Introduction

    • Volume/IssueClick here
    • Review ProcessDouble Blind
      • Publication lead time3 - 4 weeks
      • Indexing statusYes; Purview
      • Manuscript Processing ChargesClick here
      • Submission ChargesNo
      • Waiver policy for APCYes
      • Language of Full TextEnglish
      • Full-text formats availablePDF, HTML
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    • Permanent article identifierDOI (Digital Object Identifier) We provide DOI to all published papers to facilitate higher citation and classification of articles.
      Peertechz Publisher ID: 10.17352
    • Type of LicenseCreative Commons
      • Open AccessYes; Policy
      • Does the author retain unrestricted copyright?Yes
      • Does the author retain publishing rights?Yes
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    Editor-in-Chief

    Samy I. McFarlane

    Samy I. McFarlane
    State University of New York, Downstate Medical Centre, Brooklyn, New York, USA
    Email: Samy.McFarlane@downstate.edu
    Tel: 718-270-3711
    Fax: 718-270-1324

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    Malgorzata Gabriela WASNIEWSKA

    Malgorzata Gabriela WASNIEWSKA
    University of Messina, Italy
    Email: wasniewska@yahoo.it
    Tel: +393286522425
    Fax: +390902212134

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    Executive Editors

    Sze May Ng
    Consultant Paaediatric Endocrinologist , Honorary Senior Lecturer
    Southport and Ormskirk Hospitals NHS Trust
    University of Liverpool
    United Kingdom
    may.ng@nhs.net
    IJCEM

    Dr May Ng MBBS (Hons) FHEA FRCPCH MSc LLM PhD

    Dr May Ng holds a dual accreditation specialist qualification in General Paediatrics and Paediatric Endocrinology & Diabetes. She is based in Southport and Ormskirk NHS Trust and is the Associate Medical Director. She was previously Clinical Director for Paediatrics from 2012-2016.  She has an Honorary Senior Lecturer position at the Institute of Translational Medicine, University of Liverpool. She completed her undergraduate degree under full scholarship in Sydney, Australia and undertook her paediatric training in Australia and in the United Kingdom (UK). She was the recipient of the UK Medical Research Council Fellowship in 2006 and completed further training to obtain a Masters and PhD degree in paediatric endocrinology and diabetes. Dr Ng also holds a Master of Laws degree and is active in medicolegal work.

    Dr Ng has held over £300,000 in research grants and is an active researcher in paediatric endocrinology and diabetes. She has produced a book chapter and over 100+ publications (50 peer reviewed research papers, 45 as first/senior author) including three Cochrane reviews and has presented at more than 100+ scientific meetings.

    Research Interest: puberty, thyroid, diabetes , adrenal

    URL: www.paedsdoc.co.uk

    PROFESSIONAL MEMBERSHIPS AND ROLES:

    Fellow of the Royal College of Paediatrics and Child Health (FRCPCH)

    Fellow of the Higher Education Academy (FHEA)

    Member of the European Society of Paediatric Endocrinology (ESPE)

    Committee member of European Society of Paediatric Endocrinology Online Learning

    Member of the National Institute of Clinical Excellence (NICE) Adoption and Impact Programme Reference Panel

    Member of the National Steering Group for Children and Young People’s Diabetes Peer Review

    Diabetes Officer of the British Society of Paediatric Endocrinology and Diabetes (BSPED)

    Assessor for the Royal College of Paediatrics and Child Health ST7/START

    Committee Member of the RCPCH Paediatricians in Medical Management

    RCPCH CSAC Training Advisor for Endocrinology and Diabetes


    PROFESSIONAL QUALIFICATIONS:

    CCST, Certificate of Completion of Specialist Training: (1) General Paediatrics and (2) Paediatric Endocrinology and Diabetes, General Medical Council UK

