2006 – 2009
M.S. in Microbiological and Biochemical Pharmacy
Shanghai Jiaotong University, Shanghai, China
2001 - 2005
B.S. in Biotechnology (Fermentation Engineering)
Shanghai Normal University, Shanghai, China
Stem Cell Research and Therapy
Gynecological Disease Research
Autoimmune Disease Research
RESEARCH INTERESTS AND SKILLS
My scientific interests are to understand how genetic and molecular programs can yield the complex biological behaviors. As a medical research scientist, synthetic biologist and bioengineer, I am passionate about the applications of diverse biotechnological tools to understand genomics and explore the mechanism of genomic control as well as incidence of diseases, which allow comprehensive understanding, manipulating, and engineering of sophisticated biological systems. I aim to understand cellular or organismal behaviors in both space and time thus benefit the biomedical research, translational studies and cell therapy.
I am skilled in cell culture (primary/linage) and cellularity detections (CCK8, FACS etc); molecular cloning and detection (plasmid construction, RT-PCR, western blot etc); protein [removed]prokaryotic expression system) and purification (ionexchange and affinity chromatography); immunohistochemistry and immunocytochemistry detection; and animal model construction.
Research Grant Details:
National Natural Science Foundation of China (Grant No. 81502233)
Existing evidence indicates that PPI (protein-protein interaction) contributes to the tumorigenesis of endometrial carcinoma, but the mechanisms involved in it remain largely unknown. In our previous study, we found that ATF3 participating in the development of various different kinds of cancer, expressed higher in the epithelium of normal endometrial tissue than that detected in pathnological tissue, and interacted with JunB which expressing higher in the epithelium of endometrial cancer tissue than that detected in normal endometrial tissue, via yeast-two-hybrid assay. Additionally, over-expression of ATF3 led to the inhibition of cell proliferation, migration and invasion, with the down-regulation of JunB and inflammatory factor. Therefore, we put forward a hypothesis that ATF3 might inhibit the expression of inflammatory genes and the development of endometrial cancer by binding with JunB andmitigating with it. This study was designed to utilize the mRNA expression microarray analysis, CRISPR/Cas9 and orthotopic endometrial carcinoma model in nude mice combined with molecular biological techniques to explore the cell signal transductions of ATF3 and JunB in EC, demonstrate the mechanism of development of EC, and provide new therapeutic targets for it, which contributes greatly to the patients suffering from endometrial cancer.
1． Wang Fangyuan(#), Qi Stanley Lei(*). Applications of CRISPR Genome Engineering in Cell Biology. Trends in Cell Biology. 2016 Nov;26(11):875-888.
2． Wang Fangyuan(#), Zhao Dehua, Qi Lei Stanley(*). Application of genome engineering in medical synthetic biology. Sheng Wu Gong Cheng Xue Bao. 2017 Mar 25;33(3):422-435.
3． Wang Fangyuan(#), Gao Jin, Malisani Alyssa, Xi Xiaowei, Han Wei, Wan Xiaoping (*), Mouse Resistin (mRetn): cloning, expression and purification in Escherichia coli and the potential regulative effects on murine bone marrow hematopoiesis. BMC Biotechnol, 2015 Nov 16;15(1):105.
4． Wang Fangyuan(#), Wang Li, Yao Xiaofen, Lai Dongmei(*). Human amniotic epithelial cells can differentiate to granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure. Stem Cell Res Ther. 2013 Oct 14;4(5):124-134.
5． Liu Yanxia(#), Yu Chen(#), Daley Timothy Patrick(#), Wang Fangyuan, Cao William S., Bhate Salil, Lin Xueqiu, Still II Chris, Liu Honglei, Zhao Dehua, Wang Haifeng, Xie Xinmin S., Ding Sheng, Wong Wing Hung, Wernig Marius, Qi Lei Stanley. CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. Cell Stem Cell. 2018 Nov 1;23(5):758-771.
