Research Interest: Leukemia and lymphoma – clinical aspects,  Adjuvant treatments in malignant hemopathies (e.g. resveratrol, statins), Connections between malignant hemopathies and dyslipidemia or metabolic syndrome, Thrombin generation in malignant hemopathies

Research Interest: Melanoma, kidney cancer , immunotherapy with ipilimumab, nivolumab, interleukin-2 and other agents. 

Research Interest: Thoracic Oncology, Translational Research, Immuno-Oncology

Research Interest: Research areas of human physiology and pathophysiology. His research focuses on the clinical evaluation of new biomarkers and molecular mediators in several pathophysiological disease states, such as diabetes, atherosclerosis and cancer. His research interest also includes the development of quantitative structure-activity relationships (QSARs) and quantitative structure-property relationships (QSPRs) in the area of toxicology and pharmacology. Furthermore, his research interest lies in the assessment of physicochemical properties, such as lipophilicity, solubility and ionization of drugs, natural bioactive compounds and toxic chemicals in relation with their potential biological activity and toxicity endpoints, as well as their Absorption/Distribution/Metabolism/Excretion (ADME) parameters and their pharmacokinetic and toxicokinetic profiles

Research Interest: Tumours Role of transcription factors for angiogenesis, tumour invasion and metastasis Interaction of tumour cells and cells of the tumour stroma Translational research Molecular targeting therapy Biochemical, immunological and pharmacological assays for characterization of the efficacy of different therapeutic agents Tumour immunology Immune evasion mechanism of tumour cells.

Research Interest: Cancer therapy, cancer stem cells, tumour biomarkers, suicide gene therapy and antitumoral drugs, nanotechnology and regenerative medicine.

Research Interest: Biophysics; Development of animal models for human diseases (cancer, cardiac ischemia); Nuclear Oncology (from molecular biology to molecular imaging); Photodynamic therapy in models in vitro and in vivo; Radiopharmacy.

Research Interest: My research direction is the biology of cancer stem cell. 

Research Interest: Molecular biology, cytogenetics, genotoxicity, micronucleus, cytome assay, mutagenicity tests, gene expression, human cancer, pituitary adenomas, obesity.

Research Interest: Immunophenotyping, Immunocytochemistry, Multilineag differentiation, RNA isolation, RT- PCR, Cancer cell line, Immunocytochemistry, Real-Time PCR, Western blot, Transport mechanism by liquid santillation Counter, Induction of leukemia in experimental animal, Biochemical enzymatic analysis, TEM analysis, Histopathology, RT-PCR, apoptosis analysis, Western blot, MTT assay, Measurement of intracellular ROS, Analysis of mitochondrial membrane potential, Intracellular calcium levels, Quantification of endogenous GSH, DNA fragmentation, Column Chromatography, Antibiotic sensitivity assay, Extract preparation, Antibiotic sensitivity assay

Research Interest: His interests in liver fibrosis research focuses on the use of intrahepatic administration of collagenase for reversal of liver fibrosis and this work was one of the earliest that established proof-of-principle of these potential therapeutic agents. His immunological interest lies with double-stranded RNA induced immune response and its potential application in anti-virus and/or anti-cancer immunotherapy.

Research Interest: Malignant transformation, including DNA Repair mechanisms, roles of Cytoskeleton in signal transduction, Developmental processes

Research Interest: Anti-Cancer, Apoptosis, Blebbing, Caspases, Cell Cycle, Cell Signaling, Cancer, DNA Fragmentation, Drug Discovery, Flow Cytometer, Intrinsic and extrinsic apoptosis pathway, Laser Confocal Microscope, Mitochondrial Depolarization and Necrosis.

Research Interest: Cancer Biology, Epigenetics, stem cells and cancer stem cells.

Kwang-Hyun Baek is a full professor of Department of Biomedical Science and a director of Cell & Gene Therapy Research Institute at CHA University in Korea. He received his Ph.D. from the department of Zoology and Genetics at Iowa State University in US in 1995 and worked as a postdoctoral research fellow in the division of Genetics at Brigham and Women’s Hospital and in the department of Pediatric Oncology at Dana-Farber Cancer Institute, Harvard Medical School. He has been serving as an editorial board member, a regional editor, and an editor-in-chief of many international journals. Current research and clinical interests are in the molecular genetics of ubiquitination and deubiquitination systems relevant to various cancers and stem cell proliferation/differentiation. He first coined terms ubiquitomics and deubiquitomics in the field of the ubiquitin-proteasome system. In addition, he is interested in genomics and proteomics during cancer cell proliferation and apoptosis.

Grant Details:

1) Korean Ministry of Health & Welfare: The prevention of high-risk pregnancy: Development of biomarkers for recurrent pregnancy loss using multi-omics. April 2018 ~ December 2020 ($350,000)

2) Korea Research Foundation: Investigation of cellular mechanisms for DNA repair mediated by deubiquitinating enzymes and identification of their small molecules. June 2016 ~ May 2019 ($300,000)

3) Korea Ministry of Environment: Screening and pathophysiology mechanisms of environmental risk factors for premature ovarian failure. May 2016 ~ December 2019 ($600,000)

4) Korea Ministry of Science and Technology: BK21 Plus Program. September 2013 ~ August 2020 ($200,000 every year)"

Publication List:

1. Hiriyanna, K. T., Baedke, D., Baek, K.-H., Forney, B. A., Kordiyak, G., and T. S. Ingebritsen. (1994). Thiophosphorylated substrate analogs are potent active site-directed inhibitors of protein-tyrosine phosphatases. Anal. Biochem. 223: 51-58.

