Research Interest: Embryonic Stem Cells, Pluripotency, Induced Pluripotent
Cells, Differentiation, Endoderm, Beta Cell, Diabetes, Obesity, Adipose Tissue,
Brown Fat, Endothelium, Oxidative Stress, Nitric Oxide, Peroxynitrite, Superoxide,
Research Interest: Fate Decisions of Embryonic Stem Cell, Induced
Pluripotent Stem Cell (ESC/Ips): Pluripotency and Direct Lineage Specification to
the Three Germ Layers.
Ricardo Alaxandre de Azevedo, PhD, Graduated in Biological Science by the University ‘Santa Cecília’- Santos (Brazil) in 2002, MSc degree in Biotechology by the University of São Paulo (Brazil) in 2010, and Ph.D. in Toxinology by the Butantan Institute (Brazil) in 2014. Presently, Postdoctoral Fellow, Department Immunology, Laboratory of Tumor Immunology, University São Paulo, July 2014-current. Also occupy position of Research Scientist, and Coordinator of Biological Assays Division at ALCHEMY, RESEARCH AND DEVELOPMENT, February-current. I have experience and scientific production in the area of Apoptosis and cell cycle signaling, peptides and peptidases, molecular biology and cancer genetics, cells immunology, with emphasis on biochemotherapy and immunotherapy of cancer, focusing murine melanoma and human tumors.
Research Interest: Cardiac Therapy, Cardiovascular Disease,
Autologous, Tissue-Engineering, Multipotent Stem Cells, Cardiovascular
Structures, Regenerative Medicine.
Research Interest: Stem Cell Biology; Breast Cancer Dormancy; Neural
Regulation of Hematopoiesis, the Immunology and Clinical Application of Adult
Human Mesenchymal Stem Cells.
Research Interest: Cell Reprogramming and Induced Pluripotent Stem
Cells, Stem Cells and Neural Tissue Engineering, Mammalian Inner Ear
Development and Hair Cell Regeneration.
Research Interest: ES/Ips Cells; Skeletal Muscle Regeneration; Gene and
Cell Therapy; Genome Editing; Gene Targeting.
Research Interest: Leptin Receptors (Lepr) are Expressed by Various
Types of Stem Cells Including Mesenchymal Stem Cells, Hematopoietic Stem Cells,
Embryonic Stem Cells and Induced Pluripotent Stem Cells. Leptin/Lepr Signaling
is also a Central Regulator of Metabolism.
Two Major Projects are Currently Underway in the Laboratory.
A Cell Reprogramming Technique Has Been Used to Convert Heterogeneous Malignant Breast Cancer Cells into Induced Pluripotent Stem Cells Using Sox2/Oct4/Nanog Proteins. Dr. Wu’s Laboratory is Clarifying these Induced Pluripotent Stem Cells for their Differentiation Potential and Oncogenic Properties, and Try to Develop a Novel Cell Converting Therapy for Malignant Breast Cancer Treatment.
Metastasis, the Spread of Cancer Cells from the Primary Tumor To Distant Organs, Is The Most Dreadful Development Of Breast Cancer, As Well As Other Neoplastic Diseases. Although Metastasis Contributes To Over 90% Of Human Cancer Mortality, The Molecular Mechanism Of This Process Remains Largely Unknown. Dr. Wu’s Laboratory Is In The Process Of Identifying Molecular Signatures Involved In Breast Cancer Metastasis Using Integrative Genetic, Epigenetic And Proteomic Approach, As Well As Animal Models And Clinical Specimens.
Research Interest: Neuropsychopharmacology of Lipid Transmitters (CTS643,
Andalusian Ministry of Economy, Innovation, Science and Employment): The Group is
Formed in the University Regional Hospital of Malaga, in Collaboration with the
University of Malaga, and Integrated Into the Biomedical Research Institute of Malaga
(IBIMA). Our Interest Focuses on the Role that Regulatory Lipid Molecules,
Mainly Lysophosphatidic Acid, Exerted on the Central Nervous System and Related
Mainly to the Neural Genesis (Neurogenesis / Gliogenesis) and its Effect on
Behavioral Level. It Also Examines the Role of Lysophosphatidic Acid in the
Dynamic Processes that Regulate Neuroinflammation and Demyelination in Multiple
Sclerosis, Studying Animal Models and Samples from Patients with Multiple
Sclerosis, As Well As Mesenchymal Cell Therapy for the Disease.
Involved in Cell Cycle Regulation, Differentiation, Apoptosis and Senescence
Such as the Retinoblastoma (RB) Family. He has Evaluated the Role of Retinoblastoma
Genes in the Regulation of Cell Proliferation, Differentiation and Apoptosis in
Cancer and Normal Stem Cells. In Detail, his Group has Analyzed the Biology of Neural Stem Cells and Mesenchymal Stem Cells. These Studies Prompted the Attention Also on Chromatin
Remodeling Factors that Interact with RB Family Members and Play a Key Role in the Life of StemCells.
Research Interest: Regenerative Biology (Marine Invertebrates and
Mammals), Stem Cell Biology, Developmental Biology.
Research Interest: Cancer Stem Cells, Ocular Stem Cells
Research Interest: Guo Was Engaged in Research into the Induction of
Transplant Tolerance Via Bone Marrow Transplantation under the Guidance of Prof.
Research Interest: Therapeutic Application of ES and Ips Cells.
Published On: April 01, 2017 | Pages: 006 - 015Abstract View Full Article View DOI: 10.17352/sscrt.000011
Published On: March 21, 2017 | Pages: 001 - 005Abstract View Full Article View DOI: 10.17352/sscrt.000010
Published On: December 29, 2016 | Pages: 025 - 032Abstract View Full Article View DOI: 10.17352/sscrt.000009
Published On: December 29, 2016 | Pages: 017 - 024Abstract View Full Article View DOI: 10.17352/sscrt.000008
Published On: December 13, 2016 | Pages: 007 - 016Abstract View Full Article View DOI: 10.17352/sscrt.000007
Published On: November 29, 2016 | Pages: 001 - 006Abstract View Full Article View DOI: 10.17352/sscrt.000006
Published On: December 31, 2015 | Pages: 017 - 018Abstract View Full Article View DOI: 10.17352/sscrt.000005
Published On: December 31, 2015 | Pages: 012 - 016Abstract View Full Article View DOI: 10.17352/sscrt.000004
Published On: December 08, 2015 | Pages: 004 - 011Abstract View Full Article View DOI: 10.17352/sscrt.000003
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