6． Yan Qin(#), Wang Fangyuan, Miao Yi, Wu Xiaomei, Bai Mingzhu, Xi Xiaowei, Feng Youji(*). Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase. Tumour Biol. 2016 Sep;37(9):12263-12271.
7． Lai Dongmei(#)(*), Wang Fangyuan, Yao Xiaofen, Zhang Qiuwan, Wu Xiaoxing, Xiang Charlie(*). Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure. J Transl Med. 2015 May 12;13:155.
8． Lai Dongmei(#)(*), Wang Fangyuan, Dong Zhangli, Zhang Qiuwan. Skin-derived mesenchymal stem cells help restore function to ovaries in a premature ovarian failure mouse model. PLoS One. 2014 May 30;9(5):e98749.
9． Lai Dongmei(#)(*), Wang Fangyuan, Chen Yifei, Wang Li, Wang Yanlin, Cheng Weiwei. Human amniotic fluid stem cells have a potential to recover ovarian function in mice with chemotherapy-induced sterility. BMC Dev Biol. 2013 Sep 4;13(1):34.
10． Lai Dongmei(#)(*), Wang Fangyuan, Chen Yifei, Wang Chunhui, Liu Sha, Lu Bufeng, Ge Xuerui, Guo Lihe. Human ovarian cancer stem-like cells can be efficiently killed by γδ T lymphocytes. Cancer Immunol Immunother. 2012 Jul;61(7):979-89.
11． Che Qi(#), Liu Binya, Wang Fangyuan, He Yinyan, Lu Wen, Liao Yun, Gu Wei, Wan Xiaoping(*). Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERK-NF-kappaB signaling pathway. Biochem Biophys Res Commun, 2014, 446(1):167-172.
12． Lai Dongmei(#)(*), Ma Li, Wang Fangyuan. Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells. Int J Oncol. 2012 Aug;41(2):541-50.
13． Lai Dongmei(#)(*), Chen Yifei, Wang Fangyuan, Jiang Lizhen, Wei Chunsheng. LKB1 Controls the Pluripotent State of Human Embryonic Stem Cells. Cellular Reprogramming. April 2012, 14(2): 164-170.
14． Chen Zheng(#), Che Qi, He Xiaoying, Wang Fangyuan, Wang Huihui, Zhu Minjiao, Sun Jing(*), Wan Xiaoping(*). Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition. BMC Cancer, 2015 Oct 27;15:811.
15． Chen Zheng(#), Che Qi, Jiang Feizhou, Wang Huihui, Wang Fangyuan, Liao Yun, Wan Xiaoping(*). Piwil1 causes epigenetic alteration of PTEN gene via upregulation of DNA methyltransferase in type I endometrial cancer. Biochem Biophys Res Commun, 2015 Aug 7;463(4):876-80.
16． Liao Yun(#), He Xiaoying, Qiu Haifeng, Che Qi, Wang Fangyuan, Lu Wen, Chen Zheng, Qiu Meiting, Wang Jingyun, Wang Huihui, Wan Xiaoping(*). Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer. BMC Cancer. 2014, 14：487。
17． Huang Haili(#), Wang Yajing, Zhang Qingyu, Liu Bin, Wang Fangyuan, Li Jingjing, Zhu Runzhi(*). Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice. World J Gastroenterol 2012 Dec 7;18(45):6605-6613.
18． Wang Huihui(#), Bao Wei, Jiang Feizhou, Che Qi, Chen Zheng, Wang Fangyuan, Tong Huan, Dai Chenyun, He Xiaoying, Liao Yun, Liu Binya, Sun Jing, Wan Xiaoping(*). Mutant p53 (p53-R248Q) functions as an oncogene in promoting endometrial cancer by up-regulating REGgamma. Cancer Lett. 2015 May 1;360(2):269-79.
