Down syndrome (trisomy 21) is the most common autosomal chromosome aberration in human. The incidence of the syndrome varies in 1:700 and 1:1000 live births according to various studies, with 20% of cases. In aborted material proportion is even higher, with 60% of cases. While 20% of cases with Down syndrome are stillborn.
In these patients, there is a strong predisposition to cardiovascular disease, seizures , leukemia[2,3], infections with hepatitis B virus (especially within institutionalized men), upper respiratory tract infections , Alzheimer’s disease, obesity , thyroid diseases , cardiac anomalies , and obstructive sleep apnea [10,11]. Disruption of the proteostasis network and accumulation of misfolded proteins occur as a result of an abnormality in the number of hromosome 21 . Errors in protein homeostasis could contribute to the observed pathology and decreased cell viability in children with Down syndrome .
Published on: Aug 9, 2017 Pages: 58-60
William CS Cho
Queen Elizabeth Hospital, Hong Kong
International Journal of Immunotherapy and Cancer Research
Malgorzata Gabriela WASNIEWSKA
University of Messina, Italy
International Journal of Clinical Endocrinology and Metabolism
Peter Lloyd Nara
Private Compnay- Biological Mimetics, Inc., USA
Annals of Antivirals and Antiretrovirals
University of Nantes, France
Archives of Depression and Anxiety
University of Pisa, Italy
Annals of Psychiatry and Treatment