Open Journal of Parkinson's Disease and Treatment

    Introduction

    • Volume/IssueClick here
    • Review ProcessDouble Blind
      • Publication lead time3 - 4 weeks
      • Indexing statusYes; Purview
      • Manuscript Processing ChargesClick here
      • Submission ChargesNo
      • Waiver policy for APCYes
      • Language of Full TextEnglish
      • Full-text formats availablePDF, HTML
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    • Permanent article identifierDOI (Digital Object Identifier) We provide DOI to all published papers to facilitate higher citation and classification of articles.
      Peertechz Publisher ID: 10.17352
    • Type of LicenseCreative Commons
      • Open AccessYes; Policy
      • Does the author retain unrestricted copyright?Yes
      • Does the author retain publishing rights?Yes
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    Editorial Board

    Chin-Hsien
    Department of Neurology
    National Taiwan University Hospital
    Taiwan
    chlin@ntu.edu.tw
    OJPDT

    Research Interest: Parkinson's disease; Movement Disorders; Genetic study; Animal model; Drosophila.

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    Kamil Kuca
    Research
    International Relations University of Hradec Kralove
    Czech Republic
    kamil.kuca@fnhk.cz
    OJPDT

    Research Interest: Dementia, Drug Development, Nerve Agents, Treatment, Drug Design, Biomedicine.  


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    Filiiz Altug
    Pamukkale University
    Turkey
    fkural@pau.edu.tr
    OJPDT

    Research Interest: NEUROLOGİC REHABİLİTASYON, Stroke Rehabilitasyon, Parkinson’s Disease and Rehabilitation, Post Operatif Neck and Back Pain and Rehabilitation, Choronic Musculo Skeletal Pain and Rehabilitation.

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    Sandip K Dash
    Neurology Apollo Hospital
    Bangladesh
    drskdash@yahoo.co.in
    OJPDT

    Research Interest: Alzheimer’s Disease, Lipo Protein A (Lpa) In Stroke Patients Among Local Population.

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    Jifeng Guo
    Department of Neurology
    Central South University
    China
    guojifeng2003@163.com
    OJPDT

    Research Interest: Parkinson's Disease; Neurodegenerative Disease; Clinical Phenotype; Genetics; Epigenetics; Pathogenesis.

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    XAVIER MORATO ARUS
    Neuropharmacology and Pain Research group
    University of Barcelona
    Spain
    xavmoratoar@gmail.com
    OJPDT

    After some years of academic formation (I studied Pharmacy and a Master degree on Neuroscience from the University of Barcelona obtained in 2012) I was lucky to join the Neuropharmacology and Pain research lab in September 2012, where I started the Ph.D. training with a FPI Grant (Formación de Personal Investigador) from the Ministry of Economy and Competitiveness, under the supervision of Dr. Francisco Ciruela and Dr. Víctor Fernández-Dueñas.

    During this period my work was focused on deciphering the role of the Parkinson related GPR37, also known as PAEL receptor in the Central Nervous System, and looking for specific ligands for this orphan receptor. As GPR37 was an orphan receptor (which means that does not exist any ligand described that binds specifically to this receptor) we had to start building the house from the base. We produced recombinant proteins, specific antibodies and all the tools required to study this interesting and mysterious receptor implicated in the Parkinson’s neuropathological hallmarks. We also studied the interaction of this receptor with adenosine, dopamine and glutamate in different brain regions of interest such as striatum to find new potential treatments for Parkinson’s disease, and finally we focused on studying the potential use of the GPR37 as a biomarker in Parkinson’s disease (using both CSF and serum). We generated a homemade ELISA assay to detect GPR37 peptides in body fluids.

    As a result from all this work, I have participated in very different research projects, published more than 18 papers in peer-reviewed international journals and defend my work on international congress. Since 2018, I’ve been also collaborating with Laboratorios Dr. Esteve designing a new biosensor to facilitate Sigma1 receptor ligands screenings, a receptor implicated in different diseases, such as cocaine addiction, amnesia, pain, depression or Alzheimer’s disease.

