Research Interest: Cognition, Dementia, Alzheimer's Disease,
Functional Anatomy, Transcranial Doppler
Research Interest: Neurosurgical Management of Different Lesions Around
the Foramen Magnum, Evaluation of Endovascular Intervention Versus Surgery in Management
of Subarachnoid Hemorrhage.
Research Interest: Neuropsychiatric Disorders, Oxidative, Stress,
Research Interest: Anterior and Posterior Spine
Surgery; Cranio-Cervical Junction Surgery, Pain Therapy; Minimally Invasive and
Endoscopic Spine Surgery; Spinal
Neurooncology, Application of Hemocomponents in Spine Surgery; Spine Trauma, Neurotraumatology, Biomolecular
Research for Bone Augmentation.
Research Interest: Neuroanesthesia, with a focus on
interventions that affect cerebral blood flow and cerebrovascular hemodynamics
Research Interest Acoustic Neuroma, Meningioma, Glomus Tumors, Temporal Bone Cancer, Parotid Tumors, & Facial Nerve Disorders
Dr. Zhi Dong Zhou is graduated as a medical doctor in 1991 and had 5 years of postgraduate clinical training in internal medicine in China. Subsequently he acquired my Ph.D from Chinese Academy of Science, Shanghai Branch and started me research career in Singapore on dopamine (DA) neuron degeneration in Parkinson's disease (PD). Later he joined the National Neuroscience Institute (NNI) as a member of the Singapore National PD Translational Bench to Bedside team and continue to work on DA neuron degeneration in PD. Currently, he is an Associate Clinician Scientist in charge of the Translational Therapeutics Laboratory of NNI and an Assistant Professor at Duke-NUS, NBD as well as a PI of NMRC and SHF grants.
Research Interest: Dr. Zhi Dong Zhou’s interests lie in identification and verification of novel key molecular targets, signaling pathways or neuro-protective agents relevant to pathogenesis and therapy of debilitating human neurodegenerative diseases, including PD, Alzheimer’s disease (AD) and multiple sclerosis.
1). Zhi Dong Zhou & Eng King Tan. Dopamine (DA) toxicity in pathogenesis and therapy of Parkinson’s disease (PD). J Clin Bioanal Chem 2017 Volume 1 Issue 1, in press.
2). Zhi Dong Zhou & Eng King Tan. Iron Regulatory Protein (IRP)-Iron Responsive Element (IRE) Signaling Pathway in Human Neurodegenerative Diseases. Molecular Neurodegeneration, in press
3). Zhong Can Zhen., ..Zhi Dong Zhou, et al. LRRK2 Interacts with ATM and Regulates Mdm2-p53 Cell Proliferation Axis in Response to Genotoxic Stress. Human Molecular Genetics. In press.
4). Bin Xiao, Xiao Deng, Grace Lim, Shaoping Xie, Zhi Dong Zhou, and et al. Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria. Cell death and Disease. 2017. in press
5). Zhong Can Chen,,, Zhi Dong Zhou, et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease. Science Signaling. 2017. in press
6). Lifeng Qiu, Mei-Chih Liao, Allen K Chen,, Zhi Dong Zhou, et al. Immature midbrain dopaminergic neurons derived from floor-plate method improve cell transplantation therapy efficacy for Parkinson’s disease. STEM CELLS Translational Medicine, in press.
7). Bin Xiao;, Zhi Dong Zhou; et al. p62-Mediated Mitochondrial Clustering Attenuates Apoptosis Induced by Mitochondrial Depolarization. BBA - Molecular Cell Research, 2017; 1864(7):1308-1317.
8). Murni T, Wen RJ, ,Zhi Dong Zhou, et al. Varied pathological and therapeutic response effects associated with CHCHD2 mutant and risk variants. Human mutation, 2017 Apr 21, doi: 10.1002/humu.23234.
