Comparison of MELD and Child- Pugh Score for the Prediction of Survival in Portal Hypertension Undergoing Transjugular Intrahepatic Portosystemic Shunt

Objectives: Recently, the model for End-Stage Liver Disease (MELD) was proposed for the prediction of survival in transjugular intrahepatic portosystemic shunt (TIPS) patients. We therefore compared the prognostic accuracy of the MELD model and the Child-Pugh score, in an unselected cohort of TIPS patients followed long-term. Methods: A retrospective chart review and statistical analyses were done on 120 patients consecutively admitted for portal hypertension from 2009 to 2013 in the Jinling hospital (Nanjing, China). Results: The survival rate for all patients was 95.8% at 3 months, 90% at 1 year, and 85.8% at 3 years. Signifi cantly lower survival rates were found in patients with MELD scores of 15 or more in comparison to those with MELD scores of 15 or less (p<0.001).There was no signifi cant difference in survival rate between patients with Child-Pugh classifi cation A and those with Child-Pugh classifi cation B, while the patients with Child-Pugh classifi cation C has a signifi cantly lower survival rate than those with Child-Pugh classifi cation A and B (p<0.001). The discrimination powers of MELD (c statistics: 0.772, 0.680, 0.647 for 3-month, 1-year, and 3-year survival) were not signifi cantly different from the discrimination powers of Child-Pugh score at the same time points (c statistics: 0.795, 0.732, 0.678). Conclusions: The Child-Pugh classifi cation is only slightly superior to the MELD score for the prediction of long-term survival in TIPS patients. Therefore, the search continues for an entirely new scoring system to further improve prognostic accuracy. Case Report Comparison of MELD and ChildPugh Score for the Prediction of Survival in Portal Hypertension Undergoing Transjugular Intrahepatic Portosystemic Shunt Liu Kai1, Wang Shikai1, Wu Xingjiang2*, Fan Xinxin3, He Changsheng4 and Li Jieshou2 1M.D. General Surgery, Medical School of Nanjing University, China 2Chief Physician, Research Institute of General Surgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China 3A Resident Physician, Research Institute of General Surgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China 4An Attending Physician, Research Institute of General Surgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China Dates: Received: 06 January, 2017; Accepted: 20 March, 2017; Published: 22 March, 2017 *Corresponding author: Wu Xingjiang, Chief Physician of Research Institute of General Surgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China, E-Mail:


Introduction
The transjugular intrahepatic portosystemic shunt (TIPS) is a portosystemic shunt created using percutaneous endovascular techniques. This procedure was originally used to treat variceal bleeding refractory to medical management in patients with portal hypertension [1,2]. Compared to surgery, TIPS can reduce the mortality rates about these complications. However, some patients may develop progressive liver failure or other serious complications and even die shortly after TIPS procedure [2,3]. Therefore, combined with the relevant clinical data, the real and objective evaluation of liver function after TIPS implantation is particularly important. Prognostic models may help doctors in the clinical decision making and provide patients with a more reliable assessment of their potential outcome which will have a signifi cant infl uence on the choice of individualized therapy [4,5].
implanted because of transcapsular puncture with peritoneal bleeding, three not implanted for inability to puncture the main branch of the portal vein, one implanted bare stent, one operated splenectomy and azygoportal disconnection). The remaining 120 patients were treated successfully and were thus included in this report. All patients were treated when hemodynamically stable, without active infections, signs of cardiac failure or organic renal diseases.
Data were collected retrospectively through chart review of consecutive patients with the diagnosis of portal hypertension.
Baseline demographic, clinical and laboratory characteristics were retrieved from clinical records and are summarized in Table 1. In all cases, porto-systemic venous pressure gradient (PVPG) was measured both before and at the end of the TIPS procedure. MELD and Child-Pugh scores were calculated. Child-Pugh classifi cation A = 5-6 points, Child-Pugh classifi cation B = 7-9 points, and Child-Pugh classifi cation C = 10 or more points. The MELD score formula is 9.6 × Ln (creatinine mg/dl) + 3.8 × Ln (bilirubin mg/ dl) +11.2 × Ln (INR) + 6.4 × (cause of cirrhosis) in which the value for cause of cirrhosis was 0 for alcoholic or cholestatic etiology and 1 for viral or other etiology.

