Juciano Gasparotto

Designation:
Professor
Department:
Biochemistry
University:
Federal University
Country:
Brazil
Email:
juciano.gasparotto@gmail.com
Journal Associated: Archive of Biochemistry Biography:

Graduated in Physical Education from Universidade Luterana do Brasil-ULBRA. Post-graduation in

Exercise Physiology and Training Prescription by Gama Filho University of Rio de Janeiro.

Master and PhD in Biological Sciences - Biochemistry by Federal University of Rio Grande do

Sul-UFRGS. Currently is linked to the National Postdoctoral Program of CAPES (PNPD /

CAPES) and collaborator of the Department of Biochemistry of UFRGS. As a researcher, has

experience with several experimental models, including rodents, cell culture and clinical studies.

Current research projects focus on the investigation of neuronal dysfunctions associated with

inflammatory processes. Immuno-neutralization of proteins, pharmacological agents, diets and

physical exercise are some of the methods used as therapeutic alternatives to treat

neuropathologies that the inflammation is involved.

Research Interest: Biochemistry, physiology and nutrition

Grants: 2017 Travel Award - Paris, France, International Society of Neurochemistry

19. List of Publications:

1.RIBEIRO, CAMILA T. ; GASPAROTTO, JUCIANO ; PORTELA, L. V. C. ; MOREIRA, J. C. F. ; GELAIN, Daniel Pens . Immune neutralization of the receptor for advanced glycation end products reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide. JOURNAL OF BIOCHEMISTRY , p. 1-15, 2018.
2.GASPAROTTO, JUCIANO; GIRARDI, CAROLINA S. ; SOMENSI, NAUANA ; RIBEIRO, CAMILA T. ; MOREIRA, JOSÉ C. F. ; MICHELS, MONIQUE ; SONAI, BEATRIZ ; ROCHA, MARIANE ; STECKERT, AMANDA V. ; BARICHELLO, TATIANA ; QUEVEDO, JOÃO ; DAL-PIZZOL, FELIPE ; GELAIN, DANIEL P. . Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. JOURNAL OF BIOLOGICAL CHEMISTRY , v. 293, p. 226-244, 2018.
3.DE ARAÚJO, FILLIPE M. ; FERREIRA, RAFAEL S. ; SOUZA, CLEIDE S. ; DOS SANTOS, CLEONICE CREUSA ; RODRIGUES, TÁCIO L.R.S. ; E SILVA, JULIANA HELENA C. ; GASPAROTTO, JUCIANO ; GELAIN, Daniel Pens ; EL-BACHÁ, RAMON S. ; D. COSTA, MARIA DE FÁTIMA ; FONSECA, JOSÉ CLAUDIO M. ; SEGURA-AGUILAR, JUAN ; COSTA, SILVIA L. ; SILVA, VICTOR DIOGENES A. . Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures. NEUROTOXICOLOGY , v. 66, p. 98-106, 2018.
4.  GASPAROTTO, J.; RIBEIRO, C. T. ; SILVA, H. T. R. ; BORTOLIN, R. C. ; RABELO, THALLITA K. ; PEIXOTO, D. O. ; MOREIRA, J. C. F. ; GELAIN, Daniel Pens . Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas. MOLECULAR NEUROBIOLOGY , v. 31, p. 1-11, 2018.
5.GASPAROTTO, J; CHAVES, P. R. ; MARTINELLO, K. B. ; ROSA, H. ; BORTOLIN, R. C. ; SILVA, L. F. O. ; RABELO, T. K. ; SILVA, J. ; SILVA, F. R. ; NORDIN, A. P. ; SOARES, K. ; BORGES, M. S. ; GELAIN, D. P. ; MOREIRA, J. C. F. . Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY , v. 165, p. 44-51, 2018.
6.KUNZLER, ALICE ; Zeidán-Chuliá, Fares ; GASPAROTTO, J. ; GIRARDI, CAROLINA SAIBRO ; KLAFKE, KARINA ; PETIZ, LYVIA LINTZMAIER ; BORTOLIN, RAFAEL CALIXTO ; ROSTIROLLA, DIANA CAROLINA ; ZANOTTO-FILHO, Alfeu ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; DICKSON, PHILLIP ; DUNKLEY, PETER ; Moreira, José Cláudio Fonseca ; GELAIN, Daniel Pens . Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress. MOLECULAR NEUROBIOLOGY , v. 54, p. 6903-6916, 2017.
7.BORTOLIN, RAFAEL CALIXTO ; GASPAROTTO, J. ; VARGAS, AMANDA RODRIGUES ; DA SILVA MORRONE, MAURILIO ; KUNZLER, ALICE ; HENKIN, BERNARDO SALDANHA ; CHAVES, PALOMA RODRIGUES ; RONCATO, SABRINA ; GELAIN, D.P. ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Effects of Freeze-Thaw and Storage on Enzymatic Activities, Protein Oxidative Damage, and Immunocontent of the Blood, Liver, and Brain of Rats. Biopreservation and Biobanking , v. 15, p. 182-190, 2017.
