Dr. Monther AlAlwan is a scientist at the Stem Cell and Tissue Re-engineering Program (SCTRP), King Faisal Specialist Hospital and Research Centre, as well as an Associate professor at Alfaisal University, Riyadh Saudi Arabia. He holds M.Sc. and Ph.D. in Immunology from Dalhousie University (Halifax, Canada). Dr. AlAlwan conducted a 3-years postdoctoral fellowship studying signaling in immune cells at the University of Manitoba, Canada. During his graduate studies and postdoctoral fellowship, Dr. AlAlwan made substantial contribution in the immunology field, particularly his groundbreaking discovery that highlighted the significance of the dendritic cells in the immunological synapse. After joining the SCTRP in 2007, he shifted gear to study cancer, where he identified novel mechanisms that regulate cancer metastasis and chemoresistance. Currently, he is actively involved in dissecting the molecular pathways that regulate the function of cancer stem cells and how this related to chemoresistance and metastasis. Dr. AlAlwan is an author in 20 peer-reviewed publications, has delivered several invited lectures and is a regular reviewer for various international journals.
Involved in Cell Cycle Regulation, Differentiation, Apoptosis and Senescence
Such as the Retinoblastoma (RB) Family. He has Evaluated the Role of Retinoblastoma
Genes in the Regulation of Cell Proliferation, Differentiation and Apoptosis in
Cancer and Normal Stem Cells. In Detail, his Group has Analyzed the Biology of Neural Stem Cells and Mesenchymal Stem Cells. These Studies Prompted the Attention Also on Chromatin
Remodeling Factors that Interact with RB Family Members and Play a Key Role in the Life of StemCells.
Ricardo Alaxandre de Azevedo, PhD, Graduated in Biological Science by the University ‘Santa Cecília’- Santos (Brazil) in 2002, MSc degree in Biotechology by the University of São Paulo (Brazil) in 2010, and Ph.D. in Toxinology by the Butantan Institute (Brazil) in 2014. Presently, Postdoctoral Fellow, Department Immunology, Laboratory of Tumor Immunology, University São Paulo, July 2014-current. Also occupy position of Research Scientist, and Coordinator of Biological Assays Division at ALCHEMY, RESEARCH AND DEVELOPMENT, February-current. I have experience and scientific production in the area of Apoptosis and cell cycle signaling, peptides and peptidases, molecular biology and cancer genetics, cells immunology, with emphasis on biochemotherapy and immunotherapy of cancer, focusing murine melanoma and human tumors.
Research Interest: Harnessed the Biological Principle that Pregnancy and
Hormones Mimicking Pregnancy Induced Breast Cancer Prevention. The Preventive Effect of Pregnancy is
Mediated by the Induction of Differentiation of the Mammary Gland. In Studies Performed in Humans, He has Found that
During the Post-Menopausal Years the Breast of Both Parous and Nulliparous
Women Contains Preponderantly Lob 1 that Differs Biologically By Exhibiting
Different Susceptibility to Carcinogenesis, And Remodeling Of Chromatin That
Emerges As Novel Marker For Defining The Concept Of Differentiation In The
Adult Breast. His Laboratory Has Studied
The Genomic Profile Of Nulliparous And Parous Women In The Premenopausal And
Postmenopausal Period And Find That There Are Genes Only Activated During The
First Five Years After Pregnancy That May Contribute To The Increased Risk
Experimented By Certain Women After Pregnancy And At The Same Time They Have
Confirmed That Pregnancy Induces A Long Lasting Genomic Signature That Start
After Pregnancy That Explain Its Preventive Effect. The Molecular Mechanism
Related To Prevention Is Around The Chromatin Remodeling Process. Using The In
Vitro In Vivo Model Developed In His Laboratory He Is Identifying Drugs That
Can Control Chromatin Remodeling As A Preventive Strategy.
Research Interest: Effects of Chinese Herbal Medicine on Osteogenesis
and Adipogenesis of Mesenchymal Stem Cells, Inhibitory Effects of Chinese Herbal
Medicine on RANKL-Induced Osteoclastgenesis of RAW264.7 Cells, Effect of Chinese
Herbal Medicine on Different Osteoporotic Rat Models, Establishment of the
Screening Platform for Neuro-Regenerative Chinese Herbal Medicine by Using Rat
Mesenchymal Stem Cells, Topical Application of Chinese Medicine in
Musculoskeletal Injuries, Wound Healing, Cancer Stem Cells, Neuroprotection.
