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Masatsugu Masuda

Designation:
Associate Professor
Department:
Department of Otolaryngology
University:
Kyorin University School of Medicine
Country:
Japan
Journal Associated: Archives of Otolaryngology and Rhinology Biography:

Born

Graduate from Keio University School of Medicine, Tokyo, Japan

Resident in Dept of Otorhinolaryngology, Keio University School of Medicine, Tokyo, Japan

Medical Staff in Otorhinolaryngology, Hiratsuka City Hospital, Kanagawa, Japan

Medical Staff in Otorhinolaryngology, Keiyu Hospital, Kanagawa, Japan

Medical Staff in Otorhinolaryngology, Kawasaki Municipal Hospital, Kanagawa, Japan

Instructor in Otorhinolaryngology, Keio University School of Medicine, Tokyo, Japan

Research staff in Basic Otology Research group (Professor Kaoru Ogawa), Keio University School of Medicine, Tokyo, Japan

Medical staff in department of Otolaryngology of Saiseikai Kanagawa Hospital, Kanagawa, Japan

Post-doctoral fellow in the Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego

Instructor in the Department of Otolaryngology, Kyorin University School of Medicine, Tokyo, Japan

Associate Professor in the Department of Otolaryngology, Kyorin University School of Medicine, Tokyo, Japan

Adjunct Lecturer in the Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan

Professional website links:

http://www.kyorin-u.ac.jp/univ/graduate/medicine/education/departments/otolaryngology/

http://www.kyorin-u.ac.jp/hospital/clinic/surgery11/index.html

Grant Details:

2015-Present:  

A grant-in-Aid for Scientific Research (C) [15K10761] from Ministry of Education, Culture, Sports, Science and Technology. “Changes of the auditory and equilibrium functions induced by optogenetic control of the stria vascularis function.”

2011-2014:

Grant-in Aid for Young Scientists (B) [23791930] from Ministry of Education, Culture, Sports, Science and Technology. “Artificial synapse formation for the implantable artificial organ of Corti.”

List of Publications:

