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Ge Zhi-Dong

Designation:
Assistant Professor
Department:
Department of Anesthesiology
University:
Medical College of Wisconsin
Country:
USA
Email:
zdge@mcw.edu
Journal Associated: Journal of Addiction Medicine and Therapeutic Science Biography:

Research Interest: Dr. Ge’s research focuses on protection of ischemic myocardium against ischemia and reperfusion injury. This includes the application of volatile anesthetics, adenosine receptor agonists, and ischemic preconditioning, the phenomenon in which myocardium exposed to brief, repeated periods of sublethal ischemia becomes resistant to the deleterious effects of ischemia or reperfusion. Recent evidence from this lab indicates thatgenetic modulation of GTP cyclohydrolase 1 to increase cardiac tetrahydrobiopterin and nitric oxide production can protect myocardium from ischemia and reperfusion injuryand preserve the ability of ischemic preconditioning to elicit cardioprotection that is impaired by hyperglycemia. Further investigations are being actively conducted, including the mechanisms underlying myocardial protection by overexpression of GTP cyclohydrolase 1 gene in the presence of hyperglycemia and diabetes and the potential of GTP cyclohydrolase 1 overexpression in reducing maladaptive myocardial remodeling followinginfarction in diabetic and nondiabetic myocardium.

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