    FRCPCH, Royal College of Paediatrics and Child Health, UK

    DCH, Royal College of Paediatrics and Child Health, UK

    FHEA, Fellow of the Higher Education Academy, UK

    MBBS (Honours) University of Sydney, Australia

    Master of Medical Science (Child Health, Diabetes and Endocrinology) University of Liverpool

    PhD (Child Health) University of Liverpool

    Master in Laws , University of Liverpool</xml> <

    Grant details:

    Winner of 2015 Diabetes Quality in Care (QiC) award
    Finalist Commended 2017 Diabetes Team of the year Diabetes Quality in Care (QiC) award
    Pride Awards 2015 Team of the Year Southport & Ormskirk NHS Trust
    Highly Commended Diabetes Team of the Year 2015 BMJ awards
    Finalist HSJ Clinical Leader of the year 2015
    Finalist in the UK Asian Woman of Achievement Award
    Newborn Appeal Grant 2011
    Best Research Abstract Award 2010 BSPED UK
    Newborn Appeal Grant 2007
    MRC Fellowship 2006 Medical Research Council, UK
    University Prize for Paediatrics,    University of Sydney, Australia

    Number of Publications: 50

    1.    Ng SM, Turner MA, Avula S. Ultrasound measurements of thyroid gland volume at 36 weeks corrected gestational age in extreme preterm infants born before 28 weeks gestation. European Thyroid Journal 2017.

    2.    Apperley L, Ng SM. Socioeconomic Deprivation, Household Education and Employment are Associated With Increased Hospital Admissions and Poor Glycemic Control in Children With Type 1 Diabetes Mellitus. Review of Diabetic Studies 2017

    3.    Ng SM. Digital Footprints: Steps towards transformation in paediatric diabetes. Journal of MHealth 2017, March ow.ly/g6Um30aYCZU

    4.    Ng SM, Stepien K. Glucocorticoid replacement regimens in the treatment of 21-hydroxylase deficiency congenital adrenal hyperplasia (Protocol) published Cochrane Database of Systematic Reviews 2017, Issue 1. Art. No CD012517. DOI: 10.1002/14651858.CD012517

    5.    Ng SM, Edge J. Hyperglycaemic Hyperosmolar State (HHS) in children: A practical guide to management. Paediatrics and Child Health Journal 2017 http://dx.doi.org/10.1016/j.paed.2017.01.002

    6.    Ng SM, Soni A, Didi M. Neonatal Pituitary-Thyroid Axis Dysregulation with Combined Thyroid Hormone and Thyrotropin Resistance in Infant with Trisomy 21 and Maternal Subclinical Hypothyroidism. J Neonatal Biol 2016 5:4 DOI: 10.4172/2167-0897.1000243

    7.     Ng SM, Agwu JC, Dwan K. A systematic review and meta-analysis of Synacthen tests for assessing hypothalamic-pituitary-adrenal insufficiency in children. Arch Dis Child 2016 :1–7. doi:10.1136/archdischild-2015-308925

    8.    Ng SM, Turner M. The Importance of Risk Stratification and Management of Newborn Babies of Women with a History of Graves’ disease. Int J Clin Endocrinol Metab 2016, 2(1): 001-004
    9.    Soni A, Agwu JC, Kershaw M, Edge J, Wright N, Ng SM. Management of children with type 1 diabetes during illness: a national survey. Postgrad Med J 2015 doi:10.1136/postgradmedj-2015-133786

    10.    Ng SM, Vizard M. The great enabler: how technology is helping to improve patient outcomes in paediatric diabetes. British Journal of Diabetes and Vascular Disease 2015;15:86-88

    11.    Soni A, Ng SM. Type 1 and Type 2 diabetes in children and young people: updated NICE guidance. Practical Diabetes 2015;32:281-282

    12.    Ng SM. Improving patient outcomes with technology and social media in paediatric diabetes. BMJ Quality Improvement Reports 2015; 4(1) DOI:10.1136/bmjquality.u209396.w3846 (1)

    13.    Ng SM, Watson G, Turner MA, Newland P and Weindling AM. Do maternal factors influence neonatal thyroid status in the extreme premature infant? The Journal of Maternal-Fetal & Neonatal Medicine 2014:26:1-11.

    14.    Agwu C, Ng SM, Edge DA, Wright. Care of children and young people with diabetes who require surgery. Diabetes Care for Children and Young People 2014:3:106-110

    15.    Ng SM, Soni A. Intensive diabetes management and goal setting are key aspects of improving metabolic control in children and young people with Type 1 diabetes mellitus. World Journal of Diabetes 2014: 5(6): 877-881 DOI: http://dx.doi. org/10.4239/wjd.v5.i6.877

    16.    Ng SM, Finnigan L, Connellan L, Caitriona Kerinan, Coward S. Improving paediatric diabetes care with the use of an integrated paediatric electronic diabetes information management system and routine uploading of blood glucose meters and insulin pumps in outpatient clinics. Archive of Disease in Childhood 2014; 99:1059 doi:10.1136/archdischild-2014-307021

    17.    Ng SM, Mariguddi S, Coward S, Middleton H. Successful implementation of a paediatric community home nursing service as a model of service delivery in acute paediatric care. British Journal of Nursing 2014: 23 (4):209-212.

    18.    Ng SM, Turner MA, Watson G, Victor S, Isherwood DM, Newland P, Didi M and Weindling AM. Is dopamine an iatrogenic disruptor of thyroid and cortisol function in the extremely premature infant? Advances in Endocrinology 2014; DOI:http://dx.doi.org/10.1155/2014/973184

    19.    Soni A, Shaw EJ, Natarajan A, Ng SM. Children with Type 1 Diabetes mellitus developing concurrent autoimmune disease are not at risk of worsening metabolic control or growth impairment. Practical Diabetes 2014: 31(6):243-246

    20.    Ng SM, Turner MA, Didi M, Parkes L, Tietze A, Atkinson J, Sluming V and Weindling AM. Effect of thyroxine on brain microstructure in extremely premature babies: magnetic resonance imaging findings from the TIPIT study. Pediatric Radiology 2014:44 (8):987-96

    21.    Ng SM, Balmuri S. Review of insulin treatment in stress related hyperglycaemia in children without pre-existing diabetes. Acta Paediatrica 2013 doi:10.1111/apa.12442
    22.    Ng SM, Turner MA, Victor S, M Didi, C Gamble, D Manning, R Gupta, P Settle. P Newland and Weindling AM. An explanatory randomised placebo-controlled trial of thyroxine supplementation in extreme preterm Infants < 28>
    23.    Murphy A, Martin P, Jukka C, Menon A, Ng SM. Recurrent primary paediatric herpetic whitlow of the big toe. BMJ Case Reports 2013 doi:10.1136/bcr-2013-008598

    24.    Murphy C and Ng SM. Institution of multiple daily insulin regimen compared with twice daily pre-mixed insulin regimen for children with Type 1 Diabetes Mellitus. American Journal of Clinical Medicine Research 2013  1 (1). doi: 10.12691/ajcmr-1-1-2

    25.    Ng SM, Drury JA, Turner MA, M Didi, Victor S, Paul Newland, Weindling AM. A Novel Method of Collection of Saliva for Estimation of Steroid Levels in Extremely Premature Infants. Acta Paediatrica 2013:102 (4): 356-9

    26.    Gangadharan A, Hanumanthaiah H, Ng SM.  The Use of Iodine as First Line Therapy in Graves' Disease Complicated with Neutropenia at First Presentation in a Paediatric Patient. British Journal of Medicine and Medical Research, 3(2): 324-328, 2013

    27.    Hanumanthaiah H, Gangadharan A, Ng SM. Continuous insulin infusion therapy for acute stress hyperglycemia secondary to asthma exacerbation in a paediatric patient. Journal of Diabetes Research and Clinical Metabolism 2012: http://dx.doi.org/10.7243/2050-0866-1-19

    28.    Ng SM, Wong SC, Chakkrapani E, Rahman F, Newland P, Isherwood DM, Didi M.  Multivariate analysis of factors that affect neonatal screening thyrdois stimulating hormone. Journal of Pediatric Endocrinology and Metabolism 2011, 24: 727-732

    29.    Hussain M, Cheri J, Khalid M, Matouk Z, Ng SM, Chanderasekaran S, Didi M, Blair J. Growth monitoring still has a place in selected populations of children. BMJ Case Reports 2011; doi:10.1136/bcr.01.2010.2640

    30.    Ng SM, Weindling MA. The impact of networks on clinical trials in the United Kingdom . Trials 2009, 10:100

    31.    Ng SM, Turner MA, Gamble C, M Didi, Victor S, Malamateniou C, Parkes L, Tietze A, Gregory L,Sluming V, Abernethy L and Weindling AM. TIPIT: A Randomised Controlled Trial of Thyroxine in Preterm Infants under 28 weeks Gestation: Magnetic Resonance Imaging and Magnetic Resonance Angiography Protocol. BMC Pediatrics 2008, 8:26

    32.    Ng SM. Hypothyroxinemia of prematurity: cause, diagnosis and management. Expert Review of Endocrinology & Metabolism 2008, 3: 453-462

    33.    Ng SM, Dhullipala A, Weindling AM. High versus low dose of initial thyroid hormone replacement for congenital hypothyroidism. Cochrane Database of Systemic Reviews 2008, Issue 1

    34.    Ng SM, Turner MA, Gamble, Didi M, Victor S, Weindling AM. TIPIT: A Randomised controlled trial of thyroxine in preterm infants born under 28 weeks gestation. Trials 2008, 9: 17

    35.    Ng SM, Wong SC, Isherwood DM, Didi M. Biochemical severity of thyroid ectopia in congenital hypothyroidism demonstrates sexual dimorphism. European Journal of Endocrinology 2007, 156: 49-53

    36.    Ng SM, Wong SC, Chakkrapani E, Rahman F, Newland P, Isherwood DM, Didi M.  There is a delay in screening premature infants for congenital hypoithyroidism. Archives of Disease in Childhood Fetal Neonatal Ed 2006, 91: F465-466

    37.    Ng SM, May JE, Emmerson AJB. Continuous insulin infusion in hyperglycemic ELBW infants: An evaluation of treatment response. Biology of the Neonate 2005, 4: 269-272

    38.    Ng SM, Kumar Y, Cody D, Didi M and Smith CS. The gonadotrophins response to GnRH test is not a predictor of neurological lesion in girls with central precocious puberty. Journal of Pediatric Endocrinology and Metabolism 2005, 18: 849-852

    39.    Ng SM, Wong SC, Isherwood DM, Smith CS, Didi M. Multivariate analysis on factors affecting suppression of thyroid stimulating hormone in treated congenital hypothyroidism. Hormone Research 2004, 20: 245-251

    40.    Wong SC, Ng SM, Didi M. Children with congenital hypothyroidism are at risk of adult obesity due to early adiposity rebound. Clinical Endocrinology 2004, 61: 441-6

    41.    Ng SM, Wong SC, Didi M. Head circumference and linear growth during the first 3 years in treated congenital hypothyroidism in relation to aetiology and initial biochemical severity. Clinical Endocrinology 2004, 61: 155-9

    42.    Chalameau M, Hadjiaathanasiou C, Ng SM, Cassio A, Mul D, Cisternino M, Partsch CJ, Theodoris C, Didi M, Cacciari E, Oostdijk W, Borghesi A, Sippell WG, Breart G, Brauner R. How to select girls with precocious puberty for brain imaging? An evidence based approach: EUROPUB study. A multicentre trial. Journal of Pediatrics 2003, 143: 445-450

    43.    Ng SM, Jones AP. Drug therapies for reducing gastric acidity in people with cystic fibrosis. Cochrane Collaboration, Cochrane Library 2003, Issue 2

    44.    Ng SM, Kumar Y, Cody D, Didi M and Smith CS. Cranial MRI scans are indicated in all girls with central precocious puberty. Archives of Disease in Childhood 2003, 88:  414-418

    45.    Cody D, Ng SM, Didi M and Smith CS. The differing outcomes of hyperthyrotropinemia. Journal of Paediatric Endocrinology and Metabolism 2003, 16: 375-378

    46.    Ng SM, Khurana R, Hughes U, Manning D. Is prolonged use of computer games a risk factor for deep venous thrombosis in children? Clinical Medicine 2003, 6: 593-594

    47.    Ng SM, Toh EM and Sherrington CA. Clinical predictors of abnormal computed tomography scans in paediatric head injury. Journal of Paediatrics and Child Health 2002, 38: 388-392

    48.    Ng SM, Ariffin WA, Lin HP, Chan LL and Chin YM. Clinical features and treatment outcome of children with myeloid antigen coexpression in B-lineage acute lymphoblastic leukemia. Journal of Tropical Paediatrics 2000, 46: 73-78

    49.    Ng SM, Lin HP, Ariffin WA, Lam SK and Chan LL. Age, sex, hemoglobin and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treated with BFM-type protocol. Journal of Tropical Paediatrics 2000, 46:  338-343

    50.    Ng SM, Ariffin WA, Lin HP and Chan LL. Presenting features and treatment outcome of 78 Malaysian children with neuroblastoma. Southeast Asian Journal of Tropical Medicine and Public Health 1999, 30: 149-153



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    Editorial Board

    Paola Di Carlo
    Department of Infectious Disease
    University of Palermo Palermo
    Italy
    paola.dicarlo@unipa.it
    IJCEM

    Research Interest: Tuberculosis, hospital infections, HIV, pediatric infectious Disease

    More Info.
    Chandra Miryala
    Wayne State University
    USA
    csumamir@med.wayne.edu
    IJCEM

    Research Interest: Endocrinology, endocrine disorders, developmental endocrinology, endocrine pathophysiology/issues, endocrine disorders complications treatment/management.

    More Info.
    Mathias Z Strowski
    Professor
    Department of Internal Medicine
    Elbland Clinic
    Germany
    Mathias.Strowski@charite.de
    IJCEM

    Research Interest: Diabetes experimental and clinical and gastroenterology and neuroendocrine tumors

    More Info.
    Janos Szolcsanyi
    Department of Pharmacology
    University of Pecs
    Hungary
    janos.szolcsanyi@aok.pte.hu
    IJCEM

    Research Interest: Physiology and pharmacology of nociceptors by means of capsaicin to open new horizons for development nociceptor targeted analgesic/anti-inflammatory agents and to reveal sensory-efferent dual functions of capsaicin-sensitive nociceptors

    More Info.
    Arash Taheri
    Department of Internal Medicine
    Wake Forest Baptist Medical Center
    USA
    ataheri@wakehealth.edu
    IJCEM

    Research Interest: Diabetic foot, cutaneous complication of diabetes, lipodystrophy, cutaneous manifestation of thyroid diseases, Cushing disease, adrenal insufficiency, and adrenal hyperplasia.

