Editorial Board

    Fangyuan Wang
    Medical Research Scientist
    Center for Autoimmune Disease Research, Institute of Rheumatology Research, Department of Rheumatology; Renji Hospital
    Shanghai Jiaotong University
    China
    sunflowerwang@hotmail.com
    SSCRT

    EDUCATION

    2006 – 2009

    M.S. in Microbiological and Biochemical Pharmacy

    Shanghai Jiaotong University, Shanghai, China

    2001 - 2005

    B.S. in Biotechnology (Fermentation Engineering)

    Shanghai Normal University, Shanghai, China

    Research Interest:

      CRISPR technology

    Stem Cell Research and Therapy

    Gynecological Disease Research

    Autoimmune Disease Research


    RESEARCH INTERESTS AND SKILLS

    My scientific interests are to understand how genetic and molecular programs can yield the complex biological behaviors. As a medical research scientist, synthetic biologist and bioengineer, I am passionate about the applications of diverse biotechnological tools to understand genomics and explore the mechanism of genomic control as well as incidence of diseases, which allow comprehensive understanding, manipulating, and engineering of sophisticated biological systems. I aim to understand cellular or organismal behaviors in both space and time thus benefit the biomedical research, translational studies and cell therapy.
    I am skilled in cell culture (primary/linage) and cellularity detections (CCK8, FACS etc); molecular cloning and detection (plasmid construction, RT-PCR, western blot etc); protein [removed]prokaryotic expression system) and purification (ionexchange and affinity chromatography); immunohistochemistry and immunocytochemistry detection; and animal model construction.


    Research Grant Details:

    National Natural Science Foundation of China (Grant No. 81502233)

    Existing evidence indicates that PPI (protein-protein interaction) contributes to the tumorigenesis of endometrial carcinoma, but the mechanisms involved in it remain largely unknown. In our previous study, we found that ATF3 participating in the development of various different kinds of cancer, expressed higher in the epithelium of normal endometrial tissue than that detected in pathnological tissue, and interacted with JunB which expressing higher in the epithelium of endometrial cancer tissue than that detected in normal endometrial tissue, via yeast-two-hybrid assay. Additionally, over-expression of ATF3 led to the inhibition of cell proliferation, migration and invasion, with the down-regulation of JunB and inflammatory factor. Therefore, we put forward a hypothesis that ATF3 might inhibit the expression of inflammatory genes and the development of endometrial cancer by binding with JunB andmitigating with it. This study was designed to utilize the mRNA expression microarray analysis, CRISPR/Cas9 and orthotopic endometrial carcinoma model in nude mice combined with molecular biological techniques to explore the cell signal transductions of ATF3 and JunB in EC, demonstrate the mechanism of development of EC, and provide new therapeutic targets for it, which contributes greatly to the patients suffering from endometrial cancer.

    PUBLICATIONS

    1.    Wang Fangyuan(#), Qi Stanley Lei(*). Applications of CRISPR Genome Engineering in Cell Biology. Trends in Cell Biology. 2016 Nov;26(11):875-888.

    2.    Wang Fangyuan(#), Zhao Dehua, Qi Lei Stanley(*). Application of genome engineering in medical synthetic biology. Sheng Wu Gong Cheng Xue Bao. 2017 Mar 25;33(3):422-435.

    3.    Wang Fangyuan(#), Gao Jin, Malisani Alyssa, Xi Xiaowei, Han Wei, Wan Xiaoping (*), Mouse Resistin (mRetn): cloning, expression and purification in Escherichia coli and the potential regulative effects on murine bone marrow hematopoiesis. BMC Biotechnol, 2015 Nov 16;15(1):105.

    4.    Wang Fangyuan(#), Wang Li, Yao Xiaofen, Lai Dongmei(*). Human amniotic epithelial cells can differentiate to granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure. Stem Cell Res Ther. 2013 Oct 14;4(5):124-134.