Research Interest: As Is Clear From The Biography, Shigetaka Asano Accomplisheddistinguished
Performance In Research Based On Medical Needs By Full Of Enthusiasm With
State-Of-The-Art New Technology, Such As 1. Verification Of Existence Of Rabbit
Neutrophil Cell Membrane Knack+-Atpase, 2. Discovery Of Laterarity Of Mouse
Intestinal Mucous Membrane Proteins, 3. Finding Of Human Tumor Cell Mediated By
Granulocyte Colony-Stimulating Factor (G-CSF; Bioactive Substance To Stimulate
Differentiation, Proliferation And Functional Activity Of Neutrophil), 4. Analysis
Of Human G-CSF Activity, 5. Succeeding In Incubation Of Human Tumor
Infiltrating T Lymphocyte Colony, 6. Discovery Of Allogenicimmunosuppression Of
Placenta Decidual Cells, 7. Differentiation Induction Of Mesenchymalstem Cell,
8. Cloning Of G-Csfcdna And Development Of Recombinant Human Native G-CSF (Lenograstim)
As The 1st Generation Biomedicine, 9. Constitution Of International Clinical
Guideline For Transplantation Of Bone-Marrow And Cord Blood, And Construction
Of Public Bank Of Bone-Marrow And Cord Blood, 10. Non-Clinical Study Of Human
Granulocyte Colony-Stimulating Factor (GM-CSF; Bioactive Substance To Stimulate
Differentiation, Proliferation And Functional Activity Of Macrophage Besides
Neutrophil)Immunogene Therapy And Execution Of The Phase Iia Clinical Study,
11. Non-Clinical Study Of Utilizing Maxizyme For Immunogene Therapy Of Myeloid
Leukemia Cell, 12. Acquisition And Molecular Analysis Of Leukemia Stem Cell
Like Property By Stochastic Adhesion Of In Vitro Human Myelogenous Leukemic
Cell Line Cell And Stromal Cell, 13. Pathological Analysis Of Mesenchymalstem
Cell(Parental Cell Of Range Of Cell Consist Ofstroma) Differentiation And
Proliferation In Translin(Substance Found As Molecule To Bind Fusion Gene Of
Lymphatic Leukemia) Knockout Mouse.
Research Interest: Leptin Receptors (Lepr) are Expressed by Various
Types of Stem Cells Including Mesenchymal Stem Cells, Hematopoietic Stem Cells,
Embryonic Stem Cells and Induced Pluripotent Stem Cells. Leptin/Lepr Signaling
is also a Central Regulator of Metabolism.
Research Interest: Cancer Biology, Cell Biology, Breast Cancer, Cancer
Prevention, Anti-Cancer Drug Development, Cancer Metastasis, Transcription
Factors, Kinase, Glucose Metabolism.
Research Interest: Neurological Disability.
Research Interest: Cancer Stem Cell, such as Surface Marker, Biology,
Research Interest: Cardiac Therapy, Cardiovascular Disease,
Autologous, Tissue-Engineering, Multipotent Stem Cells, Cardiovascular
Structures, Regenerative Medicine.
Research Interest: Clinical Pharmacology, Gastroenterology, Pharmaceutical Development, Drug Development, Colorectal Cancer, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease
Research Interest: Drug Discovery and Development.
Research Interest: Tumor Immunology and Immunotherapy, Cancer Stem
Cell Biology and Immunology, Obstetrics and Gynecology.
Research Interest: Neurology
Published On: April 01, 2017 | Pages: 006 - 015Abstract View Full Article View DOI: 10.17352/sscrt.000011
Published On: March 21, 2017 | Pages: 001 - 005Abstract View Full Article View DOI: 10.17352/sscrt.000010
Published On: December 29, 2016 | Pages: 025 - 032Abstract View Full Article View DOI: 10.17352/sscrt.000009
Published On: December 29, 2016 | Pages: 017 - 024Abstract View Full Article View DOI: 10.17352/sscrt.000008
Published On: December 13, 2016 | Pages: 007 - 016Abstract View Full Article View DOI: 10.17352/sscrt.000007
Published On: November 29, 2016 | Pages: 001 - 006Abstract View Full Article View DOI: 10.17352/sscrt.000006
Published On: December 31, 2015 | Pages: 017 - 018Abstract View Full Article View DOI: 10.17352/sscrt.000005
Published On: December 31, 2015 | Pages: 012 - 016Abstract View Full Article View DOI: 10.17352/sscrt.000004
Published On: December 08, 2015 | Pages: 004 - 011Abstract View Full Article View DOI: 10.17352/sscrt.000003
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