    Research Interest: At this moment my research is focused in desciphering the role of different GPCRs in neurodegenerative diseases such as Parkinson’s disease, Alzheimer disease and Amyotrophic Lateral Sclerosis and Multiple Sclerosis.

    Grants: FPI grant, Eurolife Postdoctoral Mobility and Knowledge exchange

    URL: https://www.linkedin.com/in/xaviermoratoarus/

    List of Publications:

    1. Morató X; Rodrigo Antunes Cunha; Francisco Ciruela. GPR37 emerges as an important modulator of adenosinergic transmission in the striatum. Neural Regeneration Research. 2019.

    2. Morató X; Francisco Q Gonçalves; Joao Pedro Lopes; Olga Jauregui; Concepció Soler; Victor Fernández-Dueñas; Rodrigo Antunes Cunha; Francisco Ciruela. Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD in GPR37 deficient mice. J Neurochem. 2019 Mar;148(6):796-809. doi: 10.1111/jnc.14653. Epub 2019 Jan 28.

    3. Luján R, Aguado C, Ciruela F, Arus XM, Martín-Belmonte A, Alfaro-Ruiz R, Martínez-Gómez J, de la Ossa L, Watanabe M, Adelman JP, Shigemoto R, Fukazawa Y. SK2 Channels Associate With mGlu1α Receptors and CaV2.1 Channels in Purkinje Cells. Front Cell Neurosci. 2018 Sep 19;12:311. doi: 10.3389/fncel.2018.00311. eCollection 2018.

    4. Gómez-Soler M, Cordobilla B, Morató X, Fernández-Dueñas V, Domingo JC, Ciruela F. Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism. Front Neurosci. 2018 Aug 28;12:604. doi: 10.3389/fnins.2018.00604. eCollection 2018.

    5. Morató X, Luján R, Gonçalves N, Watanabe M, Altafaj X, Carvalho AL, Fernández-Dueñas V, Cunha RA, Ciruela F. Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation. Hum Mol Genet. 2018 Oct 15;27(20):3528-3541. doi: 10.1093/hmg/ddy264.

    6. Eduard Tolosa; Teresa Botta-Orfila; Morató X; Calatayud C; Ferrer-Lorente R; Martí MJ; Fernández M; Gaig C; Raya Á; Consiglio A; Mario Ezquerra; Rubén Fernández Santiago. MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients. Neurobiology of Aging. 5 - 32, pp. 283 - 291. Peter R. Rapp, 20/09/2018. ISSN 0197-4580.

    7. Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F. The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo. Sci Rep. 2017 Aug 25; 7(1):9452.

    8. Kate Sokolina1#, Saranya Kittanakom1#, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi-Chaachoua, Kenjiro Tadagak, Victoria Wong, Ramy H. Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Laura Riley, Zhong Yao, Morató X, Sara Rahmati, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, and Igor Stagljar. Systematic protein-protein interaction mapping for clinically-relevant human GPCRs. Molecular Systems Biology. 2017 Mar 15;13(3):918.

    9. Morató X, Marc López, P. M. Canas, R. A. Cunha, Francisco Ciruela. Brain membrane fractionation: An ex vivo approach to assess sub-synaptic protein localization. Journal of Visualized Experiments. J Vis Exp, May 2017, 12 (123).

    10. Paulo A. de Oliveira, James A.R. Dalton, Marc López-Cano, Adrià Ricarte, Morató X., Filipe C. Matheus, Andréia S. Cunha, Christa E. Müller, Reinaldo N. Takahashi, Víctor Fernández-Dueñas, Jesús Giraldo, Rui D. Prediger, Francisco Ciruela. Angiotensin II type 1/Adenosine A2A receptor oligomers: a novel target for tardive dyskinesia. Scientific reports. Sci Rep. 2017 May 12;7(1):1857.

    11. Víctor Fernández-Dueñas, Jhonny Azuaje, Morató X., Begoña Cordobilla, Joan Carles Domingo, Eddy Sotelo, Francisco Ciruela. Synthesis and characterization of a new bivalent ligand based on the combination of caffeine and docosahexaenoic acid. Molecules. Feb 2017. 27;22(3).

    12. Rial D, Morató X, Real JI, Gonçalves FQ, Stagljar I, Pereira FC, Fernández-Dueñas V, Cunha RA, Ciruela F. Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses. Neurosci Lett. Jan 2017. 18;638:162-166. Page 6 of 7

    13. Lopes JP1, Morató X1, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F. The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. J Neurochem. 2015 Jul; 134(1):135-46.

    14. Gandía J, Morató X, Stagljar I, Fernández-Dueñas V, Ciruela F. Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent. Behav Brain Res. 2015 Jul 15; 288:103-6.

    15. García-Negredo G, Soto D, Llorente J, Morató X, Galenkamp KM, Gómez-Soler M, Fernández-Dueñas V, Watanabe M, Adelman JP, Shigemoto R, Fukazawa Y, Luján R, Ciruela F. Coassembly and coupling of SK2 channels and mGlu5 receptors. J Neurosci. 2014 Oct 29;34(44):14793-802.

    16. Botta-Orfila T, Morató X, Compta Y, Lozano JJ, Falgàs N, Valldeoriola F, Pont-Sunyer C, Vilas D, Mengual L, Fernández M, Molinuevo JL, Antonell A, Martí MJ, Fernández-Santiago R, Ezquerra M. Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease. J Neurosci Res. 2014 Aug;92(8):1071-7. doi: 10.1002/jnr.23377. Epub 2014 Mar 20.

    17. Fernández-Dueñas V, Gómez-Soler M, Morató X, Núñez F, Das A, Kumar TS, Jaumà S, Jacobson KA, Ciruela F. Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. Neurochem Int. 2013 Jul;63(1):42-6.

    18. Gandía J, Fernández-Dueñas V, Morató X, Caltabiano G, González-Muñiz R, Pardo L, Stagljar I, Ciruela F. The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain. J Neurochem. 2013.

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    Minho Moon
    Assistant Professor
    Department of Biochemistry
    Konyang University
    Korea
    hominmoon@daum.net
    OJPDT

    Research Interest: Alzheimer ’S Disease, Parkinson’s Disease, Ghrelin, Nurr1, Adult Neurogenesis, Cognitive Behavior, Connectome, Natural Compounds.

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    AQ Rana
    Director
    Movement Disorders Centre
    Canada
    ranaaq@yahoo.com
    OJPDT

    Research Interest: Call Neurology Section, Parkinson’s Disease, Non-Motor Symptoms Of Parkinson's Disease.  


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    Diego Iacono
    Director
    Neuropathology Research Biomedical Research Institute of NJ Brinj
    USA
    diego.iacono@atlantichealth.org
    OJPDT

    Reseach Interest: Clinical and Experimental Neuropathology, Normal And Pathologic, Brain Aging, Bio-Brain Banking, Clinico-Pathologic Correlations, Animal And Cellular Models, Neuroproteomics, Neurogenomics, Quantitative Neuropathology, Neurostereology, Drug Discovery.  


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    Oxana V Galzitskaya
    Head
    Bioinformatics Group Institute of Protein Research
    Russia
    ogalzit@vega.protres.ru
    OJPDT

    Research Interest: Intrinsically Disordered Proteins, Protein Folding, Protein Biophysics, Protein-Protein Interaction, Proteins, Protein Conformation, Protein Aggregation, Protein Stability, Protein Misfolding, Protein Dynamics, Protein Biochemistry, Protein Characterization, Structural Bioinformatics And Structural Biology, Aggregation, Protein Engineering, Computational Structural Biology, Prion Diseases, Structural Bioinformatics.

