Objective: To evaluate Plavix impact on the perfusion of the uterine artery compared to low dose aspirin in women with unexplained recurrent miscarriage
Patients and Methods: It was a prospective case control study that was carried out at Ain Shams University Maternity Hospital and included women who were presented to the outpatient clinic hospital department due to unexplained recurrent miscarriage. This study was performed over a 2-year period, between January 2014 and January 2016. 105 patients were recruited and divided into two arms. Group I (plavix group) included 50 women who had a history of recurrent miscarriage and received plavix (75 mg) for 3 successive months, while group II (low dose aspirin group) included 55 women who had previously early pregnancy loss and received low dose aspirin (75 mg) for 3 successive months. After ultrasound examination had done, endometrial pattern and thickness, uterine artery resistance and pulsatility indices were measured.
Results: There was a significant effect of the two drugs in improving the endometrial thickness and pattern (trilaminar) when compared with the previously untreated cycles. Also, there was a significant difference between Plavix and Aspirin effects as regards improvement of endometrial pattern but not thickness. Also, there was a significant difference between the two groups as regards uterine artery PI and RI.
Conclusions: Compared to aspirin, plavix treatment resulted in a strikingly better endometrial pattern (trilamminar) and endometrial blood flow with no significant increase in endometrial thickness.
Published on: Feb 8, 2016 Pages: 10-13