*2. Baek, K.-H., and L. Ambrosio. (1994). An efficient method for microinjection of mRNA into Drosophila embryos. BioTechniques 17: 1024-1026. (Corresponding author)

3. Baek, K.-H., Fabian, J., Sprenger, F., Morrison, D., and L. Ambrosio. (1996). The activity of D-raf in Torso signal transduction is altered by serine substitution, N-terminal deletion, and membrane targeting. Dev. Biol. 175: 191-204.

*4. Baek, K.-H., and W. P. Hanratty. (1996). The characterization of temperature-sensitive lethal (2) giant larvae alleles in Drosophila melanogaster. Drosophila Infor. Serv. 77: 90-92. (Corresponding author)

5. Johansen, K. M., Johansen, J., Baek, K.-H., and Y. Jin. (1996). Remodeling of nuclear architecture during the cell cycle in Drosophila embryos. J. Cell. Biochem. 63: 268-279.

6. Radke, K., Baek, K.-H., and L. Ambrosio. (1997). Characterization of maternal and zygotic D-raf proteins: dominant negative effects on Torso signal transduction. Genetics 145: 163-171.

*7. Baek, K.-H., and W. P. Hanratty. (1997). The l(2)gl, a recessive oncogene, is required during embryonic and post-embryonic development in Drosophila. Cancer Lett. 111: 233-238. (Corresponding author)

8. Michelson, A. M., Gisselbrecht, S., Zhou, Y., Baek, K.-H., and E. M. Buff. (1998). Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic development. Dev. Genetics 22: 212-229.

*9. Baek, K.-H. (1999). The first oncogene in Drosophila melanogaster. Mut. Res. 436: 131-136. (Corresponding author)

*10. Baek, K.-H. (1999). The application of temperature-sensitive mutations in Drosophila. Arch. Pharm. Res. 22: 229-231. (Corresponding author)

11. Jaster, R., Baek, K.-H., and A. D'Andrea (1999). Analysis of cis-acting sequences and trans-acting factors regulating the interleukin-3 response element of the murine DUB-1 gene. Biochim. Biophys. Acta 1446: 308-316.

*12. Baek, K.-H., and K. Y. Lee. (1999). Signal transduction pathway for anterior-posterior development in Drosophila. J. Biomed. Sci. 6: 314-319. (Corresponding author)

*13. Baek K.-H., Kim M. K., Lee, K. Y., and K. Y. Cha (2000). Raf serine/threonine kinase is required for early embryogenesis in Drosophila. Kor. J. Genetics 22: 63-70. (Corresponding author)

*14. Lee, J.-H., Kim, Y.-S., Kang, W.-P., and K.-H. Baek (2001). Temporal enzymatic activity of lymphocyte-specific deubiquitinating enzymes. Kor. J. Genetics 23: 3-6. (Corresponding author)

*15. Baek, K.-H. (2001). Heartless, a fibroblast growth factor receptor, is  required for embryonic muscle development in Drosophila. Kor. J. Genetics 23: 151-156. (Corresponding author)

*16. Lee, J.-H., Kim, M., Kim, Y.-S., and K.-H. Baek (2001). Critical regions for deubiquitinating activity of DUB-2 expressed in T lymphocytes. Am. J. Hematol. 67: 270-272. (Corresponding author)

17. Baek, K.-H., Mondoux, M. A. Jaster, R., Fire-Levin, E., and A. D'Andrea (2001). DUB-2A, a new subfamily member of deubiquitinating enzymes. Blood 98: 636-642.

*18. Choi, B. C., Kim, J. W., Lee, J., Yoo, K. J., Byun, H. K., Hwang, C. S., Moon, I. K., Kim, S. N., and K.-H. Baek (2001). The effect of exocelomic fluid in the first trimester pregnancy on trophoblast cell proliferation in vitro. Kor. J. Obs. Gyn. 44: 1678-1684. (Corresponding author)

*19. Baek, K.-H., Kim., Y.-S., Jung, S., Lee, K.-Y., Choi, H.-K., and K.-S, Kim. (2002). Molecular cloning and characterization of bovine bgl-1, a novel family member of WD-40 repeat containing lethal giant lerval tumor suppressor genes. Int. J. Oncol. 20: 739-744.  (Corresponding author)

*20. Baek, K.-H., Park, K.-H., Kim, Y.-S., Kim, M.-S., and H.-K. Choi. (2002). Molecular cloning and complete cDNA sequence of UBH1 in mouse testis. DNA Seq. 13: 145-148. (Corresponding author)

*21. Kim, Y.-S., Baek, K.-H., Lee, K. Y., Jung, S., Chung, H.-M., Lee, K.-A., and K. Y. Cha. (2002). The rgl-1 is a legitimate homologue of lethal giant larvae recessive oncogene in rat. Int. J. Oncol. 20: 1219-1225.  (Corresponding author)

*22. Baek, K.-H., Choi, B. C., Lee, J.-H., Choi, H.-K. Lee, S.-H., Kim, J.-W., Hill, J. A., Chung, H.-M., Ko, J. J., and K. Y. Cha. (2002). Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loss patients. Repro. Fertil. Dev. 14: 235-240. (Corresponding author)

*23. Baek, K.-H., Kim., Y.-S., Chung, H. -M., Ko, J. J. and K. Y. Cha. (2002). Conservation of the lethal giant larvae tumor suppressor gene in Bos taurus coreanae. Kor. J. Genetics, 24: 127-132. (Corresponding author)

*24. Baek, K.-H. (2002). Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines. Am. J. Hematol. 71: 340-345. (Corresponding author)

*25. Lim, S.-K., Kim, M.-S., Lee, S.-H., and K.-H. Baek (2002). Polymorphism of CYP17 and CYP11a for polycystic ovary syndrome in a korean population. Kor. J. Genetics, 24: 343-348. (Corresponding author)
 
*26. Baek, K.-H. (2003). Conjugation and deconjugation of ubiquitin regulating the destiny of proteins. Exp. Mol. Med. 35: 1-7. (Corresponding author)

*27. Kim, Y.-S., Chung, H. M., and Baek, K.-H. (2003). WD-40 repeat containing rat lethal giant larvae recessive oncogene, but not tomosyn, restores the salt sensitivity in Saccharomyces cerevisiae. Int. J. Oncol. 23: 229-234. (Corresponding author)

28. Chung, K.-H., Kim, S.-H., Han, K.-Y., Sohn, Y.-D., Chang, S.-I., Baek, K.-H., Kim, D.-S., and Kang, l. (2003). Inhibitory effect of salmosin, a Korean snake venom-derived disintegrin, on integrin av-mediated proliferation of SK-Mel-2 human melanoma cells. J. Pharm. Pharmacol. 55: 1577-1582.

*29. Choi, H.-K., Choi, B. C., Lee, S.-H., Kim, J. W. Cha, K. Y., and Baek, K.-H. (2003). The expression of angiogenesis- and apoptosis-related genes in chorionic villi derived from recurrent pregnancy loss patients. Mol. Reprod. Dev. 66: 24-31. (Corresponding author)

*30. Kim, Y.-S., Song, J., Kim, Y.-K., Kim, I.-O., Kang, I., and Baek, K.-H. (2003). Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. Int. J. Oncol. 23: 1515-1519. (Corresponding author)

*31. Shin, J.-M., Kim, J.-W., Choi, B., Lee, S.-H., and Baek, K.-H. (2003). Expression of immunosuppression-related genes in fetal chorionic villi derived from recurrent spontaneous abortion patients. Kor. J. Fertil. Steril. 30: 233-240. (Corresponding author)

32. Lee, K.-W., Jeong, Y.-M., Lee, S.-H., Yoon, T. K., Kwak, I. P., Yoon, S. W., Choi, J. S., Kim, K. H., Han, J. S., Kim, S. D., Kim, N. K., Cha, K. Y., Baek, K.-H., and Lee, S. (2003). The study of 5,10- methylenetetrahydrofolate reductase variation (MTHFR C677T) in fertile females with polycystic ovarian syndrome (PCOS) in Korea. Kor. J. Fertil. Steril. 30: 217-222.

*33. Lim, S.-K., Shin, J.-M., Kim, Y.-S., and Baek, K.-H. (2004). Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination. Int. J. Oncol. 24: 357-364. (Corresponding author)

*34. Baek, K.-H., Kim, M.-S., Kim, Y.-S., Shin, J.-M., and Choi, H.-K. (2004). DUB-1A, a novel subfamily member of deubiquitinating enzyme, is polyubiquitinated and cytokine-inducible in B lymphocytes. J. Biol. Chem. 279: 2368-2376. (Corresponding author)

35. Jeon, S. Y., Baek, K.-H., Kim, Y.-S., Kwon, H. S., Ko, S. H., Song, K. -H., Yoo, S. J., Son, H. S., Cha, B. Y., Lee, K.W., Son, H. Y., Kang, S. K., and Yoon, K. H. (2004). Differentially up-regulated genes in proliferating porcine neonatal pancreas cells caused by epidermal growth factor. J. Cell. Biochem. 91: 354-364.

36. Burrows, J. F., McGrattan, M. J., Rascle, A., Humbert, M., Baek, K.-H., and Johnston, J. A. (2004). DUB-3, a cytokine inducible deubiquitinating enzyme that blocks proliferation. J. Biol. Chem. 279: 13993-14000.

*37. Baek, K.-H. (2004). Structural and functional conservation of the lgl recessive oncogenes. Int. J. Oncol. 24: 1257-1262. (Corresponding author)

*38. Baek, K.-H. (2004). Aberrant gene expression associated with recurrent pregnancy loss. Mol. Hum. Reprod. 10: 291-297. (Corresponding author)

*39. Kim, M.-S., Yoo, K.-J., Kang, I., Chung, H.M., and Baek, K.-H. (2004). A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human cancer cells. Int. J. Oncol. 25: 373-379. (Corresponding author)

*40. Kim, K.-S., Kim, M.-S., Kim, S.-K., and Baek, K.-H. (2004). Murine Asb-17 expression during mouse testis development and spermatogenesis. Zygote 12: 151-156. (Corresponding author)

*41. Baek, K.-H., Kim, Y.-S., Lee, H.-J., and Kang, I. (2004). The essential regions for deubiquitinating enzyme activity and enhancer funciton for DUB-2A expressed in T-lymphocytes. Arch. Biochem. Biophys. 430: 191-197. (Corresponding author)

*42 Kim, Y.-K., Kim, Y.-S., Chung, H.-M., and Baek, K.-H. (2004). Complementation of temperature tolerance by rat Rgl-1 recessive oncogene in the absence of Saccharomyces cerevisiae Sop genes. Oncol. Rep. 12: 1105-1108. (Corresponding author)

*43 Lee, H.-J., Yoo, K.-J., and Baek, K.-H. (2004). Structrual characterization of mouse HAUSP, a proteolysis regulator of p53. Kor. J. Biol. Sci. 8: 205-212. (Corresponding author)

44. Hwang, K.R., Choi, Y.M., Choi, D.S., Baek, K.-H., Jeon, H.W., Bae, K.B., Son, Y.S., Ku, S.Y., Jee, B.C., Suh, C.S., Kim, S.H., Kim, J.G., and Moon, S.Y. (2004). Effect of metformin treatment and insulin resistance in patients with polycystic ovary syndrome. Kor. J. Obs. Gyn. 47: 1949-1953.

