Research Interest: Internal Medicine and Cardiology

Research Interest: Integrated Pharmaco-Physiology, Brain-Gut Interactions, Stress-Related Functional Gastrointestinal Diseases, Ingestive Behavior-Associated Gastrointestinal Neuroendocrinology, and Bariatric Surgery

Principal Investigator (PU) – UMR Inserm UMR-S1172

"Alzheimer & Tauopathies" Jean-Pierre Aubert Research Centre, 1 Place de Verdun, Lille, France, didier.vieau@inserm.fr, didier.vieau@univ-lille.fr

Professional experience  

1986-1990: PhD in Endocrinology. Pierre et Marie Curie University of Paris (Paris VI), France. Laboratory of Endocrinology, Cochin Hospital. Thesis supervisor (Pr X. Bertagna). Thesis title: “Proopiomelanocortin and neuroendocrine differentiation markers in human tumoral pathology”

1991-1995: Laboratory of Biochemical Endocrinology (Dr. NG Seidah), Clinical Research Institute of Montreal, Montreal, Canada.

1996-1999: European Institute for Peptide Research (IFRMP 23), Laboratory of Cellular and Molecular Neuroendocrinology (Dr H Vaudry), University of Rouen, 76821 Mont-Saint-Aignan, France.

1999-2002: associate professor in the Laboratory of Endocrinology of Annelids (University of Lille 1, France, Pr M Salzet).

2002-2012: Professor of University (Animal Physiology) and head of the laboratory of maternal perinatal undernutrition (EA4489), University of Lille 1, France.

2012-2016: Dean of the department of Biology of the University Lille 1

September 2016-: Member of UMR Inserm UMR-S1172 "Alzheimer & Tauopathies" (Dr L Buée)

June 2019: Vice-President of the ‘Société des Sciences, des Arts et de l’Agriculture de Lille (SAAL)”

Research Interest: perinatal programming of metabolic disease, neuroendocrinology, Alzheimer disease, adaptation to stress.

Skype ID:  didier vieau (didiervieau@hotmail.com)

List of Publications:

Original papers

Ao 1. Vieau D, Massias JF, Girard F, Luton JP and Bertagna X. 1989. Corticotrophin like-intermediary lobe peptide as a marker of alternate proopiomelanocortin processing in ACTH producing non-pituitary tumors. Clin. Endocrinol.; 31 : 691-700.
Ao 2. Lalau JD, Vieau D, Tenenbaum F, Westeel PF, Mesmacque A, Lenne F and Quichaud J. 1990. A case of pseudo-Nelson’s syndrome : cure of ACTH hypersecretion by removal of a bronchial carcinoid tumor responsible for Cushing’s syndrome. J. Endocrinol. Invest.; 13 : 531-537.
Ao 3. de Keyzer Y, Lenne F, Massias JF, Vieau D, Luton JP, Kahn A and Bertagna X. 1990. Pituitary like proopiomelanocortin transcripts in human leydig cell tumors. J. Clin. Invest.; 86 : 871-877.
Ao 4. Massias JF, Hardouin S, Vieau D, Lenne F and Bertagna X. 1994. Phosphorylated forms of ACTH and CLIP in human tumors. Eur. J. Endocrinol.;  131 : 341-346.

Ao 5. Vieau D, Tougard C, Rosenbaum E, Lenne F and Bertagna X. 1991. The secretory granule peptide 7B2 is secreted in parallel with proopiomelanocortin and its end products by the mouse corticotrope cells At-T20. J. Neuroendocrinol.; 3 : 229-231.
Ao 6. Vieau D, Rojas-Miranda A, Verley JM, Lenne F and Bertagna X. 1991. The secretory granule peptides 7B2 and CCB are sensitive biochemicals markers of neuroendocrine bronchial tumors in man. Clin. Endocrinol.; 35 : 319-325.
Ao 7. Texier PL, de Keyzer Y, Lacave R, Vieau D, Lenne F, Rojas-Miranda A, Verley F, Luton JP, Kahn A and Bertagna X. 1991. Proopiomelanocortin gene expression in normal and tumoral human lung. J. Clin. Endocrinol. Metab.; 73 : 414-420.
Ao 8. Vieau D, Linard C, M’Bikay M, Lenne F, Chrétien M, Luton JP and Bertagna X. 1992. Expression of the neuroendocrine cell marker 7B2 in human ACTH secreting tumours. Clin. Endocrinol.; 36 : 597-603.
Ao 9. Lusson J, Vieau D, Hamelin J, Day R, Chrétien M and Seidah NG. 1993. cDNA structure of the mouse and rat subtilisin/kexin-like PC5 : a candidate proprotein convertase expressed in endocrine and nonendocrine cells. Proc. Natl. Acad. Sci. USA; 90 : 6691-6695.
Ao 10. Dong W, Marcinkiewicz M, Vieau D, Chrétien M, Seidah NG and Day R. 1995. Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary. J. Neuroscience; 15 : 1778-1796.
Ao 11. Vieau D, Seidah NG and Day R. 1995. Characterization of prodynorphin derived products in the mouse pancreatic tumoral cell line TC3 : a unique model for the study of prodynorphin processing. Endocrinology; 136 : 1187-1196.
Ao 12. Vieau D, Seidah NG, M’Bikay M, Chrétien M and Bertagna X. 1994. Expression of the prohormone convertase PC2 correlates with the presence of CLIP in human ACTH secreting tumors. J. Clin. Endocrinol. Metab.; 75 : 1503-1506. 
Ao 13. Tostivint H, Lihrmann I, Bucharles C, Vieau D, Coulouarn Y, Fournier A, Conlon JM and Vaudry H. 1996. Occurrence of two somatostatin variants in the frog brain : characterization of the cDNAs, distribution of the mRNAs and receptor-binding affinities of the peptides. Proc. Natl. Acad. Sci. USA; 93 : 12605-12610.
Ao 14. Vieau D, Gangnon F, Jégou S, Danger JM and Vaudry H. 1998. Characterization of the cDNA encoding the prohormone convertase PC2 and localization of the mRNA in the brain of the frog Rana ridibunda. Mol. Brain. Res.; 63 : 1-13.
Ao 15. Gangnon F, Danger JM, Jégou S, Vieau D, Seidah NG and Vaudry H. 1999. Molecular cloning, characterization of the cDNA, and distribution of mRNA encoding the frog prohormone convertase PC1. J. Comp. Neurol.; 405 : 160-172.
Ao 16. Tostivint H, Vieau D, Chartrel N, Boutelet I, Galas L, Fournier A, Lihrmann I and Vaudry H. 2002. Expression and processing of the Pro2,Met13Somatostatin-14 precursor in the intermediate lobe of the frog pituitary. Endocrinology ; 143 : 3472-3481. 1er auteur ex æquo.

