Open Journal of Analytical and Bioanalytical Chemistry
Editorial       Open Access      Peer-Reviewed

Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiation

Alireza Heidari*

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA
*Corresponding author: Alireza Heidari, Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA; E-mail: Scholar.Researcher.Scientist@gmail.com; Alireza.Heidari@calsu.us
Received:12 October, 2017 | Accepted: 10 November, 2017 | Published: 11 November, 2017

Cite this as

Heidari A (2017) Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiation. Open J Anal Bioanal Chem 1(1): 021-026. DOI: 10.17352/ojabc.000004

Editorial

Vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hyroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) are member of  organic compounds and an essential nutrients that an organism requires in limited amounts which plays a vital role in reducing negative effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on prostate cancer cells and tissues in prostate cancer treatment process through transformation of  malignant prostate tumors into benign prostate tumors under synchrotron radiation [1–44]. In addition, vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones), with a Cobalt (III) core, serves as catalysts for Triptorelin (Figure 1) as a Decapeptide (pGlu–His–Trp–Ser–Tyr–D–Trp–Leu–Arg–Pro–Gly–NH2) which is a Gonadotropin–Releasing Hormone agonist (GnRH agonist) used as the Acetate or Pamoate Salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) [45–99]. On the other hand, mesoporous nanomaterials are ideal supports for immobilization and extraction of these large biomolecules. It should be noted that SBA–1, SBA–3, SBA–15 and MCM–41 mesoporous silica are synthesized by Cetrimonium Bromide [(C16H33)N(CH3)3]Br; cetyltrimethylammonium bromide; hexadecyltrimethylammonium bromide; CTAB] quaternary ammonium surfactant via liquid phase deposition procedure. The synthesized mesoporous silica are characterized by  Energy Dispersive X–Ray Analysis (EDXA),  Energy Dispersive X–Ray Microanalysis (EDXMA), Scanning Electron Microscope (SEM), X–Ray Diffraction (XRD), Transmission Electron Microscope (TEM), Differential Thermal Analysis–Thermal Gravim Analysis (DTA–TGA), Energy–Dispersive X–Ray Spectroscopy (EDX), 1HNMR, 13CNMR, UV–Vis, HR–Mass, Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR–FTIR) and FT–Raman spectroscopies. Then, immobilization of vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) within the mesoporous silica are studied for the first time.

Characterization of vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) containing mesoporous support are described using Energy Dispersive X–Ray Analysis (EDXA),  Energy Dispersive X–Ray Microanalysis (EDXMA), Scanning Electron Microscope (SEM), X–Ray Diffraction (XRD), Transmission Electron Microscope (TEM), Differential Thermal Analysis–Thermal Gravim Analysis (DTA–TGA), Energy–Dispersive X–Ray Spectroscopy (EDX), 1HNMR, 13CNMR, UV–Vis, HR–Mass, Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR–FTIR) and FT–Raman spectroscopies. Effect of mesoporous pore size on immobilization of these relatively large biomolecules is taken into consideration. Results show that pore size plays a vital role on immobilization of large biomolecules. The newly synthesized mesostructured hybrid catalysts are investigated for reducing negative effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on prostate cancer cells and tissues in prostate cancer treatment process through transformation of  malignant prostate tumors into benign prostate tumors under synchrotron radiation. The ultrahigh specific area and highly dispersed catalysts species in SBA–1, SBA–3, SBA–15 and MCM–41/vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) nanomaterials create effective and active heterogeneous catalysts for oxidation purposes in presence of Hydrogen Peroxide as oxidant with high conversion 84%. Vacant SBA–1, SBA–3, SBA–15 and MCM–41 mesoporous silica are also studied for catalytic purposes. Results reveal that immobilized vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) biomolecules are the effective catalytic species responsible for reducing negative effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on prostate cancer cells and tissues in prostate cancer treatment process through transformation of  malignant prostate tumors into benign prostate tumors under synchrotron radiation.