8.GASPAROTTO, JUCIANO; RIBEIRO, CAMILA TIEFENSEE ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; FERNANDES, HENRIQUE SCHAAN ; TEIXEIRA, ALEXSANDER ALVES ; GUASSELLI, MARCELO OTAVIO RODRIGUES ; AGANI, CREPIN AZIZ JOSE O. ; SOUZA, NATÁLIA CABRAL ; GRINGS, MATEUS ; LEIPNITZ, GUILHIAN ; GOMES, HENRIQUE MAUTONE ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; DUNKLEY, PETER R. ; DICKSON, PHILLIP W. ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum. BRAIN BEHAVIOR AND IMMUNITY , v. 62, p. 124-136, 2017.
9.BORTOLIN, R C ; VARGAS, A R ; GASPAROTTO, J ; CHAVES, P R ; SCHNORR, C E ; DA BOIT MARTINELLO, K ; SILVEIRA, A K ; RABELO, T K ; GELAIN, D P ; MOREIRA, J C F . A new animal diet based on human Western diet is a robust diet-induced obesity model: Comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption. INTERNATIONAL JOURNAL OF OBESITY , v. 1, p. 1-15, 2017.
10.SOMENSI, NAUANA ; BRUM, PEDRO OZORIO ; DE MIRANDA RAMOS, VITOR ; GASPAROTTO, JUCIANO ; ZANOTTO-FILHO, ALFEU ; ROSTIROLLA, DIANA CAROLINA ; DA SILVA MORRONE, MAURILIO ; MOREIRA, JOSÉ CLAUDIO FONSECA ; PENS GELAIN, DANIEL . Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY , v. 42, p. 2507-2522, 2017.
11.MOURA, ALANA PIMENTEL ; PARMEGGIANI, BELISA ; GASPAROTTO, JUCIANO ; GRINGS, MATEUS ; FERNANDEZ CARDOSO, GABRIELA MIRANDA ; SEMINOTTI, BIANCA ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens ; WAJNER, MOACIR ; LEIPNITZ, GUILHIAN . Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia. MOLECULAR NEUROBIOLOGY , v. 1, p. 1-10, 2017.
12.KUNZLER, ALICE ; KOLLING, EDUARDO ANTÔNIO ; DA SILVA-JR, JEFERSON DELGADO ; GASPAROTTO, JUCIANO ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line. NEUROCHEMICAL RESEARCH , v. 42, p. 2788-2797, 2017.
13.PETIZ, LYVIA LINTZMAIER ; KUNZLER, ALICE ; BORTOLIN, RAFAEL CALIXTO ; GASPAROTTO, JUCIANO ; MATTÉ, CRISTIANE ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Role of vitamin A oral supplementation on oxidative stress and inflammatory response in the liver of trained rats. Applied Physiology Nutrition and Metabolism , v. 42, p. 1192-1200, 2017.
14.GASPAROTTO, JUCIANO; RIBEIRO, CAMILA TIEFENSEE ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; RABELO, THALLITA KELLY ; KUNZLER, ALICE ; SOUZA, NATÁLIA CABRAL ; PASQUALI, MATHEUS AUGUSTO DE BITTENCOURT ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation. Scientific Reports , v. 7, p. 1-12, 2017.
15.PETIZ, LYVIA LINTZMAIER ; GIRARDI, CAROLINA SAIBRO ; BORTOLIN, RAFAEL CALIXTO ; KUNZLER, ALICE ; GASPAROTTO, J. ; RABELO, THALLITA KELLY ; MATTÉ, C. ; MOREIRA, JOSÉ CLAUDIO FONSECA ; GELAIN, DANIEL PENS . Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats. Nutrients , v. 9, p. 353, 2017.
16.GASPAROTTO, J.; KUNZLER, ALICE ; SENGER, MARIO ROBERTO ; SOUZA, Celeste da Silva Freitas de ; SIMONE, SALVATORE GIOVANNI DE ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; DAL-PIZZOL, FELIPE ; MOREIRA, JOSÉ CLAUDIO FONSECA ; ABREU-SILVA, ANA LÚCIA ; CALABRESE, K. S. ; SILVA JR, FLORIANO PAES ; GELAIN, DANIEL PENS . N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz (Online) , v. 112, p. 146-154, 2017.
17.RABELO, THALLITA KELLY ; GUIMARÃES, ADRIANA GIBARA ; OLIVEIRA, MARLANGE ALMEIDA ; GASPAROTTO, JUCIANO ; SERAFINI, MAIRIM RUSSO ; DE SOUZA ARAÚJO, ADRIANO ANTUNES ; QUINTANS-JÚNIOR, LUCINDO JOSÉ ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice. International Immunopharmacology (Print) , v. 39, p. 97-105, 2016.
18.MORRONE, MAURILIO DA SILVA ; Schnorr, Carlos Eduardo ; BEHR, GUILHERME ANTÔNIO ; GASPAROTTO, JUCIANO ; BORTOLIN, RAFAEL CALIXTO ; DA BOIT MARTINELLO, KATIA ; SALDANHA HENKIN, BERNARDO ; RABELLO, THALLITA KELLY ; ZANOTTO-FILHO, ALFEU ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity , v. 2016, p. 1-12, 2016.