19． Xia Peng(#), Gao Jin, Guan Wen, Li Jingjing, Yu Xiaolan, Wang Fangyuan, He Honglin, Deng Qing, Zhou Liang, Yuan Yunsheng, Han Wei(*), Yu Yan(*). Production of bioactive recombinant rat soluble receptor for advanced glycation end products (rrsRAGE) in Pichia pastoris. Protein Expr Purif, 2017 Oct;138:81-87.
20． Zhu Minjiao(#), Che Qi, Liao Yun, Wang Huihui, Wang Jingyun, Chen Zheng, Wang Fangyuan, Dai Chenyun, Wan Xiaoping(*). Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis. Oncol Rep. 2015 Jul;34(1):129-38.
21． Che Qi(#), Liu Binya, Liao Yun, Zhang Huijuan, Yang Tingting, He Yinyan, Xia Yuhong, Lu Wen, He Xiaoying, Chen Zheng, Wang Fangyuan, Wan Xiaoping(*). Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17beta-estradiol biosynthesis in endometrial carcinoma microenvironment. Int J Cancer. 2014 Jul 15;135(2):282-94.
22． Liu Yuan(#), Murray-Stewart T, Casero RA Jr, Kagiampakis I, Jin L, Zhang J, Wang H, Che Qi, Tong Huan, Ke Jieqi, Jiang Feizhou, Wang Fangyuan, Wan Xiaoping(*). Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth. Int J Oncol. 2017 Jun;50(6):2011-2023.
23． Ke Jieqi(#), Yang Yixia(#), Che Qi, Jiang Feizhou, Wang Huihui, Chen Zheng, Zhu Minjiao, Tong Huan, Zhang Huilin, Yan Xiaofang, Wang X, Wang Fangyuan, Liu Yuan, Dai Chenyun, Wan Xiaoping(*). Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer. Tumour Biol. 2016 Sep;37(9):12203-12211.
24． Jiang Feizhou(#), He Yinyan, Wang Huihui, Zhang Huilin, Zhang Jian, Yan Xiaofang, Wang Xiaojun, Che Qi, Ke Jieqi, Chen Zheng, Tong Huan, Zhang Yongli, Wang Fangyuan, Li Yiran, Wan Xiaoping(*). Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing. Oncotarget, 2015 Dec 29;6(42):44660-74.
(#) First Author, (*) Correspondence Author.
Dr. Edgar Grinstein is a Principal Investigator at the Heinrich Heine University in Düsseldorf (Germany). He researches hematopoietic stem cells and progenitor cells, signal transduction, gene transcription regulation. He has more than 11 years of experience as Editor-In-Chief at SAGE Publications Inc. (USA) and Libertas Academica (New Zealand), and also serves as Deputy Editor-In-Chief for Baishideng Publishing Group (USA).
Raised in a family of researchers – both parents are PhD scientists - he received his PhD summa cum laude in Molecular Biology from the Humboldt University and the Max-Delbrück Center for Molecular Medicine in Berlin. He has published a number of papers in high-ranking journals and received a highly regarded Research Award from Dr.-Günther- and Imme-Wille-Foundation. Dr. Grinstein qualified as Professor in Molecular Medicine at the University of Düsseldorf in 2008 and is a Visiting Professor at the University of Latvia (Latvia, European Union) since 2010.
Dr. Grinstein`s research in the field of hematopoietic stem and progenitor cells, funded by research grants from German Research Foundation (DFG) and José Carreras Leukämie-Stiftung (José Carreras Foundation), has focused on markers, signal transduction and transcriptional control. Among other important findings made, his research group provided new insights into the role of the prominent surface marker AC133/CD133 (Leukemia 2015; 29: 2208-2220), that is expressed on stem/progenitor cells in normal hematopoiesis as well as on tumor-initiating cells in certain hematological malignancies. The study analyzed the control of AC133/CD133 expression in hematopoietic stem/progenitor cells, and revealed the impact thereof on molecular network relevant to these cells.
Research Interest: hematopoietic stem cells and progenitor cells, cancer stem cells, stem cell markers, signal transduction, cell cycle control, regulation of apoptosis, gene transcription regulation
Grants: Principal Investigator of stem cell-related projects funded by German Research Foundation (DFG) and by José Carreras Leukämie-Stiftung (José Carreras Foundation)
Grinstein, E., and H.-D. Royer. 1995. Multiple octamer-binding proteins are targets for the cell cycle regulated nuclear inhibitor I-92. DNA Cell Biol. 14: 493-500.
Grinstein, E., I. Weinert, B. Droese, M. Pagano, and H.-D. Royer. 1996. Cell cycle regulation of nuclear factor p92 DNA-binding activity by novel phase-specific inhibitors. J. Biol. Chem. 271: 9215-9222.
Bargou, R.C., C. Wagener, K. Bommert, W. Arnold, P.T. Daniel, M.Y. Mapara, E. Grinstein, H.-D. Royer, and B. Dörken. 1996. Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice. J. Exp. Med. 183: 1205-1213.
Bargou, R.C., F. Emmerich, D. Krappmann, K. Bommert, M.Y. Mapara, W. Arnold, H.-D. Royer, E. Grinstein, A. Greiner, C. Scheidereit, and B. Dörken. 1997. Constitutive nuclear factor kappaB-RelA activation is required for proliferation and survival of Hodkin’s desease tumor cells. J. Clin. Invest. 12: 2961-2969.
Janke, J., K. Schlüter, B. Jandrig, M. Theile, K. Kölble, W. Arnold, E. Grinstein, A. Schwartz, L.E. Schwarz, P.M. Schlag, B.M. Jockusch, and S. Scherneck. 2000. Suppression of tumoriginecity in breast cancer cells by the microfilament protein profilin1. J. Exp. Med. 191: 1675-1685.
Grinstein, E.,* F. Jundt, I. Weinert, P. Wernet, and H.-D. Royer. 2002. Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells. Oncogene. 21: 1485-1492.
Grinstein, E., P. Wernet, P.J. Snijders, F. Rösl, I. Weinert, W. Jia, R. Kraft, Ch. Schewe, M. Schwabe, S. Hauptmann, M. Dietel, Ch. Meijer, and H.-D. Royer. 2002. Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer. J. Exp. Med. 196: 1067-1078.
Grinstein, E.,* Y. Shan, L. Karawajew, P.J. Snijders, C.J. Meijer, H.-D. Royer, and P. Wernet. 2006. Cell cycle controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation. J. Biol. Chem. 281: 22223-22235.
Grinstein, E.,* Y. Du, S. Santourlidis, J. Christ, M. Uhrberg, and P. Wernet. 2007. Nucleolin regulates gene expression in CD34 positive hematopoietic cells. J. Biol. Chem. 282: 12439-12449.
Grinstein, E.,* and P. Wernet. 2007. Cellular signaling in normal and cancerous stem cells. Cell. Signal. 19: 2428-2433.
This was the most read article of the Journal Cell. Signal. from July 2007 till March 2008. Source: SCIENCEDIRECT TOP 25 HOTTEST ARTICLES
Wethkamp, N., H. Hanenberg, C. Suschek, W. Wetzel, S. Heikaus, E. Grinstein, U. Ramp, R. Engers, H. Gabbert, and C. Mahotka. 2011. DAXX-beta and DAXX-gamma: two novel splice variants of the transcriptional co-repressor DAXX. J. Biol. Chem. 19576-19588.
Grinstein, E.,* C. Mahotka, and A. Borkhardt. 2011. Rb and nucleolin antagonize in controlling human CD34 gene expression. Cell. Signal. 23: 1358-1365.
Bhatia, S., S. Reister, C. Mahotka, R. Meisel, A. Borkhardt, and E. Grinstein.* 2015. Control of AC133 / CD133 and impact on human hematopoietic progenitor cells through nucleolin. Leukemia. 29: 2208-2220.
