Hon. Pierre Guertin
Laval University, Canada
Tel: +1 418-525-4444
Fax: +1 418-654-2753
Research Interest: Molecular Pharmacology, Chinese Medicines and Diabetes
Mellitus, Effects and Mechanism of Natural Products on Cardio-Cerebrovascular
Research Interest: My Research has
Focused on Understanding the BBB, Changes that Occur in the Blood-Tumor-Barrier
(BTB), and Drug Uptake Therein. To this End, I Have Worked and Gained
Significant Amount of Knowledge on Factors Influencing Anticancer Delivery and
Activity in Brain aBrain Metastases Developed from Breast Cancer in Mouse
Models. These Include: (1) How BBB is Altered in Mouse Models of Brain
Metastases of Breast Cancer. (2) Pharmacokinetic-Pharmacodynamic Relationship of
Anticancer Drugs in Brain Metastases. (3) in Vitro- In Vivo Correlations (IVIVC)
to Predict Optimum Therapeutic Concentrations for Treatment of Brain
Metastases. (4) Improving Targeted Anticancer Drug Delivery to Brain Tumors by
Inhibiting Efflux Transporters and Piggy Backing Drugs to Substrates of Influx
Transporters at the BBB.
Research Interest: Nutrition,
Obesity, Weight, Diet
Research Interest: Rehabilitation,
Working with Older People, Diabetes, Stroke Care, Research
Research Interest: Integrated
Pharmaco-Physiology, Brain-Gut Interactions, Stress-Related Functional
Gastrointestinal Diseases, Ingestive Behavior-Associated Gastrointestinal
Neuroendocrinology, and Bariatric Surgery
Research Interest: Application of
Multiple Linear and Logistic Regression Models, Applied Longitudinal Data
Analysis, Generalized Linear and Non-Linear Mixed Models, and Survival
Analysis; Epidemiology of Chronic Diseases Including Alcohol use Disorders and
Drug Abuse, Alzheimer’s Disease, Cancer, Obesity and Diabetes, Heart Disease and
Stroke; Genetic Epidemiology of Complex Diseases Including Alcohol Dependence
And Comorbidity, Obesity, Diabetes and Related Conditions, Depression and
Research Interest: My
Research Interests Span Many Areas Including Bioinformatics and Metabolomics. As
a Phd Student at Center of Magnetic Resonance of University of Florence (Italy),
My Research Focused on the Metabolomic Analysis of Biofluid (E.G., Urine,
Serum, Saliva) and Tissue (E.G., Intact Human Liver) Samples. I Used Nuclear
Magnetic Resonance (NMR) Spectroscopy and Advanced Statistical Analysis
Techniques to Identify and Predict Metabolomic Fingerprints. In Particular, I Used
NMR-Based Metabolomic Analysis to Identify a Fingerprint of Poor-Survival in the
Serum of Patient with Metastatic Colorectal Cancer.
Now as Postdoc at Dana-Farber Cancer Institute, My Current Research Focuses on Identifying Metabolic Fingerprint Predictors of Prostate Cancer Development and Progression to Improve our Understanding of The Mechanisms Linking Metabolism with the Biology of Prostate Cancer. Moreover, I Will Contribute on Developing of New Standard Operation Procedures for Metabolomic Analysis in Formalin Fixed Paraffin Embedded Tissues.
Research Interest: Multicenter
Prospective Observational CREST Study (U.Penn, Vanderbilt, and University
Hospitals Case Medical Center) with Dr. James Fang, Evaluating Cardiotoxicity of
Sunitinib in Metastatic Renal Cell Carcinoma Using Tonometry Data
Research Interest: Epidemiology
of Diabetes; Mechanism of Insulin Action; Insulin Resistance; Obesity and
Insulin Resistance; Cardiovascular Risk Diabetes and Obesity; Bone Metabolism and
Diabetes and Obesity; Gene Adiposities Tissue in Diabetes and Obesity.
Dr. Mehta’s research program focuses on the role of innate immunity and inflammation in the development of cardiovascular and metabolic diseases. Using a trans-disciplinary approach that involves genetic epidemiology, translational medicine, and novel cardiovascular imaging approaches, Dr. Mehta and his team study how inflammation affects insulin resistance, the development of metabolic syndrome, and lipoprotein dysfunction, all of which are risk factors for atherosclerosis and subsequent cardiovascular disease (CVD).
Research Interest: Her
Clinical and Research Interest Focuses on Diabetes Management, Cardiovascular
Risk, Flow Cytometry-Based Study of Endothelial Dysfunction, Novel Therapy for
Type 2 Diabetes, Clinical Nutrition and Mediterranean Diet
Research Interest: A
Biomedical Researcher with a Focus on Neurobehavioral, Metabolic and Endocrine
Research Interest: Evaluation of biological activity of plant foods: anti-inflammatory, anti-glycation, anti-oxidant activities Influences of heat treatment on biological activity of foods.
List of Publications:
1. Ho, Su-Chen, Chang, Yi-Huang, “Comparison of inhibitory capacities of 6-, 8- and 10-gingerols/shogaols on the canonical NLRP3 inflammasome-mediated IL-1β secretion” Molecules, Vol. 23, 2018, 02, p. 466.
2. Ho, Su-Chen, Su, Min-Sheng, Lin, Chih- Cheng, Chiu, Chui-Feng, “Comparison of anti-glycation capacity of two new purple-colored-leaf tea cultivars with an ordinary green-colored-leaf tea cultivar in Taiwan,” Global Journal of Obesity, Diabetes and Metabolic Syndrome, Vol. 4, No. 1, 2017, 02, pp. 009-015.
3. Yang, Tzu-Ting, Ho, Su-Chen, Chuang, Lu-Te, Chuang, Hsiao-Chi, Li, Ya-Ting, Wu, Jyun-Jie, “Characterization of particulate-phase polycyclic aromatic hydrocarbons emitted from incense burning and their bioreactivity in RAW264.7 macrophage,” Environmental Pollution, Vol. 220, 2017, 01, pp. 1190-1198.
4. Ho, Su-Chen, Su, Min-Sheng, “Optimized heat treatment enhances the anti-inflammatory capacity of ginger “ International Journal of Food Properties, Vol. 19, 2016, pp. 1884-1898.
5. Ho, Su-Chen, Su, Min-Sheng, “Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds,” Molecules, Vol. 19, No. 11, 2014, pp. 17697-17714.
6. Ho, Su-Chen, Kuo, Chun-Ting, “Hesperidin, Nobiletin, and Tangeretin Are Collectively Responsible for the Anti-neuroinflammatory Capacity of Tangerine Peel (Citri reticulatae pericarpium)” Food and Chemical Toxicology, Vol. 71, 2014, pp. 176-182.
7. Ho, Su-Chen, Chang, Pei-Wen, Tong, Hui-Ting, Yu, Pin-Yuan, “Inhibition of Fluorescent Advanced Glycation End-products and N-carboxymethyllysine Formation by Several Floral Herbal Infusions,” International Journal of Food Properties, Vol. 17, 2014, pp. 617-628.
8. Ho, Su-Chen, Su, Min-Sheng, Lin, Chih-Cheng, “Comparison of Peroxynitrite-Scavenging Capacities of Several Citrus Fruit Peels,” International Journal of Food Properties, Vol. 17, 2014, pp. 111-124.
9. Ho, Su-Chen, Chang, Ku-Shang, Lin, Chih-Cheng, “Anti-neuroinflammatory Capacity of Fresh Ginger Is Attributed Mainly to 10-Gingerol,” Food Chemistry, Vol. 141, No. 3, 2013, 12, pp. 3183-3191.
10. Ho, Su-Chen, Chang, Ku-Shang, Chang, Pei-Wen, “Inhibition of Neuroinflammation by Cinnamon and its Main Components,” Food Chemistry, Vol. 138, No. 4, 2013, pp. 2275-2282.
11. Ho, Su-Chen, Chang, Pei-Wen, “Inhibitory Effects of Several Spices on Inflammation Caused by Advanced Glycation Endproducts,” American Journal of Plant Sciences, Vol. 3, No. 7, 2012, pp. 995-1002.
12. Ho, Su-Chen, Wu, Szu-Pei, Lin, Shyh-Mirn, Tang, Ya-Li, “Comparison of Anti-glycation Capacities of Several Herbal Infusions with that of Green Tea,” Food Chemistry, Vol. 122, 2010, pp. 768-744.
13. Lin, Shih-Min, Wang, Shih-Wei, Ho, Su-Chen, Tang, Ya-Li, “Protective Effect of Green Tea (-)-Epigallocatechin-3-gallate (EGCG) Against the Monoamine Oxidase B Enzyme Activity Increase in Adult Rat Brains,” Nutrition, Vol. 26, 2010, pp. 1195-1200.
14. Huang, Yung-Sheng, Ho, Su-Chen, “Polymethoxy Flavones Are Responsible for the Anti-inflammatory Activity of Citrus Fruit Peel,”Food Chemistry, Vol. 119, 2010, pp. 868-873.
15. Ho, Su-Chen, Tang, Ya-Li, Lin, Shih-Min, Liew, Yih-Fong, “Evaluation of Peroxynitrite-Scavenging Capacities of Several Commonly Used Fresh Spices,” Food Chemistry, Vol. 119, 2010, pp. 1102-1107.
16. Ho, Su-Chen, Lin, Chih-Cheng, “Investigation of Heat Treating Conditions for Enhancing the Anti-inflammatory Activity of Citrus Fruit (Citrus reticulata) Peels,”Journal of Agricultural and Food Chemistry, Vol. 56, 2008, pp. 7976-7982.
17. Lin, Chih-Cheng, Hung, Pi-Fong, Ho, Su-Chen, “Heat Treatment Enhances the NO-suppressing and Peroxynitrite-intercepting Activities of Kumquat’s (Fortunella margarita Swingle) Peel,”Food Chemistry, Vol. 109, 2008, pp. 95-103.
18. Ho, Su-Chen, Tsai, Tzung-Hsun, Tsai, Po-Jung, Lin, Chih-Cheng, “Protective Capacities of Certain Spices Against Peroxynitrite-mediated Biomolecular Damage,”Food and Chemical Toxicology, Vol. 46, 2008, pp. 920-928.