Transjugular intrahepatic portosystemic shunt procedure
The procedure was performed by a surgeon with 20 years' experience of TIPS in a dedicated interventional radiology suite under local anesthesia. After puncturing the right internal jugular vein guided by Doppler ultrasound imaging, a 10-French, 41 cm long sheath (Rosch-Uchida TIPS puncture Set; Cook, Bloomington, IN) was placed in the suprahepatic portion of the inferior vena cava. After catheterization of the right hepatic vein, the measure of hepatic venous pressure and the portal puncture were performed. With the use of a hydrophilic guidewire (Radiofocus guidewire; Terumo Europe, Leuven, Belgium), the portal vein was catheterized. The portal pressure was measured while the portography was performed. The dilation of the intrahepatic parenchymal tract was performed using a low-profi le balloon with 8 mm diameter. In patients with large varices of the gastric coronary vein, embolization using coils and a gelatin sponge was performed to reduce the risk of re bleeding. Fluency stent grafts (Bard Peripheral Vascular, Tempe, AZ) were deployed. The diameter of the stent graft was 8 mm, and the length was 4 to 6 cm. The Fluency stent graft is an expanded polytetrafl uoroethylene (ePTFE)-encapsulated grid-like cylinder made of a biocompatible nickel-titanium alloy. There are four radiopaque tantalum extensions on each end of the Nitinol stent. The Nitinol cylinder is encapsulated with two layers of ePTFE, both i considered as a useful test. For prognostic models, a c statistic of 0.9 or greater is seldom seen. Survival curves were computed by means of Kaplan-Meier product-limit estimates and were compared by means of the log-rank test. A P value of less than 0.05 was considered to indicate a statistically signifi cant difference. Statistical analyses were performed with SPSS 15.0 for Windows (SPSS, Chicago, IL).

Clinical outcome
A total of 120 patients underwent a TIPS procedure for

Baseline demographics
A total of 120 consecutive patients admitted to the liver unit with the clinical diagnosis of portal hypertension. The demographics and clinical characteristics of the patients on the basis of institution and on an overall basis are given in (Table  1). 34 (28.3%) of the 120 patients underwent TIPS creation to treat ascites, and 53 (44.2%) underwent TIPS creation to treat recurrent variceal bleeding, while 33 (27.5%) for emergency variceal bleeding.

Survival analysis
Kaplan-Meier survival analysis shown in Figures 1,2 compares survival rates based on three classifi cations of Child-Pugh score and the admission MELD score of <15 and >15. The 3-month survival rates for CPS classifi cations A, B, and C were 95.5%, 97.3%, and 91.7%, respectively. For classifi cations A, B, and C, 1-year survival rates were 95.5%, 95.9%, and 66.7%, and 3-year survival rates 95.5%, 94.5%, and 50.0%, respectively ( Figure 1). Overall survival did not differ between CPS classifi cations A and B, whereas survival of patients of classifi cation C was poorer (p<0.001) than that of patients of classifi cation B.
The survival curves based on MELD scores are shown ( Figure 2). Survival rates were signifi cantly lower in patients with MELD scores of >15 than in those with MELD scores of <15 (P<0.001). The 3-month survival rates for MELD scores of <15 and >15 were 97.1% and 87.5%, respectively. For the MELD scores of <15 and >15, 1-year survival rates were 94.2% and 62.5%, and 3-year survival rates 93.2% and 37.5%, respectively.
Differences in 3-month and 1-year mortality rates based on patients who underwent elective or emergency TIPS procedure for variceal hemorrhage are given in Table 2.
Due to insuffi cient sample size, the difference in the mortality based on MELD scores or Child-Pugh classifi cation between elective TIPS and emergency TIPS was not signifi cant (P>0.05). 16 of the 120 patients died during follow up; however, 5 (31.3%) of the 16 patients died within 30 days after TIPS creation in Table 3A,B. the early death rate for this series was 4.17%. The cause of early death was liver failure in 3 patients, renal failure in one, and multiple organ failure in one.

