Introduction

    • Volume/IssueClick here
    • Review ProcessDouble Blind
      • Publication lead time3 - 4 weeks
      • Indexing statusYes; Purview
      • Manuscript Processing ChargesClick here
      • Submission ChargesNo
      • Waiver policy for APCYes
      • Language of Full TextEnglish
      • Full-text formats availablePDF, HTML
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    • Permanent article identifierDOI (Digital Object Identifier) We provide DOI to all published papers to facilitate higher citation and classification of articles.
      Peertechz Publisher ID: 10.17352
    • Type of LicenseCreative Commons
      • Open AccessYes; Policy
      • Does the author retain unrestricted copyright?Yes
      • Does the author retain publishing rights?Yes
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    Editorial Board

    Guojun Wu
    Associate Professor
    Department of Oncology
    Wayne State University School of Medicine
    USA
    wugu@karmanos.org
    SSCRT

    Research Interest:

    Two Major Projects are Currently Underway in the Laboratory.
    A Cell Reprogramming Technique Has Been Used to Convert Heterogeneous Malignant Breast Cancer Cells into Induced Pluripotent Stem Cells Using Sox2/Oct4/Nanog Proteins. Dr. Wu’s Laboratory is Clarifying these Induced Pluripotent Stem Cells for their Differentiation Potential and Oncogenic Properties, and Try to Develop a Novel Cell Converting Therapy for Malignant Breast Cancer Treatment.
    Metastasis, the Spread of Cancer Cells from the Primary Tumor To Distant Organs, Is The Most Dreadful Development Of Breast Cancer, As Well As Other Neoplastic Diseases. Although Metastasis Contributes To Over 90% Of Human Cancer Mortality, The Molecular Mechanism Of This Process Remains Largely Unknown. Dr. Wu’s Laboratory Is In The Process Of Identifying Molecular Signatures Involved In Breast Cancer Metastasis Using Integrative Genetic, Epigenetic And Proteomic Approach, As Well As Animal Models And Clinical Specimens. 

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    Yuval Rinkevich
    Department of Pathology
    Stanford University
    USA
    yuvalrinkevich@gmail.com
    SSCRT

    Research Interest: Regenerative Biology (Marine Invertebrates and Mammals), Stem Cell Biology, Developmental Biology.

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    George Kolios
    Professor
    Head of the Laboratory of Pharmacology
    Democritus University of Thrace
    Greece
    gkolios@med.duth.gr
    SSCRT

    Research Interest: Clinical Pharmacology, Gastroenterology, Pharmaceutical Development, Drug Development, Colorectal Cancer, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease

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    Lixin Kan
    Adjunct Professor
    University of Chicago IL
    USA
    l-kan@northwestern.edu
    SSCRT

    Research Interest: Neurology

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    Han Wang
    Department of Cellular and Structural Biology
    University of Texas
    USA
    cherrywangh@hotmail.com
    SSCRT

    Research Interest: Embryonic Stem Cells, Pluripotency, Induced Pluripotent Cells, Differentiation, Endoderm, Beta Cell, Diabetes, Obesity, Adipose Tissue, Brown Fat, Endothelium, Oxidative Stress, Nitric Oxide, Peroxynitrite, Superoxide, Nanosensors.

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    Dong Li
    Department of Cell and Developmental Biology
    University of Illinois
    USA
    dongly@illinois.edu
    SSCRT

    Research Interest: Fate Decisions of Embryonic Stem Cell, Induced Pluripotent Stem Cell (ESC/Ips): Pluripotency and Direct Lineage Specification to the Three Germ Layers.

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    Edgar Grinstein
    Ph.D., Senior Scientist
    Center for Child and Adolescent Health
    Heinrich Heine University, Dusseldorf
    Germany
    Edgar.Grinstein@uni-duesseldorf.de
    SSCRT

    Dr. Edgar Grinstein is a Principal Investigator at the Heinrich Heine University in Düsseldorf (Germany). He researches hematopoietic stem cells and progenitor cells, signal transduction, gene transcription regulation. He has more than 11 years of experience as Editor-In-Chief at SAGE Publications Inc. (USA) and Libertas Academica (New Zealand), and also serves as Deputy Editor-In-Chief for Baishideng Publishing Group (USA).

    Raised in a family of researchers – both parents are PhD scientists - he received his PhD summa cum laude in Molecular Biology from the Humboldt University and the Max-Delbrück Center for Molecular Medicine in Berlin. He has published a number of papers in high-ranking journals and received a highly regarded Research Award from Dr.-Günther- and Imme-Wille-Foundation. Dr. Grinstein qualified as Professor in Molecular Medicine at the University of Düsseldorf in 2008 and is a Visiting Professor at the University of Latvia (Latvia, European Union) since 2010.  