19.DA SILVA MORRONE, MAURILIO ; Schnorr, Carlos Eduardo ; BEHR, GUILHERME ANTÔNIO ; GASPAROTTO, JUCIANO ; BORTOLIN, RAFAEL CALIXTO ; MORESCO, KARLA SUZANA ; BITTENCOURT, LEONARDO ; ZANOTTO-FILHO, ALFEU ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats. JOURNAL OF NUTRITIONAL BIOCHEMISTRY , v. 32, p. 181-188, 2016.
20.DE MIRANDA RAMOS, VITOR ; ZANOTTO-FILHO, ALFEU ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; KLAFKE, KARINA ; GASPAROTTO, JUCIANO ; DUNKLEY, PETER ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation. MOLECULAR NEUROBIOLOGY , v. 53, p. 6124-6135, 2016.
21.RABELO, THALLITA KELLY ; ZEIDÁN-CHULIÁ, FARES ; CAREGNATO, FERNANDA FREITAS ; Schnorr, Carlos Eduardo ; GASPAROTTO, JUCIANO ; SERAFINI, MAIRIM RUSSO ; DE SOUZA ARAÚJO, ADRIANO ANTUNES ; QUINTANS-JUNIOR, LUCINDO JOSÉ ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . In Vitro Neuroprotective Effect of Shikimic Acid Against Hydrogen Peroxide-Induced Oxidative Stress. Journal of Molecular Neuroscience , v. 1, p. 1-10, 2015.
22.SANTOS, JULIANA CÉLIA F. ; DE ARAÚJO, ORLANDO R. P. ; VALENTIM, IARA B. ; DE ANDRADE, KÍVIA QUEIROZ ; MOURA, FABIANA ANDRÉA ; SMANIOTTO, SALETE ; DOS SANTOS, JOHN MARQUES ; GASPAROTTO, JUCIANO ; GELAIN, DANIEL P. ; GOULART, MARÍLIA O. F. . Choline and Cystine Deficient Diets in Animal Models with Hepatocellular Injury: Evaluation of Oxidative Stress and Expression of RAGE, TNF- α , and IL-1 β. Oxidative Medicine and Cellular Longevity , v. 2015, p. 1-11, 2015.
23.GASPAROTTO, JUCIANO; SENGER, MARIO ROBERTO ; KUNZLER, ALICE ; DEGROSSOLI, ADRIANA ; DE SIMONE, SALVATORE GIOVANNI ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; GIRARDI, CAROLINA SAIBRO ; DE SOUZA, CELESTE DA SILVA FREITAS ; CALABRESE, KÁTIA DA SILVA ; DAL-PIZZOL, FELIPE ; Moreira, José Claudio Fonseca ; SILVA-JR, FLORIANO PAES ; GELAIN, Daniel Pens . Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis. BRAIN BEHAVIOR AND IMMUNITY , v. 43, p. 37-45, 2015.
24.GASPAROTTO, JUCIANO; PETIZ, LYVIA LINTZMAIER ; GIRARDI, CAROLINA SAIBRO ; BORTOLIN, RAFAEL CALIXTO ; DE VARGAS, AMANDA RODRIGUES ; HENKIN, BERNARDO SALDANHA ; CHAVES, PALOMA RODRIGUES ; RONCATO, SABRINA ; MATTÉ, CRISTIANE ; ZANOTTO-FILHO, ALFEU ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . Supplementation with vitamin A enhances oxidative stress in the lungs of rats submitted to aerobic exercise. Applied Physiology Nutrition and Metabolism , v. 40, p. 1253-1261, 2015.
25.TONIN, ANELISE MIOTTI ; AMARAL, ALEXANDRE UMPIERREZ ; BUSANELLO, ESTELA NATACHA ; GASPAROTTO, JUCIANO ; GELAIN, DANIEL P. ; GREGERSEN, NIELS ; WAJNER, MOACIR . Mitochondrial bioenergetics deregulation caused by long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies in rat brain: A possible role of mPTP opening as a pathomechanism in these disorders?. Biochimica et Biophysica Acta. Molecular Basis of Disease , v. 1842, p. 1658-1667, 2014.
26.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; BORTOLIN, RAFAEL CALIXTO ; MORESCO, KARLA SUZANA ; GIRARDI, CAROLINA SAIBRO ; KLAFKE, KARINA ; RABELO, THALLITA KELLY ; MORRONE, MAURILIO DA SILVA ; VIZZOTTO, MÁRCIA ; RASEIRA, MARIA DO CARMO BASSOLS ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Effects of different products of peach (Prunus persica L. Batsch) from a variety developed in southern Brazil on oxidative stress and inflammatory parameters in vitro and ex vivo. Journal of Clinical Biochemistry and Nutrition , v. 55, p. 110-119, 2014.
27.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; KUNZLER, ALICE ; GIRARDI, CAROLINA ; PASQUALI, MATHEUS ; RAMOS, VITOR ; SIMOES-PIRES, ANDRE ; QUINTANS-JUNIOR, LUCINDO ; BRANCO, ALEXSANDRO ; MOREIRA, JOSE ; GELAIN, DANIEL . Hecogenin Acetate Inhibits Reactive Oxygen Species Production and Induces Cell Cycle Arrest and Senescence in the A549 Human Lung Cancer Cell Line. Anti-Cancer Agents in Medicinal Chemistry , v. 14, p. 1128-1135, 2014.
