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Engineering Group

Peertechz Journal of Biomedical Engineering

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Research Article PTZAID: PJBE-1-104

Nanoderm Extracellular Matrix for Reconstructive Surgery Applications

Gabriel Molina de Olyveira*, Pierre Basmaji, Ligia Maria Manzine Costa, Gino Bruno Francozo, José Domingos da Costa Oliveira

Introduction: Bacterial cellulose (BC) can be used in wide area of applied scientific, especially for tissue regeneration and regenerative medicine, lately, bacterial cellulose mats are used in the treatment of skin conditions such as burns and ulcers, because of the morphology of fibrous biopolymers serving as a support for cell proliferation, its pores allow gas exchange between the organism and the environment. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this scope, Natural ECM is the ideal biological scaffold since it contains all the components of the tissue.The development of mimicking biomaterials and hybrid biomaterial can further advance directed cellular differentiation without specific induction. 

Methods: The acetic fermentation process was achieved by using glucose as a carbohydrate source. Results of this process are vinegar and a nanobiocellulose biomass. The modifying process is based on the addition of hyaluronic acid and chondroitin sulfate (1% w/w) to the culture medium before the bacteria is inoculated. After, vegetal stem cells were added in the system, which were chosen because has wound healing properties that help new skin formation. (Casearia Sylvestris).

Result: Bacterial cellulose (Nanoskin®) was successfully modified by changing the fermentation medium as shown by FTIR and TGA, which produced necessary materials for regenerative medicine. Nanoskin Natural extracellular matrix (ECMs) perform the tasks necessary for tissue formation,maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials.

Conclusion: Nanoderm® Natural extracellular matrix (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. Understanding how cells interact with these to assemble their own ECM and how the scaffolds can be used to control delivery of signals in a temporal and spatial manner to guide or maintain cell differentiations need future investigation. But,undoubtedly, natural-origin polymers or nature-inspired materials appear as the natural and desired choice for medical applications.

Published on: Dec 17, 2015 Pages: 21-24

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