Studies on Stem Cells Research and Therapy

Research Interest: Cancer Biology, Cell Biology, Breast Cancer, Cancer Prevention, Anti-Cancer Drug Development, Cancer Metastasis, Transcription Factors, Kinase, Glucose Metabolism.

Research Interest: Neurology

Research Interest: Drug Discovery and Development.

Research Interest: Bone Marrow Transplantation, Immunology, Autoimmunity, Thymus and Bone Marrow Derived-Mesenchymal Stem Cells. His Cutting-Edge Technology for Bone Marrow Cell Harvesting and Intra-Bone Marrow-Bone Marrow Transplantation has Led to Significant Research Into Allogeneic Stem Cell Transplantation. 

Research Interest: Clinical Pharmacology, Gastroenterology, Pharmaceutical Development, Drug Development, Colorectal Cancer, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease

Research Interest: In his Consulting Experience, Devyn Led a Wide Range of Projects, Across Multiple Therapeutic Areas and a Host of Technology Platforms, Including Basic R&D Tools, Regenerative Medicine, Gene Therapy and Macromolecules/Biologic Products.

Research Interest: Effects of Chinese Herbal Medicine on Osteogenesis and Adipogenesis of Mesenchymal Stem Cells, Inhibitory Effects of Chinese Herbal Medicine on RANKL-Induced Osteoclastgenesis of RAW264.7 Cells, Effect of Chinese Herbal Medicine on Different Osteoporotic Rat Models, Establishment of the Screening Platform for Neuro-Regenerative Chinese Herbal Medicine by Using Rat Mesenchymal Stem Cells, Topical Application of Chinese Medicine in Musculoskeletal Injuries, Wound Healing, Cancer Stem Cells, Neuroprotection.

Research Interest: During those Years She Extended her Initial Research Interests on Endothelial Progenitor Cell (EPC) Biology and their Potential use in Regenerative Medicine. 

Research Interest: Stem Cell Biology; Breast Cancer Dormancy; Neural Regulation of Hematopoiesis, the Immunology and Clinical Application of Adult Human Mesenchymal Stem Cells. 

Research Interest: Neuropsychopharmacology of Lipid Transmitters (CTS643, Andalusian Ministry of Economy, Innovation, Science and Employment): The Group is Formed in the University Regional Hospital of Malaga, in Collaboration with the University of Malaga, and Integrated Into the Biomedical Research Institute of Malaga (IBIMA). Our Interest Focuses on the Role that Regulatory Lipid Molecules, Mainly Lysophosphatidic Acid, Exerted on the Central Nervous System and Related Mainly to the Neural Genesis (Neurogenesis / Gliogenesis) and its Effect on Behavioral Level. It Also Examines the Role of Lysophosphatidic Acid in the Dynamic Processes that Regulate Neuroinflammation and Demyelination in Multiple Sclerosis, Studying Animal Models and Samples from Patients with Multiple Sclerosis, As Well As Mesenchymal Cell Therapy for the Disease.

Research Interest: Harnessed the Biological Principle that Pregnancy and Hormones Mimicking Pregnancy Induced Breast Cancer Prevention.  The Preventive Effect of Pregnancy is Mediated by the Induction of Differentiation of the Mammary Gland.  In Studies Performed in Humans, He has Found that During the Post-Menopausal Years the Breast of Both Parous and Nulliparous Women Contains Preponderantly Lob 1 that Differs Biologically By Exhibiting Different Susceptibility to Carcinogenesis, And Remodeling Of Chromatin That Emerges As Novel Marker For Defining The Concept Of Differentiation In The Adult Breast.  His Laboratory Has Studied The Genomic Profile Of Nulliparous And Parous Women In The Premenopausal And Postmenopausal Period And Find That There Are Genes Only Activated During The First Five Years After Pregnancy That May Contribute To The Increased Risk Experimented By Certain Women After Pregnancy And At The Same Time They Have Confirmed That Pregnancy Induces A Long Lasting Genomic Signature That Start After Pregnancy That Explain Its Preventive Effect. The Molecular Mechanism Related To Prevention Is Around The Chromatin Remodeling Process. Using The In Vitro In Vivo Model Developed In His Laboratory He Is Identifying Drugs That Can Control Chromatin Remodeling As A Preventive Strategy.

Research Interest: Stem Cell Injection, Cardiovascular Disease, Medical Diffusion in Arteries, Hemodynamics.

Research Interest: As Is Clear From The Biography, Shigetaka Asano Accomplisheddistinguished Performance In Research Based On Medical Needs By Full Of Enthusiasm With State-Of-The-Art New Technology, Such As 1. Verification Of Existence Of Rabbit Neutrophil Cell Membrane Knack+-Atpase, 2. Discovery Of Laterarity Of Mouse Intestinal Mucous Membrane Proteins, 3. Finding Of Human Tumor Cell Mediated By Granulocyte Colony-Stimulating Factor (G-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Neutrophil), 4. Analysis Of Human G-CSF Activity, 5. Succeeding In Incubation Of Human Tumor Infiltrating T Lymphocyte Colony, 6. Discovery Of Allogenicimmunosuppression Of Placenta Decidual Cells, 7. Differentiation Induction Of Mesenchymalstem Cell, 8. Cloning Of G-Csfcdna And Development Of Recombinant Human Native G-CSF (Lenograstim) As The 1st Generation Biomedicine, 9. Constitution Of International Clinical Guideline For Transplantation Of Bone-Marrow And Cord Blood, And Construction Of Public Bank Of Bone-Marrow And Cord Blood, 10. Non-Clinical Study Of Human Granulocyte Colony-Stimulating Factor (GM-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Macrophage Besides Neutrophil)Immunogene Therapy And Execution Of The Phase Iia Clinical Study, 11. Non-Clinical Study Of Utilizing Maxizyme For Immunogene Therapy Of Myeloid Leukemia Cell, 12. Acquisition And Molecular Analysis Of Leukemia Stem Cell Like Property By Stochastic Adhesion Of In Vitro Human Myelogenous Leukemic Cell Line Cell And Stromal Cell, 13. Pathological Analysis Of Mesenchymalstem Cell(Parental Cell Of Range Of Cell Consist Ofstroma) Differentiation And Proliferation In Translin(Substance Found As Molecule To Bind Fusion Gene Of Lymphatic Leukemia) Knockout Mouse. 

Research Interest:

Two Major Projects are Currently Underway in the Laboratory.
A Cell Reprogramming Technique Has Been Used to Convert Heterogeneous Malignant Breast Cancer Cells into Induced Pluripotent Stem Cells Using Sox2/Oct4/Nanog Proteins. Dr. Wu’s Laboratory is Clarifying these Induced Pluripotent Stem Cells for their Differentiation Potential and Oncogenic Properties, and Try to Develop a Novel Cell Converting Therapy for Malignant Breast Cancer Treatment.
Metastasis, the Spread of Cancer Cells from the Primary Tumor To Distant Organs, Is The Most Dreadful Development Of Breast Cancer, As Well As Other Neoplastic Diseases. Although Metastasis Contributes To Over 90% Of Human Cancer Mortality, The Molecular Mechanism Of This Process Remains Largely Unknown. Dr. Wu’s Laboratory Is In The Process Of Identifying Molecular Signatures Involved In Breast Cancer Metastasis Using Integrative Genetic, Epigenetic And Proteomic Approach, As Well As Animal Models And Clinical Specimens. 

Research Interest: Tumor Immunology and Immunotherapy, Cancer Stem Cell Biology and Immunology, Obstetrics and Gynecology.