28.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; BORTOLIN, RAFAEL CALIXTO ; GIRARDI, CAROLINA SAIBRO ; KUNZLER, ALICE ; RABELO, THALLITA KELLY ; Schnorr, Carlos Eduardo ; MORESCO, KARLA SUZANA ; BASSANI, VALQUIRIA LINCK ; YATSU, FRANCINI KIYONO JORGE ; VIZZOTTO, MÁRCIA ; RASEIRA, MARIA DO CARMO BASSOLS ; ZANOTTO-FILHO, ALFEU ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage. JOURNAL OF NUTRITIONAL BIOCHEMISTRY , v. 25, p. 1282-1295, 2014.
29.GRINGS, MATEUS ; MOURA, ALANA P. ; AMARAL, ALEXANDRE U. ; PARMEGGIANI, BELISA ; GASPAROTTO, JUCIANO ; MOREIRA, JOSÉ C.F. ; GELAIN, DANIEL P. ; WYSE, ANGELA T.S. ; WAJNER, MOACIR ; LEIPNITZ, GUILHIAN . Sulfite disrupts brain mitochondrial energy homeostasis and induces mitochondrial permeability transition pore opening via thiol group modification. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE , v. 1842, p. 1413-1422, 2014.
30.GRUNWALD, MARCELO SARTORI ; PIRES, ANDRÉ SIMÕES ; ZANOTTO-FILHO, ALFEU ; GASPAROTTO, JUCIANO ; GELAIN, Daniel Pens ; DEMARTINI, DIOGO RIBEIRO ; SCHÖLER, CINTHIA MARIA ; DE BITTENCOURT, PAULO IVO HOMEM ; MOREIRA, JOSÉ CLÁUDIO FONSECA . The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity. CELL STRESS & CHAPERONES , v. 19, p. 913-925, 2014.
31.GASPAROTTO, JUCIANO; BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; SOMENSI, NAUANA ; VASQUES, LAURA MILÁN ; Moreira, José Claudio Fonseca ; ALMEIDA, REINALDO NOBREGA ; BARBOSA-FILHO, JOSE MARIA ; FÁTIMA VANDERLEI DE SOUZA, MARIA ; GUTIERREZ, STANLEY JUAN CHAVEZ ; JÚNIOR, LUCINDO JOSÉ QUINTANS ; GELAIN, Daniel Pens . Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages. Cell Biology and Toxicology , v. 29, p. 175-187, 2013.
32.DE OLIVEIRA, RAMATIS BIRNFELD ; SENGER, MARIO ROBERTO ; VASQUES, LAURA MILAN ; GASPAROTTO, JUCIANO ; DOS SANTOS, JOÃO PAULO ALMEIDA ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; Moreira, José Claudio Fonseca ; SILVA, FLORIANO PAES ; GELAIN, Daniel Pens . Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice. International Journal for Parasitology , v. 43, p. 371-379, 2013.
33.DA SILVA MORRONE, MAURILIO ; DE ASSIS, ADRIANO MARTIMBIANCO ; DA ROCHA, RICARDO FAGUNDES ; GASPAROTTO, JUCIANO ; GAZOLA, ANDRESSA CÓRNEO ; COSTA, GEISON MODESTI ; ZUCOLOTTO, SILVANA MARIA ; CASTELLANOS, LEONARDO H. ; RAMOS, FREDDY A. ; SCHENKEL, ELOIR PAULO ; REGINATTO, FLÁVIO HENRIQUE ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ C.F. . Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models. Food and Chemical Toxicology , v. 60, p. 45-51, 2013.
34.DA ROSA, M. S. ; SEMINOTTI, B. ; AMARAL, A. U. ; FERNANDES, C. G. ; GASPAROTTO, J. ; MOREIRA, J. C. F. ; GELAIN, D. P. ; WAJNER, M. ; LEIPNITZ, G. . Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver. Free Radical Research , v. 47, p. 1066-1075, 2013.
35.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; CAREGNATO, FERNANDA F. ; RABELO, THALLITA K. ; DABOIT, KÁTIA ; OLIVEIRA, MARCOS L.S. ; MOREIRA, JOSÉ C.F. ; GELAIN, DANIEL P. . Coal and tire burning mixtures containing ultrafine and nanoparticulate materials induce oxidative stress and inflammatory activation in macrophages. SCIENCE OF THE TOTAL ENVIRONMENT , v. 463-464, p. 743-753, 2013.
36.DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; GELAIN, Daniel Pens ; ZEIDÁN-CHULIÁ, FARES ; PIRES, ANDRÉ SIMÕES ; GASPAROTTO, JUCIANO ; TERRA, SILVIA RESENDE ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells. CELLULAR SIGNALLING , v. 1, p. 939-954, 2013.
37.BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; Oliveira, Marcos Roberto ; DE BASTIANI, MARCO ANTÔNIO ; Rocha, Ricardo Fagundes ; Schnorr, Carlos Eduardo ; GASPAROTTO, JUCIANO ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . L-NAME co-treatment prevent oxidative damage in the lung of adult Wistar rats treated with vitamin A supplementation. Cell Biochemistry and Function , v. 30, p. 256-263, 2012.


