Neuro-urological surveillance of Spina bifida in Morocco

Objective: Spina bifida is one of the first caused of disability with children in USA. This incidence was estimated to 3.5 per 10000 habitants. In France, it was mostly, 0.5 per 1000 habitants. The improvement in neuro surgy and in urology allowed a veritable reduction of mortality with spina bifida. 
Method: It was a retrospective descriptive and analytic study with children suffering of spina bifida and followed up between january 2013 and december 2015 at the department of Physical Medicine of Casablanca. 
Results: Twenty six patients were followed up. The average age was 11.9 +/- 5.8 years. These urinary disorders were frequency 100%, urinary incontinence 65.4%, urgency 73.1% and intermittent stream or training 46.2% with significant post void residual 26.9%. In urodynamic studies, bladder sphincter dysynergia was 7.7%, low bladder compliance with 61.5%, phasic or terminal detrusor overactivity 84.6% with 38.5% dangerous. In ultrason, they were 23.1% fight bladder with urinary retrogress and two children had dilatation of upper urinary tract and end stage renal disease, in list for renal transplantation.


Introduction
A spina bifi da is a leading cause of disability among children and adolescents in the United State of America [1].Its incidence is estimated in 3.5 to 3.7 per 10,000 people in the United State of America (Centers for Disease Control and Prevention.Data and Statistics in the United States, Spina Bifi da Homepage [2,3].In French it is more signifi cant and estimated at 0.5 per 1,000 inhabitants [4], while in Tunisia the prevalence is 2 to 10,000 [5].Advances in neurosurgery and urology have reduced effi ciently mortality among children.This mortality was related to hydrocephalus frequently associated with myelomeningocele, cardiovascular disease and kidney failure [3][4][5][6].These patients must come today to adulthood [7].It is clear that myelomeningocele is the fi rst congenital disease causing neurogenic bladder [3].A several types of neurogenic bladder have been described.The overactive detrusor and hypoactive bladder combined with hypertonic sphincter or sphincter hypotonic [4]. In Africa, the therapeutic arsenal is quite poor and is mainly limited to anticholinergic and alpha-blockers.We report the experience of the Department of Physical Medicine and Phys Rehabil 6(1): 001-004.DOI: http://doi.org/10.17352/2455-5487.000061

Study Type
We have conducted a retrospective, descriptive and analytical study of patients enrolled in the Department of

Physical Medicine and Rehabilitation of Ibn Rochd in University
Teaching Hospital of Casablanca, Morocco, for neurogenic bladder in spina bifi da between january 2013 and december 2015.

Evaluation
Beside neurological and perinea examination, the patients underwent urodynamics composed of a fl ow measurement coupled to the electromyography (EMG) produced by using skin patches, two located on either side of peri anal region or a thigh.As soon as the need to urinate is felt by the child, he was asked to urinate in the fl ow meter, connected to the computer.A screen was placed to prevent mental block.A catheterization was performed after urination to determine the post voiding residue.This residue is signifi cant when it exceeds 10% of the volume urinated.Dysuria was defi ned as voiding by abdominal thrusts, for very long with a weak stream and the lack of overall appearance bell curve for fl ow measurement.A lack Relaxation of perineal muscles during miction, resulting in a signifi cant and frequent recruitment on the EMG: it's bladder sphincter dyssynergia.Cystometry was conducted through bladder fi lling with saline 0.9% at a rate of 20ml/min on a patient in the dorsal position.The fi lling was stopped at "strong urge" and compared to the bladder capacity calculated for the patient's

Analysis of data
The data were entered and analyzed using Epi Info version 3.4.3.The quantitatives variables were compared with those qualitatives through statistical test Anova.The signifi cance level was p < 0.05

Ethical considerations
The information was collected with the strict and rigorous respect of anonymity, confi dentiality and medical secrecy.