Ao 17. Sebaai N, Lesage J, Vieau D, Alaoui A, Dupouy JP, Deloof S. 2002. Altered control of the hypothalamo-pituitary-adrenal axis in adult male rats exposed perinatally to food deprivation and/or dehydration. Neuroendocrinology ; 76 : 243-253.
Ao 18. Gangnon F, Jegou S, Vallarino M, Vieau D and Vaudry H. 2003. Molecular characterization of the cDNA and localization of the mRNA encoding the Prohormone Convertase PC5-A in the European Green Frog. J. Comp. Neurol. ;456 : 60-72.

Ao 19. Matias I, Leonhardt M, Lesage J, De  Petrocellis L, Dupouy JP, Vieau D, Di Marzo V. 2003. Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels. Cell Mol Life Sci. ; 60 : 382-389.

Ao 20. Deloffre L, Salzet B, Vieau D, Andries JC, Salzet M. 2003. Antibacterial properties of hemerythrin of the sand worm Nereis diversicolor. Neuro Endocrinol Lett. ; 24 : 39-45.

Ao 21. Lesage J, Del-Favero F, Leonhardt M, Louvart H, Maccari S, Vieau D, Darnaudery M. 2004. Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat. J. Endocrinol. ; 181: 291-296. 

Ao 22. Deloffre L, Sautiere PE, Huybrechts R, Hens K, Vieau D, Salzet M. 2004. Angiotensin-converting enzyme inhibition studies by natural leech inhibitors by capillary electrophoresis and competition assay. Eur. J. Biochem. ; 271: 2101-2106.

Ao 23. Sebaai N, Lesage J, Breton C, Vieau D, Deloof S. 2004. Perinatal food deprivation induces marked alterations of the hypothalamo-pituitary-adrenal axis in 8-month-old male rats both under basal conditions and after a dehydration period. Neuroendocrinology; 79 : 163-173.

Ao 24. Riviere G, Michaud A, Deloffre L, Vandenbulcke F, Levoye A, Breton C, Corvol P, Salzet M, Vieau D. 2004. Characterization of the first non-insect invertebrate functional angiotensin-converting enzyme (ACE): leech TtACE resembles the N-domain of mammalian ACE. Biochem J. ; 382 : 565-573.

Ao 25. Vergote D, Sautiere PE, Vandenbulcke F, Vieau D, Mitta G, Macagno ER, Salzet M. 2004. Up-regulation of neurohemerythrin expression in the central nervous system of the medicinal leech, Hirudo medicinalis, following septic injury. J. Biol. Chem. ; 279 : 43828-43837.

Ao 26. Levoye A, Mouillac B, Riviere G, Vieau D, Salzet M, Breton C. 2005. Cloning, expression and pharmacological characterization of a vasopressin-related receptor in an annelid, the leech Theromyzon tessulatum. J. Endocrinol. ; 184 : 277-289.

Ao 27. Laborie C, Dutriez-Casteloot I, Montel V, Dickes-Coopman A, Lesage J, Vieau D. 2005. Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress. Neurosci. Lett. ; 381:211-216.