1    Masuda, M., Goto, F., Hasegawa, T., Matsumoto, J., Kasakura-Kimura, N., Miyama, Y., Saito, K. & Kito, S. Transcranial magnetic stimulation for the treatment of vestibular decompensation. E-BENT, (in press).
2    Watabe, T., Xu, M., Watanabe, M., Nabekura, J., Higuchi, T., Hori, K., Sato, M. P., Nin, F., Hibino, H., Ogawa, K., Masuda, M. & Tanaka, K. F. Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice. Sci Rep 7, 13605, doi:10.1038/s41598-017-13997-7 (2017).
3    Sato, M. P., Higuchi, T., Nin, F., Ogata, G., Sawamura, S., Yoshida, T., Ota, T., Hori, K., Komune, S., Uetsuka, S., Choi, S., Masuda, M., Watabe, T., Kanzaki, S., Ogawa, K., Inohara, H., Sakamoto, S., Takebayashi, H., Doi, K., Tanaka, K. F. & Hibino, H. Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear. Front Mol Neurosci 10, 300, doi:10.3389/fnmol.2017.00300 (2017).
4    Oishi, N., Yamada, H., Kanzaki, S., Kurita, A., Takiguchi, Y., Yuge, I., Asama, Y., Masuda, M. & Ogawa, K. Assessment of hyperacusis with a newly produced Japanese version of the Khalfa hyperacusis questionnaire. Acta Otolaryngol 137, 957-961, doi:10.1080/00016489.2017.1306654 (2017).
5    Masuda, M., Li, Y., Pak, K., Chavez, E., Mullen, L. & Ryan, A. F. The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol 54, 5414-5426, doi:10.1007/s12035-016-0060-7 (2017).
6    Kasakura-Kimura, N., Masuda, M., Mutai, H., Masuda, S., Morimoto, N., Ogahara, N., Misawa, H., Sakamoto, H., Saito, K. & Matsunaga, T. WFS1 and GJB2 mutations in patients with bilateral low-frequency sensorineural hearing loss. Laryngoscope 127, E324-E329, doi:10.1002/lary.26528 (2017).
7    Masuda, M., Mutai, H., Arimoto, Y., Nakano, A. & Matsunaga, T. A novel frameshift variant of COCH supports the hypothesis that haploinsufficiency is not a cause of autosomal dominant nonsyndromic deafness 9. Biochem Biophys Res Commun 469, 270-274, doi:10.1016/j.bbrc.2015.11.106 (2016).
8        Masuda, M., Matsumoto, J., Nakamura, T., Matsuda, T., Naoyuki, K. & Saito, K. The impact of postoperative antrum pneumatization on hearing outcome after canal wall-down tympanoplasty with softwall reconstruction for cholesteatoma. Abstract for the 10th International Conference on Cholesteatoma,Edinburgh UK. J Laryngol Otol 130, S201-S202, https://doi.org/10.1017/S0022215116006228 (2016).
9    Ryan, A. F., Ikeda, R. & Masuda, M. The regulation of gene expression in hair cells. Hear Res 329, 33-40, doi:10.1016/j.heares.2014.12.013 (2015).
10    Masuda, M. & Kanzaki, J. Cause of idiopathic sudden sensorineural hearing loss: The stress response theory. World Journal of Otorhinolaryngology 3, 42-57, doi:10.5319/wjo.v3.i3.42 (2013).
11    Masuda, M., Pak, K., Chavez, E. & Ryan, A. F. TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1. Dev Biol 372, 68-80, doi:10.1016/j.ydbio.2012.09.002 (2012).
12    Masuda, M., Kanzaki, S., Minami, S., Kikuchi, J., Kanzaki, J., Sato, H. & Ogawa, K. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 33, 1142-1150, doi:10.1097/MAO.0b013e3182635417 (2012).
13    Masuda, M., Dulon, D., Pak, K., Mullen, L. M., Li, Y., Erkman, L. & Ryan, A. F. Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice. Neuroscience 197, 48-64, doi:10.1016/j.neuroscience.2011.09.033 (2011).
14    Wakabayashi, K., Fujioka, M., Kanzaki, S., Okano, H. J., Shibata, S., Yamashita, D., Masuda, M., Mihara, M., Ohsugi, Y., Ogawa, K. & Okano, H. Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neurosci Res 66, 345-352, doi:10.1016/j.neures.2009.12.008 (2010).
15    Taura, A., Taura, K., Choung, Y. H., Masuda, M., Pak, K., Chavez, E. & Ryan, A. F. Histone deacetylase inhibition enhances adenoviral vector transduction in inner ear tissue. Neuroscience 166, 1185-1193, doi:10.1016/j.neuroscience.2009.12.064 (2010).
16    Choung, Y. H., Taura, A., Pak, K., Choi, S. J., Masuda, M. & Ryan, A. F. Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience 161, 214-226, doi:10.1016/j.neuroscience.2009.02.085 (2009).
17    Masuda, M., Tanaka, K. F., Kanzaki, S., Wakabayashi, K., Oishi, N., Suzuki, T., Ikenaka, K. & Ogawa, K. GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease. Neurosci Res 62, 15-24, doi:10.1016/j.neures.2008.05.005 (2008).
18    Masuda, M., Inoue, Y., Tanosaki, R., Kanzaki, S. & Ogawa, K. Development of solitary plasmacytoma in the internal auditory canal and inner ear after allogeneic hematopoietic stem cell transplantation for plasma cell leukemia. Jpn J Clin Oncol 37, 701-703, doi:10.1093/jjco/hym079 (2007).
19    Masuda, M., Nagashima, R., Kanzaki, S., Fujioka, M., Ogita, K. & Ogawa, K. Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation. Brain Res 1068, 237-247, doi:10.1016/j.brainres.2005.11.020 (2006).
20    Fujioka, M., Kanzaki, S., Okano, H. J., Masuda, M., Ogawa, K. & Okano, H. Proinflammatory cytokines expression in noise-induced damaged cochlea. J Neurosci Res 83, 575-583, doi:10.1002/jnr.20764 (2006).

