Background:Ovarian granulosa cell tumours are low-grade malignant sex cord-stromal tumours. They represent 2 to 3% of all ovarian cancers and occur mainly within the adult population.
Aim: to provide an updated overview on ovarian adult granulosa cell tumours.Patients
Methods:in our retrospective study, we reviewed seven cases of adult granulosa cell tumours that were diagnosed at the pathology department of Mongi Slim hospital over a fourteen-year period (2002- 2015). Clinical and pathRIiological characteristics were retrospectively analyzed.
Results: The patients of our series ranged in age between 39 and 64 years (mean = 53 years). The most common presenting symptom was abnormal uterine bleeding (n=5) followed by pelvic pain (n=4). All patients underwent surgical treatment including total hysterectomy with bilateral salpingo-oophorectomy (n=4), hysterectomy with right salpingo-oophorectomy (n=1) and salpingo-oophorectomy (n=2). Histopathological examination of the surgical specimen confirmed the diagnosis of adult granulosa cell tumour in all cases.
Conclusions:Adult granulosa cell tumours of the ovary are considered as low grade malignancies with a relatively more favourable prognosis compared with much more commonly encountered epithelial ovarian tumours. A prolonged post-therapeutic follow-up is necessary because of the risk of recurrences.
Published on: Dec 24, 2015 Pages: 13-16
Wei Min HUANG
Nanyang Technological University, Singapore
Archive of Biomedical Science and Engineering
Osmar Antonio Centurion
Asuncion National University, Paraguay
Global Journal of Medical and Clinical Case Reports
Metaxas Memorial Anticancer Hospital , Greece
Annals of Bone Marrow Research
Malgorzata Gabriela WASNIEWSKA
University of Messina, Italy
International Journal of Clinical Endocrinology and Metabolism
ReGenera R&D International for Aging Intervention & San Babila Clinic, Milano, Italy
Archives of Clinical Gastroenterology