Research Interest: Biochemistry, physiology and nutritionml> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-fareast-language:EN-US;} </style> Research Interest: Biochemistry, physiology and nutritionGrants: 2017 Travel Award - Paris, France, International Society of NeurochemistryList of Publications: 1.RIBEIRO, CAMILA T. ; GASPAROTTO, JUCIANO ; PORTELA, L. V. C. ; MOREIRA, J. C. F. ; GELAIN, Daniel Pens . Immune neutralization of the receptor for advanced glycation end products reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide. JOURNAL OF BIOCHEMISTRY , p. 1-15, 2018.2.GASPAROTTO, JUCIANO; GIRARDI, CAROLINA S. ; SOMENSI, NAUANA ; RIBEIRO, CAMILA T. ; MOREIRA, JOSÉ C. F. ; MICHELS, MONIQUE ; SONAI, BEATRIZ ; ROCHA, MARIANE ; STECKERT, AMANDA V. ; BARICHELLO, TATIANA ; QUEVEDO, JOÃO ; DAL-PIZZOL, FELIPE ; GELAIN, DANIEL P. . Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. JOURNAL OF BIOLOGICAL CHEMISTRY , v. 293, p. 226-244, 2018.3.DE ARAÚJO, FILLIPE M. ; FERREIRA, RAFAEL S. ; SOUZA, CLEIDE S. ; DOS SANTOS, CLEONICE CREUSA ; RODRIGUES, TÁCIO L.R.S. ; E SILVA, JULIANA HELENA C. ; GASPAROTTO, JUCIANO ; GELAIN, Daniel Pens ; EL-BACHÁ, RAMON S. ; D. COSTA, MARIA DE FÁTIMA ; FONSECA, JOSÉ CLAUDIO M. ; SEGURA-AGUILAR, JUAN ; COSTA, SILVIA L. ; SILVA, VICTOR DIOGENES A. . Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures. NEUROTOXICOLOGY , v. 66, p. 98-106, 2018.4.  GASPAROTTO, J.; RIBEIRO, C. T. ; SILVA, H. T. R. ; BORTOLIN, R. C. ; RABELO, THALLITA K. ; PEIXOTO, D. O. ; MOREIRA, J. C. F. ; GELAIN, Daniel Pens . Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas. MOLECULAR NEUROBIOLOGY , v. 31, p. 1-11, 2018.5.GASPAROTTO, J; CHAVES, P. R. ; MARTINELLO, K. B. ; ROSA, H. ; BORTOLIN, R. C. ; SILVA, L. F. O. ; RABELO, T. K. ; SILVA, J. ; SILVA, F. R. ; NORDIN, A. P. ; SOARES, K. ; BORGES, M. S. ; GELAIN, D. P. ; MOREIRA, J. C. F. . Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY , v. 165, p. 44-51, 2018.6.KUNZLER, ALICE ; Zeidán-Chuliá, Fares ; GASPAROTTO, J. ; GIRARDI, CAROLINA SAIBRO ; KLAFKE, KARINA ; PETIZ, LYVIA LINTZMAIER ; BORTOLIN, RAFAEL CALIXTO ; ROSTIROLLA, DIANA CAROLINA ; ZANOTTO-FILHO, Alfeu ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; DICKSON, PHILLIP ; DUNKLEY, PETER ; Moreira, José Cláudio Fonseca ; GELAIN, Daniel Pens . Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress. MOLECULAR NEUROBIOLOGY , v. 54, p. 6903-6916, 2017.7.BORTOLIN, RAFAEL CALIXTO ; GASPAROTTO, J. ; VARGAS, AMANDA RODRIGUES ; DA SILVA MORRONE, MAURILIO ; KUNZLER, ALICE ; HENKIN, BERNARDO SALDANHA ; CHAVES, PALOMA RODRIGUES ; RONCATO, SABRINA ; GELAIN, D.P. ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Effects of Freeze-Thaw and Storage on Enzymatic Activities, Protein Oxidative Damage, and Immunocontent of the Blood, Liver, and Brain of Rats. Biopreservation and Biobanking , v. 15, p. 182-190, 2017.8.GASPAROTTO, JUCIANO; RIBEIRO, CAMILA TIEFENSEE ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; FERNANDES, HENRIQUE SCHAAN ; TEIXEIRA, ALEXSANDER ALVES ; GUASSELLI, MARCELO OTAVIO RODRIGUES ; AGANI, CREPIN AZIZ JOSE O. ; SOUZA, NATÁLIA CABRAL ; GRINGS, MATEUS ; LEIPNITZ, GUILHIAN ; GOMES, HENRIQUE MAUTONE ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; DUNKLEY, PETER R. ; DICKSON, PHILLIP W. ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum. BRAIN BEHAVIOR AND IMMUNITY , v. 62, p. 124-136, 2017.9.BORTOLIN, R C ; VARGAS, A R ; GASPAROTTO, J ; CHAVES, P R ; SCHNORR, C E ; DA BOIT MARTINELLO, K ; SILVEIRA, A K ; RABELO, T K ; GELAIN, D P ; MOREIRA, J C F . A new animal diet based on human Western diet is a robust diet-induced obesity model: Comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption. INTERNATIONAL JOURNAL OF OBESITY , v. 1, p. 1-15, 2017.10.SOMENSI, NAUANA ; BRUM, PEDRO OZORIO ; DE MIRANDA RAMOS, VITOR ; GASPAROTTO, JUCIANO ; ZANOTTO-FILHO, ALFEU ; ROSTIROLLA, DIANA CAROLINA ; DA SILVA MORRONE, MAURILIO ; MOREIRA, JOSÉ CLAUDIO FONSECA ; PENS GELAIN, DANIEL . Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY , v. 42, p. 2507-2522, 2017.11.MOURA, ALANA PIMENTEL ; PARMEGGIANI, BELISA ; GASPAROTTO, JUCIANO ; GRINGS, MATEUS ; FERNANDEZ CARDOSO, GABRIELA MIRANDA ; SEMINOTTI, BIANCA ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens ; WAJNER, MOACIR ; LEIPNITZ, GUILHIAN . Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia. MOLECULAR NEUROBIOLOGY , v. 1, p. 1-10, 2017.12.KUNZLER, ALICE ; KOLLING, EDUARDO ANTÔNIO ; DA SILVA-JR, JEFERSON DELGADO ; GASPAROTTO, JUCIANO ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line. NEUROCHEMICAL RESEARCH , v. 42, p. 2788-2797, 2017.13.PETIZ, LYVIA LINTZMAIER ; KUNZLER, ALICE ; BORTOLIN, RAFAEL CALIXTO ; GASPAROTTO, JUCIANO ; MATTÉ, CRISTIANE ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Role of vitamin A oral supplementation on oxidative stress and inflammatory response in the liver of trained rats. Applied Physiology Nutrition and Metabolism , v. 42, p. 1192-1200, 2017.14.GASPAROTTO, JUCIANO; RIBEIRO, CAMILA TIEFENSEE ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; RABELO, THALLITA KELLY ; KUNZLER, ALICE ; SOUZA, NATÁLIA CABRAL ; PASQUALI, MATHEUS AUGUSTO DE BITTENCOURT ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation. Scientific Reports , v. 7, p. 1-12, 2017.15.PETIZ, LYVIA LINTZMAIER ; GIRARDI, CAROLINA SAIBRO ; BORTOLIN, RAFAEL CALIXTO ; KUNZLER, ALICE ; GASPAROTTO, J. ; RABELO, THALLITA KELLY ; MATTÉ, C. ; MOREIRA, JOSÉ CLAUDIO FONSECA ; GELAIN, DANIEL PENS . Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats. Nutrients , v. 9, p. 353, 2017.16.GASPAROTTO, J.; KUNZLER, ALICE ; SENGER, MARIO ROBERTO ; SOUZA, Celeste da Silva Freitas de ; SIMONE, SALVATORE GIOVANNI DE ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; DAL-PIZZOL, FELIPE ; MOREIRA, JOSÉ CLAUDIO FONSECA ; ABREU-SILVA, ANA LÚCIA ; CALABRESE, K. S. ; SILVA JR, FLORIANO PAES ; GELAIN, DANIEL PENS . N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz (Online) , v. 112, p. 146-154, 2017.17.RABELO, THALLITA KELLY ; GUIMARÃES, ADRIANA GIBARA ; OLIVEIRA, MARLANGE ALMEIDA ; GASPAROTTO, JUCIANO ; SERAFINI, MAIRIM RUSSO ; DE SOUZA ARAÚJO, ADRIANO ANTUNES ; QUINTANS-JÚNIOR, LUCINDO JOSÉ ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice. International Immunopharmacology (Print) , v. 39, p. 97-105, 2016.18.MORRONE, MAURILIO DA SILVA ; Schnorr, Carlos Eduardo ; BEHR, GUILHERME ANTÔNIO ; GASPAROTTO, JUCIANO ; BORTOLIN, RAFAEL CALIXTO ; DA BOIT MARTINELLO, KATIA ; SALDANHA HENKIN, BERNARDO ; RABELLO, THALLITA KELLY ; ZANOTTO-FILHO, ALFEU ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats. Oxidative Medicine and Cellular Longevity , v. 2016, p. 1-12, 2016.19.DA SILVA MORRONE, MAURILIO ; Schnorr, Carlos Eduardo ; BEHR, GUILHERME ANTÔNIO ; GASPAROTTO, JUCIANO ; BORTOLIN, RAFAEL CALIXTO ; MORESCO, KARLA SUZANA ; BITTENCOURT, LEONARDO ; ZANOTTO-FILHO, ALFEU ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats. JOURNAL OF NUTRITIONAL BIOCHEMISTRY , v. 32, p. 181-188, 2016.20.DE MIRANDA RAMOS, VITOR ; ZANOTTO-FILHO, ALFEU ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; KLAFKE, KARINA ; GASPAROTTO, JUCIANO ; DUNKLEY, PETER ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation. MOLECULAR NEUROBIOLOGY , v. 53, p. 6124-6135, 2016.21.RABELO, THALLITA