Background: Jaundice is frequently associated with extrahepatic systemic infections. The important causes include increased bilirubin levels due to hemolysis, hepatic dysfunction, reduced excretion and cholestasis. Sepsis induced cholestasis has a unique pathophysiologic basis. Although common in gram negative sepsis among neonates, the clinical features of sepsis induced cholestasis are not widely recognized older children.
Case report: We present a 6 year old, premorbidly asymptomatic boy with community acquired MRSA sepsis-pneumonia and ARDS (Acute respiratory distress syndrome) with isolated conjugated hyperbilirubinemia. A diagnosis of sepsis induced isolated cholestasis was considered after ruling out other possible causes of cholestasis. The hyperbilirubinemia improved with improvement in the primary pathology.
Conclusion: Early recognition of sepsis as a cause of isolated cholestatic jaundice would avoid unnecessary investigations and therapy would help in early institution of appropriate therapy.
Published on: Dec 6, 2016 Pages: 10-12
Wei Min HUANG
Nanyang Technological University, Singapore
Peertechz Journal of Biomedical Engineering
National Center for Toxicological Research (NCTR)/FDA, USA
Global Journal of Anesthesiology
Domenico Antonio Restivo
Nuovo Garibaldi Hospital, Italy
Journal of Neurology, Neurological Science and Disorders
University of Nantes, France
Archives of Depression and Anxiety
Marco Matteo Ciccone
University of Bari , Italy
Archives of Organ Transplantation