ISSN: 2455-5363
Global Journal of Infectious Diseases and Clinical Research
Opinion       Open Access      Peer-Reviewed

A strategy for finding new medicines against the novel coronavirus disease (COVID-19) derived from base pairing with DNA damages

Katsuhito Kino*, Takayuki Ohshima, Taishu Kawada, Takanobu Kobayashi and Hiroshi Miyazawa

Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan
*Corresponding author: Katsuhito Kino, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan, E-mail: kkino@kph.bunri-u.ac.jp
Received: 04 December, 2020 | Accepted: 21 December, 2020 | Published: 22 December, 2020

Cite this as

Kino K, Ohshima T, Kawada T, Kobayashi T, Miyazawa H (2020) A strategy for finding new medicines against the novel coronavirus disease (COVID-19) derived from base pairing with DNA damages. Glob J Infect Dis Clin Res 6(1): 060-061. DOI: 10.17352/2455-5363.000038

The spread of the novel coronavirus disease (COVID-19) has caused a global pandemic. Exiting agents that act on proteins including 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), helicase, RNA-dependent RNA polymerase (RdRp), spike glycoprotein (S protein), and others in similar viruses [1,2] are likely used as antiviral drugs against the novel coronavirus (SARS-CoV-2). Data on Chemical Abstract Service show that the potential drug candidates against 3CLpro and RdRp are more than those against other targets [2].

Remdesivir is a nucleoside analog and a substrate for RdRps of several RNA viruses [3]. Especially, remdesivir has antiviral activity against SARS-CoV-2 [4]. Remdesivir, which mimics the structure of adenosine and forms the base pair with uridine [4], delayed chain termination of RNA synthesis using RdRps of SARS-CoV-2 [5]. Also, favipiravir, ribavirin and N4-hydroxycytidine forming base pairs [3] are suggested to have broad-spectrum antiviral activities. Therefore, some unknown ribonucleoside analogs capable of forming base pairs are likely to be effective in SARS-CoV-2.

By the way, many DNA damages [6] are ribonucleoside analogs, and the base pairs containing DNA damages were described [3]. Some known and/or unknown DNA damage mimics capable of forming base pairs may be drug candidates for SARS-CoV-2 (The section 13 of the previous review [3]).

There is an urgent need to find new medicines against COVID-19. Instead of synthesizing compounds and examining those effects one by one, the reaction mixtures obtained by the reacting nucleic acid analogs under various conditions are screened as it is, and researchers verify whether each reaction mixture has antiviral activity against SARS-CoV-2. Thereafter some reaction mixtures having antiviral activity are fractionated with high-performance liquid chromatography and so on, and isolating active ingredients will lead to finding any drug candidates quickly (Figure 1). We hope that other researchers will quickly find drug candidates using this strategy, and that COVID-19 will be converged.

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  3. Kino K, Kawada T, Hirao-Suzuki M, Morikawa M, Miyazawa H (2020) Products of oxidative guanine damage form base pairs with guanine. Int J Mol Sci 21: 7645. Link: http://bit.ly/3p94tAs
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  6. manner. Toxics 7: 36. Link: http://bit.ly/2WzLBOQ
© 2020 Kino K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.