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Clinical Group

Journal of Gynecological Research and Obstetrics



Abstract Open Access
Research Article PTZAID: JGRO-3-130

Effect of Intrauterine Infusion of Granulocyte Colony Stimulating Factor on IVF Outcomes in Infertile Women

Mostafa F* and Farid L

Objective: The primary goal of this study was to assess the G-CSF effects on IVF outcomes in women with normal endometrial thickness. 

Patients and Methods: This was a randomized controlled study performed at Assisted Reproductive Techniques Center of Ain Shams University Maternity Hospital, over a 2-year period, between Jan 2014 and Jan 2016, and included 60 infertile women with normal endometrial thickness. Women were scheduled for IVF and randomized into two groups. Exclusion criteria were positive history of repeated implantation failure (RIF), endocrine disorders, severe endometriosis, congenital or acquired uterine anomaly and contraindication for G-CSF (renal disease, sickle cell disease, or malignancy). In G-CSF group (n=30), 300 μg trans-cervical intrauterine of G-CSF was administered at the oocyte retrieval day. Controls (n=30) were treated with standard protocol. Chemical, clinical and ongoing pregnancy rates, implantation rate, and miscarriage rate were compared between groups.

Results: Biochemical pregnancy had occurred in 27.3% of participants in group I and 21.3% of women in group II with a significant difference between the two groups. The clinical pregnancy rate was 22% and 16% in group I and II respectively with no significant difference between the two groups. The acceptability of women in group I was 68%, mild discomfort occurred in 44.7%, moderate discomfort was in 28.7%, severe discomfort was in 11.3% and 15.3% of women in group I had no discomfort at all. Difficult flushing had occurred in 14.7% of women. 

Conclusion: It looks that the clinical pregnancy rates were significantly higher by intracavitary infusion of granulocyte colony stimulating factor

Published on: Mar 3, 2017 Pages: 11-14

Full Text PDF Full Text HTML DOI: 10.17352/jgro.000030