Mahotka, C., S. Bhatia, J. Kollet, and E. Grinstein.* 2018. Nucleolin promotes execution of the hematopoietic stem cell gene expression program. Leukemia. 32: 1865–1868.
Reister, S., C. Mahotka, N. van den Höfel, and E. Grinstein.* 2019. Nucleolin promotes Wnt signaling in human hematopoietic stem/progenitor cells. Leukemia. 33: 1052-1054.
Research Interest: Stem Cell Injection, Cardiovascular Disease,
Medical Diffusion in Arteries, Hemodynamics.
Research Interest: Harnessed the Biological Principle that Pregnancy and
Hormones Mimicking Pregnancy Induced Breast Cancer Prevention. The Preventive Effect of Pregnancy is
Mediated by the Induction of Differentiation of the Mammary Gland. In Studies Performed in Humans, He has Found that
During the Post-Menopausal Years the Breast of Both Parous and Nulliparous
Women Contains Preponderantly Lob 1 that Differs Biologically By Exhibiting
Different Susceptibility to Carcinogenesis, And Remodeling Of Chromatin That
Emerges As Novel Marker For Defining The Concept Of Differentiation In The
Adult Breast. His Laboratory Has Studied
The Genomic Profile Of Nulliparous And Parous Women In The Premenopausal And
Postmenopausal Period And Find That There Are Genes Only Activated During The
First Five Years After Pregnancy That May Contribute To The Increased Risk
Experimented By Certain Women After Pregnancy And At The Same Time They Have
Confirmed That Pregnancy Induces A Long Lasting Genomic Signature That Start
After Pregnancy That Explain Its Preventive Effect. The Molecular Mechanism
Related To Prevention Is Around The Chromatin Remodeling Process. Using The In
Vitro In Vivo Model Developed In His Laboratory He Is Identifying Drugs That
Can Control Chromatin Remodeling As A Preventive Strategy.
Research Interest: Stem Cell Biology; Breast Cancer Dormancy; Neural
Regulation of Hematopoiesis, the Immunology and Clinical Application of Adult
Human Mesenchymal Stem Cells.
Two Major Projects are Currently Underway in the Laboratory.
A Cell Reprogramming Technique Has Been Used to Convert Heterogeneous Malignant Breast Cancer Cells into Induced Pluripotent Stem Cells Using Sox2/Oct4/Nanog Proteins. Dr. Wu’s Laboratory is Clarifying these Induced Pluripotent Stem Cells for their Differentiation Potential and Oncogenic Properties, and Try to Develop a Novel Cell Converting Therapy for Malignant Breast Cancer Treatment.
Metastasis, the Spread of Cancer Cells from the Primary Tumor To Distant Organs, Is The Most Dreadful Development Of Breast Cancer, As Well As Other Neoplastic Diseases. Although Metastasis Contributes To Over 90% Of Human Cancer Mortality, The Molecular Mechanism Of This Process Remains Largely Unknown. Dr. Wu’s Laboratory Is In The Process Of Identifying Molecular Signatures Involved In Breast Cancer Metastasis Using Integrative Genetic, Epigenetic And Proteomic Approach, As Well As Animal Models And Clinical Specimens.
Research Interest: Cancer Biology, Cell Biology, Breast Cancer, Cancer
Prevention, Anti-Cancer Drug Development, Cancer Metastasis, Transcription
Factors, Kinase, Glucose Metabolism.
Research Interest: In his Consulting Experience, Devyn Led a Wide
Range of Projects, Across Multiple Therapeutic Areas and a Host of Technology
Platforms, Including Basic R&D Tools, Regenerative Medicine, Gene Therapy and
Research Interest: Primarily in the Area of Behavioral Neuroscience.
