Open Journal of Pharmacology and Pharmacotherapeutics

    Abstract

    Open Access Review Article Article ID: OJPP-3-107

    Mini review on emerging methods of preparation of liposome and its application as Liposome drug delivery systems

    Ateeq Rahman*, Veikko Uahengo and Daniel Likius

    Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were fi rst

    described in the mid-60s. Nowadays, they are a very useful reproduction, reagent, and device in various

    scientifi c disciplines, including medicine, chemistry, biochemistry, colloid science, biology, physics,

    biophysics, mathematics and theoretical. After the initial discoveries liposomes have made their way to

    the market. Among numerous brilliant new drug delivery systems developed, liposomes characterize an

    advanced technology to deliver active molecules to the site of action, and at present, several formulations

    are in clinical use. Research on liposome technology has progressed from conventional vesicles to

    ‘second-generation liposomes’, in which long-circulating liposomes are obtained by modulating the lipid

    composition, size, and charge of the vesicle. Liposomes with modifi ed surfaces have also been developed

    using several molecules, such as glycolipids or sialic acid. This paper mini review summarizes exclusively

    Nano-lipids, its applications in medicine scalable techniques in treating dreadful diseases cancer, AIDS,

    paralysis etcand focuses on strengths, respectively, limitations in respect to industrial applicability and

    regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.

    Keywords: Liposome; Drug delivery; Methods; Cell; Carriers

    Published on: Oct 26, 2018 Pages: 5-21

    Full Text PDF Full Text HTML DOI: 10.17352/ojpp.000007
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