    5.    Liu Yanxia(#), Yu Chen(#), Daley Timothy Patrick(#), Wang Fangyuan, Cao William S., Bhate Salil, Lin Xueqiu, Still II Chris, Liu Honglei, Zhao Dehua, Wang Haifeng, Xie Xinmin S., Ding Sheng, Wong Wing Hung, Wernig Marius, Qi Lei Stanley. CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. Cell Stem Cell. 2018 Nov 1;23(5):758-771.

    6.    Yan Qin(#), Wang Fangyuan, Miao Yi, Wu Xiaomei, Bai Mingzhu, Xi Xiaowei, Feng Youji(*). Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase. Tumour Biol. 2016 Sep;37(9):12263-12271.

    7.    Lai Dongmei(#)(*), Wang Fangyuan, Yao Xiaofen, Zhang Qiuwan, Wu Xiaoxing, Xiang Charlie(*). Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure. J Transl Med. 2015 May 12;13:155.

    8.    Lai Dongmei(#)(*), Wang Fangyuan, Dong Zhangli, Zhang Qiuwan. Skin-derived mesenchymal stem cells help restore function to ovaries in a premature ovarian failure mouse model. PLoS One. 2014 May 30;9(5):e98749.

    9.    Lai Dongmei(#)(*), Wang Fangyuan, Chen Yifei, Wang Li, Wang Yanlin, Cheng Weiwei. Human amniotic fluid stem cells have a potential to recover ovarian function in mice with chemotherapy-induced sterility. BMC Dev Biol. 2013 Sep 4;13(1):34.

    10.    Lai Dongmei(#)(*), Wang Fangyuan, Chen Yifei, Wang Chunhui, Liu Sha, Lu Bufeng, Ge Xuerui, Guo Lihe. Human ovarian cancer stem-like cells can be efficiently killed by γδ T lymphocytes. Cancer Immunol Immunother. 2012 Jul;61(7):979-89.

    11.    Che Qi(#), Liu Binya, Wang Fangyuan, He Yinyan, Lu Wen, Liao Yun, Gu Wei, Wan Xiaoping(*). Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERK-NF-kappaB signaling pathway. Biochem Biophys Res Commun, 2014, 446(1):167-172.

    12.    Lai Dongmei(#)(*), Ma Li, Wang Fangyuan. Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells. Int J Oncol. 2012 Aug;41(2):541-50.

    13.    Lai Dongmei(#)(*), Chen Yifei, Wang Fangyuan, Jiang Lizhen, Wei Chunsheng. LKB1 Controls the Pluripotent State of Human Embryonic Stem Cells. Cellular Reprogramming. April 2012, 14(2): 164-170.

    14.    Chen Zheng(#), Che Qi, He Xiaoying, Wang Fangyuan, Wang Huihui, Zhu Minjiao, Sun Jing(*), Wan Xiaoping(*). Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition. BMC Cancer, 2015 Oct 27;15:811.

    15.    Chen Zheng(#), Che Qi, Jiang Feizhou, Wang Huihui, Wang Fangyuan, Liao Yun, Wan Xiaoping(*). Piwil1 causes epigenetic alteration of PTEN gene via upregulation of DNA methyltransferase in type I endometrial cancer. Biochem Biophys Res Commun, 2015 Aug 7;463(4):876-80.

    16.    Liao Yun(#), He Xiaoying, Qiu Haifeng, Che Qi, Wang Fangyuan, Lu Wen, Chen Zheng, Qiu Meiting, Wang Jingyun, Wang Huihui, Wan Xiaoping(*). Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer. BMC Cancer. 2014, 14:487。

    17.    Huang Haili(#), Wang Yajing, Zhang Qingyu, Liu Bin, Wang Fangyuan, Li Jingjing, Zhu Runzhi(*). Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice. World J Gastroenterol 2012 Dec 7;18(45):6605-6613.

    18.    Wang Huihui(#), Bao Wei, Jiang Feizhou, Che Qi, Chen Zheng, Wang Fangyuan, Tong Huan, Dai Chenyun, He Xiaoying, Liao Yun, Liu Binya, Sun Jing, Wan Xiaoping(*). Mutant p53 (p53-R248Q) functions as an oncogene in promoting endometrial cancer by up-regulating REGgamma. Cancer Lett. 2015 May 1;360(2):269-79.

    19.    Xia Peng(#), Gao Jin, Guan Wen, Li Jingjing, Yu Xiaolan, Wang Fangyuan, He Honglin, Deng Qing, Zhou Liang, Yuan Yunsheng, Han Wei(*), Yu Yan(*). Production of bioactive recombinant rat soluble receptor for advanced glycation end products (rrsRAGE) in Pichia pastoris. Protein Expr Purif, 2017 Oct;138:81-87.

    20.    Zhu Minjiao(#), Che Qi, Liao Yun, Wang Huihui, Wang Jingyun, Chen Zheng, Wang Fangyuan, Dai Chenyun, Wan Xiaoping(*). Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis. Oncol Rep. 2015 Jul;34(1):129-38.

    21.    Che Qi(#), Liu Binya, Liao Yun, Zhang Huijuan, Yang Tingting, He Yinyan, Xia Yuhong, Lu Wen, He Xiaoying, Chen Zheng, Wang Fangyuan, Wan Xiaoping(*). Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17beta-estradiol biosynthesis in endometrial carcinoma microenvironment. Int J Cancer. 2014 Jul 15;135(2):282-94.

    22.    Liu Yuan(#), Murray-Stewart T, Casero RA Jr, Kagiampakis I, Jin L, Zhang J, Wang H, Che Qi, Tong Huan, Ke Jieqi, Jiang Feizhou, Wang Fangyuan, Wan Xiaoping(*). Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth. Int J Oncol. 2017 Jun;50(6):2011-2023.

    23.    Ke Jieqi(#), Yang Yixia(#), Che Qi, Jiang Feizhou, Wang Huihui, Chen Zheng, Zhu Minjiao, Tong Huan, Zhang Huilin, Yan Xiaofang, Wang X, Wang Fangyuan, Liu Yuan, Dai Chenyun, Wan Xiaoping(*). Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer. Tumour Biol. 2016 Sep;37(9):12203-12211.

    24.    Jiang Feizhou(#), He Yinyan, Wang Huihui, Zhang Huilin, Zhang Jian, Yan Xiaofang, Wang Xiaojun, Che Qi, Ke Jieqi, Chen Zheng, Tong Huan, Zhang Yongli, Wang Fangyuan, Li Yiran, Wan Xiaoping(*). Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing. Oncotarget, 2015 Dec 29;6(42):44660-74.

    (#) First Author, (*) Correspondence Author.


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    John P Abraham
    Professor
    University of St. Thomas
    USA
    JPABRAHAM@stthomas.edu
    SSCRT

    Research Interest: Stem Cell Injection, Cardiovascular Disease, Medical Diffusion in Arteries, Hemodynamics.

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    Jose Russo
    Professor
    Temple University
    USA
    Jose.Russo@fccc.edu
    SSCRT

    Research Interest: Harnessed the Biological Principle that Pregnancy and Hormones Mimicking Pregnancy Induced Breast Cancer Prevention.  The Preventive Effect of Pregnancy is Mediated by the Induction of Differentiation of the Mammary Gland.  In Studies Performed in Humans, He has Found that During the Post-Menopausal Years the Breast of Both Parous and Nulliparous Women Contains Preponderantly Lob 1 that Differs Biologically By Exhibiting Different Susceptibility to Carcinogenesis, And Remodeling Of Chromatin That Emerges As Novel Marker For Defining The Concept Of Differentiation In The Adult Breast.  His Laboratory Has Studied The Genomic Profile Of Nulliparous And Parous Women In The Premenopausal And Postmenopausal Period And Find That There Are Genes Only Activated During The First Five Years After Pregnancy That May Contribute To The Increased Risk Experimented By Certain Women After Pregnancy And At The Same Time They Have Confirmed That Pregnancy Induces A Long Lasting Genomic Signature That Start After Pregnancy That Explain Its Preventive Effect. The Molecular Mechanism Related To Prevention Is Around The Chromatin Remodeling Process. Using The In Vitro In Vivo Model Developed In His Laboratory He Is Identifying Drugs That Can Control Chromatin Remodeling As A Preventive Strategy.

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    Pranela Rameshwar
    Professor
    Departmebt of Medicine-Hematology/Oncology
    Rutgers-New Jersey Medical School
    USA
    rameshwa@njms.rutgers.edu
    SSCRT

    Research Interest: Stem Cell Biology; Breast Cancer Dormancy; Neural Regulation of Hematopoiesis, the Immunology and Clinical Application of Adult Human Mesenchymal Stem Cells. 

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    Guojun Wu
    Associate Professor
    Department of Oncology
    Wayne State University School of Medicine
    USA
    wugu@karmanos.org
    SSCRT

    Research Interest:

    Two Major Projects are Currently Underway in the Laboratory.
    A Cell Reprogramming Technique Has Been Used to Convert Heterogeneous Malignant Breast Cancer Cells into Induced Pluripotent Stem Cells Using Sox2/Oct4/Nanog Proteins. Dr. Wu’s Laboratory is Clarifying these Induced Pluripotent Stem Cells for their Differentiation Potential and Oncogenic Properties, and Try to Develop a Novel Cell Converting Therapy for Malignant Breast Cancer Treatment.
    Metastasis, the Spread of Cancer Cells from the Primary Tumor To Distant Organs, Is The Most Dreadful Development Of Breast Cancer, As Well As Other Neoplastic Diseases. Although Metastasis Contributes To Over 90% Of Human Cancer Mortality, The Molecular Mechanism Of This Process Remains Largely Unknown. Dr. Wu’s Laboratory Is In The Process Of Identifying Molecular Signatures Involved In Breast Cancer Metastasis Using Integrative Genetic, Epigenetic And Proteomic Approach, As Well As Animal Models And Clinical Specimens. 

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    Qiang Shen
    Assistant Professor
    Department of Clinical Cancer Prevention
    University of Texas MD Anderson Cancer Center
    USA
    qshen@mdanderson.org
    SSCRT

    Research Interest: Cancer Biology, Cell Biology, Breast Cancer, Cancer Prevention, Anti-Cancer Drug Development, Cancer Metastasis, Transcription Factors, Kinase, Glucose Metabolism.

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    Devyn M Smith
    Pharma Therapeutics Division
    Worldwide Research and Development
    USA
    Devyn.M.Smith@pfizer.com
    SSCRT

    Research Interest: In his Consulting Experience, Devyn Led a Wide Range of Projects, Across Multiple Therapeutic Areas and a Host of Technology Platforms, Including Basic R&D Tools, Regenerative Medicine, Gene Therapy and Macromolecules/Biologic Products.

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    Gary L Dunbar
    Director
    Brain Research Laboratory
    Central Michigan University
    USA
    gdunbar@stmarysofmichigan.org
    SSCRT

    Research Interest: Primarily in the Area of Behavioral Neuroscience.

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    Dong Li
    Department of Cell and Developmental Biology
    University of Illinois
    USA
    dongly@illinois.edu
    SSCRT

    Research Interest: Fate Decisions of Embryonic Stem Cell, Induced Pluripotent Stem Cell (ESC/Ips): Pluripotency and Direct Lineage Specification to the Three Germ Layers.

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    Bhuvnesh K Sharma
    Senior Director
    Department of Translational Oncology
    ScyTek Labs.Inc.
    USA
    bkumar111@hotmail.com
    SSCRT

    Research Interest: Centered on Translational Oncology with Main Emphasis on Identification of Novel Targets in Cancer Stem Cells, Validation of Targeted Cancer Therapeutics, Nanomedicine and Drug Development Program.

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    Han Wang
    Department of Cellular and Structural Biology
    University of Texas
    USA
    cherrywangh@hotmail.com
    SSCRT

    Research Interest: Embryonic Stem Cells, Pluripotency, Induced Pluripotent Cells, Differentiation, Endoderm, Beta Cell, Diabetes, Obesity, Adipose Tissue, Brown Fat, Endothelium, Oxidative Stress, Nitric Oxide, Peroxynitrite, Superoxide, Nanosensors.

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    Xiefan Fang
    Department of Pediatrics
    University of Florida
    USA
    xiefanfang@ufl.edu
    SSCRT

    Research Interest: Cardiology, Toxicology, Epigenetics, Stem Cell Differentiation, and Bioinformatics.

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    Yuval Rinkevich
    Department of Pathology
    Stanford University
    USA
    yuvalrinkevich@gmail.com
    SSCRT

    Research Interest: Regenerative Biology (Marine Invertebrates and Mammals), Stem Cell Biology, Developmental Biology.

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    Ambrish Kumar
    Department of Pathology, Microbiology and Immunology
    University of South Carolina
    USA
    Ambrish.Kumar@uscmed.sc.edu
    SSCRT

    Research Interest: Cancer Stem Cell, Anticancer Agent, Metastasis, Cell Survival, Cell Migration, Apoptosis, Molecular and Cell Signaling, Transcription Factors, Xenograft Model, Stem Cell Based Therapy.

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    Zhong Ye
    Department of Medical Oncology
    Thomas Jefferson University
    USA
    Zhong.Ye@jefferson.edu
    SSCRT

    Research Interest: Cell Biology, Genetics, Cancer Research, Cancer Biology, Cell Culture, PCR, Gene Regulation, Signaling Pathways

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    Valarmathi Mani Thiruvanamalai
    Department of Comparative Biosciences
    University of Illinois
    USA
    valarmathi64@hotmail.com
    SSCRT

    Research Interest: Cardiac Therapy, Cardiovascular Disease, Autologous, Tissue-Engineering, Multipotent Stem Cells, Cardiovascular Structures, Regenerative Medicine.

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    Manoj Gupta
    Research Fellow
    Joslin Diabetes Center
    USA
    manoj.gupta@joslin.harvard.edu
    SSCRT

    Research Interest: Leptin Receptors (Lepr) are Expressed by Various Types of Stem Cells Including Mesenchymal Stem Cells, Hematopoietic Stem Cells, Embryonic Stem Cells and Induced Pluripotent Stem Cells. Leptin/Lepr Signaling is also a Central Regulator of Metabolism.

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    Praveen Shukla
    Department of Radiology and Medicine
    Stanford University School of Medicine
    USA
    praveenniper@gmail.com
    SSCRT

    Research Interest: Drug Discovery and Development.

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    Jianbo Wu
    Postdoctoral Fellow
    University of Texas Health Science Center at Houston
    USA
    Jianbo.Wu@uth.tmc.edu
    SSCRT

    Research Interest: ES/Ips Cells; Skeletal Muscle Regeneration; Gene and Cell Therapy; Genome Editing; Gene Targeting. 

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    Yongqing Liu
    Assistant Professor
    Department of Ophthalmology and Visual Sciences
    University of Louisville
    USA
    yongqing.liu@louisville.edu
    SSCRT

    Research Interest: Cancer Stem Cells, Ocular Stem Cells

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    XiuJun (James) Li
    University of Texas at El Paso
    USA
    xli4@utep.edu
    SSCRT

    Research Interest: Nanotechnology, Bioanalytical chemistry, infectious disease diagnosis, cellular analysis

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    Lixin Kan
    Adjunct Professor
    University of Chicago IL
    USA
    l-kan@northwestern.edu
    SSCRT

    Research Interest: Neurology

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    Madhu Basetti
    Research Scientist
    Department of Molecular Imaging Group
    University of Cambridge
    UK
    Madhu.Basetti@cruk.cam.ac.uk
    SSCRT

    Research Interest: Cancer Metabolism, Metabolomics, NMR and MRI Methods, Systems Biology.

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    Filomain Nguemo
    Institute of Neurophysiology
    Medical School University of Cologne
    Germany
    filo.nguemo@uni-koeln.de
    SSCRT

    Research Interest: Therapeutic Application of ES and Ips Cells.

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    George Kolios
    Professor
    Head of the Laboratory of Pharmacology
    Democritus University of Thrace
    Greece
    gkolios@med.duth.gr
    SSCRT

    Research Interest: Clinical Pharmacology, Gastroenterology, Pharmaceutical Development, Drug Development, Colorectal Cancer, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease

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    Ko Chun Hay
    Scientific Officer
    Chinese University
    Hong Kong
    gohey@cuhk.edu.hk
    SSCRT

    Research Interest: Effects of Chinese Herbal Medicine on Osteogenesis and Adipogenesis of Mesenchymal Stem Cells, Inhibitory Effects of Chinese Herbal Medicine on RANKL-Induced Osteoclastgenesis of RAW264.7 Cells, Effect of Chinese Herbal Medicine on Different Osteoporotic Rat Models, Establishment of the Screening Platform for Neuro-Regenerative Chinese Herbal Medicine by Using Rat Mesenchymal Stem Cells, Topical Application of Chinese Medicine in Musculoskeletal Injuries, Wound Healing, Cancer Stem Cells, Neuroprotection.

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    Umberto Galderisi
    Professor
    Department of Experimental Medicine
    University of Naples
    Italy
    umberto.galderisi@unina2.it
    SSCRT

    Research Interest: Genes Involved in Cell Cycle Regulation, Differentiation, Apoptosis and Senescence Such as the Retinoblastoma (RB) Family. He has Evaluated the Role of Retinoblastoma Genes in the Regulation of Cell Proliferation, Differentiation and Apoptosis in
    Cancer and Normal Stem Cells. In Detail, his Group has Analyzed the Biology of Neural Stem Cells and Mesenchymal Stem Cells. These Studies Prompted the Attention Also on Chromatin
    Remodeling Factors that Interact with RB Family Members and Play a Key Role in the Life of StemCells.

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    Maria Cristina Vinci
    Senior Scientist
    Laboratory of Cardiovascular Tissue Engineering
    University of Florence
    Italy
    cristina.vinci@ccfm.it
    SSCRT

    Research Interest: During those Years She Extended her Initial Research Interests on Endothelial Progenitor Cell (EPC) Biology and their Potential use in Regenerative Medicine. 

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    Shigetaka Asano
    Professor
    Department of Systemic Bio-Pathology
    Kobe University
    Japan
    asgtkmd@waseda.jp
    SSCRT

    Research Interest: As Is Clear From The Biography, Shigetaka Asano Accomplisheddistinguished Performance In Research Based On Medical Needs By Full Of Enthusiasm With State-Of-The-Art New Technology, Such As 1. Verification Of Existence Of Rabbit Neutrophil Cell Membrane Knack+-Atpase, 2. Discovery Of Laterarity Of Mouse Intestinal Mucous Membrane Proteins, 3. Finding Of Human Tumor Cell Mediated By Granulocyte Colony-Stimulating Factor (G-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Neutrophil), 4. Analysis Of Human G-CSF Activity, 5. Succeeding In Incubation Of Human Tumor Infiltrating T Lymphocyte Colony, 6. Discovery Of Allogenicimmunosuppression Of Placenta Decidual Cells, 7. Differentiation Induction Of Mesenchymalstem Cell, 8. Cloning Of G-Csfcdna And Development Of Recombinant Human Native G-CSF (Lenograstim) As The 1st Generation Biomedicine, 9. Constitution Of International Clinical Guideline For Transplantation Of Bone-Marrow And Cord Blood, And Construction Of Public Bank Of Bone-Marrow And Cord Blood, 10. Non-Clinical Study Of Human Granulocyte Colony-Stimulating Factor (GM-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Macrophage Besides Neutrophil)Immunogene Therapy And Execution Of The Phase Iia Clinical Study, 11. Non-Clinical Study Of Utilizing Maxizyme For Immunogene Therapy Of Myeloid Leukemia Cell, 12. Acquisition And Molecular Analysis Of Leukemia Stem Cell Like Property By Stochastic Adhesion Of In Vitro Human Myelogenous Leukemic Cell Line Cell And Stromal Cell, 13. Pathological Analysis Of Mesenchymalstem Cell(Parental Cell Of Range Of Cell Consist Ofstroma) Differentiation And Proliferation In Translin(Substance Found As Molecule To Bind Fusion Gene Of Lymphatic Leukemia) Knockout Mouse. 

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    Susumu Ikehara
    Professor
    Department of Stem Cell Disorders
    Kansai Medical University
    Japan
    ikehara@hirakata.kmu.ac.jp
    SSCRT

    Research Interest: Bone Marrow Transplantation, Immunology, Autoimmunity, Thymus and Bone Marrow Derived-Mesenchymal Stem Cells. His Cutting-Edge Technology for Bone Marrow Cell Harvesting and Intra-Bone Marrow-Bone Marrow Transplantation has Led to Significant Research Into Allogeneic Stem Cell Transplantation. 

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    Toru Hosoda
    Associate Professor
    Tokai University
    Japan
    thosoda@zeus.bwh.harvard.edu
    SSCRT

    Research Interest: Resident Cardiac Stem Cells, Myocardial Regeneration in Basic and Clinical/Translational Studies.

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    Ming Li
    Associate Professor
    Department of Stem Cell Disorders
    Kansai Medical University
    Japan
    lg6763@yahoo.co.jp
    SSCRT

    Research Interest: Focuses on Aging-Related Diseases and Stem Cell Transplantation. 

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    Jesus Vaquero
    Professor
    Department of Neurosurgery
    Autonomous University
    Spain
    jvaqueroc@telefonica.net
    SSCRT

    Research Interest: Neurological Disability.

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    Guillermo Estivill-Torrus
    Civil Hospital Research Laboratory
    Spain
    guillermo.estivill@ibima.eu
    SSCRT

    Research Interest: Neuropsychopharmacology of Lipid Transmitters (CTS643, Andalusian Ministry of Economy, Innovation, Science and Employment): The Group is Formed in the University Regional Hospital of Malaga, in Collaboration with the University of Malaga, and Integrated Into the Biomedical Research Institute of Malaga (IBIMA). Our Interest Focuses on the Role that Regulatory Lipid Molecules, Mainly Lysophosphatidic Acid, Exerted on the Central Nervous System and Related Mainly to the Neural Genesis (Neurogenesis / Gliogenesis) and its Effect on Behavioral Level. It Also Examines the Role of Lysophosphatidic Acid in the Dynamic Processes that Regulate Neuroinflammation and Demyelination in Multiple Sclerosis, Studying Animal Models and Samples from Patients with Multiple Sclerosis, As Well As Mesenchymal Cell Therapy for the Disease.

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    Monther Al-Alwan
    Stem Cell and Tissue Re-engineering Program
    King Faisal Specialist Hospital and Research Centre
    Saudi Arabia
    MAlwan@kfshrc.edu.sa
    SSCRT

    Dr. Monther AlAlwan is a scientist at the Stem Cell and Tissue Re-engineering Program (SCTRP), King Faisal Specialist Hospital and Research Centre, as well as an Associate professor at Alfaisal University, Riyadh Saudi Arabia. He holds M.Sc. and Ph.D. in Immunology from Dalhousie University (Halifax, Canada). Dr. AlAlwan conducted a 3-years postdoctoral fellowship studying signaling in immune cells at the University of Manitoba, Canada. During his graduate studies and postdoctoral fellowship, Dr. AlAlwan made substantial contribution in the immunology field, particularly his groundbreaking discovery that highlighted the significance of the dendritic cells in the immunological synapse. After joining the SCTRP in 2007, he shifted gear to study cancer, where he identified novel mechanisms that regulate cancer metastasis and chemoresistance. Currently, he is actively involved in dissecting the molecular pathways that regulate the function of cancer stem cells and how this related to chemoresistance and metastasis. Dr. AlAlwan is an author in 20 peer-reviewed publications, has delivered several invited lectures and is a regular reviewer for various international journals.   

