Introduction: The present work aimed to investigate the association between G10398A polymorphism in mtDNA with type 2 diabetes mellitus (T2DM) susceptibility among Chinese northwestern population.
Methods: Polymerase chain reaction followed by the restriction digestion of the amplicon to clarify the restriction fragment length polymorphism (PCR-RFLP) was used to score the G10398A variation of mtDNA NADH dehydrogenase3 (ND3) locus in a case-control study (n=422), including 209 patients with T2DM and 213 healthy controls.
Results: The genotypes of G10398A were AA, AG, GG and the frequencies of genotypes and allele distributions were not significantly different in T2DM patients compared to healthy controls (P>0.05, χ2 test). There were no significant differences between genotypes and clinic indicators (P>0.05, single factor analysis of variance).
Conclusions: The findings indicated that G10398A SNPs in ND3 locus of mtDNA were not in association with T2DM susceptibility in this population.
Published on: May 4, 2016 Pages: 14-17
Huazong University of Science and Technology, China
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Southeastern University, China
Peertechz Journal of Computer Science and Engineering
Cardiometabolic Research Institute, USA
Journal of Cardiovascular Medicine and Cardiology
Dr. Pierre Guertin
Laval University, Canada
Peertechz Journal of Gerontology and Geriatric Research
Saint Joseph Hospital , Germany
Journal of Neurology, Neurological Science and Disorders