*45. Kim, M.-S., Kim, Y.-K., Kim, Y.-S., Seong, M., Choi, J.-K., and Baek, K.-H. (2005). Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated. Biochem. Biophys. Res. Commun. 330: 797-804. (Corresponding author)

46. Lee, J., Choi, B.C., Cho, C., Hill, J.A, Baek, K.-H., and Kim, J.W. (2005).  Trophoblast apoptosis is increased in women with evidence of Th-1 immunity. Fertil. Steril. 83: 1407-1409.

*47. Yoo, K.-J., Lee, H.-J., Lee, H., Lee, K.-Y., Lee, S.-H., Chung, H.-M., and Baek, K.-H. (2005). Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells. Int. J. Oncol. 27: 97-104. (Corresponding author)

*48. Kim, Y.-K., Kim, Y.-S., and Baek, K.-H. (2005). The WD-40 repeat motif of Lgl tumor suppressor proteins associated with salt tolerance and temperature sensitivity. Biochem. Biophys. Res. Commun. 331: 922-928. (Corresponding author)

*49. Lee, E.-J., Yoo, K.-J., Kim, S.-J., Lee, S.-H., Choi, D.-H., Cha, K.-.Y., Choi, D.-S., and Baek, K.-H. (2005). Relationship between the C/T single nucleotide polymorphism in exon 17 of the insulin receptor gene and polycystic ovary syndrome. J. Biol. Sci. 5: 832-836. (Corresponding author)

50. Kang, I.-C., Min, B., Ahn, E., Son, H., and Baek, K.-H. (2005). Expression of soluble recombinant integrin alpha V and beta 3 from SF21 cells with baculovirus expression vector for targeted screening of integrin antagonists. Kor. J. Genetics 27: 211-217.

*51. Lee, H.-J., Kim, M.-S., Kim, Y.-K., Oh, Y.-K., and Baek, K.-H. (2005). HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated,  polyneddylated, and dimerized. FEBS Lett. 579: 4867-4872. (Corresponding author)

*52. Seong, M., Kim, M.-S., Kim, Y.-S., Lee, S.-H., Lee, H.-J., Cha, K.-Y., and Baek, K.-H. (2005). HIDE, a testis specific deubiquitinating enzyme, interacts with HSP90. Kor. J. Fertil. Steril. 32: 231-242. (Corresponding author)

*53. Lee, M.-Y., and Baek, K.-H. (2005). Regulation of insulin signaling through protein degradation. Kor. J. Endocrinol. 20: 434-440. (Corresponding author) 

*54. Baek, K.-H. Lee, H.-J., Kim, M.-S., Kim, Y.-S., Lee, E.-J., and Lee, M.-Y. (2006). Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in a rat testis. Oncol. Rep. 15: 173-177. (Corresponding author)

*55. Lee, H.-J., Kim, M.-S., Shin, J.-M., Park, T.-J., Chung, H.-M., and Baek, K.-H. (2006). The expression patterns of deubiquitinating enzymes, USP22 and Usp22. Mech. Dev. (Gene Exp. Patterns) 6: 277-284. (Corresponding author)

56. Gu, Y.-M., Jin, Y.-H., Choi, J.-K., Baek, K.-H., Yeo, C.-Y., and Lee, K.-Y. (2006). Protein kinase A phosphorylates and regulates dimerization of 14-3-3 zeta. FEBS Lett. 580: 305-310.

*57. Baek, K.-H. (2006). Cytokine-regulated degradation by the ubiquitination system. Curr. Protein Pept. Sci. 7: 171-177. (Corresponding author)

*58. Lee, E.-J., Yoo, K.-J., Kim, S.-J., Lee, S.-H., Cha, K.Y., and Baek, K.-H. (2006). Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population. Fertil. Steril. 86: 380-385. (Corresponding author)

*59. Cheon, K.-W., and Baek, K.-H.  (2006). HAUSP as a therapeutic target for hematopoietic tumors. Int. J. Oncol. 28: 1209-1215. (Corresponding author)

*60. Kim, Y.-S., Kim, M.-S., Lee, S.-H., Choi, B.-C., Lim, J.-M., Cha, K.-Y., and Baek, K.-H. (2006). Proteomic analysis of recurrent spontaneous abortion: identification of an inadequately expressed set of proteins in human follicular fluid. Proteomics, 6: 3445-3454. (Corresponding author)

*61. Kim, Y.-S., Kim, Y.-K., Park, J.-M., Han, I.-S., Ajjappala, B.S., Kang, I., and Baek, K.-H.  (2006). Disruption of protein-protein interaction for Mgl-1 oncoprotein. Oncol. Rep. 16: 795-800. (Corresponding author)

62. Kim, S.-J., Lee, S.-Y., Lee, C., Kim, I., An, H.-J., Kim, J.-Y., Baek, K.-H., Kim, E.-J., Kim J.-M., Lee, J.-B., Lee, J.-W., Jung, W.-W., Chun, T., and Oh, Y.-K. (2006). Differential expression profiling of genes in a complete hydatidiform mole using cDNA microarray analysis. Gynecol. Oncol. 103: 654-660.