Research Interest: Fate Decisions of Embryonic Stem Cell, Induced
Pluripotent Stem Cell (ESC/Ips): Pluripotency and Direct Lineage Specification to
the Three Germ Layers.
Research Interest: Centered on Translational Oncology with Main
Emphasis on Identification of Novel Targets in Cancer Stem Cells, Validation of
Targeted Cancer Therapeutics, Nanomedicine and Drug Development Program.
Research Interest: Embryonic Stem Cells, Pluripotency, Induced Pluripotent
Cells, Differentiation, Endoderm, Beta Cell, Diabetes, Obesity, Adipose Tissue,
Brown Fat, Endothelium, Oxidative Stress, Nitric Oxide, Peroxynitrite, Superoxide,
Research Interest: Cardiology, Toxicology, Epigenetics, Stem Cell
Differentiation, and Bioinformatics.
Research Interest: Regenerative Biology (Marine Invertebrates and
Mammals), Stem Cell Biology, Developmental Biology.
Research Interest: Cancer Stem Cell, Anticancer Agent, Metastasis, Cell
Survival, Cell Migration, Apoptosis, Molecular and Cell Signaling, Transcription
Factors, Xenograft Model, Stem Cell Based Therapy.
Research Interest: Cell Biology, Genetics, Cancer Research, Cancer Biology, Cell Culture, PCR, Gene Regulation, Signaling Pathways
Research Interest: Cardiac Therapy, Cardiovascular Disease,
Autologous, Tissue-Engineering, Multipotent Stem Cells, Cardiovascular
Structures, Regenerative Medicine.
Research Interest: Leptin Receptors (Lepr) are Expressed by Various
Types of Stem Cells Including Mesenchymal Stem Cells, Hematopoietic Stem Cells,
Embryonic Stem Cells and Induced Pluripotent Stem Cells. Leptin/Lepr Signaling
is also a Central Regulator of Metabolism.
Research Interest: Drug Discovery and Development.
Research Interest: ES/Ips Cells; Skeletal Muscle Regeneration; Gene and
Cell Therapy; Genome Editing; Gene Targeting.
Research Interest: Cancer Stem Cells, Ocular Stem Cells
Research Interest: Nanotechnology, Bioanalytical chemistry, infectious disease diagnosis, cellular analysis
Research Interest: Neurology
Research Interest: Cancer Metabolism, Metabolomics, NMR and MRI Methods,
Research Interest: Therapeutic Application of ES and Ips Cells.
Research Interest: Clinical Pharmacology, Gastroenterology, Pharmaceutical Development, Drug Development, Colorectal Cancer, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease
Research Interest: Effects of Chinese Herbal Medicine on Osteogenesis
and Adipogenesis of Mesenchymal Stem Cells, Inhibitory Effects of Chinese Herbal
Medicine on RANKL-Induced Osteoclastgenesis of RAW264.7 Cells, Effect of Chinese
Herbal Medicine on Different Osteoporotic Rat Models, Establishment of the
Screening Platform for Neuro-Regenerative Chinese Herbal Medicine by Using Rat
Mesenchymal Stem Cells, Topical Application of Chinese Medicine in
Musculoskeletal Injuries, Wound Healing, Cancer Stem Cells, Neuroprotection.
Involved in Cell Cycle Regulation, Differentiation, Apoptosis and Senescence
Such as the Retinoblastoma (RB) Family. He has Evaluated the Role of Retinoblastoma
Genes in the Regulation of Cell Proliferation, Differentiation and Apoptosis in
Cancer and Normal Stem Cells. In Detail, his Group has Analyzed the Biology of Neural Stem Cells and Mesenchymal Stem Cells. These Studies Prompted the Attention Also on Chromatin
Remodeling Factors that Interact with RB Family Members and Play a Key Role in the Life of StemCells.
Years She Extended her Initial Research Interests on Endothelial Progenitor
Cell (EPC) Biology and their Potential use in Regenerative Medicine.
