Objective: To verify alterations in lipid profile, blood glucose and pressure, and morphological aspects of the adrenal gland in animals with hypogonadism secondary to total bilateral epididymectomy and orchiectomy.
Methods: Young and adult male Wistar rats were distributed into the following groups: Group 1 – control, animals submitted only to scrotal incision and suture. Group 2 – animals submitted to total bilateral epididymectomy and orchiectomy. After these operations, studies were carried out to analyze possible repercussions of hypogonadism. In Study A, serum levels of free testosterone were measured, along with the body weight and cortical thickness of the adrenal gland of 30 adult rats. In Study B, serum values of glucose, triglycerides, and total cholesterol, and HDL, LDL and VLDL fractions were measured in 20 young rats and 10 adult rats. In Study C, pressure of the caudal artery was measured by plethysmography in 24 adult animals.
Results: Total bilateral epididymectomy and orchiectomy reduced serum levels of testosterone regardless of the age of the animal, and apparently does not modify macro- or microscopically the morphology of the adrenal gland. Hypogonadism secondary to total bilateral epididymectomy and orchiectomy did not modify the serum values of glucose, total cholesterol, LDL and HDL fractions. However, orchiectomy reduced the blood levels of triglycerides and VLDL cholesterol when performed in young rats. Testosterone deficiency was related to smaller weight gain and increased arterial pressure.
Conclusions: Orchiectomy reduces blood levels of triglycerides and VLDL cholesterol in young rats whereas in adult animals, arterial pressure increasing and smaller weight gain are verified.
Published on: Jan 23, 2016 Pages: 1-6
Dr. Pierre Guertin
Laval University, Canada
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