Thyrotoxicosis leading to Renal Tubular Acidosis presenting as periodic paralysis – A case report

Periodic fl accid paralysis is related to loss of tone and power transiently and which occurs repeatedly over time. Etiologies like channelopathies, myasthenia gravis and thyroid disorders are common. There have been case reports of thyroid disorders leading to periodic paralysis. The pathophysiology attributed to it is the increased uptake of potassium by the cells in the thyrotoxic state. Thyrotoxicosis is also an uncommon cause for distal renal tubular acidosis. In our case, we present a case of thyrotoxicosis leading to distal RTA presenting as periodic paralysis. On correction of thyrotoxic state with radioactive iodine ablation the renal tubular acidosis remmited both clinically and on arterial blood gas analysis. We report this case as there are very few cases of such nature which are reported worldwide. Case Report Thyrotoxicosis leading to Renal Tubular Acidosis presenting as periodic paralysis – A case report Sourya Sourabh Mohakuda1*, Rajiv Pakhetra2 and Naveen Yadav3 1Clinical Tutor, General Medicine, AFMC, Pune, India 2Endocrinologist, Command Hospital, Pune, India 3Resident in General Medicine, AFMC, Pune, India Received: 18 June, 2019 Accepted: 15 July, 2019 Published: 16 July, 2019 *Corresponding author: Dr. Sourya Sourabh Mohakuda, Clinical Tutor, Department of Internal Medicine, Armed Forces Medical College, Pune, India, Tel: +919145630535; E-mail:


Introduction
Thyrotoxic Periodic Paralysis is an important consideration in patients of South-east Asian origin presenting with acute onset proximal muscle weakness with hypokalemia and features of thyrotoxicosis. Renal Tubular Acidosis is due to inability of renal tubule to acidify urine, out of proportion to any reduction in glomerular fi ltration rate. Thyrotoxic periodic paralysis without any renal tubular acidosis has a normal arterial blood gas study with no evidence of metabolic acidosis.The case study herein described depicts a young male presenting with thyrotoxic periodic paralysis with an underlying Renal Tubular Acidosis, which in association with low potassium level and higher urine pH is suggestive of a distal RTA [1]. It is rare to have coexistence of both Thyrotoxicosis and distal RTA causing hypokalemic periodic paralysis. The case report highlights importance of extensive workup for secondary cause of distal RTA and resolution of RTA with treatment of thyrotoxicosis suggesting thyrotoxic state as etiology of distal RTA.  Urea/ creat-35/0.7 mg/dl, Na/ K-137/2.1meq/L (Table 1).

Case Presentation
SerumChloride -110 mmol/l.Urinay pH -5.8,Urine anion Gap-11 ( Urine Na -80 meq/L, Urine K-29meq/L , Urine Cl -98 meq/L ) ( Thyroid function test revealed T3-2.08ng/ml (0.78-1.82), T4-24.21mcg/ml (4.6-13.0) and TSH-0.19μIU/ml (0.5-6.5). Thyroid scan was done which revealed a diffuse high uptake in the thyroid gland. USG KUB-Normal study.R Factor/anti Ro/ La/ANA -Neg In view of the clinical features and above investigation fi ndings, he was supplemented with parenteral potassium replacement. Following normalisation of potassium levels in blood his symptoms reversed. However he continued to be on oral potassium replacement. He underwent radioactive iodine ablation for graves' disease [2]. His requirement of potassium gradually decreased and his ABG normalised over three months. He has been under follow up for one year. He has a euthyroid state, normal potassium levels and normal ABG readings. There has been no recurrence of symptoms post radioactive ablation.

Discussion
Hypokalemia is one of the most common cause for periodic paralysis. Literature suggests hypokalemia occurs in 2% of patients with thyrotoxicosis of any cause. It is because of the over sensitisation of Na+/K+-ATPase in thyrotoxic state [3]. The major triggering factors are cessation of effort following strenuous exercise and carbohydrate-rich evening meals. Similar presentation in males in the 2 nd -4 th decade with signs of thyrotoxicosis raises the suspicion of thyrotoxic periodic paralysis [4]. However in such cases of periodic paralysis due to thyrotoxic state the arterial blood gas analysis is normal and there is no urinary potassium loss. Renal tubular acidosis per se is an important independent cause of periodic paralysis. Arterial blood gas changes suggestive of distal renal tubular acidosis in presence of hypokalemia points towards hyperthyroidism being a possible aetiology for renal tubular acidosis. However other common causes like drugs, sjogrens and rheumatoid arthritis needs to be ruled out. The mainstay of treatment remains correcting the underlying hyperthyroid state and potassium supplementation. The reversal of renal tubular acidosis with correction of thyrotoxic state clinches the diagnosis of thyrotoxicosis being aetiology for distal renal tubular acidosis.
The coexistence of dual aetiology ie thyrotoxicosis and renal tubular acidosis, such as in our case is rare for causing periodic paralysis. Our review of literature revealed three such cases been reported earlier. The fi rst case report was of a lady from Mexico who had thyrotoxic periodic paralysis, renal tubular acidosis, nephrocalcinosis and nephrogenic diabetes insipidus (DI). Our case had all of the above except for DI [5]. The second case was reported from China where a lady had thyrotoxic periodic paralysis and renal tubular acidosis. However she was positive for anti -Ro antibodies [6]. The third case was reported from Korea where the case had thyrotoxic periodic paralysis, diabetes insipidus, renal tubular acidosis with anti Ro titres positive but not signifi cant enough to be labelled as Sjogrens. A possibility of Sjogrens in subclinical stage was considered in the above case [7]. If we consider the second and third case, the possibility of Sjogrens still could not be conclusively ruled out for being the aetiology for renal tubular acidosis. In our case, the work up for secondary cause of renal tubular acidosis was negative. The reversibility of the renal tubular acidosis with the case becoming euthyroid suggested thyroid being the aetiology for RTA. The nephrocalcinosis can be explained by impaired calcium metabolism in thyrotoxic state.
We conclude that our patient had distal renal tubular acidosis and nephrocalcinosis secondary to thyrotoxic state which reverted after achieving euthyroid status. However alternate commoner causes for renal tubular acidosis needs to be ruled out prior to labelling it being due to thyrotoxicosis. On follow up for an year, our case has been asymptomatic, remained euthyroid with a normal arterial blood gas analysis.