSR