Research Interest: Aspect of biochemistry,
molecular biology, endocrinology, metabolism, nutrition, pharmacology, and
toxicology. Dr. Yamaguchi has an interesting for cell signaling mechanism, bone
biology, nutritional factor and osteoporosis prevention, diabetes and diabetic
osteoporosis, cancer biology, and cancer bone metastasis. Dr. Yamaguchi
discovered two novel proteins and genes; cell signaling suppressor protein
(named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene
promoter region-related protein; 2001) in mammalian cells. Dr. Yamaguchi
generated regucalcin transgenic rats, which were registered as international
patents (USA, EU, Japan, and Korea), and this animal was found to induce
osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential
role of regucalcin as a key suppressor protein in carcinogenesis. Currently, the research of regucalcin is
focused as a scientific topic
Research Interest: Production of monoclonal and
polyclonal antibodies Microbiology and Immunology Development of biomedical
protein chips Development of mmunochromatographic
strip with nano-gold particle technique Immunosensing analysis technique:
Surface plasmon resonance (Optical sensor) and Quartz crystal microbalance
Research Interest: Drug Delivery, Pharmacokinetics, Controlled
Release, Drug Targeting, Prodrug
Research Interest: Polyhydroxyalkanoates (PHAs),
bioprocess engineering, biopolymer fermentation, biogas, environmental
biotechnology, and environmental microbiology
Research Interest: A versatile biotechnologist with research experience
ranging from searching for novel microbial enzymes using classical and
metagenomic approaches, genetic engineering to tailor them for specific
applications, fermentation, downstream processing and their biotechnological
application. Biotechnological applications range from developing “Green
Chemistry technologies”/processes, developing antimicrobial systems, and
systems/and or products for preventing, monitoring and therapy of oxidative
stress related human diseases (cancer, cardiovascular, respiratory,
atherosclerosis, diabetes, neurodegenerative diseases).
Research Interest: To explore the molecular biology
and their use in genetic toxicology. currently held to identify the genetic
research hazard of chemicals, physical and biological
Research Interest: Designing and preparing new nanobiomaterials, Characterizing physical and chemical
properties, biocompatibility and bioactivity of the nanobiomaterials
Research Interest: Obesity, metabolic syndrome, diabetes type 2,dyslipidemia,hypertension.
Research Interest: Polymeric Biomaterials and Green Materials: -Synthesis and Characterization, Surface Modification, and Patterning (soft and dip-pen lithography) and Polymers processing, Synthesis of Polyurethanes/Polyesters and Bio-based resins. Nanomaterials and Energy Materials: Polymer-HA or Polymer-CNT Nanocomposites, Synthesis of Nanofibers and Nanoparticles for cancer drug delivery, Chemical modification of Nanodiamond particles and Metallization of CNTs, Polymeric and silica Nanorods as reinforcing fillers for dental restoration materials for flowable composites), Polymer/graphene composite materials and Polymer/polyoxometalate composites for energy applications. Tissue Engineering/ Drug Delivery: Polymeric 3D-Nanofibrous Scaffolds for Bone, Vascular, Neural and Dental, Salivary glands and multifunctional nanoparticles for lung cancer drug and growth factor delivery, Nasal/mucosal delivery of therapeutics), Electrospining and Force-spinning techniques for polymer and ceramic composite nanofabrication. Additive bio-manufacturing and We-laid Process for biomaterials/scaffolds of complex tissues and interfaces. Characterization of Materials: Microscopic and Spectroscopic characterization (SEM, AFM, FT-IR, XPS), mechanical properties characterization (Tensile, compression, dynamic mechanical (DMA) and nanoindentation), thermal properties (TGA, DSC, TMA) and Rheological characterization of polymeric biomaterials, nanomaterials and hybrid polymer/inorganic composites and in vitro Cell Studies for biocompatibility and toxicity. In Vitro Evaluation of nano-structured materials/ nanodiamond wear-debris from orthopedic joint implants: Nanoscaled wear-debris isolation from Hip and knee Simulator (AMTI) and its inflammatory effect evaluation.
Research Interest: Fungal biotechnology, Marine bacterial
phylogenetics and taxonomy
Research Interest: pharmacological approaches in human ex vivo /
in vitro models targeted against inflammation&proliferation&migration
in atherosclerosis and restenosis following angioplasty.
Research Interest: Biological activity of blood
platelets; inflammatory properties of platelets; interaction of blood platelets
with the cells of the immune system; autoimmune diseases; activation and
platelet reactivity in neurodegenerative diseases (multiple sclerosis);
proteome, transcriptome and metabolome of platelets; molecular markers of
platelets in the diagnosis of acute coronary syndromes
Research Interest: Molecular biology as well as
signaling pathways involved in apoptosis.
Research Interest: Studying the pathogenic process
in betanodavirus and iridovirus infection in grouper GF-1 and larval grouper
fish systems. His laboratory pioneered the use of grouper model to study
betanodavirus in vivo on brain damaged, which as a model.
Research Interest: Neurogenesis. Screening the leading chemical
to stimulate the neurogenesis after CNS, diseases, including: Stroke, Multiple
sclerosis, Alzheimers disease et al. Brain tumor. To study the oncogenesis
mechanisms of mellablastoma and glioblastoma.At the same time, to screen the
inhibitor of Sonic hedgehog pathway to treat the brain tumor.
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Published On: April 14, 2017 | Pages: 001 - 007Abstract View Full Article View
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Published On: July 06, 2015 | Pages: 009 - 009Abstract View Full Article View
Published On: May 25, 2015 | Pages: 004 - 008Abstract View Full Article View
Published On: April 17, 2015 | Pages: 001 - 003Abstract View Full Article View
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