Ao 28. Rivière G, Michaud A, Breton C, VanCamp G, Laborie C, Enache M, Lesage J, Deloof S, Corvol P, Vieau D. 2005. ACE2 and ACE display tissue-specific sensitivity to programmed hypertension by maternal undernutrition in the adult rat. Hypertension ; 46: 1169-1174.
Ao 29. Molendi-Coste O,  Grumolato L, Laborie C, Lesage J, Maubert E, Ghzili H, Vaudry H, Anouar Y, Breton C, Vieau D. 2006. Maternal perinatal undernutrition alters neuronal and neuroendocrine differentiation in the rat adrenal medulla at weaning. Endocrinology ; 147 : 2050-2059.
Ao 30. Salomé N, Viltart O, Lesage J, Landgraf R, Vieau D, Laborie C. 2006. Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates. Psychoneuroendocrinology ; 31 : 724-735.
Ao 31. Vallarino M, Bruzzone F, Mathieu M, Chartrel N, Vieau D, Ciarlo M, Fournier A, Vaudry H. 2006. Ontogeny of the somatostatin variant [Pro(2), Met(13)]somatostatin-14 in the brain, pituitary, and sensory organs of the frog Rana esculenta. J. Comp. Neurol. ; 497: 717-733.
Ao 32 Brulle F, Mitta G, Cocquerelle C, Vieau D, Lemiere S, Lepretre A, Vandenbulcke F. 2006. Cloning and real-time PCR testing of 14 potential biomarkers in Eisenia fetida following cadmium exposure. Environ. Sci. Technol. 40: 2844-2850.
Ao 33. Van Waes V, Enache M, Dutriez I, Lesage J, Morley-Fletcher S, Vinner E, Lhermitte M, Vieau D, Maccari S, Darnaudery M. 2006. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Eur. J. Neurosci. 2:1193-200. 
Ao 34. Mairesse  J, Lesage J, Breton C, Bréant B, Hahn T, Darnaudéry M, Dickson S, Seckl J, Vanbesien-Mailliot C, Blondeau B, Vieau D, Maccari S, Viltart O. 2007. Maternal stress alters endocrine function of the feto-placental unit in rats. Am. J. Physiol. Endocrinol. Metab. 292 :E1526-E1533.
Ao 35. Rivière G, Michaud A, Corradi HR, Cogez V, Sturrock ED, Acharya KR, Bohin JP, Vieau D, Corvol P. 2007. Characterization of the first angiotensin-converting-like enzyme in bacteria : ancestor XcACE is already active. Gene 399: 81-90.
Ao 36. Dutriez-Casteloot, Breton C, Coupé B, Hawchar O, de Keyzer Y, Deloof S, Lesage J, Vieau D. 2008. Distribution and tissue-specific programming expression of glucocorticoid receptors and 11beta-HSDs by maternal perinatal undernutrition in the adult male rat: focus on HPA axis. Horm.Metab.Res. 40: 257-261.

Ao 37. Molendi-Coste O, Mairesse J, Aubert N, H. Ghzili H, Abbadie C, Vaudry H, Gonzalez B, Anouar Y, Vieau D, Breton C, Laborie C. 2008. Maternal perinatal undernutrition impairs chromaffin cells proliferation in the postnatal rat. Horm. Metab. Res. 40 : 386-390.
Ao 38. Grumolato L, Ghzili H, Montero-Hadjadje M, Lesage J, Galas L, Ait-Ali D, Guerineau N, Elkahloun A, Fournier A, Vieau D, Vaudry H, Anouar Y. 2008. Selenoprotein T is a PACAP- and cAMP responsive gene that localizes to the ER and regulates intracellular calcium. FASEB J. 22:1756-1768.
Ao 39. Delahaye F, Breton C, Risold PY, Enache M, Dutriez-Casteloot I, Laborie C, Lesage J, Vieau D. 2008. Maternal Perinatal Undernutrition Impedes Postnatal Leptin Surge and Affects the Development of Arcuate Nucleus POMC Neurons in Neonatal Male Rat Pups. Endocrinology 149 :470-475.

Ao 40. Coupé B, Dutriez-Casteloot I, Breton C, Lefèvre F, Mairesse J, Dickes-Coopman A, Silhol M,  Tapia-Arancibia L, Lesage J, Vieau D. 2009. Maternal undernutrition modifies brain-derived neurotrophic factor expression and cell proliferation in the hippocampus and hypothalamus of the developing male rat. J. Neuroendocrinol. 21:40-48.
Ao 41. Molendi-Coste O, Laborie C, Scarpa MC, Montel V, Vieau D, Breton C. Maternal perinatal undernutrition alters postnatal development of chromaffin cells in the male rat adrenal medulla. Neuroendocrinology 90:54-66.
Ao 42. Breton C, Risold PY, Lukaszewski MA, Enache M, Guillemot J, Rivière G, Delahaye F, Lesage J, Dutriez-Casteloot I, Laborie C, Vieau D. 2009. Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring. Am. J. Physiol. Endocrinol. Metab. 296: E462-E472.
Ao 43. Delahaye F, Lukaszewski MA, Cisse O, Dutriez-Casteloot I, Montel V, Dickes-Coopman A, Laborie C, Lesage J, Breton C, Vieau D. 2010. Maternal perinatal undernutrition programs a « brown-like » phenotype of gonadal white fat in male rat at weaning. Am J Physiol Regul Integr Comp Physiol. 299: R101-R110.