KELLY ; ZEIDÁN-CHULIÁ, FARES ; CAREGNATO, FERNANDA FREITAS ; Schnorr, Carlos Eduardo ; GASPAROTTO, JUCIANO ; SERAFINI, MAIRIM RUSSO ; DE SOUZA ARAÚJO, ADRIANO ANTUNES ; QUINTANS-JUNIOR, LUCINDO JOSÉ ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . In Vitro Neuroprotective Effect of Shikimic Acid Against Hydrogen Peroxide-Induced Oxidative Stress. Journal of Molecular Neuroscience , v. 1, p. 1-10, 2015.22.SANTOS, JULIANA CÉLIA F. ; DE ARAÚJO, ORLANDO R. P. ; VALENTIM, IARA B. ; DE ANDRADE, KÍVIA QUEIROZ ; MOURA, FABIANA ANDRÉA ; SMANIOTTO, SALETE ; DOS SANTOS, JOHN MARQUES ; GASPAROTTO, JUCIANO ; GELAIN, DANIEL P. ; GOULART, MARÍLIA O. F. . Choline and Cystine Deficient Diets in Animal Models with Hepatocellular Injury: Evaluation of Oxidative Stress and Expression of RAGE, TNF- α , and IL-1 β. Oxidative Medicine and Cellular Longevity , v. 2015, p. 1-11, 2015.23.GASPAROTTO, JUCIANO; SENGER, MARIO ROBERTO ; KUNZLER, ALICE ; DEGROSSOLI, ADRIANA ; DE SIMONE, SALVATORE GIOVANNI ; BORTOLIN, RAFAEL CALIXTO ; SOMENSI, NAUANA ; GIRARDI, CAROLINA SAIBRO ; DE SOUZA, CELESTE DA SILVA FREITAS ; CALABRESE, KÁTIA DA SILVA ; DAL-PIZZOL, FELIPE ; Moreira, José Claudio Fonseca ; SILVA-JR, FLORIANO PAES ; GELAIN, Daniel Pens . Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis. BRAIN BEHAVIOR AND IMMUNITY , v. 43, p. 37-45, 2015.24.GASPAROTTO, JUCIANO; PETIZ, LYVIA LINTZMAIER ; GIRARDI, CAROLINA SAIBRO ; BORTOLIN, RAFAEL CALIXTO ; DE VARGAS, AMANDA RODRIGUES ; HENKIN, BERNARDO SALDANHA ; CHAVES, PALOMA RODRIGUES ; RONCATO, SABRINA ; MATTÉ, CRISTIANE ; ZANOTTO-FILHO, ALFEU ; MOREIRA, JOSÉ CLÁUDIO FONSECA ; GELAIN, Daniel Pens . Supplementation with vitamin A enhances oxidative stress in the lungs of rats submitted to aerobic exercise. Applied Physiology Nutrition and Metabolism , v. 40, p. 1253-1261, 2015.25.TONIN, ANELISE MIOTTI ; AMARAL, ALEXANDRE UMPIERREZ ; BUSANELLO, ESTELA NATACHA ; GASPAROTTO, JUCIANO ; GELAIN, DANIEL P. ; GREGERSEN, NIELS ; WAJNER, MOACIR . Mitochondrial bioenergetics deregulation caused by long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies in rat brain: A possible role of mPTP opening as a pathomechanism in these disorders?. Biochimica et Biophysica Acta. Molecular Basis of Disease , v. 1842, p. 1658-1667, 2014.26.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; BORTOLIN, RAFAEL CALIXTO ; MORESCO, KARLA SUZANA ; GIRARDI, CAROLINA SAIBRO ; KLAFKE, KARINA ; RABELO, THALLITA KELLY ; MORRONE, MAURILIO DA SILVA ; VIZZOTTO, MÁRCIA ; RASEIRA, MARIA DO CARMO BASSOLS ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Effects of different products of peach (Prunus persica L. Batsch) from a variety developed in southern Brazil on oxidative stress and inflammatory parameters in vitro and ex vivo. Journal of Clinical Biochemistry and Nutrition , v. 55, p. 110-119, 2014.27.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; KUNZLER, ALICE ; GIRARDI, CAROLINA ; PASQUALI, MATHEUS ; RAMOS, VITOR ; SIMOES-PIRES, ANDRE ; QUINTANS-JUNIOR, LUCINDO ; BRANCO, ALEXSANDRO ; MOREIRA, JOSE ; GELAIN, DANIEL . Hecogenin Acetate Inhibits Reactive Oxygen Species Production and Induces Cell Cycle Arrest and Senescence in the A549 Human Lung Cancer Cell Line. Anti-Cancer Agents in Medicinal Chemistry , v. 14, p. 1128-1135, 2014.28.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; BORTOLIN, RAFAEL CALIXTO ; GIRARDI, CAROLINA SAIBRO ; KUNZLER, ALICE ; RABELO, THALLITA KELLY ; Schnorr, Carlos Eduardo ; MORESCO, KARLA SUZANA ; BASSANI, VALQUIRIA LINCK ; YATSU, FRANCINI KIYONO JORGE ; VIZZOTTO, MÁRCIA ; RASEIRA, MARIA DO CARMO BASSOLS ; ZANOTTO-FILHO, ALFEU ; Moreira, José Claudio Fonseca ; GELAIN, Daniel Pens . Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage. JOURNAL OF NUTRITIONAL BIOCHEMISTRY , v. 25, p. 1282-1295, 2014.29.GRINGS, MATEUS ; MOURA, ALANA P. ; AMARAL, ALEXANDRE U. ; PARMEGGIANI, BELISA ; GASPAROTTO, JUCIANO ; MOREIRA, JOSÉ C.F. ; GELAIN, DANIEL P. ; WYSE, ANGELA T.S. ; WAJNER, MOACIR ; LEIPNITZ, GUILHIAN . Sulfite disrupts brain mitochondrial energy homeostasis and induces mitochondrial permeability transition pore opening via thiol group modification. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE , v. 1842, p. 1413-1422, 2014.30.GRUNWALD, MARCELO SARTORI ; PIRES, ANDRÉ SIMÕES ; ZANOTTO-FILHO, ALFEU ; GASPAROTTO, JUCIANO ; GELAIN, Daniel Pens ; DEMARTINI, DIOGO RIBEIRO ; SCHÖLER, CINTHIA MARIA ; DE BITTENCOURT, PAULO IVO HOMEM ; MOREIRA, JOSÉ CLÁUDIO FONSECA . The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity. CELL STRESS & CHAPERONES , v. 19, p. 913-925, 2014.31.GASPAROTTO, JUCIANO; BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; SOMENSI, NAUANA ; VASQUES, LAURA MILÁN ; Moreira, José Claudio Fonseca ; ALMEIDA, REINALDO NOBREGA ; BARBOSA-FILHO, JOSE MARIA ; FÁTIMA VANDERLEI DE SOUZA, MARIA ; GUTIERREZ, STANLEY JUAN CHAVEZ ; JÚNIOR, LUCINDO JOSÉ QUINTANS ; GELAIN, Daniel Pens . Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages. Cell Biology and Toxicology , v. 29, p. 175-187, 2013.32.DE OLIVEIRA, RAMATIS BIRNFELD ; SENGER, MARIO ROBERTO ; VASQUES, LAURA MILAN ; GASPAROTTO, JUCIANO ; DOS SANTOS, JOÃO PAULO ALMEIDA ; DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; Moreira, José Claudio Fonseca ; SILVA, FLORIANO PAES ; GELAIN, Daniel Pens . Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice. International Journal for Parasitology , v. 43, p. 371-379, 2013.33.DA SILVA MORRONE, MAURILIO ; DE ASSIS, ADRIANO MARTIMBIANCO ; DA ROCHA, RICARDO FAGUNDES ; GASPAROTTO, JUCIANO ; GAZOLA, ANDRESSA CÓRNEO ; COSTA, GEISON MODESTI ; ZUCOLOTTO, SILVANA MARIA ; CASTELLANOS, LEONARDO H. ; RAMOS, FREDDY A. ; SCHENKEL, ELOIR PAULO ; REGINATTO, FLÁVIO HENRIQUE ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ C.F. . Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models. Food and Chemical Toxicology , v. 60, p. 45-51, 2013.34.DA ROSA, M. S. ; SEMINOTTI, B. ; AMARAL, A. U. ; FERNANDES, C. G. ; GASPAROTTO, J. ; MOREIRA, J. C. F. ; GELAIN, D. P. ; WAJNER, M. ; LEIPNITZ, G. . Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver. Free Radical Research , v. 47, p. 1066-1075, 2013.35.GASPAROTTO, JUCIANO; SOMENSI, NAUANA ; CAREGNATO, FERNANDA F. ; RABELO, THALLITA K. ; DABOIT, KÁTIA ; OLIVEIRA, MARCOS L.S. ; MOREIRA, JOSÉ C.F. ; GELAIN, DANIEL P. . Coal and tire burning mixtures containing ultrafine and nanoparticulate materials induce oxidative stress and inflammatory activation in macrophages. SCIENCE OF THE TOTAL ENVIRONMENT , v. 463-464, p. 743-753, 2013.36.DE BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; GELAIN, Daniel Pens ; ZEIDÁN-CHULIÁ, FARES ; PIRES, ANDRÉ SIMÕES ; GASPAROTTO, JUCIANO ; TERRA, SILVIA RESENDE ; MOREIRA, JOSÉ CLÁUDIO FONSECA . Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells. CELLULAR SIGNALLING , v. 1, p. 939-954, 2013.37.BITTENCOURT PASQUALI, MATHEUS AUGUSTO ; Oliveira, Marcos Roberto ; DE BASTIANI, MARCO ANTÔNIO ; Rocha, Ricardo Fagundes ; Schnorr, Carlos Eduardo ; GASPAROTTO, JUCIANO ; GELAIN, Daniel Pens ; MOREIRA, JOSÉ CLÁUDIO FONSECA . L-NAME co-treatment prevent oxidative damage in the lung of adult Wistar rats treated with vitamin A supplementation. Cell Biochemistry and Function , v. 30, p. 256-263, 2012.

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