Background:Ovarian granulosa cell tumours are low-grade malignant sex cord-stromal tumours. They represent 2 to 3% of all ovarian cancers and occur mainly within the adult population.
Aim: to provide an updated overview on ovarian adult granulosa cell tumours.Patients
Methods:in our retrospective study, we reviewed seven cases of adult granulosa cell tumours that were diagnosed at the pathology department of Mongi Slim hospital over a fourteen-year period (2002- 2015). Clinical and pathRIiological characteristics were retrospectively analyzed.
Results: The patients of our series ranged in age between 39 and 64 years (mean = 53 years). The most common presenting symptom was abnormal uterine bleeding (n=5) followed by pelvic pain (n=4). All patients underwent surgical treatment including total hysterectomy with bilateral salpingo-oophorectomy (n=4), hysterectomy with right salpingo-oophorectomy (n=1) and salpingo-oophorectomy (n=2). Histopathological examination of the surgical specimen confirmed the diagnosis of adult granulosa cell tumour in all cases.
Conclusions:Adult granulosa cell tumours of the ovary are considered as low grade malignancies with a relatively more favourable prognosis compared with much more commonly encountered epithelial ovarian tumours. A prolonged post-therapeutic follow-up is necessary because of the risk of recurrences.
Published on: Dec 24, 2015 Pages: 13-16