    Dr. Grinstein`s research in the field of hematopoietic stem and progenitor cells, funded by research grants from German Research Foundation (DFG) and José Carreras Leukämie-Stiftung (José Carreras Foundation), has focused on markers, signal transduction and transcriptional control. Among other important findings made, his research group provided new insights into the role of the prominent surface marker AC133/CD133 (Leukemia 2015; 29: 2208-2220), that is expressed on stem/progenitor cells in normal hematopoiesis as well as on tumor-initiating cells in certain hematological malignancies. The study analyzed the control of AC133/CD133 expression in hematopoietic stem/progenitor cells, and revealed the impact thereof on molecular network relevant to these cells.

    Research Interest: hematopoietic stem cells and progenitor cells, cancer stem cells, stem cell markers, signal transduction, cell cycle control, regulation of apoptosis, gene transcription regulation

    Grants: Principal Investigator of stem cell-related projects funded by German Research Foundation (DFG) and by José Carreras Leukämie-Stiftung (José Carreras Foundation)

    URL: https://www.wjgnet.com/2218-6204/MemberDetail/42530

    publications:

    Grinstein, E., and H.-D. Royer. 1995. Multiple octamer-binding proteins are targets for the cell cycle regulated nuclear inhibitor I-92. DNA Cell Biol. 14: 493-500.

    Grinstein, E., I. Weinert, B. Droese, M. Pagano, and H.-D. Royer. 1996. Cell cycle regulation of nuclear factor p92 DNA-binding activity by novel phase-specific inhibitors. J. Biol. Chem. 271: 9215-9222.

    Bargou, R.C., C. Wagener, K. Bommert, W. Arnold, P.T. Daniel, M.Y. Mapara, E. Grinstein, H.-D. Royer, and B. Dörken. 1996. Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice. J. Exp. Med. 183: 1205-1213.

    Bargou, R.C., F. Emmerich, D. Krappmann, K. Bommert, M.Y. Mapara, W. Arnold, H.-D. Royer, E. Grinstein, A. Greiner, C. Scheidereit, and B. Dörken. 1997. Constitutive nuclear factor kappaB-RelA activation is required for proliferation and survival of Hodkin’s desease tumor cells. J. Clin. Invest. 12: 2961-2969.

    Janke, J., K. Schlüter, B. Jandrig, M. Theile, K. Kölble, W. Arnold, E. Grinstein, A.  Schwartz, L.E. Schwarz, P.M. Schlag, B.M. Jockusch, and S. Scherneck. 2000. Suppression of tumoriginecity in breast cancer cells by the microfilament protein profilin1. J. Exp. Med. 191: 1675-1685.

    Grinstein, E.,* F. Jundt, I. Weinert, P. Wernet, and H.-D. Royer. 2002. Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells. Oncogene. 21: 1485-1492.

    Grinstein, E., P. Wernet, P.J. Snijders, F. Rösl, I. Weinert, W. Jia, R. Kraft, Ch. Schewe, M. Schwabe, S. Hauptmann, M. Dietel, Ch. Meijer, and H.-D. Royer. 2002. Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer. J. Exp. Med. 196: 1067-1078.

    Grinstein, E.,* Y. Shan, L. Karawajew, P.J. Snijders, C.J. Meijer, H.-D. Royer, and P. Wernet. 2006. Cell cycle controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation.  J. Biol. Chem. 281: 22223-22235.

    Grinstein, E.,* Y. Du, S. Santourlidis, J. Christ, M. Uhrberg, and P. Wernet. 2007. Nucleolin regulates gene expression in CD34 positive hematopoietic cells. J. Biol. Chem. 282: 12439-12449.

    Grinstein, E.,* and P. Wernet. 2007. Cellular signaling in normal and cancerous stem cells. Cell. Signal. 19: 2428-2433.
    This was the most read article of the Journal Cell. Signal. from July 2007 till March 2008. Source: SCIENCEDIRECT TOP 25 HOTTEST ARTICLES

    Wethkamp, N., H. Hanenberg, C. Suschek, W. Wetzel, S. Heikaus, E. Grinstein, U. Ramp, R. Engers, H. Gabbert, and C. Mahotka. 2011. DAXX-beta and DAXX-gamma: two novel splice variants of the transcriptional co-repressor DAXX. J. Biol. Chem. 19576-19588.

    Grinstein, E.,* C. Mahotka, and A. Borkhardt. 2011. Rb and nucleolin antagonize in controlling human CD34 gene expression. Cell. Signal. 23: 1358-1365.