9). Zhi Dong Zhou, Chao YX, Tan EK. Potential Implications of Mitochondrial Unfolded Protein Response in the Pathogenesis and Therapy of Dopaminergic Neuron Degeneration in Parkinson’s Disease. JSM Biotechnol Bioeng 2017; 4(1): 1075.
10), Zhi Dong Zhou* et al. Dopamine (DA) Dependent Toxicity Relevant to DA Neuron Degeneration in Parkinson’s Disease (PD). Austin Journal Of Drug Abuse And Addiction. 2016; 3(1): 1010. Corresponding author.....
Research Interest: His research interests include neuroscience,
brain science, molecular cell biology, physical therapist, and intellectual
property rights law
Research Interest: Cerebrovascular Diseases,
Vascular-Related Cognitive Disorders, Neuropsychiatric Diseases, Clinical
Neurophysiology, Transcranial Magnetic Stimulation (TMS) And, More Recently,
Sleep Disorders And Gluten-Related Neuropathology
Research Interest: Comprehension, at Molecular
and Functional Level, of
The Physiopathological Roles of
Cholesterol Metabolism In
Neurodegeneration, Behavior and
Research Interest: Brain MRI, Brain MR-perfusion Brain
CT, Brain 4D-CT, Brain CT-perfusion
PET, Head and neck PET, Spinal cord PET Brain SPECT Brain Tumour. Tumour of the
head and neck
Research Interest: Neuroimaging, fMRI, EEG, denial (
defense mechanism ), epilepsy, psychogenic seizures, neurodegeneration ,mirror
neurons, autism and autism spectrum,
psychosomatics, psychodermatology , neurosurgery, cultural psychiatry, social psychiatry,
different techniques of neuroimaging, nanotechnology and its relevance to
neuroimaging, Psychopharmacology, Anti-GAD syndrome and Stiff person syndrome ,
Schizophrenia, psychosis ,dissociative Identity disorder, Alzheimer’s Disease,
Parkinson’s Disease, Amyotrophic Lateral Sclerosis and Stroke.
Research Interest: On the Elucidating of Mechanisms of
Cell Death, Gliosis, Inflammation and Neurogenesis Via
Several Models of Brain Damage and
How Inflammatory Mediators Connect The Brain With The Periphery. To Date,
My Research Has Mainly Been Dedicated Towards
The Development of
Novel Therapeutics to Repair
The Brain After Damage.
Research Interest: Intervertebral Disc Arthroplasty
, Microneurosurgery , Neuro-Oncology , Brain Injury , Craniotomy, Traumatic Brain Injury , Traumatic Brain Hemorrhage , Astrocytoma ,
Medulloblastoma , Intracranial
Research Interest: Migraine, Headaches,
Cerebrovascular Disorders, Neuroinflammation, Neurocysticercosis.
Published On: December 13, 2017 | Pages: 053 - 055Abstract View Full Article View DOI: 10.17352/jnnsd.000022
Published On: September 15, 2017 | Pages: 051 - 052Abstract View Full Article View DOI: 10.17352/jnnsd.000021
Published On: August 30, 2017 | Pages: 043 - 050Abstract View Full Article View DOI: 10.17352/jnnsd.000020
Published On: August 07, 2017 | Pages: 038 - 042Abstract View Full Article View DOI: 10.17352/jnnsd.000019
Published On: July 17, 2017 | Pages: 033 - 037Abstract View Full Article View DOI: 10.17352/jnnsd.000018
Published On: July 03, 2017 | Pages: 028 - 032Abstract View Full Article View DOI: 10.17352/jnnsd.000017
Published On: June 24, 2017 | Pages: 025 - 027Abstract View Full Article View DOI: 10.17352/jnnsd.000017
Published On: June 01, 2017 | Pages: 023 - 024Abstract View Full Article View DOI: 10.17352/jnnsd.000015
Published On: May 05, 2017 | Pages: 016 - 022Abstract View Full Article View DOI: 10.17352/jnnsd.000014
Published On: March 23, 2017 | Pages: 012 - 015Abstract View Full Article View DOI: 10.17352/jnnsd.000013