*63. Shin, J.-M., Yoo, K.-J., Kim, M.-S., Kim, D., and Baek, K.-H.  (2006). Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. BMC Genomics 7: 292. (Corresponding author)

64. Park, J.-E, Jang, M.-H., Cho, S.-W., Kim, Y.-S., Won, H.-J., Cho, J.-H., Baek, K.-H., and Lee, S.-H. (2006). Mitochondrial DNA copy number in the patients of Korean polycystic ovary syndrome (PCOS). Kor. J. Fertil. Steil. 33: 245-251.

*65. Kim, Y.-K., Kim, Y.-S., Yoo, K.-J., Lee, H.-J., Lee, D.-R., Yeo, C.Y., and Baek, K.-H.  (2007). The expression of Usp42 during embryogenesis and spermatogenesis in mouse. Mech. Dev. (Gene Exp. Patterns) 7: 143-148.  (Corresponding author)

*66. Noh, S.M., Kim, W.-K., Kim, S.J., Kim, J.M., Baek, K.-H., and Oh, Y.-K. (2007). Enhanced cellular delivery and transfection efficiency of plasmid DNA using positively charged biocompatible colloidal gold nanoparticles. Biochim. Biophys. Acta 1770: 747-752. (Corresponding author)

*67. Baek, K.-H., Lee, E.-J., and Kim, Y.-S. (2007). Recurrent pregnancy loss: the key possible mechanisms. Trends Mol. Med. 13: 310-317. (Corresponding author)

*68. Kim, D.C., Noh, S.M., Park, K.T., Kim, Y.B., Baek, K.-H., and Oh, Y.-K. (2007). Transdermal delivery of porcine placenta extracts using linolenic acid-based emulsion formulations. J. Kor. Pharm. Sci. 37: 281-286. (Corresponding author)

*69. Park, J.-M., Gu, B.-H., Lee, E.-J., Kim, J.-Y., Choi, S.-W., and Baek, K.-H. (2008). A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients. Mol. Med. Rep. 1: 93-97. (Corresponding author)

70. Jin, Y.-H., Kim, Y.-J., Kim, D.-W., Baek, K.-H., Kang, B. Y., Yeo, C.-Y., and Lee, K.-Y. (2008). Sirt2 interacts with 14-3-3 β/γ and down-regulates the activity of p53. Biochem. Biophys. Res. Commun. 368: 690-695.

*71. Lee, E.-J., Oh, B., Lee, J.-Y., Kimm, K., Lee, S.-H., and Baek, K.-H. (2008). A single nucleotide polymorphism of INSR gene for polycystic ovary syndrome. Fertil. Steril. 89: 1213-1220. (Corresponding author)

*72. Lee, E.-J., Oh, B., Lee, J.-Y., Kimm, K., Park, J.-M., and Baek, K.-H. (2008). Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome (PCOS). Fertil. Steril. 89: 1751-1759. (Corresponding author)

*73. Park, J.-M., Lee, E.-J., Ramakrishna, S., Cha, D.-H., and Baek, K.-H. (2008). Association study for single nucleotide polymorphisms in CYP17A1 gene and polycystic ovary syndrome. Int. J. Mol. Med. 22: 249-254. (Corresponding author)

*74. Kim, D.C., Noh, S.M., Kim, Y.B., Baek, K.-H., and Oh, Y.-K. (2008). Transdermal delivery of ceramide using sodium deoxycholate-based deformable liposomes. J. Kor. Pharm. Sci. 38: 319-323. (Corresponding author)

*75. Lee, M.-Y., Ajjappala, B.S., Kim, M.-S., Oh, Y.-K., and Baek, K.-H. (2008). DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway. J. Cell. Biochem. 105: 1420-1429. (Corresponding author)

*76. Ajjappala, B.S., Kim, Y.-S., Kim, M.-S., Lee, M.-Y., Lee, K.-Y., Ki, H.-Y., Cha, D.-H., and Baek, K.-H. (2009). 14-3-3γ is stimulated by IL-3 and promotes cell proliferation. J. Immunol. 182: 1050-1060. (Corresponding author)

*77. Gu, B.H., and Baek, K.-H. (2009). Pro12Ala and His447His polymorphisms of PPAR-gamma are associated with polycystic ovary syndrome. Reprod. BioMed. Online, 18: 644-650. (Corresponding author)

78. Ait-Ali, T., Wilson, A.W., Finlayson, H., Carre, W., Ramaiahgari, S.C., Westcott, D.G., Waterfall, M., Frossard, J.P., Baek, K.-H., Drew, T.W., Bishop, S.C., and Archibald, A.L. (2009). Functional analysis of the porcine USP18 and its role during porcine arterivirus replication. Gene 439: 35-42.
*79. Choi, S.-W., Gu, B.-H., Ramakrishna, S., Park, J.-M., and Baek, K.-H. (2009). Association between a single nuclotide polymorphism in MTHFR gene and polycystic ovary syndrome. Eur. J. Obs. Gyn. Reprod. Biol. 145: 85-88. (Corresponding author)
*80. Ajjappala, B., Kim, M.-S., Kim, E.-Y., Kim, J.-H., Kang, I.-C., and Baek, K.-H. (2009). Protein chip analysis of pluripotency associated proteins in NIH3T3 fibroblast. Proteomics 9: 3968-3978. (Corresponding author)
81. Jo, A.-Y., Kim, M.-Y., Lee, H.-S., Rhee, Y.-H., Lee, J.-E., Baek, K.-H., Park, C.-H., Koh, H.-C., Shin, I., Lee, Y.-S., and Lee, S.-H. (2009). Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant Nurr1 mutant. Stem Cells 27: 2238-2246.
*82. Gu, B.-H., and Baek, K.-H. (2009). Follicular-stimulating hormone receptor (FSHR) polymorphisms and polycystic ovary syndrome (PCOS). Fertil. Steril. 92: e55. (Corresponding author)