    Bhatia, S., S. Reister, C. Mahotka, R. Meisel, A. Borkhardt, and E. Grinstein.* 2015. Control of AC133 / CD133 and impact on human hematopoietic progenitor cells through nucleolin. Leukemia. 29: 2208-2220.

    Mahotka, C., S. Bhatia, J. Kollet, and E. Grinstein.* 2018. Nucleolin promotes execution of the hematopoietic stem cell gene expression program. Leukemia. 32: 1865–1868.

    Reister, S., C. Mahotka, N. van den Höfel, and  E. Grinstein.* 2019. Nucleolin promotes Wnt signaling in human hematopoietic stem/progenitor cells. Leukemia. 33: 1052-1054.


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    Yongqing Liu
    Assistant Professor
    Department of Ophthalmology and Visual Sciences
    University of Louisville
    USA
    yongqing.liu@louisville.edu
    SSCRT

    Research Interest: Cancer Stem Cells, Ocular Stem Cells

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    Ambrish Kumar
    Department of Pathology, Microbiology and Immunology
    University of South Carolina
    USA
    Ambrish.Kumar@uscmed.sc.edu
    SSCRT

    Research Interest: Cancer Stem Cell, Anticancer Agent, Metastasis, Cell Survival, Cell Migration, Apoptosis, Molecular and Cell Signaling, Transcription Factors, Xenograft Model, Stem Cell Based Therapy.

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    Jesus Vaquero
    Professor
    Department of Neurosurgery
    Autonomous University
    Spain
    jvaqueroc@telefonica.net
    SSCRT

    Research Interest: Neurological Disability.

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    Maria Cristina Vinci
    Senior Scientist
    Laboratory of Cardiovascular Tissue Engineering
    University of Florence
    Italy
    cristina.vinci@ccfm.it
    SSCRT

    Research Interest: During those Years She Extended her Initial Research Interests on Endothelial Progenitor Cell (EPC) Biology and their Potential use in Regenerative Medicine. 

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    Bhuvnesh K Sharma
    Senior Director
    Department of Translational Oncology
    ScyTek Labs.Inc.
    USA
    bkumar111@hotmail.com
    SSCRT

    Research Interest: Centered on Translational Oncology with Main Emphasis on Identification of Novel Targets in Cancer Stem Cells, Validation of Targeted Cancer Therapeutics, Nanomedicine and Drug Development Program.

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    Qiang Shen
    Assistant Professor
    Department of Clinical Cancer Prevention
    University of Texas MD Anderson Cancer Center
    USA
    qshen@mdanderson.org
    SSCRT

    Research Interest: Cancer Biology, Cell Biology, Breast Cancer, Cancer Prevention, Anti-Cancer Drug Development, Cancer Metastasis, Transcription Factors, Kinase, Glucose Metabolism.

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    Praveen Shukla
    Department of Radiology and Medicine
    Stanford University School of Medicine
    USA
    praveenniper@gmail.com
    SSCRT

    Research Interest: Drug Discovery and Development.

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    Shigetaka Asano
    Professor
    Department of Systemic Bio-Pathology
    Kobe University
    Japan
    asgtkmd@waseda.jp
    SSCRT

    Research Interest: As Is Clear From The Biography, Shigetaka Asano Accomplisheddistinguished Performance In Research Based On Medical Needs By Full Of Enthusiasm With State-Of-The-Art New Technology, Such As 1. Verification Of Existence Of Rabbit Neutrophil Cell Membrane Knack+-Atpase, 2. Discovery Of Laterarity Of Mouse Intestinal Mucous Membrane Proteins, 3. Finding Of Human Tumor Cell Mediated By Granulocyte Colony-Stimulating Factor (G-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Neutrophil), 4. Analysis Of Human G-CSF Activity, 5. Succeeding In Incubation Of Human Tumor Infiltrating T Lymphocyte Colony, 6. Discovery Of Allogenicimmunosuppression Of Placenta Decidual Cells, 7. Differentiation Induction Of Mesenchymalstem Cell, 8. Cloning Of G-Csfcdna And Development Of Recombinant Human Native G-CSF (Lenograstim) As The 1st Generation Biomedicine, 9. Constitution Of International Clinical Guideline For Transplantation Of Bone-Marrow And Cord Blood, And Construction Of Public Bank Of Bone-Marrow And Cord Blood, 10. Non-Clinical Study Of Human Granulocyte Colony-Stimulating Factor (GM-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Macrophage Besides Neutrophil)Immunogene Therapy And Execution Of The Phase Iia Clinical Study, 11. Non-Clinical Study Of Utilizing Maxizyme For Immunogene Therapy Of Myeloid Leukemia Cell, 12. Acquisition And Molecular Analysis Of Leukemia Stem Cell Like Property By Stochastic Adhesion Of In Vitro Human Myelogenous Leukemic Cell Line Cell And Stromal Cell, 13. Pathological Analysis Of Mesenchymalstem Cell(Parental Cell Of Range Of Cell Consist Ofstroma) Differentiation And Proliferation In Translin(Substance Found As Molecule To Bind Fusion Gene Of Lymphatic Leukemia) Knockout Mouse. 

