Down syndrome (trisomy 21) is the most common autosomal chromosome aberration in human. The incidence of the syndrome varies in 1:700 and 1:1000 live births according to various studies, with 20% of cases. In aborted material proportion is even higher, with 60% of cases. While 20% of cases with Down syndrome are stillborn.
In these patients, there is a strong predisposition to cardiovascular disease, seizures , leukemia[2,3], infections with hepatitis B virus (especially within institutionalized men), upper respiratory tract infections , Alzheimer’s disease, obesity , thyroid diseases , cardiac anomalies , and obstructive sleep apnea [10,11]. Disruption of the proteostasis network and accumulation of misfolded proteins occur as a result of an abnormality in the number of hromosome 21 . Errors in protein homeostasis could contribute to the observed pathology and decreased cell viability in children with Down syndrome .
Published on: Aug 9, 2017 Pages: 58-60