Ao 44. Mayeur S, Silhol M, Moitrot E, Barbaux S, Breton C, Gabory A, Vaiman D, Dutriez-Casteloot I, Fajardy I, Vambergue A, Tapia-Arancibia L, Bastide B, Storme L, Junien C, Vieau D, Lesage J. 2010. The placental BDNF/TRKB signaling system is modulated by fetal growth in rat and human. Placenta 31: 785-791.
Ao 45 Gallou-Kabani C., Gabory A., Tost J., Karimi M., Mayeur S., Lesage J., Boudadi E., Gross M.S., Taurelle J., Vige A., Breton C., Reusens B., Remacle C., Vieau D., Ekström T., Jais J.P., Junien C. 2010. Sex- and diet-specific dysregulation of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet. PLoS One 5: e14398.
Ao 46. Rivière G, Lienhard D, Andrieu T, Vieau D, Frey BM, Frey FJ. 2011. Epigenetic regulation of somatic angiotensin-converting enzyme by DNA methylation and histone acetylation. Epigenetics 6:478-89.
Ao 47. Tanguy Y., Falluel-Morel A., Arthaud S., Boukhzar L., Manecka D.L., Chagraoui A., Prevost G., Elias S., Dorval-Coiffec I., Lesage J., Vieau D., Lihrmann I., Jégou B., Anouar Y. 2011. The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes. Endocrinology 152: 4322-35.
Ao 48. Laborie C., Molendi-Coste O., Breton C., Montel V., Vandenbulcke F., Grumolato L., Anouar Y., Vieau D. 2011. Maternal perinatal undernutrition has long-term consequences both on morphology, function and gene expression of the adrenal medulla in the adult male rat. J. Neuroendocrinol. 23: 711-24.
Ao 49. Guillemot J.*, Lukaszewski M.A.*, Montel V., Delahaye F., Mayeur S., Laborie C., Dickes-Coopman A., Dutriez-Casteloot I., Lesage J., Breton C., Vieau D. 2011. Influence of prenatal undernutrition of clozapine and aripiprazole in the adult male rat: relevance to a neurodevelopmental origin of schizophrenia. Eur. J. Pharmacol. 667: 402-9. (*co-premier auteur).
Ao 50.  Lukaszewski M.A., Mayeur S., Fajardy I., Delahaye F., Dutriez-Casteloot I., Montel V., Dickes-Coopman A., Laborie C., Lesage J., Vieau D., Breton C. 2011. Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet. Am. J. Physiol. Endocrinol. Metab. 301: E548-59.
Ao 51. Ivars J., Butruille L., Knauf C., Bouckenooghe T., Mayeur S., Vieau D., Valet P., Deruelle P., Lesage J. 2012. Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat. Peptides 35: 136-8.
Ao 52. Gabory A., Ferry L. Fajardy I., Jouneau L., Gothié J.D., Vigé A., Fleur C., Mayeur S., Gallou-Kabani C., Gross M.S., Attig l., Vambergue A., Lesage J., Reusens B., Vieau D., Remacle C., Jais J.P., Junien C. 2012. Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. PLoS One 7: e47986.
Ao 53. Mayeur S., Lancel S., Theys N., Lukaszewski M.A., Duban-Deewer S., Bastide B., Hachani J., Cecchelli R., Breton C., Gabory A., Storme L., Reusens B., Junien C., Vieau D., Lesage J. 2013. Maternal caloric restriction induces placental mitochondrial biogenesis, optimizes bioenergetic efficiency but alterates ATP production: putative involvement of mitochondria in feto-placental growth defects. Am. J. Physiol. Endocrinol. Metab. 304: E14-22.
    Ao 54. Lukaszewski M.A., Butruille L., Moitrot E., Montel V., Dickes-Coopman A., Lesage J., Laborie C., Vieau D., Breton C. 2013. The hypothalamic POMC gene expression exhibits long-term programming in prenatally undernourished male rat offspring under high-fat diet. Peptides 43: 146-54.
    Ao 55. Cisse O., Fajardy I., Dickes-Coopman A., Moitrot E., Montel V., Deloof S., Rousseaux J., Vieau D., Laborie C. 2013. Mild gestational hyperglycemia in rat induces fetal overgrowth and modulates placental growth factors and nutrient transporters expression. PLoS One 8: e64251.
Ao 56. Mayeur S., Cisse O., Gabory A., Barbaux S., Vaiman D., Vambergue A., Fajardy I., Deloof S., Junien C., Laborie C., Vieau D., Lesage J. 2013. Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rat and human. J. Dev. Orig. Health Dis. 4: 134-138.
Ao 57. Wattez JS, Ravallec R, Cudennec B, Knauf C, Dhulster P, Valet P, Breton C, Vieau D, Lesage J.2013. Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents. Peptides. Oct;48:134-6.

Ao 58. Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C.2014. Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes. .Antioxid Redox Signal. 20 : 557-573.

Ao 59. Wattez JS, Delahaye F, Barella LF, Dickes-Coopman A, Montel V, Breton C, Mathias P, Foligné B, Lesage J, Vieau D. 2014. Short- and long-term effects of maternal perinatal undernutrition are lowered by cross-fostering during lactation in the male rat. J. Dev. Orig. Health Dis. Doi: 10.1017/S2040174413000548: 1-12.

Ao 60. Elmhiri G, Barella LF, Vieau D, Camous S, Mathias PC, Abdennebi-Najar L. 2014. Acute exposure to a precursor of Advanced Glycation End Products induces a dual effect on the rat pancreatic islet function. Int Journal Endocrinol 2014:378284.

Ao 61. Wattez JS, Delmont A, Bouvet M, Beseme O, Goers S, Delahaye F, Laborie C, Lesage J, Foligné B, Breton C, Metges C, Vieau D, Pinet . 2015. Maternal perinatal undernutrition modifies lactose and serotransferrin in milk: relevance to the programming of metabolic diseases? Am J Physiol Endocrinol Metab, 308 : E393-E401. Dernier auteur ex aequo.

Ao 62. Malta A, de Moura EG, Ribeiro TA, Tófolo LP, Abdennebi-Najar L, Vieau D, Barella LF, de Freitas Mathias PC, Lisboa PC, de Oliveira JC. 2016. Protein-energy malnutrition at mid-adulthood does not imprint long-term metabolic consequences in male rats. Eur J Nutr. 55(4):1423-33.

Ao 63. Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. 2016. Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition. Diabetes. 65(3):554-60.

Ao 64. Lecoutre S, Deracinois B, Laborie C, Eberlé D, Guinez C, Panchenko PE, Lesage J, Vieau D, Junien C, Gabory A, Breton C. 2016. Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue. J Endocrinol 230 : 39-53.