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    View more
    mendeley

    Effect of culture environement on mesenchymal stem cell immunomodulatory ability

    DOI Logo 10.17352/sscrt.000015

    Published On: April 11, 2020 | Pages: 009 - 015

    Author(s): Aisha Nasef*, Alain Chapel and Loic Fouillard
    Abstract View Full Article View
    mendeley

    Bovine whey improved the myocardial and lung damage of mother rats fed on a high fat diet

    DOI Logo 10.17352/sscrt.000014

    Published On: February 28, 2020 | Pages: 001 - 008

    Author(s): Hassan IH El-Sayyad*, Hebat A el-Ghawet, Khaled SM El-Bayomi and Eman Emara
    Abstract View Full Article View
    mendeley

    The potential effects of pomegranate peel extract and bee venom in improving the diabetes induced damaging of spiral artery

    DOI Logo 10.17352/sscrt.000013

    Published On: December 27, 2019 | Pages: 007 - 011

    Author(s): El-Sayyad HIH*, El-Ghawet HA and El-Sayed AMA
    Abstract View Full Article View
    mendeley

    Evaluation of success and toxicity of autologous stem cell transplantation in patients with multiple myeloma in the geriatric age group

    DOI Logo 10.17352/sscrt.000012

    Published On: August 03, 2019 | Pages: 000 - 006

    Author(s): Mehmet Ali Uçar*, Simten Dağdaş, Funda Ceran, Mesude Falay and Gülsüm Özet
    Abstract View Full Article View
    mendeley

    Cell-Penetrating Peptides as a Tool to Deliver Biologically Active Recombinant Proteins to Generate Transgene-Free Induced Pluripotent Stem Cells

    DOI Logo 10.17352/sscrt.000011

    Published On: April 01, 2017 | Pages: 006 - 015

    Author(s): Chandrima Dey, Gloria Narayan, H Krishna Kumar, Manash P Borgohain, Nibedita Lenka and Rajkumar P Thummer*
    Abstract View Full Article View
    mendeley

    Comparison of 18F-FDG PET/CT and ceCT Results in the Assessment of RCC Recurrence

    DOI Logo 10.17352/sscrt.000010

    Published On: December 31, 2016 | Pages: 001 - 005

    Author(s): Elgin OZKAN*, Mine ARAZ, Cigdem SOYDAL and Gulseren ARAS
    Abstract View Full Article View
    mendeley

    Adipogenic and Osteogenic Markers Characterization of Human Amniotic Fluid Stem Cells

    DOI Logo 10.17352/sscrt.000009

    Published On: December 29, 2016 | Pages: 025 - 032

    Author(s): Hassan IH El-Sayyad*, Mohamed A Sobh, Soad A Khalifa, Omnia KRA El-Sayyad
    Abstract View Full Article View
    mendeley

    Adipose Derived Mesenchymal Stem Cell Differentiation into Adipogenic and Osteogenic Stem Cells

    DOI Logo 10.17352/sscrt.000008

    Published On: December 29, 2016 | Pages: 017 - 024

    Author(s): Hassan IH El Sayyad1*, Mohamed A Sobh2, Soad A Khalifa1 and Omnia KR El-Sayyad
    Abstract View Full Article View
    mendeley

    A New Catheter Technology to Deliver Vascular Stem-Cells

    DOI Logo 10.17352/sscrt.000007

    Published On: December 13, 2016 | Pages: 007 - 016

    Author(s): Brian D Plourde, John R Stark and John P Abraham*
    Abstract View Full Article View
    mendeley

    Cytokine Production by Circulating Endothelial Progenitor Cells before and after G-CSF Mobilization

    DOI Logo 10.17352/sscrt.000006

    Published On: November 29, 2016 | Pages: 001 - 006

    Author(s): Alexander Lykov*, Olga Poveschenko, Natalia Bondarenko, Alexander Poveschenko, Irina Kim, Eugenie Pokushalov, Alexander Romanov and Vladimir Konenkov
    Abstract View Full Article View

     

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