*83. Baek, K.-H., and Ramakrishna, S. (2009). USP7 (ubiquitin specific peptidase 7 (herpes virus-associated)). Atlas Genet Cytogenet Oncol Haematol. 2009; 13(8): 576-579. (Corresponding author)

84. Noh, S.M., Park, M.O., Shim, G., Han, S.E., Lee, H.Y., Huh, J.H., Kim, M.S., Bang, S.S., Kim, K., Kwon, I.C., Kim, J.-S., Baek, K.-H., and Oh, Y.-K. (2010). Pegylated poly-L-arginine derivatives of chitosan for effective delivery of siRNA. J. Control. Release, 145: 159-164.

*85. Ramakrishnam, S., Suresh, B., Kang, I.-C., and Baek, K.-H. (2010). Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. Hybridoma, 29: 311-319. (Corresponding author)

*86. Choi, J.-H., Lee, M.-Y., Kim, Y., Shim, J.-Y., Han, S.-M., Lee, K.-A., Choi, Y.-K., Jeon, H.-M., and Baek, K.-H. (2010). Isolation of genes involved in pancreas regeneration by subtractive hybridization. Biol. Chem. 391: 1019-1029. (Corresponding author)

*87. Gu, B.-H., Park, J.-M., and Baek, K.-H. (2010). Genetic variations of FSHR are associated with polycystic ovary syndrome. Int. J. Mol. Med. 26: 107-112. (Corresponding author)

*88. Suresh, B., Ramakrishna, S., Lee, H.-J., Choi, J.-H., Kim, J.-Y., Ahn, W.-S., and Baek, K.-H. (2010). K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44. Cell Biol. Int. 34: 799-808.  (Corresponding author)

*89. Suresh, B., Ramakrishna, S., Kim, Y.-S., Kim, S.-M., Kim, M.-S., and Baek, K.-H. (2010). Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM. J. Biol Chem. 285: 35340-35349. (Corresponding author)

*90. Ramakrishna, S., Suresh, B., and Baek, K.-H. (2011). The role of deubiquitinating enzymes in apoptosis. Cell. Mol. Life Sci. 68: 15-26. (Corresponding author)

*91. Lan, L., Yun, J.-H., Lee, J.-H., Song, S., Choi, B.-C., and Baek, K.-H. (2011). Association study of +45G15G (T/G) and +276 (G/T) polymorphisms in the adiponectin gene with polycystic ovary syndrome. Int. J. Mol. Med. 27: 283-287. (Corresponding author)

*92. Kim, M.-S., Ramakrishna, S., Lim, K.-H., Kim, J.-H., and Baek, K.-H. (2010). Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36. J. Cell. Biochem. 112: 498-508. (Corresponding author)

*93. Ramakrishna, S., Suresh, B., Lee, E.-J., Lee, H.-J., Ahn, W.-S., and Baek, K.-H. (2011). Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. J. Biol. Chem. 286: 10505-10514. (Corresponding author)

*94. Kim, M.-S., Gu, B.-H., Song, S., Choi, B.-C., Cha, D.-H., and Baek, K.-H. (2011). ITI-H4, as a biomarker in the serum of recurrent pregnancy loss patients. Mol. Biosyst. 7: 1430-1440. (Corresponding author)

*95. Kim, J.-H., Li, L., Yun, J.-H., Choi, B.-C., and Baek, K.-H. (2011). Association study between the -866G/A polymorphism in the promoter of uncoupling protein-2 gene and polycystic ovary syndrome. Mol. Med. Rep. 4: 747-751. (Corresponding author)

*96. Ramakrishna, S., Suresh, B., Lim, K.-H., Cha, B.-H., Lee, S.-H., Kim, K.-S., and Baek, K.-H. (2011). PEST motif sequence regulating human NANOG for proteasomal degradation. Stem Cells Dev. 20: 1511-1519.  (Corresponding author)

97. Bang, J.-Y., Kim, E.-Y., Kang, D.-K., Chang, S.-I., Han, M.-H., Baek, K.-H., and Kang, I.-C. (2011). Pharmaco-proteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol. Cell. Proteomics, Mol. Cell. Proteomics, 10: M110.005264

*98. Choi, J.-H., Lee, M.-Y., Ramakrishna, S., Kim, Y., Shim, J.-Y. Han, S.-M., Kim, J.-Y., Lee, D.-H., Choi, Y.-K., and Baek, K.-H. (2011). LCP1 up-regulated by partial pancreatectomy supports cell proliferation and differentiation. Mol. BioSyst. 7: 3104-3111. (Corresponding author)

*99. Yun, J.-H., Choi, J.-W., Lee, K.-J.,Shin, J.-S., and Baek, K.-H. (2011). The promoter -1031(T/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary syndrome. Reprod. Biol. Endocrinol. 9: 131. (Corresponding author)

*100. Baek, K.-H., and Suresh, B. (2012). RANBP9 (RAN binding protein 9). Atlas Genet Cytogenet Oncol Haematol. 2009; 16 (8): 549-551. (Corresponding author)

*101. Suresh, B., Ramakrishna, S., and Baek, K.-H. (2012). Diverse roles of a scaffolding protein RanBPM. Drug Discov. Today, 17: 379-387. (Corresponding author)