Research Interest: As Is Clear From The Biography, Shigetaka Asano Accomplisheddistinguished
Performance In Research Based On Medical Needs By Full Of Enthusiasm With
State-Of-The-Art New Technology, Such As 1. Verification Of Existence Of Rabbit
Neutrophil Cell Membrane Knack+-Atpase, 2. Discovery Of Laterarity Of Mouse
Intestinal Mucous Membrane Proteins, 3. Finding Of Human Tumor Cell Mediated By
Granulocyte Colony-Stimulating Factor (G-CSF; Bioactive Substance To Stimulate
Differentiation, Proliferation And Functional Activity Of Neutrophil), 4. Analysis
Of Human G-CSF Activity, 5. Succeeding In Incubation Of Human Tumor
Infiltrating T Lymphocyte Colony, 6. Discovery Of Allogenicimmunosuppression Of
Placenta Decidual Cells, 7. Differentiation Induction Of Mesenchymalstem Cell,
8. Cloning Of G-Csfcdna And Development Of Recombinant Human Native G-CSF (Lenograstim)
As The 1st Generation Biomedicine, 9. Constitution Of International Clinical
Guideline For Transplantation Of Bone-Marrow And Cord Blood, And Construction
Of Public Bank Of Bone-Marrow And Cord Blood, 10. Non-Clinical Study Of Human
Granulocyte Colony-Stimulating Factor (GM-CSF; Bioactive Substance To Stimulate
Differentiation, Proliferation And Functional Activity Of Macrophage Besides
Neutrophil)Immunogene Therapy And Execution Of The Phase Iia Clinical Study,
11. Non-Clinical Study Of Utilizing Maxizyme For Immunogene Therapy Of Myeloid
Leukemia Cell, 12. Acquisition And Molecular Analysis Of Leukemia Stem Cell
Like Property By Stochastic Adhesion Of In Vitro Human Myelogenous Leukemic
Cell Line Cell And Stromal Cell, 13. Pathological Analysis Of Mesenchymalstem
Cell(Parental Cell Of Range Of Cell Consist Ofstroma) Differentiation And
Proliferation In Translin(Substance Found As Molecule To Bind Fusion Gene Of
Lymphatic Leukemia) Knockout Mouse.
Research Interest: Bone Marrow
Transplantation, Immunology, Autoimmunity, Thymus and Bone Marrow
Derived-Mesenchymal Stem Cells. His Cutting-Edge Technology for Bone Marrow
Cell Harvesting and Intra-Bone Marrow-Bone Marrow Transplantation has Led to
Significant Research Into Allogeneic Stem Cell Transplantation.
Research Interest: Resident Cardiac Stem Cells, Myocardial
Regeneration in Basic and Clinical/Translational Studies.
Research Interest: Focuses on Aging-Related Diseases and Stem Cell
Research Interest: Neurological Disability.
Research Interest: Neuropsychopharmacology of Lipid Transmitters (CTS643,
Andalusian Ministry of Economy, Innovation, Science and Employment): The Group is
Formed in the University Regional Hospital of Malaga, in Collaboration with the
University of Malaga, and Integrated Into the Biomedical Research Institute of Malaga
(IBIMA). Our Interest Focuses on the Role that Regulatory Lipid Molecules,
Mainly Lysophosphatidic Acid, Exerted on the Central Nervous System and Related
Mainly to the Neural Genesis (Neurogenesis / Gliogenesis) and its Effect on
Behavioral Level. It Also Examines the Role of Lysophosphatidic Acid in the
Dynamic Processes that Regulate Neuroinflammation and Demyelination in Multiple
Sclerosis, Studying Animal Models and Samples from Patients with Multiple
Sclerosis, As Well As Mesenchymal Cell Therapy for the Disease.
