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Peertechz Publisher ID: 10.17352

Jose Russo

Designation:
Professor
Department:
University:
Temple University
Country:
USA
Email:
Jose.Russo@fccc.edu
Journal Associated: Studies on Stem Cells Research and Therapy Biography:

Research Interest: Harnessed the Biological Principle that Pregnancy and Hormones Mimicking Pregnancy Induced Breast Cancer Prevention.  The Preventive Effect of Pregnancy is Mediated by the Induction of Differentiation of the Mammary Gland.  In Studies Performed in Humans, He has Found that During the Post-Menopausal Years the Breast of Both Parous and Nulliparous Women Contains Preponderantly Lob 1 that Differs Biologically By Exhibiting Different Susceptibility to Carcinogenesis, And Remodeling Of Chromatin That Emerges As Novel Marker For Defining The Concept Of Differentiation In The Adult Breast.  His Laboratory Has Studied The Genomic Profile Of Nulliparous And Parous Women In The Premenopausal And Postmenopausal Period And Find That There Are Genes Only Activated During The First Five Years After Pregnancy That May Contribute To The Increased Risk Experimented By Certain Women After Pregnancy And At The Same Time They Have Confirmed That Pregnancy Induces A Long Lasting Genomic Signature That Start After Pregnancy That Explain Its Preventive Effect. The Molecular Mechanism Related To Prevention Is Around The Chromatin Remodeling Process. Using The In Vitro In Vivo Model Developed In His Laboratory He Is Identifying Drugs That Can Control Chromatin Remodeling As A Preventive Strategy.

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