C-Statistics
To further assess prognostic utilities of the two scores, ROC curves were plotted and AUCs were compared. The area under the curves showed a decrease in the predictive value for both scores during follow up. The ROC for 3-month survival is shown (Figure 3, Table 4). The discrimination powers of MELD (c statistics: 0.772, 0.680, 0.647 for 3-month, 1-year, and 3-year survival) were not signifi cantly different from the discrimination powers of CPS at the same time points (c statistics: 0.795, 0.732, 0.678) in Table 5.

Discussion
TIPS has been widely employed to treat patients with severe portal hypertension [2].      [4,7]. A relatively new approach is the MELD score which was initially used as a prognostic indicator for patients undergoing elective TIPS [6,8]. The ME L D score was widely employed for patient selection and allocation of or-gans among patients awaiting liver transplantation because of its reproducibility, objectivity [7]. indocyanine green clearance (a measure of liver blood fl ow) [12][13][14][15].
In the Child-Pugh scoring system, bilirubin and prothrombin time can accurately refl ect the liver function. However, hepatic encephalopathy, ascites and albumin are vul n erable to medical intervention [16]. Moreover, as a result of the "ceiling effect" of the Child-Pugh score, classifi cation C patients cannot b e conducted in-depth assessment [17].
Our study demonstrated that increasing laboratory levels of creatinine, INR, PT, APTT, GPT, GOT, hyperammonemia increased signifi cantly the risk of death (p<0.05) ( Table  5). Decreasing levels of serum sodium also increased the risk of mortality (p<0.05). Presence of refractory ascites or hypovolemia, or hepatorenal syndrome increased the risk of early death. Although the MELD score has already replaced the Child-Pugh score in some areas, such as liver transplant allocation, so far no multicentric and random study has demonstrated an advantage of the MELD model over the Child-Pugh score with respect to prediction of survival. So Hector Ferral et al. indicated that it would be interesting to evaluate discrimination for mortality with the combination of these two scores in a larger series of patients [18].
TIPS placement changes intravascular blood distribution by shifting trapped prehepatic venous blood volume to central venous blood volume in effect like a side-to-side portocaval shunt and promptly reduces portal pressure. A hemodynamic imbalance with portal and hepatic arterial fl ows induced by the TIPS creation may worsen liver function. If with a blunted hepatic arterial compensation, patients may have an unfavorable outcome after TIPS, even liver failure [2,19].
A relatively precise estimate of the prognosis of an individual cannot in any way replace careful clinical information of    the individual patient. Unpredictable complications such as stenosis of TIPS, development of malignant tumors, or nonliver related events affect the accuracy of the assessment [4,5,20].
Therefore, in patients undergoing TIPS, a better prognostic model should stratify patients into those with a good prognosis and those with a poor one. Our goal is to apply the model in an attempt to identify those patients in whom the invasive procedure may be potentially harmful. With this information, we should be able to discuss risks and benefi ts of the procedure with a more objective approach.

Conclusions
At present, to obtain a better prognostic model in the future, we should acquire suffi cient amounts of relevant clinical information including follow-up data to a greater extent. Some studies report that gene technology and molecular biology including the infl uence of certain genotypes will improve the precision of prognostic estimates for individual patients [21]. In conclusion, to build a large-scale information network, pooled analysis of data collected in accordance with uniform standards, it will be the direction of building such predictive models.