Dr. Monther AlAlwan is a scientist at the Stem Cell and Tissue Re-engineering Program (SCTRP), King Faisal Specialist Hospital and Research Centre, as well as an Associate professor at Alfaisal University, Riyadh Saudi Arabia. He holds M.Sc. and Ph.D. in Immunology from Dalhousie University (Halifax, Canada). Dr. AlAlwan conducted a 3-years postdoctoral fellowship studying signaling in immune cells at the University of Manitoba, Canada. During his graduate studies and postdoctoral fellowship, Dr. AlAlwan made substantial contribution in the immunology field, particularly his groundbreaking discovery that highlighted the significance of the dendritic cells in the immunological synapse. After joining the SCTRP in 2007, he shifted gear to study cancer, where he identified novel mechanisms that regulate cancer metastasis and chemoresistance. Currently, he is actively involved in dissecting the molecular pathways that regulate the function of cancer stem cells and how this related to chemoresistance and metastasis. Dr. AlAlwan is an author in 20 peer-reviewed publications, has delivered several invited lectures and is a regular reviewer for various international journals.
Research Interest: Tumor Immunology and Immunotherapy, Cancer Stem
Cell Biology and Immunology, Obstetrics and Gynecology.
Research Interest: Clinical Nephrology, Metabolic Syndrome, Hypertension, Inflammation
Research Interest: Actually Works
as Young Researcher in Projects Regarding Genomics, Proteomics and Inflammatory
Aspects of Human Breast Cancer and Chronic Diseases.
Research Interest: Hematopoietic Stem Cell Transplanting, Cell Therapy
and Everything in the Field of Publication and Education.
Ricardo Alaxandre de Azevedo, PhD, Graduated in Biological Science by the University ‘Santa Cecília’- Santos (Brazil) in 2002, MSc degree in Biotechology by the University of São Paulo (Brazil) in 2010, and Ph.D. in Toxinology by the Butantan Institute (Brazil) in 2014. Presently, Postdoctoral Fellow, Department Immunology, Laboratory of Tumor Immunology, University São Paulo, July 2014-current. Also occupy position of Research Scientist, and Coordinator of Biological Assays Division at ALCHEMY, RESEARCH AND DEVELOPMENT, February-current. I have experience and scientific production in the area of Apoptosis and cell cycle signaling, peptides and peptidases, molecular biology and cancer genetics, cells immunology, with emphasis on biochemotherapy and immunotherapy of cancer, focusing murine melanoma and human tumors.
Research Interest: Cancer Stem Cell, such as Surface Marker, Biology,
Research Interest: Stem Cells, Cancer, Immune Therapy, Regenerative Medicine.
Research Interest: Guo Was Engaged in Research into the Induction of
Transplant Tolerance Via Bone Marrow Transplantation under the Guidance of Prof.
Research Interest: Cell Reprogramming and Induced Pluripotent Stem
Cells, Stem Cells and Neural Tissue Engineering, Mammalian Inner Ear
Development and Hair Cell Regeneration.
Malgorzata Gabriela WASNIEWSKA
University of Messina, Italy
International Journal of Clinical Endocrinology and Metabolism
Southeastern University, China
Trends in Computer Science and Information Technology
ReGenera R&D International for Aging Intervention & San Babila Clinic, Milano, Italy
Archives of Clinical Gastroenterology
University of Siena, Italy
International Journal of Oral and Craniofacial Science
Metaxas Memorial Anticancer Hospital , Greece
Annals of Bone Marrow Research
Rafal Tomasz Pawliczak
Medical University of Lodz, Poland
Open Journal of Asthma
Catholic University of Rome, Italy
Open Journal of Orthopedics and Rheumatology
Osmar Antonio Centurion
Asuncion National University, Paraguay
Global Journal of Medical and Clinical Case Reports
Wei Min HUANG
Nanyang Technological University, Singapore
Archive of Biomedical Science and Engineering
Samy I. McFarlane
State University of New York, Downstate Medical Centre, Brooklyn, New York, USA
International Journal of Clinical Endocrinology and Metabolism