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    Nadia Soussi-Yanicostas
    Nationaldela Research Centre Paris Diderot University
    France
    nadia.soussi@inserm.fr
    OJPDT

    Research Interest: Neurodegenerative Diseases, Animal Model, Zebrafish (Danio Rerio), Microglia, Neuro-Inflammation, Tauopathies, Models Of Human Diseases, Scientific Interests, Bevaviour, Physiopathology Of Tauopathy, Molecular And Cellular Neuroscience, Wnt/ß-Catenin Signalling, New Drugs, Translational Research.  

     
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    Kexin Liu
    Professor
    Dalian Medical University
    China
    liukexin89@163.com
    OJPDT

    Research Interest: Pharmacokinetics, Pharmacology, Drug-drug interaction, Transporter, Excretion, P-gp

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    Keun A Chang
    Assistant Professor
    Department of Pharmacology
    Gachon University
    Korea
    kachang74@gmail.com
    OJPDT

    Research Interest: Neurodegenerative Disorder, Alzheimer's Disease, Parkinson's Disease, Stem Cell And Cognition.

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    Natascia De Lucia
    Researcher
    Department of Psychology
    Second University of Naples
    Italy
    Natascia.DELUCIA@unina2.it
    OJPDT

    Research Interest: Neuropsychology,Neuropsychological Assessment, Cognitive,Memory, Executive Function.

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    View more
    mendeley

    A new technique to test the effect of cognition on standing balance in Parkinson’s disease

    DOI Logo 10.17352/ojpdt.000007

    Published On: September 20, 2019 | Pages: 006 - 013

    Author(s): Mayank Bhatt, Bhuvan Mahana, Jonathan J Marotta, Ji Hyun Ko, Douglas Everett Hobson and Tony Szturm*
    Abstract View Full Article View
    mendeley

    Parkon as a treatment of the Parkinson’s disease

    DOI Logo 10.17352/ojpdt.000006

    Published On: March 19, 2019 | Pages: 001 - 005

    Author(s): Golubev VL, Sadekov PA, Pilipovich AA, Goldstein NI*
    Abstract View Full Article View
    mendeley

    Genes involved in the development of Parkinson

    DOI Logo 10.17352/ojpdt.000005

    Published On: October 14, 2017 | Pages: 039 - 051

    Author(s): Diana Teixeira and Inês Lopes Cardoso*
    Abstract View Full Article View
    mendeley

    Divergent Effects of Haloperidol on Motor Versus Spatial Functions

    DOI Logo 10.17352/ojpdt.000004

    Published On: September 20, 2017 | Pages: 032 - 038

    Author(s): Robert Lalonde* and Catherine Strazielle
    Abstract View Full Article View
    mendeley

    A proposal for a semantic change in the current diagnostic criteria of Parkinson’s disease Psychosis

    DOI Logo 10.17352/ojpdt.000003

    Published On: July 06, 2017 | Pages: 030 - 031

    Author(s): Francisco Appiani, Marcelo Miranda, Carlos Zúniga-Ramírez, Michel Saenz-Farret, Vanderci Borges and Federico Micheli*
    Abstract View Full Article View
    mendeley

    Effectiveness of deep Brain Stimulation on early onset Dystonia: A Case Report

    DOI Logo 10.17352/ojpdt.000002

    Published On: June 10, 2017 | Pages: 027 - 029

    Author(s): Ayse Unal, Ali Yalman, Filiz Altug* and Uğur Cavlak
    Abstract View Full Article View
    mendeley

    Restoration of Mitochondrial Dysfunction in 6-Hydroxydopamine Induced Parkinson’s disease: a Complete Review

    DOI Logo 10.17352/ojpdt.000001

    Published On: April 26, 2017 | Pages: 001 - 026

    Author(s): Sidharth Mehan*, Gurpreet Kaur, Rajesh Dudi, Manju Rajput and Sanjeev Kalra
    Abstract View Full Article View

     

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