ISSN: 2455-5452
International Journal of Vascular Surgery and Medicine
Case Report       Open Access      Peer-Reviewed

Right Iliofemoral Venous Thrombosis in a Prothrombin 20210GA carrier with Duplicated Inferior Vena Cava. An Unusual Case Report

Konstantinos Tigkiropoulos1*, Emmanouil Papadakis2, Ioannis Lazaridis1 and Nikolaos Saratzis1

1Vascular Unit,1st University Department of Surgery, Aristotle university of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece
2Hematology Department, Papageorgiou General Hospital, Thessaloniki, Greece
*Corresponding author: Konstantinos Tigkiropoulos, 1st University Surgical Department, Aristotle University, Thessaloniki, University of Nikolaos Saratzis, Greece, Tel: 00306944173723; E-mail: kostastig@yahoo.com; ktig78@gmail.com
Received: 12 August, 2017 | Accepted: 02 September, 2017 | Published: 04 September, 2017
Keywords: Double inferior vena cava; Iliofemoral venous thrombosis; Magnetic resonance venography; Prothrombin G20210A gene mutation

Cite this as

Tigkiropoulos K, Papadakis E, Lazaridis I, Saratzis N (2017) Right Iliofemoral Venous Thrombosis in a Prothrombin 20210GA carrier with Duplicated Inferior Vena Cava. An Unusual Case Report. Int J Vasc Surg Med 3(3): 043-045. DOI: 10.17352/2455-5452.000028

Venous thromboembolism, presenting as deep vein thrombosis (DVT) is a disease affected by aging, with a low rate of about 1 per 10,000 annually before the fourth decade of life, rising rapidly after age 45 years, and approaching 5–6 per 1000 annually by age 80. We present the case of a 69-years old woman who presented to our emergency department with unilateral lower limb pain and swelling. Subsequent imaging revealed a right iliofemoral deep vein thrombosis, with associated duplication of her inferior vena cava. Thrombophilic screening revealed a prothrombin 20210A gene mutation. She was treated conservatively with Low Molecular Weight Heparin (LMWH) and elastic stockings.

Case Report

A 69-years old woman presented to the emergency ward with a 24 hour history of right leg pain with associated swelling. She was under treatment for osteoporosis and arterial hypertension. Her obstetrics history was free of pregnancy or miscarriage. On examination the right limb appeared swollen, warm with tenderness of calf muscles during palpation. Homans sign was positive. Sensation and motor function were not disturbed. Pulses were palpable in both legs. She didn’t report difficulty in breathing, tachycardia or pain in the chest. A provisional diagnosis of DVT was made and the patient was hospitalized for further investigation and treatment.

Investigations

Laboratory tests-Haematological (Hct:39 and INR:1,07) and biochemical- were normal on admission apart from D-Dimers which were markedly elevated (6.700 ng/ml-n.v<500). ECG showed sinus rhythm. Tumors markers (CEA, CA 15-3,CA 19-9, CA 125) were normal. Thrombophilia screen including Protein C, Protein S, Antithrombin III, APC Resistance-V, Factor VIII, homocysteine and Anticardiolipin antibodies was negative. A genetic thrombophilia test showed that patient is heterozygous for prothrombin G202101A gene.

A U/S Duplex of the venous system was performed that confirmed thrombosis of the right common femoral extending to external iliac vein. A MR venography was scheduled to determine the extent of thrombosis. It revealed duplication of the inferior vena cava below renal veins with (Figures 1-3):

1. Thrombosis of the right IVC, common-external iliac veins, common femoral, superficial and deep femoral vein.

2. Venous drainage is performed via superficial collateral network from the left venous system.

3. Right internal iliac vein is drained through collateral venous network from the left internal iliac vein.

4. At the level of renal veins double IVC is joined retroaorticaly and cephalically it continues as azygos vein.

Treatment

In addition to the application of elastic stockings, patient was commenced on LMWH (Tinzaparin, 14000 anti-Xa IU,0.7 ml). Her anticoagulation therapy was initially planned to continue for 6 months in agreement with our Hemostasis specialist and to be reexamined in outpatient clinic after 3 months. She was discharged after 6 days in good clinical condition with oedema and pain been subsided.

Follow up

The patient was scheduled to perform an MRV 3 months after initiation of therapy with LMWH. It showed partial recanalization of the right inferior vena cava with increase of collateral circulation (Figure 4). The patient is followed up in outpatient department of hemostasis and vascular unit every 6 months and is under indefinite antithrombotic therapy with rivaroxaban 20mg.

Discussion

Venous thrombosis is a disease entity including deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs with an incidence of approximately 1 per 1000 annually in adult populations [1]. It is a disease of aging, with a low rate of about 1 per 10,000 annually before the fourth decade of life, rising rapidly after age 45 years, and approaching 5–6 per 1000 annually by age 80 [2]. Etiology includes inherited and acquired factors. The most frequent site of venous thromboembolism (VTE) is deep vein thrombosis (DVT) of the legs [3].

Prothrombin G20210A gene mutation is the second most common cause of inherited DVT. It is present in 2 percent of the general population [4] and increases the risk of deep venous thrombosis by a factor of 2.7 to 3.8 [5,6].

Anatomical variations of the inferior vena cava occurs in 0.4‑4% of the population [7]. The most common variant is duplication of the inferior vena cava in 0.3-3% [8]. Which in most cases is identified incidentally. Double IVC is caused by persistence of left supracardinal veins during embryonic development, specifically between the sixth and tenth weeks of gestation [9]. It is believed that this venous malformation can predispose to DVT due to anatomical changes that promote venous stasis [10]. In our case, it was interesting that our patient was asymptomatic for a long time. She didn’t experience a miscarriage or pregnancy during reproductive period that could provoke venous thrombosis and her heterozygosity for prothrombin G20210A gene mutation could trigger the clotting cascade.

Anticoagulation therapy is the mainstay treatment of DVT. Warfarin, LMWH, direct oral anticoagulants and fondaparinux are the main modalities that can be used in inpatients as well as in outpatients. The duration of therapy depends on the triggering factor that causes thrombosis. Provoked thrombosis usually requires 3 months of therapy, whereas unprovoked thrombosis in the setting of inherited thrombophilia causes could need life-long treatment. Our patient may need indefinite anticoagulation therapy due to the presence of 2 risk factors, prothrombin G20210A mutation and double inferior vena cava with high risk of recurrency [11].

There are less than 20 cases series worldwide involving double IVC and venous thrombosis. Most of them concern young patients under the age of 35 years. It is not described any other case report worldwide associated with double IVC and thrombosis due to prothrombin gene G20210A mutation in a patient over 50 years old.

Consent

The patient has consented for the publication of case report.

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© 2017 Tigkiropoulos K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.