Ao 65. Lecoutre S, Marousez L, Drougard A, Knauf C, Guinez C, Eberlé D, Laborie C, Vieau D, Lesage J, Breton C. 2017. Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring. J Dev Orig Health Dis. Feb;8(1):3-7.

Ao 66. Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy E, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D. 2017. Tau deletion promotes brain insulin resistance. J Exp Med.214 (8): 2257-2269.
Ao 67. Lecoutre S, Oger F, Butruille L, Marousez L, Dickes-Coopman A, Pourpe C, Laborie C, Eberlé D, Guinez C, Lesage J, Vieau D, Junien C, Gabory A, Eeckhoute J, Breton C. 2017. Maternal obesity affects leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner. Molecular Metab.6 (8): 922-930.
Ao 68. Lecoutre S, Pourpe C, Butruille L, Marousez L, Laborie C, Guinez C, Lesage J, Vieau D, Eeckhoute J, Gabory A, Oger F, Eberle D, Breton C. 2018. Reduced PPARgamma 2 expression in adipose tissue of male rat offspring from obese dams is associated with epigenetic modifications. Faseb J. Jan 2. pii: fj.201700997R. doi: 10.1096/fj.201700997R.
Ao 69. Cissé O, Fajardy I, Delahaye F, Dickes A, Montel V, Moitrot E, Breton C, Vieau D, Laborie C. 2018. Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific. Eur J Nutr. doi: 10.1007/s00394-018-1794-y.

Ao 70. Leboucher A, Ahmed T, Caron E, Tailleux A, Raison S, Joly-Amado A, Marciniak E, Carvalho K, Hamdane M, Bantubungi K, Lancel S, Eddarkaoui S, Caillierez R, Vallez E, Staels B, Vieau D, Balschun D, Buee L, Blum D. 2019. Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model. Neurobiol Dis. 125:14-22.

Reviews and chapters of books

R1. Vieau D, Gicquel C et Proeschel MF. 1991. La proopiomélanocortine et ses fragments : applications à l’investigation clinique. Médecine Sciences; 7: 918-926.
R2. Day R, Vieau D and Seidah NG. 1994. Approaches in the study of the posttranslational processing of opioid peptide precursors : focus on prodynorphin. Regul. Peptides; 54 : 77-78.
R3. Raffin-Sanson ML, Vieau D, de Keyzer Y et Bertagna X. 1995. Hormones corticolipotropes et endorphines. Encyclopédie Médico-chirurgicale.
R 4. de Keyzer Y, Vieau D, Picon A and Bertagna X. 1996. Molecular aspects of the ectopic ACTH syndrome. Endocrine-Related Cancer; 3 : 99-112.
R5. Tostivint H, Lihrmann I, Bucharles C, Vieau D, Coulouarn Y, Fournier A, Conlon JM, Vaudry H, Dournaud P, Gardette R, Viollet C et Epelbaum J. 1996. Un deuxième gène codant pour la somatostatine est exprimé dans le cerveau. Médecine Sciences; 12 : 1131-1133.
R6. Chartrel N, Braun B, Collin F, Pierreuse B, Coulouarn Y, Tostivint H, Jeandel L, Trabucchi M, Vieau D, Lihrmann I, Tonon MC, Anouar Y, Conlon JM et Vaudry H. 1998. Stratégie d’identification de nouveaux neuropeptides. CR. Soc. Biol.; 192 : 619-638.
R7. Tostivint H, Lihrmann I, Bucharles C, Vieau D, Coulouarn Y, Boutelet I, Fournier A, Conlon JM, Vaudry H. 1998. A second somatostatin gene is expressed in the brain of the frog Rana ridibunda . Trends in Comparative Endocrinology and Neurobiology. Annals of the New York Academy of sciences 839: 496-497.

