Background and Study Aims: as there is no single golden rule for the diagnosis and activity of ulcerative colitis disease, this study is going to discuss the clinical relevance of calprotectin and PTX 3 in cases of ulcerative colitis and their roles as non-invasive methods to diagnose UC and determine disease activity.
Patients and Methods: Patients were classifi ed into two groups; group 1 include 40 patients of different phases of activity of UC. Group 2 included 20 healthy volunteers as a Controls. Measurement of feacal calprotectin by using the ELISA (enzyme-linked immunosorbent assay) kit. Measurement of serum Pentraxin3 (PTX 3) by enzyme-linked immunosorbent assay (ELISA).
Results: PTX 3 levels were signifi cantly different between mild, moderate and sever patients with Cwhich the same as calprotectin level. Moreover, PTX 3 was signifi cantly increased more than calprotectin in mild and severe UC patients.
Conclusions: PTX 3 is directly produced from the infl amed gut in UC. Plasma PTX 3 concentration is thought to be a useful marker for understanding the disease activity in patients with UC. PTX 3 was found to be more sensitive and specifi c than faecal calprotectin as a marker for infl ammation and disease activity in UC.
Published on: Feb 10, 2017 Pages: 11-16
Former member of MGH, USA
International Journal of Immunotherapy and Cancer Research
Prof. Pierre Guertin
Laval University, Canada
International Journal of Pharmaceutical Sciences and Developmental Research
University of Siena, Italy
Archives of Renal Diseases and Management
Beijing University of Technology , PR China
Journal of Civil Engineering and Environmental Sciences
University of Athens , Greece
International Journal of Oral and Craniofacial Science