Acinetobacter species are important nosocomial pathogens because they can develop resistance to antibiotics and survive for a long time in the hospital environment. This study aimed to investigate the changes in antibiotic resistance profiles of Acinetobacter spp. strains isolated from blood speciemens of hospitalized patients in our hospital.
Between 01.01.2014 – 31.12.2015, 19244 blood samples from hospitalized patients with suspected bacteremia in different departments of the Meram Medical Faculty were incubated by automated blood culture system BacT / Alert 3D ( BioMerieux, France).
Of the 19244 blood specimens collected from different wards of the hospital, 3347samples (17,3%) showed bacterial growth after incubation. Identification and antimicrobial susceptibilities of clinical isolates were determined by conventional methods and an automated system (VITEK 2 Compact, Biomerieux, France) according to Clinical and Laboratory Standards Institute (CLSI).
Distribution of strains isolated from blood culture were identified as Coagulase Negative Staphylococcus
(n=1755, 52 %), Enterococcus spp. ( n=267, 8 %), Klebsiella spp. (n=182, 5 %), E.coli (n=182, 5 %), Candida spp. (n=153, 5 %), Pseudomonas spp. (n=91, 3 %), Staphylococcus aureus ( n=72, 2 %) and other bacteria. The identified isolates as Acinetobacter baummanii (n=152, 5 %) and Acinetobacter spp. (n=2, 0,1 % ) from blood specimens which were collected from intensive care units (n=111, 72.2 %) and other clinics (n=43, 27.8 %) of our hospital, all specimens in the study were consisted of hospitalized patients.
In this study, the results of in vitro antibiotic susceptibility test of Acinetotobacter strains isolated from blood culture will be evaluated. Susceptibility to ceftazidime was 8 %, amikacin 25 %, imipenem 5 %, meropenem 6 %, tigesiklin 94 %, colistin 98 %, gentamicin 34 %, cefepime 5 %, ceftazidim 8 %, piperacillintazobactam 5 %, ampicillin-sulbactam 7 %, ciprofl oxacin 5 %, levofl oxacin 4 %. Results of antibiotic susceptibility tests for Acinetobacter species initiated that the most effective antibio tics were colistin and tigecycline with the resistance ratio 2 %, 6 %, respectively. Compared with other antibiotics, lower rates of resistance to amikacin and gentamicin were observed.
The in-vitro antimicrobial susceptibility test results of this study reveal that Acinetobacter species strains demostrated high resistance ratio against all beta-lactam drugs including carbapenems and quinolones.
In conclusion, the presents of this study determine that colistin has the best activity against Acinetobacter species strains. Morever, amicasin and gentamicin may be good choices for the empirical treatment because of lower resistance ratio than other antibiotics.
Published on: Jan 19, 2017 Pages: 4-8