    More Info.
    Theun de Groot
    Researcher
    The Jackson Laboratory
    USA
    theun.degroot@jax.org
    IJCEM

    Research Interest: Primary: Kidney (patho-)physiology Secondary: Diabetes mellitus, oxidative stress, ion transport

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    Beata Ewa Pyrzak
    Assistant Professor
    Department of Paediatric and Endocrinology
    Clinic of the Medical University
    Poland
    bpyrzak@wum.edu.pl
    IJCEM

    Research Interest: Endocrinology, diabetes, obesity, genetics, children

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    Iwona Ben-Skowronek
    Head of the Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin
    Department of Pediatric Endocrinology and Diabetology
    Medical University of Lublin
    Poland
    skowroneki@interia.pl
    IJCEM

    Health Sciences,Medicine,Immunology, Allergology and Rheumatology

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    Anthony C Hackney
    Professor
    Department of Exercise and Sport Science
    University of North Carolina
    USA
    thackney@med.unc.edu
    IJCEM

    Research Interest: His research has concentrated on how physical, environmental, and emotional stress affects the hormonal responses of the endocrine system; in particular, focusing on dysfunctions and dis-regulations that develop in the system from stress exposure, that ultimately can compromise physiological responses and adaptations

    More Info.
    Damian Romero
    Associate Professor
    Department of Biochemistry
    University of Mississippi Medical Center
    USA
    dromero@umc.edu
    IJCEM

    Research Interest: Aldosterone, mineralocorticoids, mineralocorticoid receptor, gene expression, miRNAs, animal models, microarrays, renin-angiotensin system, steroid hormones, nuclear receptors, hypertension, intracellular signaling.

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    Shu-Pin Huang
    Professor
    Department of Urology
    Kaohsiung Medical University and Hospital
    Taiwan
    shpihu@yahoo.com.tw
    IJCEM

    Research Interest: Prostate Cancer, Molecular Epidemiology, Pharmacogenomic studies, Metabolic syndrome, Endocrine-Related Cancer, Urolithiasis, Andrology, Male Erectile dysfunction

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    Nicolic Dragan M
    Department of NeurologyDiabetes and Metabolic Diseases
    University of Belgrade
    Serbia
    dragannikolic8@yahoo.com
    IJCEM

    Research Interest: Diabetes,  transplantation,  pancreatic islets culture, influence of microorganism on onset of the diabetes, human microbiom.

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    Sai Prasad Pydi
    Research Assistant
    Department of Bioorganic Chemistry
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
    USA
    saiprasadbt@gmail.com
    IJCEM
    Department of Bioorganic  Chemistry,
    Diabetes, Obesity,
    Receptor Pharmacology Gpcrs and Metabolism
    More Info.
    Angelos Kyriacou
    Department of Endocrinology and Diabetes
    Salford Royal Foundation Trust
    UK
    angelos5@doctors.org.uk
    IJCEM

    Research Interest: Thyroid disease and in particular thyroid nodules and thyroid cancer, as well as postgraduate medical education..

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    Dominik Rachon
    Head
    Department of Clinical and Experimental Endocrinology
    Medical University Of Gdansk
    Poland
    drachon@gumed.edu.pl
    IJCEM

    Research Interest: Menopause and oestrogen replacement therapy (ERT) Metabolic syndrome and metabolic effects of estrogens Phytoestrogens, SERM and Endocrine Disruptors Polycystic ovary syndrome (PCOS) Polymorphisms of the oestrogen receptor geneAnti-inflammatory and anti-atherogenic properties of estrogens

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    DOI Logo 10.17352/ijcem.000044

    Published On: February 24, 2020 | Pages: 008 - 010

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    DOI Logo 10.17352/ijcem.000043

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    DOI Logo 10.17352/ijcem.000042

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    DOI Logo 10.17352/ijcem.000041

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    DOI Logo 10.17352/ijcem.000040

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    Thyrotoxicosis leading to Renal Tubular Acidosis presenting as periodic paralysis – A case report

    DOI Logo 10.17352/ijcem.000039

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    DOI Logo 10.17352/ijcem.000038

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    DOI Logo 10.17352/ijcem.000037

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    A fatal case of myxedema coma

    DOI Logo 10.17352/ijcem.000036

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    DOI Logo 10.17352/ijcem.000035

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