mendeley

    The Paradoxes of Neoantigenes in Predicting Better Prognosis of Cancer Patients

    DOI Logo 10.17352/gjct.000011

    Published On: December 30, 2016 | Pages: 030 - 031

    Author(s): Rui-An Wang*, Qing-Guo Yan and Jian-Guo Shi
    Increased neoantigens of cancer generated by mutations are reported to be associated with favorable prognosis of cancer patients. The interesting findings contradict the notions that cancers were caused by accumulation of gene mutations. ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos
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    mendeley

    Gamma-Delta T Cell Acute Lymphoblastic Leukemia: A Single-Center Experience

    DOI Logo 10.17352/gjct.000010

    Published On: December 29, 2016 | Pages: 026 - 029

    Author(s): Donnellan W, Mineishi S, Wicker J and Paluri R *
    Gamma-delta (γδ) T cell neoplasms are a rare disease entity characterized by an aggressive clinical course [1,2]. The management of these neoplasms associated with high incidence of induction failures and poor clinical outcomes [3]. ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos
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    Lenvatinib Suppresses Angiogenesis through the Inhibition of both the VEGFR and FGFR Signaling Pathways

    DOI Logo 10.17352/gjct.000009

    Published On: July 02, 2016 | Pages: 019 - 025

    Author(s): Kenji Ichikawa, Saori Watanabe Miyano, Yusuke Adachi, Masahiro Matsuki, Kiyoshi Okamoto and Junji Matsui*
    Lenvatinib mesilate (lenvatinib) is an oral multiple-receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of Vascular Endothelial Growth Factor Receptor (VEGFR) 1­­-3, Fibroblast Growth Factor Receptor (FGFR) 1­­-4, Platelet-Derived Growth Factor Receptor (PDGFR) α, KIT, and RET. The VEGFR and FGFR signaling pathways are the master regula ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos
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    A Novel Small-Molecule Integrin Antagonist Inhibits Cells Adhesion Followed By Anoikis in Endothelial Cells - A Comparative Analysis with Cilengitide

    DOI Logo 10.17352/gjct.000008

    Published On: March 18, 2016 | Pages: 009 - 018

    Author(s): Agnieszka Christenheit*, Petra Heffeter and Edgar Selzer
    Background: Despite the crucial role of integrin receptors in cancer pathogenesis and massive efforts towards establishing clinically relevant drugs, to the present no effective integrin antagonist for the treatment of malignant diseases has been introduced into the clinic. Context and purpose of the study: The purpose of the study was to examine the cellular effec ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos
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    Bortezomib in Anti-Cancer Activity: A Potential Drug

    DOI Logo 10.17352/gjct.000007

    Published On: March 08, 2016 | Pages: 005 - 008

    Author(s): Rajagopal Appavu* and Deepa Mohan
    26S proteasome is an intracellular; ATP dependent enzymatic complex degrades ubiquitin-tagged proteins and maintains cellular homeostasis. The orderly degraded proteins including cyclins, caspases, Bcl-xL, p53, cell adhesion molecules are involved in cell-cycle progression, tumor suppression, DNA replication, inflammation, and apoptosis. So, proteasome inhibition is a ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos
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    Primary Leiomyosarcoma of the Mandibular Gingiva

    DOI Logo 10.17352/gjct.000006

    Published On: March 03, 2016 | Pages: 001 - 004

    Author(s): Stylianos N Zanakis*, Vasileios Lyris, Sotirios Kyriakou, George Agrogiannis and Penelope Korkolopoulou
    Primary oral leiomyosarcomas are exceptionally rare lesions often associated with poor prognosis. We report a case of leiomyosarcoma arising in the anterior mandibular gingiva, which is a non-prevalent site of occurrence. Clinically, the tumor was far from being firm and solid as it is usually described in the literature. Light microscopy failed to confirm the true na ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate GrowKudos
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