*102. Ramakrishna, S., Suresh, B., Bae, S.-M., Ahn, W.-S., Lim, K.-H., and Baek, K.-H. (2012). Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity. PLoS One, 7: e37772. (Corresponding author)

*103. Yun, J.-H., Gu, B.-H., Kang, Y.-B., Choi, B.-C., Song, S., and Baek, K.-H. (2012). Association between INS-VNTR polymorphism and polycystic ovary syndrome in a Korean population. Gynecol. Endocrinol, 28: 525-528. (Corresponding author)

*104. Baek, K.-H., Lee, H., Yang, S., Lim, S.-B., Lee, W., Lee, J.E., Lim, J.-J., Jun, K., Lee, D.-R., Chung, Y. (2012). Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. PLoS One, 7: e44223. (Corresponding author)

*105. Choi, J.-H., Lim, K.-H., Park, E., Kim, J.-Y., Choi, Y.-K., and Baek, K.-H. (2012). Glutamate-ammonia ligase and reduction of G0 population in PANC-1 cells. J. Cell. Biochem. 114(2): 303-313. (Corresponding author)

*106. Kim, Y.-S., Gu, B.-H. Choi, B.-C. Kim, M.-S., Song, S., Yun, J.-H., Chung, M.-K., Choi, C.-H., and Baek, K.-H. (2012). Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome. Int. J. Mol. Med. 31(3): 707-716. (Corresponding author)

*107. Lim, K.-H., and Baek, K.-H. (2012). Deubiquitinating enzymes as therapeutic targets in cancer. Curr. Pharm. Des. 19(22) 4039-4052. (Corresponding author)

*108. Park, J.-J., Yun, J.-H., and Baek, K.-H. (2013). Polyclonal and monoclonal antibodies for ubiquitin specific protease 20. Mono. Ant. Immuno. Immunoth. 32(3): 193-199. (Corresponding author)

*109. Lim, K.-H., Ramakrishna, S., and Baek, K.-H. (2013). Molecular mechanisms and functions of cytokine-inducible deubiquitinating enzymes. Cyt. Growth Factor Rev. 24(5): 427-431. (Corresponding author)

*110. Li, L., Lee, K.-J., Choi, B.-C., and Baek, K.-H. (2013). Relationship between leptin receptor and polycystic ovary syndrome. Gene, 527(1): 71-74. (Corresponding author)

111. Lee, K.W., Cho, J.G., Kim, C.M. Kang, A.Y., Kim, M., Ahn, B.Y., Chung, S.S., Lim, K.-H., Baek, K.-H., Park, K.S., Sung, J.-H., and Park, S.G. (2013). Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor gamma (PPARr) stability through its deubiquitinating activity. J Biol Chem, 288(46): 32886-32896.

*112. Lim, K.-H., Kim, S.-R., Ramakrishna, S., and Baek, K.-H. (2014). Critical lysine residues of Klf4 required for protein stabilization and degradation. Biochem. Biophys. Res. Commun. 443(4): 1206-1210. (Corresponding author)

*113. Ramakrishna, S., Kim, K.-S., and Baek, K.-H. (2014). Posttranslational modifications of defined embryonic reprogramming transcription factors. Cell Reprogram. 16(2): 108-120. (Corresponding author)

*114. Ramakrishna, S., Suresh, B., and Baek, K.-H. (2015). Biological functions of hyaluronan and cytokine-inducible deubiquitinating enzymes. BBA - Rev. Cancer, 1855: 83-91 (Corresponding author)

*115. Park, J.-J., Lim, K.-H., and Baek, K.-H. (2015). Annexin-1 regulated by HAUSP is essential for UV-induced damage response. Cell Death & Dis. 6:e1654. (Corresponding author)

*116. Kim, S.-R., Kim, J.-O., Lim, K.-H., Yun, J.-H., and Han, I., and Baek, K.-H. (2015). Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20. Int. J. Oncol. 46: 2116-2124. (Corresponding author)

*117. Li, L., Yun, J.-H., Yoo, J.-E., Lee, K.-J., Choi, B.-C., and Baek, K.-H. (2015). 54G/C polymorphism of SREBF-1 gene is associated with polycystic ovary syndrome. Eur. J. Obs. Gyn. Reprod. Biol. 188: 95–99. (Corresponding author)

*118. Park, J.-H., Li, L., and Baek, K.-H. (2015). Association of T869C polymorphism of transforming growth factor-β1 gene with polycystic ovary syndrome. Mol. Med. Rep. 12(3): 4560-4565. (Corresponding author)

*119. Li, L., and Baek, K.-H. (2015). Molecular genetics of polycystic ovary syndrome: an update. Curr. Mol. Med. 15(4): 331-342. (Corresponding author)

*120. Li, L., Ryoo, J.-E., Lee, K.-J., Choi, B.-C., and Baek, K.-H. (2015). Genetic Variation in the Mcp-1 gene promoter associated with the risk of polycystic ovary syndrome. PLoS One. 10(4): e0123045. (Corresponding author)

121. Schvartz, D., Bergsten, P., Baek, K.-H.. Barba De La Rosa, A., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y.A., Moulder, R., Goodlett, D., Johnson, J.D., Konvalinka, A., Mulde,r H., Priego-Capote, F., Sechi, S., Snyder, M., Tiss, A., Wiederkehr, A., Xenarios, I., Kussmann, M., and Sanchez, J-C. (2015). The human diabetes proteome project (HDPP): The 2014 update. Translational Proteomics. 8-9: 1-7.