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Transcranial magnetic stimulation for the treatment of vestibular decompensation. E-BENT, (in press).2    Watabe, T., Xu, M., Watanabe, M., Nabekura, J., Higuchi, T., Hori, K., Sato, M. P., Nin, F., Hibino, H., Ogawa, K., Masuda, M. & Tanaka, K. F. Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice. Sci Rep 7, 13605, doi:10.1038/s41598-017-13997-7 (2017).3    Sato, M. P., Higuchi, T., Nin, F., Ogata, G., Sawamura, S., Yoshida, T., Ota, T., Hori, K., Komune, S., Uetsuka, S., Choi, S., Masuda, M., Watabe, T., Kanzaki, S., Ogawa, K., Inohara, H., Sakamoto, S., Takebayashi, H., Doi, K., Tanaka, K. F. & Hibino, H. Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear. Front Mol Neurosci 10, 300, doi:10.3389/fnmol.2017.00300 (2017).4    Oishi, N., Yamada, H., Kanzaki, S., Kurita, A., Takiguchi, Y., Yuge, I., Asama, Y., Masuda, M. & Ogawa, K. Assessment of hyperacusis with a newly produced Japanese version of the Khalfa hyperacusis questionnaire. Acta Otolaryngol 137, 957-961, doi:10.1080/00016489.2017.1306654 (2017).5    Masuda, M., Li, Y., Pak, K., Chavez, E., Mullen, L. & Ryan, A. F. The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol 54, 5414-5426, doi:10.1007/s12035-016-0060-7 (2017).6    Kasakura-Kimura, N., Masuda, M., Mutai, H., Masuda, S., Morimoto, N., Ogahara, N., Misawa, H., Sakamoto, H., Saito, K. & Matsunaga, T. WFS1 and GJB2 mutations in patients with bilateral low-frequency sensorineural hearing loss. Laryngoscope 127, E324-E329, doi:10.1002/lary.26528 (2017).7    Masuda, M., Mutai, H., Arimoto, Y., Nakano, A. & Matsunaga, T. A novel frameshift variant of COCH supports the hypothesis that haploinsufficiency is not a cause of autosomal dominant nonsyndromic deafness 9. Biochem Biophys Res Commun 469, 270-274, doi:10.1016/j.bbrc.2015.11.106 (2016).8        Masuda, M., Matsumoto, J., Nakamura, T., Matsuda, T., Naoyuki, K. & Saito, K. The impact of postoperative antrum pneumatization on hearing outcome after canal wall-down tympanoplasty with softwall reconstruction for cholesteatoma. Abstract for the 10th International Conference on Cholesteatoma,Edinburgh UK. J Laryngol Otol 130, S201-S202, https://doi.org/10.1017/S0022215116006228 (2016).9    Ryan, A. F., Ikeda, R. & Masuda, M. The regulation of gene expression in hair cells. Hear Res 329, 33-40, doi:10.1016/j.heares.2014.12.013 (2015).10    Masuda, M. & Kanzaki, J. Cause of idiopathic sudden sensorineural hearing loss: The stress response theory. World Journal of Otorhinolaryngology 3, 42-57, doi:10.5319/wjo.v3.i3.42 (2013).11    Masuda, M., Pak, K., Chavez, E. & Ryan, A. F. TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1. Dev Biol 372, 68-80, doi:10.1016/j.ydbio.2012.09.002 (2012).12    Masuda, M., Kanzaki, S., Minami, S., Kikuchi, J., Kanzaki, J., Sato, H. & Ogawa, K. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 33, 1142-1150, doi:10.1097/MAO.0b013e3182635417 (2012).13    Masuda, M., Dulon, D., Pak, K., Mullen, L. M., Li, Y., Erkman, L. & Ryan, A. F. Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice. Neuroscience 197, 48-64, doi:10.1016/j.neuroscience.2011.09.033 (2011).14    Wakabayashi, K., Fujioka, M., Kanzaki, S., Okano, H. J., Shibata, S., Yamashita, D., Masuda, M., Mihara, M., Ohsugi, Y., Ogawa, K. & Okano, H. Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neurosci Res 66, 345-352, doi:10.1016/j.neures.2009.12.008 (2010).15    Taura, A., Taura, K., Choung, Y. H., Masuda, M., Pak, K., Chavez, E. & Ryan, A. F. Histone deacetylase inhibition enhances adenoviral vector transduction in inner ear tissue. Neuroscience 166, 1185-1193, doi:10.1016/j.neuroscience.2009.12.064 (2010).16    Choung, Y. H., Taura, A., Pak, K., Choi, S. J., Masuda, M. & Ryan, A. F. Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience 161, 214-226, doi:10.1016/j.neuroscience.2009.02.085 (2009).17    Masuda, M., Tanaka, K. F., Kanzaki, S., Wakabayashi, K., Oishi, N., Suzuki, T., Ikenaka, K. & Ogawa, K. GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease. Neurosci Res 62, 15-24, doi:10.1016/j.neures.2008.05.005 (2008).18    Masuda, M., Inoue, Y., Tanosaki, R., Kanzaki, S. & Ogawa, K. Development of solitary plasmacytoma in the internal auditory canal and inner ear after allogeneic hematopoietic stem cell transplantation for plasma cell leukemia. Jpn J Clin Oncol 37, 701-703, doi:10.1093/jjco/hym079 (2007).19    Masuda, M., Nagashima, R., Kanzaki, S., Fujioka, M., Ogita, K. & Ogawa, K. Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation. Brain Res 1068, 237-247, doi:10.1016/j.brainres.2005.11.020 (2006).20    Fujioka, M., Kanzaki, S., Okano, H. J., Masuda, M., Ogawa, K. & Okano, H. P
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