19. Ho, Su-Chen, Hwang, Lucy Sun, Shen, Yi-Jane, Lin, Chih-Cheng, “Suppressive Effect of a Proanthocyanidin-rich Extract from Longan (Dimocarpus longan Lour.) Flowers on Nitric Oxide Production in LPS-Stimulated Macrophage Cells,”Journal of Agricultural and Food Chemistry, Vol. 55, No. 26, 2007, pp. 10664-10670.
20. Tsai, Po-Jung, Tsai, Tzung-Hsun, Ho, Su-Chen, “In vitro Inhibitory Effects of Rosemary Extracts on Growth and Glucosyltransferase Activity of Streptococcus sobrinus,” Food Chemistry, Vol. 105, 2007, pp. 311-316.
21. Tsai, Po-Jung, Tsai, Tzung-Hsun, Yu, Chun-Hsien, Ho, Su-Chen, “Evaluation of NO-suppressing Activity of Several Mediterranean Culinary Spices,” Food and Chemical Toxicology, Vol. 45, 2007, pp. 440-447.
22. Tsai, Po-Jung, Tsai, Tzung-Hsun, Yu, Chun-Hsien, Ho, Su-Chen, “Comparison of NO-scavenging and NO-suppressing Activities of Different Herbal Teas with those of Green Tea,” Food Chemistry, Vol. 103, 2007, pp. 181-187.
23. Lin, Chih-Cheng, Lu, Min-Jer, Chen, Shen-Jen, Ho, Su-Chen, “Heavy Fermentation Impacts NO-Suppressing Activity of Tea in LPS-activated RAW 264.7 Macrophages,” Food Chemistry, Vol. 98, 2006, pp. 483-489.
24. Tsai, Tzung-Hsun, Tsai, Po-Jung, Ho, Su-Chen, “Antioxidant and Antiinflammatory Activities of Several Commonly Used Spices,” Journal of Food Science, Vol. 70, No. 1, 2005, pp. pp. C93-C97.
25. Tsai, Po-Jung, Yu, Chun-Hsien, Hsu SP, Lee YH, Huang IT, Ho, Su-Chen, Chu CH “Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: Negative association with gestational diabetes mellitus” Nutrition, Vol. 21, No. 11-12, 2005, pp.1095-9 •
26. Tsai, Po-Jung, Ho, Su-Chen, Tsai LP, Lee YH, Hsu SP, Yang SP, Chu CH, Yu, Chun-Hsien, “Lack of relationship between beta3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese population” Metabolism, Vol. 53, No. 9, 2004, pp.1136-9.
27. Tsai, Po-Jung, Yu, Chun-Hsien, Hsu SP, Lee YH, Chiou CH, Hsu YW, Ho, Su-Chen, Chu CH. “Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity” Clin. Endocrinol. Vol. 61, 2004, pp. 88-93.
28. Ho, Su-Chen, Tsai, Po-Jung, ”Comparison of the effects of "hot" and "cold" Chinese medicinal plants on the production of inflammatory mediators by RAW 264.7 cells” Journal of Food and Drug Analysis, Vol. 12, No. 2, 2004, pp. 120-127.
Research Interest: Own
Publications in Different Areas of Health, among them Obesity and Metabolic
Syndrome which is a Major Focus of Interest, Pricipalmente when Combined with
Dr. Gorelik has nearly 35 years of experience in clinical medicine and research. He has published more than 60 scientific publications. Currently, Dr. Gorelik serves as the Head of the Department of Internal Medicine "F" in the Assaf Harofeh Medical Center, Zerifin, Israel. He is also a Clinical Senior Lecturer in the Sackler Faculty of Medicine of the Tel Aviv University.
Research Interest: Diabetes,
Orthostatic Hypotension, Magnesium Metabolism, Heart Failure and Hospital
Number of Publications: 57
Published On: November 13, 2018 | Pages: 022 - 025Abstract View Full Article View Get Citation
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Published On: September 12, 2017 | Pages: 072 - 076Abstract View Full Article View Get Citation
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Published On: August 24, 2017 | Pages: 062 - 062Abstract View Full Article View Get Citation
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University of Siena, Italy
Archives of Renal Diseases and Management
Nikolaos A Chrysanthakopoulos
National and Kapodistrian University of Athens , Greece
Journal of Dental Problems and Solutions
Dr. Rath Research Institute
1260 Memorex Drive, Santa Clara, USA
Global Journal of Cancer Therapy
Saint Joseph Hospital , Germany
Journal of Neurology, Neurological Science and Disorders
Journal of Addiction Medicine and Therapeutic Science
Kyushu University, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Global Journal of Cancer Therapy
Southeastern University, China
Trends in Computer Science and Information Technology
Peter Lloyd Nara
Private Compnay- Biological Mimetics, Inc., USA
Annals of Antivirals and Antiretrovirals
University of Parma, Italy
International Journal of Dermatology and Clinical Research
Hon. Pierre Guertin
Laval University, Canada
Global Journal of Obesity, Diabetes and Metabolic Syndrome