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    Chih-long Chang
    Director
    Department of Obstetrics and Gynecology
    Mackay Memorial Hospital
    Taiwan
    clchang@mmc.edu.tw
    SSCRT

    Research Interest: Tumor Immunology and Immunotherapy, Cancer Stem Cell Biology and Immunology, Obstetrics and Gynecology.

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    Te-Chao Fang
    Department of Internal Medicine
    Taipei Medical University
    Taiwan
    fangtechao@yahoo.com.tw
    SSCRT

    Research Interest: Clinical Nephrology, Metabolic Syndrome, Hypertension, Inflammation

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    Carolina Panis
    Nacional Instituto do Cancer
    State University of Londrina
    Brazil
    carolpanis@sercomtel.com.br
    SSCRT

    Research Interest: Actually Works as Young Researcher in Projects Regarding Genomics, Proteomics and Inflammatory Aspects of Human Breast Cancer and Chronic Diseases. 

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    Milton Artur Ruiz
    VP South and Central America International Society for Cellular Therapy
    Brazil
    milruiz@yahoo.com.br
    SSCRT

    Research Interest: Hematopoietic Stem Cell Transplanting, Cell Therapy and Everything in the Field of Publication and Education.

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    Ricardo Alexandre Azevedo
    Professor
    Department of Immunology
    University of São Paulo
    Brazil
    ricardoaazevedo@hotmail.com
    SSCRT

    Ricardo Alaxandre de Azevedo, PhD, Graduated in Biological Science by the University ‘Santa Cecília’- Santos (Brazil) in 2002, MSc degree in Biotechology by the University of São Paulo (Brazil) in 2010, and Ph.D. in Toxinology by the Butantan Institute (Brazil) in 2014. Presently, Postdoctoral Fellow, Department Immunology, Laboratory of Tumor Immunology, University São Paulo, July 2014-current. Also occupy position of  Research Scientist, and Coordinator of Biological Assays Division at ALCHEMY, RESEARCH AND DEVELOPMENT, February-current.  I have experience and scientific production in the area of Apoptosis and cell cycle signaling, peptides and peptidases, molecular biology and cancer genetics, cells immunology, with emphasis on biochemotherapy and immunotherapy of cancer, focusing murine melanoma and human tumors. 

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    Xia Pu
    Department of Biochemistry and Molecular Biology
    China Medical University
    China
    nn001007@163.com
    SSCRT

    Research Interest: Cancer Stem Cell, such as Surface Marker, Biology, and Mechanism.

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    Hua Wang
    Department of Molecular Oral Medicine and Maxillofacial Surgery
    Sun Yat-sen University
    China
    wanghua9@mail.sysu.edu.cn
    SSCRT

    Research Interest: Stem Cells, Cancer, Immune Therapy, Regenerative Medicine.

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    Kequan Guo
    Department of Cardiac Surgery
    Beijing Anzhen Hospital
    China
    guokequan@hotmail.com
    SSCRT

    Research Interest: Guo Was Engaged in Research into the Induction of Transplant Tolerance Via Bone Marrow Transplantation under the Guidance of Prof. Susumu Ikehara.

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    Xiangxin Lou
    College of Chemistry, Chemical Engineering and Biotechnology
    Donghua University
    China
    xiangxin@dhu.edu.cn
    SSCRT

    Research Interest: Cell Reprogramming and Induced Pluripotent Stem Cells, Stem Cells and Neural Tissue Engineering, Mammalian Inner Ear Development and Hair Cell Regeneration.

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