Research Interest: Methodology of solid phase
peptide synthesis and synthetic peptides with bioactivity
Research Interest: Polymeric Biomaterials and Green Materials: -Synthesis and Characterization, Surface Modification, and Patterning (soft and dip-pen lithography) and Polymers processing, Synthesis of Polyurethanes/Polyesters and Bio-based resins. Nanomaterials and Energy Materials: Polymer-HA or Polymer-CNT Nanocomposites, Synthesis of Nanofibers and Nanoparticles for cancer drug delivery, Chemical modification of Nanodiamond particles and Metallization of CNTs, Polymeric and silica Nanorods as reinforcing fillers for dental restoration materials for flowable composites), Polymer/graphene composite materials and Polymer/polyoxometalate composites for energy applications. Tissue Engineering/ Drug Delivery: Polymeric 3D-Nanofibrous Scaffolds for Bone, Vascular, Neural and Dental, Salivary glands and multifunctional nanoparticles for lung cancer drug and growth factor delivery, Nasal/mucosal delivery of therapeutics), Electrospining and Force-spinning techniques for polymer and ceramic composite nanofabrication. Additive bio-manufacturing and We-laid Process for biomaterials/scaffolds of complex tissues and interfaces. Characterization of Materials: Microscopic and Spectroscopic characterization (SEM, AFM, FT-IR, XPS), mechanical properties characterization (Tensile, compression, dynamic mechanical (DMA) and nanoindentation), thermal properties (TGA, DSC, TMA) and Rheological characterization of polymeric biomaterials, nanomaterials and hybrid polymer/inorganic composites and in vitro Cell Studies for biocompatibility and toxicity. In Vitro Evaluation of nano-structured materials/ nanodiamond wear-debris from orthopedic joint implants: Nanoscaled wear-debris isolation from Hip and knee Simulator (AMTI) and its inflammatory effect evaluation.
Research Interest: Food Processing, health food and
cosmetics, Research of Chinese herbal medicine research, Agricultural
biotechnology, Supercritical fluid, and Mycology
Research Interest: Designing and preparing new nanobiomaterials, Characterizing physical and chemical
properties, biocompatibility and bioactivity of the nanobiomaterials
Research Interest: To explore the molecular biology
and their use in genetic toxicology. currently held to identify the genetic
research hazard of chemicals, physical and biological
Research Interest: Obesity, metabolic syndrome, diabetes type 2,dyslipidemia,hypertension.
Research Interest: Aspect of biochemistry,
molecular biology, endocrinology, metabolism, nutrition, pharmacology, and
toxicology. Dr. Yamaguchi has an interesting for cell signaling mechanism, bone
biology, nutritional factor and osteoporosis prevention, diabetes and diabetic
osteoporosis, cancer biology, and cancer bone metastasis. Dr. Yamaguchi
discovered two novel proteins and genes; cell signaling suppressor protein
(named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene
promoter region-related protein; 2001) in mammalian cells. Dr. Yamaguchi
generated regucalcin transgenic rats, which were registered as international
patents (USA, EU, Japan, and Korea), and this animal was found to induce
osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential
role of regucalcin as a key suppressor protein in carcinogenesis. Currently, the research of regucalcin is
focused as a scientific topic
Research Interest: A versatile biotechnologist with research experience
ranging from searching for novel microbial enzymes using classical and
metagenomic approaches, genetic engineering to tailor them for specific
applications, fermentation, downstream processing and their biotechnological
application. Biotechnological applications range from developing “Green
Chemistry technologies”/processes, developing antimicrobial systems, and
systems/and or products for preventing, monitoring and therapy of oxidative
stress related human diseases (cancer, cardiovascular, respiratory,
atherosclerosis, diabetes, neurodegenerative diseases).
Research Interest: Drug Delivery, Pharmacokinetics, Controlled
Release, Drug Targeting, Prodrug
Research Interest: Plant Tissue Culture and Biotechnology, Crop
Protection and Stress Physiology, Biological Control of Plant Diseases,
Bio-herbicides, Food Chemistry and Plant Breeding, Water Pollution
Research Interest: pharmacological approaches in human ex vivo /
in vitro models targeted against inflammation&proliferation&migration
in atherosclerosis and restenosis following angioplasty.
Research Interest: Neurogenesis. Screening the leading chemical
to stimulate the neurogenesis after CNS, diseases, including: Stroke, Multiple
sclerosis, Alzheimers disease et al. Brain tumor. To study the oncogenesis
mechanisms of mellablastoma and glioblastoma.At the same time, to screen the
inhibitor of Sonic hedgehog pathway to treat the brain tumor.
Research Interest: Molecular biology as well as
signaling pathways involved in apoptosis.
Research Interest: With a combination of molecular
biology, biochemistry, cell biology, nutrition metabolism,transgenic/knockout
mice model, I aim to uncover the complex molecular programs that regulates
physiological or pathological biological pathways, such as cell commitment,
cell metabolism, embryonic development, brain development, nutrition
regulation, and the pathological mechanisms of human metabolic diseases, such
as obesity, diabetes and neurological disease..
Research Interest: Polyhydroxyalkanoates (PHAs),
bioprocess engineering, biopolymer fermentation, biogas, environmental
biotechnology, and environmental microbiology
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