Open Journal of Chemistry

Research Interest: Enzymology; Biocatalysis in Organic Solvent; Protein Biochemistry.

Research Interest: Nanotechnology, Photodynamic Therapy, Sonodynamic Therapy, Anti-Cancer and Anti-Infectious Medicines, Functional Food and Food Safety.

Research Interest: Drug Design, Phytochemistry, Medicinal chemistry and Analytical Chemistry.

Research Interest: Conventional solid dosage forms especially powders, granules, and tablets; Modified release solid dosage forms especially colonic delivery of tablets containing peptides and proteins; Physics of tablets, tabletting technology, coated dosage forms, andmicroparticulate delivery systems.

Research Interest: Ischemic Stroke, Diabetic Foot, Anderson-Fabry Disease, Congestive Heart Failure.

Research Interest: Isolation and structural elucidation of biologically active metabolites from natural sources (Plants and Fungi); Marine natural products chemistry and biology; Phytochemical characterization of plant extracts used in traditional medicine, their pharmacological evaluation, and the isolation and identification of their active constituents.

Research Interest: Military toxicology; Acetylcholinesterase reactivators as treatment of nerve agent and pesticide intoxications; Acetylcholinesterase inhibitors in Alzheimer´s disease and Myasthenia Gravis treatment; Synthesis of the detergents as disinfectants, decontamination means and environment for micellar catalysis; Drug design and Development; Chemical warfare agents; Biological warfare agents; Pharmaceutical Industry; Project Management; Scientific Management; Technology Transfer; Commercialization; Fund Raising; Cloud computing; Parallel computing; medical devices development; toxins.

Research Interest: Bioassay guided isolation of active constituents-Phytochemsitry and analytical pharmacognosy. Wound healing assessment of medicinal plants and their secondary metabolites. Analgesic and anti-inflammatory activities of medicinal plants. Isolation of natural compounds from the medicinal plants used against gynecological diseases.

My specific research interests are synthetic methodology development, total synthesis, medicinal chemistry, natural product isolation and derivatization, proteomics, drug discovery and development, translational oncology

Research Interest:     Organic chemistry, medicinal chemistry, natural products, translational oncology, proteomics

