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Clinical Group

Annals of Circulation



Abstract Open Access
Research Article PTZAID: AC-2-107

Zero-Flow Pressure of the Cerebral Microcirculatory Bed at Concomitant Traumatic Brain Injury

Trofimov A, Dobrzeniecki M, Kalentyev G, Karelsky M, Abashkin A, et al.,

Zero-fl ow pressure (ZFP) is an important parameter of a microcirculation. The aim is to determine the status of the ZFP at concomitant traumatic brain injury with and without the development of intracranial hematomas.

Material and Methods: The results of the treatment of 80 patients with severe head injury and polytrauma was studied. M:F - 44:36. Their average age was 34.3 ± 14.5 years (min 15: max 73). Depending on the presence of intracranial hemorrhages the patients were divided into 2 groups. Wakefulness according to Glasgow Coma Score (GCS) was 10.4 ± 2.6 in the 1st group and 10.6 ± 2.8 in the 2nd group. The Injury Severity Score (ISS) was 32 ± 8 in the 1st group and 31 ± 11 in the 2nd group. Epidural hematomas were revealed in the 2nd group in 7 patients, subdural hematomas in 27 persons and multiple hematomas in 4 sufferers. All the sufferers were operated within the fi rst 3 days. During the fi rst day 30 patients (78.9%) were operated. All the patients were subjected to the transcranial Doppler of the both middle cerebral arteries and the evaluation of the mean arterial pressure. Based on the data obtained the cerebral perfusion pressure and the ZFP were calculated. The comparisons between the groups were performed by using the Student’s t-criterion.

Results: There was no signifi cant difference in ZFP between the left side and the right side in 1st group (46.88±14.05 mmHg vs. 45.44±10.73 mmHg, respectively, t=0.45; р=0.65) The average ZFP values in each of the groups (with or without hematomas) appeared to be statistically signifi cantly higher than a mean value in control group (32,9 ± 3,6 mmHg, р<0.01). The intergroup comparison of the ZFP showed a statistically reliable increase in its level in the 2nd group on the side of the removed hematoma as compared with opposite side (56.02±21.68 mmHg vs. 45.43±16.71 mmHg, respectively, t=2.38; р=0.019p=0,019).

Published on: May 22, 2017 Pages: 19-23

Full Text PDF Full Text HTML DOI: 10.17352/ac.000007


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