R8. Salzet M, Vieau D and Stefano G. 1999. Serpins : a survival strategy in immunity. Immunol. Today ; 20 : 541-544. Ce journal est devenu Trends in Immunology.
R9. Salzet M, Vieau D and Day R. 2000. Crosstalk between nervous and immune systems through the animal kingdom : focus on opioids. Trends in Neuroscience; 23 : 550-555.
R10. Tasiemski A, Lefebvre C, Vieau D and Salzet M. 2000. Immune response stimulation pathway : implications of opioid peptides. Crit. Trends in Immunol.; 2 : 209-216.
R11. Salzet M, Deloffre L, Breton C, Vieau D and Schoofs L. 2001. The angiotensin system elements in invertebrates. Brain Res. Rev. ; 36 : 35-45.
R12. Gangnon F, Danger JM, Jégou S, Vieau D, Vaudry H. 2002. Characterization of the three prohormone-convertases potentially involved in the processing of neuropeptide precursors in the european green frog. Proceedings of the 21st Conference of European Comparative Endocrinologists : 507-512.
R13. Gangnon F, Vieau D, Jégou S and Vaudry H. 2003. Cloning of the cDNA and comparative distribution of frog PC1 and PC2, the major proteolytic enzymes involved in the processing of neuropeptides. Recent Progress in Comparative Endocrinology and Neurobiology.
R14. Chartrel N, Braun B, Desrues L, Yon L, Vieau D, Kodjo M, Cellier E, Kikuyama S, Delarue C, Tonon MC and Vaudry H. 2003. Identification of novel neuropeptides from the amphibian brain. Recent Progress in Comparative Endocrinology and Neurobiology.
R15. Salzet M., Vieau, D., Breton, C. 2004. Cell signalling in prokaryotes and lower metazoa. (Ed. Fairweather I), Kluwer Publisher. Evidence for an annelid neuroendocrine system (Chapter 9).
R16. Lesage J, Sebaai N, Léonhardt M, Dutriez-Casteloot I, Breton C, Deloof S, Vieau D. 2006. Maternal undernutrition and HPA axis in the offspring. Stress ; 9 : 183-198.
R17. Vieau D, Sebaai N, Léonhardt M, Dutriez-Casteloot I, Molendi-Coste O, Laborie C, Breton C, Deloof S, Lesage J. 2007. HPA axis programming by maternal undernutrition in the male rat offspring. Psychoneuroendocrinology 32 (supl 1): S16-S20.
R18. Vieau D, Mayeur S, Lukaszewski MA, Delahaye F, Dutriez-Casteloot I, Laborie C, Deloof, S, Lesage J, Breton C. 2009. Perinatal undernutrition and brain derived nerve factor. The International Handbook of behavior, diet and nutrition.
R19. Vieau D. 2009. La dénutrition maternelle programme les systèmes neuroendocriniens impliqués dans la réponse au stress chez le rat mâle adulte : rôle dans la genèse du syndrome métabolique ? Médecine et nutrition 45 (1) : 1-6.
R20. Vieau D. 2009. Maternal undernutrition programs hypothalamo-pituitary-adrenal (HPA) axis activity. Endocrinologia & Diabetes Clinica e experimental 9 (4): 1068-1070.
R21. Mayeur S., Lukaszewski M.A., Breton C., Storme L., Vieau D., Lesage J. 2011. Do neurotrophins regulate the feto-placental development? Med. Hypotheses 76: 726-8.
R22. Vieau D. 2011. Perinatal nutritional programming of health and metabolic adult disease. World J Diabetes 2: 133-6.
R23. Mayeur S., Lukaszewski M.A., Breton C., Storme L., Junien C., Vieau D., Lesage J.  2011. BDNF in feto-placental development. Med. Sci. (Paris) 27: 251-2.
R 24. Guillemot J., Laborie C., Dutriez-Casteloot I., Maron M., Deloof S., Lesage J., Breton C., Vieau  D. 2011. Could maternal perinatal atypical antipsychotic treatments program later metabolic diseases in the offspring? Eur. J. Pharmacol. 667: 13-6.
R25. Lukaszewski M.A., Delahaye F., Vieau D., Breton C. 2012. Is the adipose tissue a key target of developmental programming of adult adiposity by maternal undernutrition? Adipocyte 1:64-7.
R26. Wattez J.S., Delahaye F., Lukaszewski M.A., Eberlé D., Vieau D., Breton C. 2013. Maternal nutrition programs hypothalamic POMC neurons in the offspring. Horm. Metab. Res. 45: 980-990.
    R27. Vieau D., Breton C., Dutriez-Casteloot I., Montel V., Dickes-Coopman A., Deloof S., Lesage J., Laborie C. 2011. Maternal perinatal undernutrition programs stress neuroendocrine systems in the male rat. Lee JE. Undernutrition: Effects, Causes and Management. Hauppage, New York: Nova Science Publishers, 1-23.
    R28. Vieau D., Mayeur S., Dutriez-Casteloot I., Lukaszewski M.A., Delahaye F.,  Laborie C., Deloof S., Lesage J., Breton C. 2013. Perinatal undernutrition and brain derived factor. International Handbook of Behavior, Diet and Nutrition (Preedy V.R., eds.), Springer.
R29. Lukaszewski MA, Eberlé D, Vieau D, Breton C. 2013. Nutritional manipulations in the perinatal period program adipose tissue in offspring. Am J Physiol Endocrinol Metab. 305 : E1195-E1207.

R30. Vieau D, Laborie C, Eberlé D, Lesage J, Breton C. 2016. Nutrition périnatale et programmation : le tissu adipeux est en dans le collimateur. Médecine Sciences 32 : 81-84.

R31. Vercruysse P, Vieau D, Blum D, Petersen A, Dupuis L. 2018. Hypothalamic alterations in neurodegenerative diseases and their relation to abnormal energy metabolism. Front. Mol. Neurosci. 11:2. doi: 10.3389/fnmol.2018.00002.

R32. Gratuze M, Joly-Amado A, Vieau D, Buée L, Blum D. 2018. Mutual relationship between Tau and central insulin signalling: consequences for Alzheimer disease and Tauopathies. Neuroendocrinology 107(2):181-195.

R33. Cellai L, Carvalho K, Faivre E, Deleau A, Vieau D, Buée L, Blum D, Mériaux C, Gomez Murcia V. 2018. The adenosinergic signaling : a complex but promising therapeutic target for Alzheimer’s disease. Front. Neurosci. 12:520.

R34. Joly-Amado A, Gratuze M, Benderradji H, Vieau D, Buée L, Blum D. 2018. Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies. Med Sci (Paris). 2018 Nov;34(11):929-935.

Research Interest: Kidney transplantation, glomerular disease and pathological basics of the diseases

Research Interest: A Biomedical Researcher with a Focus on Neurobehavioral, Metabolic and Endocrine Disorders.

Research Interest: Metabolomics Studies, Particularly on the Fetal-Neonatal Nutrition and Prevention of Chronic Diseases in Adults such as Obesity, Diabetes and Metabolic Syndrome.