URL:     https://www.linkedin.com/in/hashim-motiwala-a278b699

List of Publications:
1.    Charaschanya, M.; Li, K.; Motiwala, H. F.; Aubé, J. An Interrupted Schmidt Reaction: C–C Bond Formation Arising from Nitrilium Ion Capture. Org. Lett. 2018, 20, 6354–6358. DOI: 10.1021/acs.orglett.8b02531.
2.    Roy, S.; Motiwala, H. F.; Koshlap, K. M.; Aubé, J. Hexafluoroisopropanol and Acetyl Chloride Promoted Catalytic Hydroarylation with Phenols. Eur. J. Org. Chem. 2018, 2018, 306–315. DOI: 10.1002/ejoc.201701256.
3.    Tom, C. T. M. B.; Crellin, J. E.; Motiwala, H. F.; Stone, M. B.; Davda, D.; Walker, W.; Kuo, Y-H.; Hernandez, J. L.; Labby, K. J.; Gomez-Rodriguez, L.; Jenkins, P. M.; Veatch, S. L.; Martin, B. R. Chemoselective Ratiometric Imaging of Protein S-Sulfenylation. Chem. Commun. 2017, 53, 7385–7388. DOI: 10.1039/C7CC02285A.
4.    Motiwala, H. F.; Martin, B. R. Trail-BlAIZin New Directions for Conditional Proteomics. Nature Methods 2016, 13, 917–918. DOI: 10.1038/nmeth.4043.
5.    White, P. T.; Subramanian, C.; Motiwala, H. F.; Cohen, M. S., Natural Withanolides in the Treatment of Chronic Diseases. In Anti-inflammatory Nutraceuticals and Chronic Diseases; Gupta, C. S.; Prasad, S.; Aggarwal, B. B., Eds.; Springer International Publishing: Cham, 2016; pp 329–373. DOI: 10.1007/978-3-319-41334-1_14.
6.    Byrd, K. M.; Subramanian, C.; Sanchez, J.; Motiwala, H. F.; Liu, W.; Cohen, M. S.; Holzbeierlein, J.; Blagg, B. S. J. Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors. Chem. Eur. J. 2016, 22, 6921–6931. DOI: 10.1002/chem.201504955.
7.    Motiwala, H. F.; Charaschanya, M.; Day, V. W.; Aubé, J. Remodeling and Enhancing Schmidt Reaction Pathways in Hexafluoroisopropanol. J. Org. Chem. 2016, 81, 1593–1609. DOI: 10.1021/acs.joc.5b02764.
8.    Motiwala, H. F.; Yin, Q.; Aubé, J. Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol. Molecules 2016, 21, 45. DOI: 10.3390/molecules21010045.
9.    Motiwala, H. F., Vekariya, R. H., Aubé, J. Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol. Org. Lett. 2015, 17, 5484–5487. DOI: 10.1021/acs.orglett.5b02851.
10.    Aubé, J.; Fehl, C.; Liu, R.; McLeod, M. C.; Motiwala, H. F. Hofmann, Curtius, Schmidt, Lossen, and Related Reactions. In Comprehensive Organic Synthesis II, Molander, G. A.; Knochel, P., Eds.; 2nd ed.; Vol 6, Elsevier: Amsterdam, 2014; pp 598–635. http://dx.doi.org/10.1016/B978-0-08-097742-3.00623-6.
11.    Motiwala, H. F.; Bazzill, J.; Samadi, A.; Zhang, H.; Timmermann, B. N.; Cohen, M. S.; Aubé, J. Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues. ACS Med. Chem. Lett. 2013, 4, 1069–1073. DOI: 10.1021/ml400267q.
12.    Jadhav, R. D.; Mistry, H. D.; Motiwala, H.; Kadam, K. S.; Kandre, S.; Gupte, A.; Gangopadhyay, A. K.; Sharma, R. A Facile One-Pot Synthesis of 3,5-Disubstituted Isoxazole Derivatives Using Hydroxy (Tosyloxy) Iodobenzene. J. Heterocycl. Chem. 2013, 50, 774–780. DOI: 10.1002/jhet.1556.
13.    Motiwala, H. F.; Fehl, C.; Li, S.-W.; Hirt, E.; Porubsky, P.; Aubé, J. Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction. J. Am. Chem. Soc. 2013, 135, 9000–9009. DOI: 10.1021/ja402848c.
14.    Zhang, H.; Motiwala, H.; Samadi, A.; Day, V.; Aubé, J.; Cohen, M.; Kindscher, K.; Gollapudi, R.; Timmermann, B. Minor Withanolides of Physalis longifolia: Structure and Cytotoxicity. Chem. Pharm. Bull. 2012, 60, 1234–1239. DOI: 10.1248/cpb.c12-00305.
15.    Timmermann, B. N.; Aubé, J.; Zhang, H.; Gollapudi, R.; Cohen, M. S.; Samadi, A.; Fakhruddin–Motiwala, H. Withanolides Isolated From Physalis longifolia and Analogs and Methods of Use Thereof. US20120196815A1, 2012.
16.    Motiwala, H. F.; Gülgeze, B.; Aubé, J. Copper-Catalyzed Oxaziridine-Mediated Oxidation of C–H Bonds. J. Org. Chem. 2012, 77, 7005–7022. DOI: 10.1021/jo3012336.
17.    Motiwala, H.; Kandre, S.; Birar, V.; Kadam, K. S.; Rodge, A.; Jadhav, R. D.; Mahesh, K. R. M.; Brahma, M. K.; Deshmukh, N. J.; Dixit, A.; Doshi, L.; Gupte, A.; Gangopadhyay, A. K.; Vishwakarma, R. A.; Srinivasan, S.; Sharma, M.; Nemmani, K. V. S.; Sharma, R. Exploration of Pyridine Containing Heteroaryl Analogs of Biaryl Ureas as DGAT1 Inhibitors. Bioorg. Med. Chem. Lett. 2011, 21, 5812–5817. DOI: 10.1016/j.bmcl.2011.07.109.
18.    Chakraborti, A. K.; Garg, S. K.; Kumar, R.; Motiwala, H. F.; Jadhavar, P. S. Progress in COX-2 Inhibitors: A Journey So Far. Curr. Med. Chem. 2010, 17, 1563–1593. DOI: 10.2174/092986710790979980.
19.    Doshi, L. S.; Brahma, M. K.; Sayyed, S. G.; Dixit, A. V.; Chandak, P. G.; Pamidiboina, V.; Motiwala, H. F.; Sharma, S. D.; Nemmani, K. V. S. Acute Administration of GPR40 Receptor Agonist Potentiates Glucose-Stimulated Insulin Secretion In Vivo in the Rat. Metabolism 2009, 58, 333–343. DOI: 10.1016/j.metabol.2008.10.005.
20.    Motiwala, H. F.; Kumar, R.; Chakraborti, A. K. Microwave-Accelerated Solvent- and Catalyst-Free Synthesis of 4-Aminoaryl/alkyl-7-chloroquinolines and 2-Aminoaryl/alkylbenzothiazoles. Aust. J. Chem. 2007, 60, 369–374. DOI: 10.1071/ch06391.

Research Interest: Natural Product Chemistry, Medicinal Chemistry, Chemical Biolgoy

Research Interest: "Organometallic: Transition Metal-catalyzed Nitrogenation of Hydrocarbons; edicinal Inorganic Chemistry: Ruthenium-based Metallopharmaceuticals; Renewable Biomass Energy: Metal-catalyzed Conversion of Cellulosic Biomass for fuels and value-added chemicals"