Results
After the recount, 26 patients were recruited.It was the youth of these patients, the average age was 11.9 +/-5.8 years, table

Discussion
Improve life expectancy of children suffering from myelomeningocele, correlates with new problems such as impaired quality of life of patients and their parents, mothers in particular, multidisciplinary medical care, which must be rigorous and codifi ed and the question of sexuality of these future adults [6][7][8][9][10][11][12].The management and the neurourology monitoring of children victims of spina bifi da in the Department of Physical Medicine and Rehabilitation of Ibn Rochd in University Teaching Hospital of Casablanca, was the result of inter department collaboration that allows to make many observations.It was the youth of these patients [13], the average age of 11.9 +/-5.8 years table 1.A study by Szymanski and al., [8], on a larger population (369 patients) reported a similar mean age 10.8 years.More than 21years patients were excluded in their study, however this young population of patients with myelomeningocele was important.
Only sexual disorders studies in this pathology report an adult who remains as young as 27.7 +/-5.9 [11].Although life expectancy has improved [14,15], it remains very low.The follow-up study of Szymanski and al., [8], clearly showed that these patients did not die or fewly by kidney complications but by infections or obstruction of peritoneal shunt, urological or other origin sepsis, lung infections and birth defects, public road accidents and even suicide.Our study suggests a neurourology profi le that correlates with the four neurogenic bladder profi les described by Gamé and al., [4].This dysfunction caused complications such as alteration of the bladder wall, upper urinary tract refl ux, dilatation of the upper urinary tract with, urinary tract infections, stones and kidney failure.No bladder cancer has been reported today in spina bifi da patients.
Knowledge of urinary tract functioning in myelomeningocele has given rise to the current therapeutic arsenal [8,12].This diffi culty has already been neuropsychological disorders in these children associated hydrocephalus.In addition to this tremors, incoordination and grip that give heavier disability related to myelomeningocele.We understand that 30.8% of these children were at hetero-catheterization with their risks table 2. In Casablanca, detrusor injections of botulinum toxin just started and are sparingly.Although without authorization on the market for children, its effi cacy is recognized and could be offered to these patients.In our study population, two children had end stage kidney failure and were waiting to a kidney transplantation.This fact limits the spring for monitoring these fragile people, followed though highly codifi ed in French and in other countries [14], still suffers from shortcomings of the Moroccan health organization that has undoubtedly bright future with development of the medical assistance regime of Morocco, RAMED.Therapeutic efforts are needed to improve the quality of life expectancy of these patients in Morocco.Moroccan prevalence myelomeningocele [15], is well above that reported in the United States (Centers for Disease Control and Prevention.Data and Statistics in the United States, Spina Bifi da Homepage [2][3][4], French [4], Tunisia [5] and Kenya [16], 12.1 per 10,000 live births children.The weight of this failure on quality of life of children, their parents, the quality of the sexuality of these children reach adulthood, independence and life expectancy are to be evaluate.On the neuro-urology level, rigorous monitoring is to be organized.This monitoring will prevent the occurrence of complications or take care and improve the quality of life of these patients.According to the parameters covered, only urge incontinence seemed to be related to the occurrence of complications uro-nephrologics while compliance problems, reported in studies as a prognostic factor in neurogen bladder [17,18], was not related to the occurrence of complications table 3. Our statistical analysis confi rmed the lack of parallelism between the clinic and the results of urodynamics.Therefore, it is essential to have a good exploration before the initiation of the most suitable therapy.
The limitations of this work are mainly the reduced sample size and the need to analyze the becoming of these children.

Conclusion
age.Compliance was assessed by the ratio of fi lling volume on the change in pressure.The hypocompliance was defi ned by a lower compliance to 20 mL/cmH2O and detrusor overactivity by a sudden change of more than 15 cmH2O pressures.When phasic or terminal hyperactivity, lasts over time and exceeds 40 cmH2O, it is dangerous for upper urinary tract.Profi lometry was not performed because no interest in the exploration of children.The parameters studied were: age, sex, level of injury, urinary and anorectal disorders, abnormalities of the bladder wall and the expansion of the upper urinary tract and urodynamic abnormalities.Therapy proposed to these patients was also noted.
, compatible with the management of myelomeningocele in Morocco.Anticholinergics are widely command and fairly well accepted by children and their parents.While, self-and hetero-catheterization were most diffi cult to accept for those children, it was proposed for them.
Children victims of spina bifi da have follow-up and management problem with many care needs imposed by the affection for both children and their parents.The few children who come to the neuro-urology balance in UTH of Casablanca have a fairly standard profi le.Therapeutic efforts are needed to improve the quality of life and life expectancy of these patients Morocco.

Table 1 :
Distribution of patients like sociodemographic and clinical data.

Table 3 :
Distribution of patients according to factors associated with complications and compliance abnomalies.

Table 2 :
Distribution of patients according to the paraclinical and therapeutic data.