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  69. Alireza Heidari (2017) Polymorphism in Nano–Sized Graphene Ligand–Induced Transformation of Au38–xAgx/xCux(SPh–tBu)24 to Au36–xAgx/xCux(SPh–tBu)24 (x = 1–12) Nanomolecules for Synthesis of Au144–xAgx/xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p–MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] Nano Clusters as Anti–Cancer Nano Drugs. J Nanomater Mol Nanotechnol 6: 3. Link: https://goo.gl/a8Nq9r
  70. Alireza Heidari (2017) Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research. Int J Biomed Data Min 6: e103, 2017. Link: https://goo.gl/M4p6XL
  71. Alireza Heidari (2017) Study of Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Olympiadane Nanomolecules as Agent for Cancer Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy under Synchrotorn Radiation. J Dev Drugs 6: e154. Link:
  72. Alireza Heidari (2017) A Novel Approach to Future Horizon of Top Seven Biomedical Research Topics to Watch in 2017: Alzheimer's, Ebola, Hypersomnia, Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Microbiome/Antibiotic Resistance and Endovascular Stroke. J Bioengineer & Biomedical Sci 7: e127. Link: https://goo.gl/U8db1r
  73. Alireza Heidari (2017) Opinion on Computational Fluid Dynamics (CFD) Technique. Fluid Mech Open Acc 4: 157. Link: https://goo.gl/XJ5SPb
  74. Alireza Heidari (2017) Concurrent Diagnosis of Oncology Influence Outcomes in Emergency General Surgery for Colorectal Cancer and Multiple Sclerosis (MS) Treatment Using Magnetic Resonance Imaging (MRI) and Au329(SR)84, Au329–xAgx(SR)84, Au144(SR)60, Au68(SR)36, Au30(SR)18, Au102(SPh)44, Au38(SPh)24, Au38(SC2H4Ph)24, Au21S(SAdm)15, Au36(pMBA)24 and Au25(pMBA)18 Nano Clusters. J Surgery Emerg Med 1: 21. Link: https://goo.gl/Xyyhqa
  75. Alireza Heidari (2017) Developmental Cell Biology in Adult Stem Cells Death and Autophagy to Trigger a Preventive Allergic Reaction to Common Airborne Allergens under Synchrotron Radiation Using Nanotechnology for Therapeutic Goals in Particular Allergy Shots (Immunotherapy). Cell Biol (Henderson, NV) 6: 1. Link: https://goo.gl/d1KNpC
  76. Alireza Heidari (2017) Changing Metal Powder Characteristics for Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins Adjustment in Cancer Metastases Induced by Osteosarcoma, Chondrosarcoma, Carcinoid, Carcinoma, Ewing’s Sarcoma, Fibrosarcoma and Secondary Hematopoietic Solid or Soft Tissue Tumors. J Powder Metall Min 6: 170. Link: https://goo.gl/qx7yB4
  77. Alireza Heidari (2017) Nanomedicine–Based Combination Anti–Cancer Therapy between Nucleic Acids and Anti–Cancer Nano Drugs in Covalent Nano Drugs Delivery Systems for Selective Imaging and Treatment of Human Brain Tumors Using Hyaluronic Acid, Alguronic Acid and Sodium Hyaluronate as Anti–Cancer Nano Drugs and Nucleic Acids Delivery under Synchrotron Radiation. Am J Drug Deliv 5: 2. Link: https://goo.gl/YzECww
  78. Alireza Heidari (2017) Clinical Trials of Dendritic Cell Therapies for Cancer Exposing Vulnerabilities in Human Cancer Cells’ Metabolism and Metabolomics: New Discoveries, Unique Features Inform New Therapeutic Opportunities, Biotech's Bumpy Road to the Market and Elucidating the Biochemical Programs that Support Cancer Initiation and Progression. J Biol Med Science 1: e103. Link: https://goo.gl/5YMGni
  79. Alireza Heidari (2017) The Design Graphene–Based Nanosheets as a New Nanomaterial in Anti–Cancer Therapy and Delivery of Chemotherapeutics and Biological Nano Drugs for Liposomal Anti–Cancer Nano Drugs and Gene Delivery. Br Biomed Bull 5: 305. Link: https://goo.gl/BrdrFx
  80. Alireza Heidari (2017) Integrative Approach to Biological Networks for Emerging Roles of Proteomics, Genomics and Transcriptomics in the Discovery and Validation of Human Colorectal Cancer Biomarkers from DNA/RNA Sequencing Data under Synchrotron Radiation. Transcriptomics 5: e117. Link: https://goo.gl/DF4iEu
  81. Alireza Heidari (2017) Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation. Lett Health Biol Sci 2: 1–4. Link: https://goo.gl/3Y4zpB
  82. Alireza Heidari (2017) Treatment of Breast Cancer Brain Metastases through a Targeted Nanomolecule Drug Delivery System Based on Dopamine Functionalized Multi–Wall Carbon Nanotubes (MWCNTs) Coated with Nano Graphene Oxide (GO) and Protonated Polyaniline (PANI) in Situ During the Polymerization of Aniline Autogenic Nanoparticles for the Delivery of Anti–Cancer Nano Drugs under Synchrotron Radiation. Br J Res 4: 16. Link: https://goo.gl/GCskU1
  83. Alireza Heidari (2017) Sedative, Analgesic and Ultrasound–Mediated Gastrointestinal Nano Drugs Delivery for Gastrointestinal Endoscopic Procedure, Nano Drug–Induced Gastrointestinal Disorders and Nano Drug Treatment of Gastric Acidity. Res Rep Gastroenterol 1:1. Link: https://goo.gl/Qze2Xg
