Cite this asKammoun S, Rekik M, Amor SB, Feki J (2020) Invasive squamous cell carcinoma of the conjunctiva. Int J Immunother Cancer Res 6(1): 022-024. DOI: 10.17352/2455-8591.000026
Introduction: Squamous cell carcinoma of the conjunctiva is generally a low-grade tumor. Invasive squamous cell carcinoma, however, is uncommon, and intraocular extension has rarely been reported. We report a case of invasive squamous cell carcinoma of the conjunctiva with intra-ocular involvement in 94 year-old man.
Methods: A case report.
Results: A 94-year-old male patient presented with a rapidly growing exophytic mass involving the right eyeball for 2 months.The biopsy performed a well differentiated squamous cell carcinoma of the conjunctiva.
The extension assessment showed local bone extension. The patient underwent exenteration with good postoperative consequences.
Conclusion: This disease has a variable appearance. Late presentation with large orbital tumours are not uncommon. Early diagnosis is crucial to improve the visual prognosis.
Squamous cell carcinoma is the most common epithelial malignancy of the conjunctiva . The tumor primarily affects middle-aged to elderly male patients . Sun injury, viral infections, and immunocompromised states are known etiological factors. The limbal epithelial cells appear to be the progenitors of this disease .
It is generally a low-grade tumor. Invasive squamous cell carcinoma, however, is uncommon, and intraocular extension has rarely been reported .
Here, we report an unusual case of invasive squamous cell carcinoma of the conjunctiva with intra-ocular involvement.
A 94 year-old man presented with a rapidly growing mass in the right eye for 2 months. The ophthalmological examination of the right eye showed an exophytic lesion protruding through the lids and involving the eyeball (Figure 1). The left eye was entirely normal. The magnetic resonance imaging of the orbits showed a large heterogeneous anterior lesion, measuring 2.8 * 3.3cm, adjacent to the inner canthus of the right orbit and involving the lacrimal gland (Figure 2). A small excision biopsy was taken from the exophytic lesion and performed a well differentiated squamous cell carcinoma of the conjunctiva. The extension assessment showed local bone extension to the inner wall of the right orbit and the lower part of the frontal sinus. Subsequently, exenteration was done. The patient was followed up for 1 year, and during this period, no recurrence was noted. After that, we lost the patient for follow-up.
Conjunctival squamous cell carcinomas (SCCC ) are rare neoplasms affecting commonly aged male patients [4,5].
There are several predisposing factors like exposure to ultraviolet-B radiation, HIV/AIDS and other types of immunodeficiencies such as medical immunosuppression, xeroderma pigmentosum and atopic diseases. The aetiological role of human papilloma virus (HPV) has been determined, due to the well-documented role in other lesions of the eye, such as conjunctival papilloma and lacrimal sac neoplasia, and squamous cell carcinomas of the skin .
Although it is the most frequently seen malignant neoplasm of the conjunctival epithelium, the literature suggests that it normally behaves in a nonaggressive fashion .
The manifestations of SCCC are highly variable and depend on the stage of the tumor. They are sometimes misleading, assuming the appearance of a benign lesion neglected by the patient, resulting in diagnostic and therapeutic delay.
Majority of the patients present with a nodular lesion in the limbus or other parts of the conjunctiva . Most lesions occur in the interpalpebral fissure, especially on the nasal side. Rarely, late presentation with large orbital tumors and diffuse involvement is seen . Invasion deep in the stroma, in the orbit, or in the eye can result in vision loss .
Large exophytic tumor, as we saw in our case, is a rare presentation. To our knowledge, large orbital tumor involving the eyeball as the presenting sign of squamous cell carcinoma has not been previously reported.
The mean delay of diagnosis is usually 7 months after onset . Our patient sought medical attention at 2 months after tumor development, but the mass was aggressive enough to cause blindness.
We postulated that the short interval from the tumor’s first appearance to the time the patient seeks medical attention may be explained by rapid growth from strong sunlight exposure in this environment or because of ignorance of the patient at the first appearance of the tumor.
Histopathology is the gold standard for diagnosis . The treatment of conjunctival SCC is wide excision. Enucleation is advised when cornea or sclera has been invaded, and exenteration is recommended in cases of invasion of anterior orbit , like in the case of our patient. Exenteration is a radical technique that involves removing all the orbital contents including the periosteum .
Metastasis occurs rarely, and commonly parotid or submandibular glands are involved. Even with metastasis, the chance of survival is good [5,10].
Invasive malignancy of conjunctiva is a rare neoplasm. However, it should be suspected in all aged patients with a conjunctival lesion, particularly with the rapid rate of growth. Late presentation with large orbital tumours are uncommon. The possibility of an intraocular diffusion of this tumour must be always evaluated, and the need for prompt surgical treatment considered. Proper management is crucial to improve the visual prognosis.
We are presenting this rare case report to promote awareness about this uncommon malignancy which will help in accurate management in future.
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient has given his consent for his images and other clinical information to be reported in the journal.
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