*122. Lim, K.-H., Park, J.-J., Gu, B.-H., Kim, J.-O, Park, S.-G, and Baek, K.-H. (2015). HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. Sci. Rep. 5: 12793. (Corresponding author)

*123. Kim, J.-O,, Kim, S.-R., Lim, K.-H., Kim, J.-H., Ajjappala, B., Lee, H.-J., Choi, J.-I., and Baek, K.-H. (2015). Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3γ. Oncotarget, 6(34): 36551-36576. (Corresponding author)

124. Kim, K. E., Cho, Y. S., Baek, K. S., Li, L., Baek, K.-H., Kim, J. H., Kim, H.-S., Sheen, Y. H. (2016). Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents. Kor. J. Pediatr. 59(5): 231-238.

125. Ahn, H.-J., Kim, K.-S., Shin, K.-W., Lim, K.-H., Kim, J.-O., Lee, J.-Y., Kim, J., Park, J.-H., Yang, K.-M., Baek, K.-H., Ko, J.-J., and Park, K.-S. (2016). Ell3 induces p53 stabilization following CDDP treatment by modulating ubiquitin-dependent and -independent proteasomal degradation pathways in the breast cancer cells. Oncotarget, 6(42): 44523-44537.

*126. Lim, K.-H., Song, M.-H., and Baek, K.-H. (2016). Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint. Cell Mol Life Sciences, 73(7): 1439-1455. (Corresponding author)

*127. Lim, K.-H., Suresh, B., Park, J.-H., Kim, Y.-S., Ramakrishna, S., and Baek, K.-H. (2016). Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth. Oncotarget, 7(22): 14441-14457.

128. Chung, S., Rho, S., Kim, G., Kim, S.-R., Baek, K.-H., Kang, M., and Lew, H. (2016). Human cord blood cells and chorionic plate-derived mesenchymal stem cells promote axon survival in an optic nerve crush rat model. Int. J. Mol. Med. 37(5): 1170-1180.

*129. Baek, K.-H. (2016). Meet Our Editorial Board Member. Curr. Protein & Pept. Sci. 17(4): 1.

*130. Lim, K.-H., Choi, J.-H., Park, J.-H., Cho, H.-J., Park, J.-J., Lee, E.-J., Li, L., Choi, Y.-K., and Baek, K.-H. (2016). Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A. Oncotarget, 7(23): 34759-34772.

*131. Park, J.-H., Li, L., Choi, J.-W., and Baek, K.-H. (2016). The association of-429T>C and -374T>A polymorphisms in the RAGE gene with polycystic ovary syndrome. Int. J. Med. Sci. 13(6): 451-456.

*132. Kwon, S.-K., Lee, D.-H., Kim, S.-Y., Park, J.-H., Choi, J.-H., and Baek, K.-H. (2017). Ubiquitin-specific protease 21 regulating the K48-linked polyubiquitination of NANOG. Biochem. Biophys. Res. Commun. 482: 1443-1448..

*133. Kwon, S.-K., Kim, E.-H., and Baek, K.-H. (2017). RNPS1 is modulated by ubiquitin-specific protease 4. FEBS Lett. 591(2): 369-381.

134. Kim, Y.-J., Hur, J., Cho, E.-H., Baek, K.-H., and Lee, K.-J. (2017). Prediction of gestational diabetes mellitus by unconjugated estriol levels in maternal serum. Int. J. Med. Sci. 14(2): 123-127.

*135. Kwon, S.-K., Saindane, M., and Baek, K.-H. (2017). p53 stability is regulated by diverse deubiquitinating enzymes. BBA - Rev. on Cancer, 1868: 404-411 (Corresponding author)

*136. Kim, S.-Y., Kwon, S.-K., Lee, S.-Y., and Baek, K.-H. (2018). Ubiquitin-specific protease 5 and OTU deubiquitinase 6A differentially expressed by the expression level of p53. Int. J. Oncol. 552: 1705-1714. (Corresponding author)

137. Kim, J.H., Heo, J.S., Baek, K.S., Kim, S.-Y., Kim, J.H., Baek, K.-H., Kim, K.E., and Sheen, Y.H. (2018). Zonulin level, a marker of intestinal permeability, is increased in association with liver enzymes in young adolescents. Clin. Chim. Acta 481: 218-224.

*138. Choi, J., and Baek, K.-H. (2018). Cellular functions of stem cell factors mediated by the ubiquitin-proteasome system. Cell. Mol. Life Sci. 75: 1947-1957. (Corresponding author)

*139. Kim, S.-Y., Choi, J., Lee, D.-H., Park, J.-H., Hwang, Y.-J., and Baek, K.-H. (2018). PME-1 is regulated by USP36 in ERK and Akt signaling pathways. FEBS Lett. 592(9): 1575-1588. Corresponding author)

140. Baek, K.-H. (2018). Regulation of protein degradation and homeostasis by the cytokine-inducible deubiquitinating enzymes. Int. J. Immunother Cancer Res. 4: 1-3. (Corresponding author)

141. Kim, K.E., Heo, J. S., Han, S., Kwon, S.-K., Kim, S.-Y., Kim, J.H., Baek, K.-H., and Sheen, Y. H. (2018). Blood concentrations of lipopolysaccharide-binding protein, high-sensitivity C-reactive protein, tumor necrosis factor-α, and Interleukin-6 in relation to insulin resistance in young adolescents. Clin. Chim. Acta 486: 115-121.

*142. Li, L., Choi, B.-C., Ryoo, J.E., Song, S.-J., Pei, C.-Z., Lee, K.Y., Paek, J., and Baek, K.-H. (2018). Opposing roles of inter--trypsin inhibitor heavy chain 4 in recurrent pregnancy loss. EBioMedicine, in press.