  84. Alireza Heidari (2017) Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Orphan Nano Drugs to Treat High Cholesterol and Related Conditions and to Prevent Cardiovascular Disease under Synchrotron Radiation. J Pharm Sci Emerg Drugs 5: 1. Link: https://goo.gl/coQkxe
  85. Alireza Heidari (2017) Non–Linear Compact Proton Synchrotrons to Improve Human Cancer Cells and Tissues Treatments and Diagnostics through Particle Therapy Accelerators with Monochromatic Microbeams. J Cell Biol Mol Sci 2: 1–5. Link: https://goo.gl/zRKG9Q
  86. Alireza Heidari (2017) Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood–Brain Barrier (BBB) Translocation to Targeted Deliver Anti–Cancer Nano Drugs into the Human Brain to Treat Alzheimer’s Disease under Synchrotron Radiation. J Nanotechnol Material Sci 4: 1–5. Link: https://goo.gl/7iLSqH
  87. Ricardo Gobato, Alireza Heidari (2017) Calculations Using Quantum Chemistry for Inorganic Molecule Simulation BeLi2SeSi. American Journal of Quantum Chemistry and Molecular Spectroscopy 2: 37–46. Link: https://goo.gl/AB8AFg
  88. Alireza Heidari (2014) An Investigation of the Role of DNA as Molecular Computers: A Computational Study on the Hamiltonian Path Problem. International Journal of Scientific and Engineering Research 5: 1884-1889. Link: https://goo.gl/of4mxz
  89. Alireza Heidari (2017) Different High–Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Lung Cancer Translational Anti–Cancer Nano Drugs Delivery Treatment Process under Synchrotron and X–Ray Radiations. J Med Oncol 1: 1. Link: https://goo.gl/Z6Z7NY
  90. Alireza Heidari (2017) A Modern Ethnomedicinal Technique for Transformation, Prevention and Treatment of Human Malignant Gliomas Tumors into Human Benign Gliomas Tumors under Synchrotron Radiation. Am J Ethnomed 4: 10. Link: https://goo.gl/2xvMpq
  91. Alireza Heidari (2017) Active Targeted Nanoparticles for Anti–Cancer Nano Drugs Delivery across the Blood–Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer's Diseases Using Chemical Modifications of Anti–Cancer Nano Drugs or Drug–Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation. J Med Chem Toxicol 2: 1–5. Link: https://goo.gl/hXYbt5
  92. Alireza Heidari (2017) Investigation of Medical, Medicinal, Clinical and Pharmaceutical Applications of Estradiol, Mestranol (Norlutin), Norethindrone (NET), Norethisterone Acetate (NETA), Norethisterone Enanthate (NETE) and Testosterone Nanoparticles as Biological Imaging, Cell Labeling, Anti–Microbial Agents and Anti–Cancer Nano Drugs in Nanomedicines Based Drug Delivery Systems for Anti–Cancer Targeting and Treatment. Parana Journal of Science and Education (PJSE) 3.
  93. Alireza Heidari (2017) A Comparative Computational and Experimental Study on Different Vibrational Biospectroscopy Methods, Techniques and Applications for Human Cancer Cells in Tumor Tissues Simulation, Modeling, Research, Diagnosis and Treatment. Open J Anal Bioanal Chem 1: 014–020. Link: https://goo.gl/XULDTr
  94. Alireza Heidari (2017) Combination of DNA/RNA Ligands and Linear/Non–Linear Visible–Synchrotron Radiation–Driven N–Doped Ordered Mesoporous Cadmium Oxide (CdO) Nanoparticles Photocatalysts Channels Resulted in an Interesting Synergistic Effect Enhancing Catalytic Anti–Cancer Activity. Enz Eng 6: 1. Link: https://goo.gl/B6gmN5
  95. Alireza Heidari (2017) Modern Approaches in Designing Ferritin, Ferritin Light Chain, Transferrin, Beta–2 Transferrin and Bacterioferritin–Based Anti–Cancer Nano Drugs Encapsulating Nanosphere as DNA–Binding Proteins from Starved Cells (DPS). Mod Appro Drug Des 1: MADD.000504. Link: https://goo.gl/bVVf2i
  96. Alireza Heidari (2017) Potency of Human Interferon β–1a and Human Interferon β–1b in Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus Enter and Targets Liver Cells. J Proteomics Enzymol 6: 1. Link: https://goo.gl/Kev81F
  97. Alireza Heidari (2017) Transport Therapeutic Active Targeting of Human Brain Tumors Enable Anti-Cancer Nanodrugs Delivery across the Blood-Brain Barrier (BBB) to Treat Brain Diseases Using Nanoparticles and Nanocarriers under Synchrotron Radiation. J Pharm Pharmaceutics 4: 1-5. Link: https://goo.gl/55dMeu
  98. Alireza Heidari, Christopher Brown (2017) Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti-Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems. Ann Adv Chem 1: 061-069. Link: https://goo.gl/Akkifi
  99. Alireza Heidari (2017) High–Resolution Simulations of Human Brain Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron Radiation. J Transl Res 1: 1–3. Link: https://goo.gl/JVgHrN
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