Research Interest: It is Mainly Lies in Two Areas. First I Focused on Applying Statistical Methods and Multilevel Modeling in Randomized Clinical Trials and Family-Based Health-Related Interventions, Particularly in Substance Abuse, HIV/AIDS, STD, Sexual Risk Behaviors and Minority Health Disparities. Second, I am Interested in Epidemiology Studies 0f Chronic Disease Including Alcohol Use Disorder, Drug Abuse, Obesity, Diabetes, Metabolic Syndrome, Hypertension, Cardiovascular Disease and Stroke; and Also from Genetic Epidemiology Point of View to Examine Complex Disease Including Alcohol Dependence and Co-Morbidity, and Alzheimer Disease Etc. 

Dr. Gorelik has nearly 35 years of experience in clinical medicine and research. He has published more than 60 scientific publications. Currently, Dr. Gorelik serves as the Head of the Department of Internal Medicine "F" in the Assaf Harofeh Medical Center, Zerifin, Israel. He is also a Clinical Senior Lecturer in the Sackler Faculty of Medicine of the Tel Aviv University.

Research Interest: Diabetes, Orthostatic Hypotension, Magnesium Metabolism, Heart Failure and Hospital Internal Medicine.

Number of Publications: 57

Research Interest: Has Experience in Physical Therapy, with an Emphasis on Cardiopulmonary Physical Therapy, Acting on the Following Topics: Health Promotion, Cardiac Rehabilitation, Exercise Prescription for People with Special Needs, Assessment of Autonomic Function, Analysis of Biological Signals, Cardiorespiratory Physiotherapy in Morbid Obesity and Physical Therapy in Intensive Care. 

Research Interest: Multicenter Prospective Observational CREST Study (U.Penn, Vanderbilt, and University Hospitals Case Medical Center) with Dr. James Fang, Evaluating Cardiotoxicity of Sunitinib in Metastatic Renal Cell Carcinoma Using Tonometry Data

Research Interest: He Also Conducted Basic Research in Regard to the Investigation of the Role of Immunological Aspects in Kidney Diseases Including Nephritic Syndrome and Diabetic Nephropathy.

Research Interest: Molecular Pharmacology, Chinese Medicines and Diabetes Mellitus, Effects and Mechanism of Natural Products on Cardio-Cerebrovascular Disease.

Research Interest: Evaluation of biological activity of plant foods: anti-inflammatory, anti-glycation, anti-oxidant activities Influences of heat treatment on biological activity of foods.

List of Publications:

1.    Ho, Su-Chen, Chang, Yi-Huang, “Comparison of inhibitory capacities of 6-, 8- and 10-gingerols/shogaols on the canonical NLRP3 inflammasome-mediated IL-1β secretion” Molecules, Vol. 23, 2018, 02, p. 466.
2.    Ho, Su-Chen, Su, Min-Sheng, Lin, Chih- Cheng, Chiu, Chui-Feng, “Comparison of anti-glycation capacity of two new purple-colored-leaf tea cultivars with an ordinary green-colored-leaf tea cultivar in Taiwan,” Global Journal of Obesity, Diabetes and Metabolic Syndrome, Vol. 4, No. 1, 2017, 02, pp. 009-015.
3.    Yang, Tzu-Ting, Ho, Su-Chen, Chuang, Lu-Te, Chuang, Hsiao-Chi, Li, Ya-Ting, Wu, Jyun-Jie, “Characterization of particulate-phase polycyclic aromatic hydrocarbons emitted from incense burning and their bioreactivity in RAW264.7 macrophage,” Environmental Pollution, Vol. 220, 2017, 01, pp. 1190-1198.
4.    Ho, Su-Chen, Su, Min-Sheng, “Optimized heat treatment enhances the anti-inflammatory capacity of ginger “ International Journal of Food Properties, Vol. 19, 2016, pp. 1884-1898.
5.    Ho, Su-Chen, Su, Min-Sheng, “Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds,” Molecules, Vol. 19, No. 11, 2014, pp. 17697-17714.
6.    Ho, Su-Chen, Kuo, Chun-Ting, “Hesperidin, Nobiletin, and Tangeretin Are Collectively Responsible for the Anti-neuroinflammatory Capacity of Tangerine Peel (Citri reticulatae pericarpium)” Food and Chemical Toxicology, Vol. 71, 2014, pp. 176-182.
7.    Ho, Su-Chen, Chang, Pei-Wen, Tong, Hui-Ting, Yu, Pin-Yuan, “Inhibition of Fluorescent Advanced Glycation End-products and N-carboxymethyllysine Formation by Several Floral Herbal Infusions,” International Journal of Food Properties, Vol. 17, 2014, pp. 617-628.
8.    Ho, Su-Chen, Su, Min-Sheng, Lin, Chih-Cheng, “Comparison of Peroxynitrite-Scavenging Capacities of Several Citrus Fruit Peels,” International Journal of Food Properties, Vol. 17, 2014, pp. 111-124.
9.    Ho, Su-Chen, Chang, Ku-Shang, Lin, Chih-Cheng, “Anti-neuroinflammatory Capacity of Fresh Ginger Is Attributed Mainly to 10-Gingerol,” Food Chemistry, Vol. 141, No. 3, 2013, 12, pp. 3183-3191.
10.    Ho, Su-Chen, Chang, Ku-Shang, Chang, Pei-Wen, “Inhibition of Neuroinflammation by Cinnamon and its Main Components,” Food Chemistry, Vol. 138, No. 4, 2013, pp. 2275-2282.
11.    Ho, Su-Chen, Chang, Pei-Wen, “Inhibitory Effects of Several Spices on Inflammation Caused by Advanced Glycation Endproducts,” American Journal of Plant Sciences, Vol. 3, No. 7, 2012, pp. 995-1002.
12.    Ho, Su-Chen, Wu, Szu-Pei, Lin, Shyh-Mirn, Tang, Ya-Li, “Comparison of Anti-glycation Capacities of Several Herbal Infusions with that of Green Tea,” Food Chemistry, Vol. 122, 2010, pp. 768-744.
13.    Lin, Shih-Min, Wang, Shih-Wei, Ho, Su-Chen, Tang, Ya-Li, “Protective Effect of Green Tea (-)-Epigallocatechin-3-gallate (EGCG) Against the Monoamine Oxidase B Enzyme Activity Increase in Adult Rat Brains,” Nutrition, Vol. 26, 2010, pp. 1195-1200.
14.    Huang, Yung-Sheng, Ho, Su-Chen, “Polymethoxy Flavones Are Responsible for the Anti-inflammatory Activity of Citrus Fruit Peel,”Food Chemistry, Vol. 119, 2010, pp. 868-873.
15.    Ho, Su-Chen, Tang, Ya-Li, Lin, Shih-Min, Liew, Yih-Fong, “Evaluation of Peroxynitrite-Scavenging Capacities of Several Commonly Used Fresh Spices,” Food Chemistry, Vol. 119, 2010, pp. 1102-1107.
16.    Ho, Su-Chen, Lin, Chih-Cheng, “Investigation of Heat Treating Conditions for Enhancing the Anti-inflammatory Activity of Citrus Fruit (Citrus reticulata) Peels,”Journal of Agricultural and Food Chemistry, Vol. 56, 2008, pp. 7976-7982.
17.    Lin, Chih-Cheng, Hung, Pi-Fong, Ho, Su-Chen, “Heat Treatment Enhances the NO-suppressing and Peroxynitrite-intercepting Activities of Kumquat’s (Fortunella margarita Swingle) Peel,”Food Chemistry, Vol. 109, 2008, pp. 95-103.
18.    Ho, Su-Chen, Tsai, Tzung-Hsun, Tsai, Po-Jung, Lin, Chih-Cheng, “Protective Capacities of Certain Spices Against Peroxynitrite-mediated Biomolecular Damage,”Food and Chemical Toxicology, Vol. 46, 2008, pp. 920-928.
19.    Ho, Su-Chen, Hwang, Lucy Sun, Shen, Yi-Jane, Lin, Chih-Cheng, “Suppressive Effect of a Proanthocyanidin-rich Extract from Longan (Dimocarpus longan Lour.) Flowers on Nitric Oxide Production in LPS-Stimulated Macrophage Cells,”Journal of Agricultural and Food Chemistry, Vol. 55, No. 26, 2007, pp. 10664-10670.
20.    Tsai, Po-Jung, Tsai, Tzung-Hsun, Ho, Su-Chen, “In vitro Inhibitory Effects of Rosemary Extracts on Growth and Glucosyltransferase Activity of Streptococcus sobrinus,” Food Chemistry, Vol. 105, 2007, pp. 311-316.
21.    Tsai, Po-Jung, Tsai, Tzung-Hsun, Yu, Chun-Hsien, Ho, Su-Chen, “Evaluation of NO-suppressing Activity of Several Mediterranean Culinary Spices,” Food and Chemical Toxicology, Vol. 45, 2007, pp. 440-447.
22.    Tsai, Po-Jung, Tsai, Tzung-Hsun, Yu, Chun-Hsien, Ho, Su-Chen, “Comparison of NO-scavenging and NO-suppressing Activities of Different Herbal Teas with those of Green Tea,” Food Chemistry, Vol. 103, 2007, pp. 181-187.
23.    Lin, Chih-Cheng, Lu, Min-Jer, Chen, Shen-Jen, Ho, Su-Chen, “Heavy Fermentation Impacts NO-Suppressing Activity of Tea in LPS-activated RAW 264.7 Macrophages,” Food Chemistry, Vol. 98, 2006, pp. 483-489.
24.    Tsai, Tzung-Hsun, Tsai, Po-Jung, Ho, Su-Chen, “Antioxidant and Antiinflammatory Activities of Several Commonly Used Spices,” Journal of Food Science, Vol. 70, No. 1, 2005, pp. pp. C93-C97.
25.    Tsai, Po-Jung, Yu, Chun-Hsien, Hsu SP, Lee YH, Huang IT, Ho, Su-Chen, Chu CH “Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: Negative association with gestational diabetes mellitus” Nutrition, Vol. 21, No. 11-12, 2005, pp.1095-9 •
26.    Tsai, Po-Jung, Ho, Su-Chen, Tsai LP, Lee YH, Hsu SP, Yang SP, Chu CH, Yu, Chun-Hsien, “Lack of relationship between beta3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese population” Metabolism, Vol. 53, No. 9, 2004, pp.1136-9.
27.    Tsai, Po-Jung, Yu, Chun-Hsien, Hsu SP, Lee YH, Chiou CH, Hsu YW, Ho, Su-Chen, Chu CH. “Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity” Clin. Endocrinol. Vol. 61, 2004, pp. 88-93.
28.    Ho, Su-Chen, Tsai, Po-Jung, ”Comparison of the effects of "hot" and "cold" Chinese medicinal plants on the production of inflammatory mediators by RAW 264.7 cells” Journal of Food and Drug Analysis, Vol. 12, No. 2, 2004, pp. 120-127.

Research Interest: Diabetes; Metabolic Syndrome; Osteoporosis

Research Interest: Blood Brain Barrier; Neurovascular Pharmacokinetics; Stroke; Ischemia; Neurodegneration; Neuroprotection; Neuropharmacology; Nutrient and Ion Transporters; Diabetes