Malignant hyperthermia in Lesch-Nyhan disease

    DOI Logo 10.17352/acn.000034

    Published On: May 08, 2019 | Pages: 001 - 002

    Author(s): William L Nyhan* and Michelle Lucas
    Lesch-Nyhan disease is a heritable disorder of purine metabolism. Inheritance is X-linked and the disease occurs almost exclusively in males. Defective activity of hypoxanthine phosphoribosyltransferase leads to hyperuricemia and increased quantities of uric acid in the urine. All patients may develop urinary calculi, urate nephropathy, tophaceous deposits and clinica ...
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