Aim: To investigate the long-term effects of anabolic androgenic steroids (AAS) on renal status in rats.
Methods: Twenty Wistar rats were distributed into 2 groups: AAS or placebo, for 3 months.The animal received 10mg/kg body weight of Stanozonol once a week by intramuscular injection in the gluteus, or saline solution as placebo.
Results: Urinary pH was more acidic in the AAS compared to the placebo group (p<0.05). Kidney weight was 15% higher in the AAS compared to the placebo group (p<0.001). Renal glomerular area was 12% higher in the AAS compared to the placebo group (p=0.001). Animals injected with AAS also displayed a no significant but clinically relevant ~20% higher kidney interstitial connective tissue, glomerular tufts and mesangiums.
Conclusion: Overall, AAS negatively affected urinary pH and kidney morphology leading to a worse renal status. More attention should be taken to the use of AAS among populations at high risk for kidney disease.
Published on: Jun 26, 2017 Pages: 34-37
Prof. Pierre Guertin
Laval University, Canada
International Journal of Pharmaceutical Sciences and Developmental Research
Sassari University, Italy
Archive of Urological Research
International Iberian Nanotechnology Laboratory (INL), Portugal
International Journal of Nanomaterials, Nanotechnology and Nanomedicine
University of Siena, Italy
International Journal of Oral and Craniofacial Science
Nikolaos A Chrysanthakopoulos
National and Kapodistrian University of Athens , Greece
Journal of Dental Problems and Solutions